diff --git a/.changeset/hot-poems-march.md b/.changeset/hot-poems-march.md
new file mode 100644
index 000000000000..e5133c58b7ff
--- /dev/null
+++ b/.changeset/hot-poems-march.md
@@ -0,0 +1,7 @@
+---
+"wrangler": patch
+---
+
+fix: Error if Workers + Assets are run in remote mode
+
+Workers + Assets are currently supported only in local mode. We should throw an error if users attempt to use Workers with assets in remote mode.
diff --git a/packages/wrangler/src/__tests__/dev.test.tsx b/packages/wrangler/src/__tests__/dev.test.tsx
index 88c4c8eec29b..d34e053b0bc7 100644
--- a/packages/wrangler/src/__tests__/dev.test.tsx
+++ b/packages/wrangler/src/__tests__/dev.test.tsx
@@ -345,7 +345,7 @@ describe("wrangler dev", () => {
 					directory: "assets",
 				},
 			});
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			await expect(runWrangler(`dev`)).rejects
 				.toThrowErrorMatchingInlineSnapshot(`
 				[Error: Invalid Routes:
@@ -1505,7 +1505,7 @@ describe("wrangler dev", () => {
 
 	describe("--experimental-assets", () => {
 		it("should not require entry point if using --experimental-assets", async () => {
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			writeWranglerToml({
 				experimental_assets: { directory: "assets" },
 			});
@@ -1522,7 +1522,7 @@ describe("wrangler dev", () => {
 				},
 			});
 			fs.writeFileSync("index.js", `export default {};`);
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			await expect(
 				runWrangler("dev")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1538,7 +1538,7 @@ describe("wrangler dev", () => {
 				},
 			});
 			fs.writeFileSync("index.js", `export default {};`);
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			await expect(
 				runWrangler("dev --experimental-assets assets")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1559,7 +1559,7 @@ describe("wrangler dev", () => {
 				},
 			});
 			fs.writeFileSync("index.js", `export default {};`);
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			await expect(
 				runWrangler("dev")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1569,7 +1569,7 @@ describe("wrangler dev", () => {
 
 		it("should error if --experimental-assets and --legacy-assets are used together", async () => {
 			fs.writeFileSync("index.js", `export default {};`);
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			await expect(
 				runWrangler("dev --experimental-assets assets --legacy-assets assets")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1589,7 +1589,7 @@ describe("wrangler dev", () => {
 				},
 			});
 			fs.writeFileSync("index.js", `export default {};`);
-			fs.openSync("assets", "w");
+			fs.mkdirSync("assets");
 			await expect(
 				runWrangler("dev --experimental-assets assets")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1605,7 +1605,7 @@ describe("wrangler dev", () => {
 				},
 			});
 			fs.writeFileSync("index.js", `export default {};`);
-			fs.openSync("xyz", "w");
+			fs.mkdirSync("xyz");
 			await expect(
 				runWrangler("dev --legacy-assets xyz")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1646,7 +1646,7 @@ describe("wrangler dev", () => {
 			writeWranglerToml({
 				tail_consumers: [{ service: "<TAIL_WORKER_NAME>" }],
 			});
-			fs.openSync("public", "w");
+			fs.mkdirSync("public");
 			await expect(
 				runWrangler("dev --experimental-assets public")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
@@ -1659,13 +1659,34 @@ describe("wrangler dev", () => {
 				experimental_assets: { directory: "./public" },
 				tail_consumers: [{ service: "<TAIL_WORKER_NAME>" }],
 			});
-			fs.openSync("public", "w");
+			fs.mkdirSync("public");
 			await expect(
 				runWrangler("dev")
 			).rejects.toThrowErrorMatchingInlineSnapshot(
 				`[Error: Cannot use Experimental Assets and tail consumers in the same Worker. Tail Workers are not yet supported for Workers with assets.]`
 			);
 		});
+
+		it("should error if --experimental-assets and --remote are used together", async () => {
+			fs.mkdirSync("public");
+			await expect(
+				runWrangler("dev --experimental-assets public --remote")
+			).rejects.toThrowErrorMatchingInlineSnapshot(
+				`[Error: Cannot use Experimental Assets in remote mode. Workers with assets are only supported in local mode. Please use \`wrangler dev\`.]`
+			);
+		});
+
+		it("should error if config.experimental_assets and --remote are used together", async () => {
+			writeWranglerToml({
+				experimental_assets: { directory: "./public" },
+			});
+			fs.mkdirSync("public");
+			await expect(
+				runWrangler("dev --remote")
+			).rejects.toThrowErrorMatchingInlineSnapshot(
+				`[Error: Cannot use Experimental Assets in remote mode. Workers with assets are only supported in local mode. Please use \`wrangler dev\`.]`
+			);
+		});
 	});
 
 	describe("--inspect", () => {
diff --git a/packages/wrangler/src/dev.tsx b/packages/wrangler/src/dev.tsx
index 9e971c5f54ce..36cc20e0ac65 100644
--- a/packages/wrangler/src/dev.tsx
+++ b/packages/wrangler/src/dev.tsx
@@ -612,6 +612,15 @@ export async function startDev(args: StartDevOptions) {
 			);
 		}
 
+		if (
+			(args.experimentalAssets || config.experimental_assets) &&
+			args.remote
+		) {
+			throw new UserError(
+				"Cannot use Experimental Assets in remote mode. Workers with assets are only supported in local mode. Please use `wrangler dev`."
+			);
+		}
+
 		verifyMutuallyExclusiveAssetsArgsOrConfig(args, config);
 
 		let experimentalAssetsOptions = processExperimentalAssetsArg(args, config);