diff --git a/system/CodeIgniter.php b/system/CodeIgniter.php
index a8ebeef1b5cf..1a5469213937 100644
--- a/system/CodeIgniter.php
+++ b/system/CodeIgniter.php
@@ -14,6 +14,7 @@
 use Closure;
 use CodeIgniter\Debug\Timer;
 use CodeIgniter\Events\Events;
+use CodeIgniter\Exceptions\CustomExceptionHandlerInterface;
 use CodeIgniter\Exceptions\FrameworkException;
 use CodeIgniter\Exceptions\PageNotFoundException;
 use CodeIgniter\HTTP\CLIRequest;
@@ -394,23 +395,27 @@ protected function handleRequest(?RouteCollectionInterface $routes, Cache $cache
             }
         }
 
-        $returned = $this->startController();
+        try {
+            $returned = $this->startController();
 
-        // Closure controller has run in startController().
-        if (! is_callable($this->controller)) {
-            $controller = $this->createController();
+            // Closure controller has run in startController().
+            if (! is_callable($this->controller)) {
+                $controller = $this->createController();
 
-            if (! method_exists($controller, '_remap') && ! is_callable([$controller, $this->method], false)) {
-                throw PageNotFoundException::forMethodNotFound($this->method);
-            }
+                if (! method_exists($controller, '_remap') && ! is_callable([$controller, $this->method], false)) {
+                    throw PageNotFoundException::forMethodNotFound($this->method);
+                }
 
-            // Is there a "post_controller_constructor" event?
-            Events::trigger('post_controller_constructor');
+                // Is there a "post_controller_constructor" event?
+                Events::trigger('post_controller_constructor');
 
-            $returned = $this->runController($controller);
-        } else {
-            $this->benchmark->stop('controller_constructor');
-            $this->benchmark->stop('controller');
+                $returned = $this->runController($controller);
+            } else {
+                $this->benchmark->stop('controller_constructor');
+                $this->benchmark->stop('controller');
+            }
+        } catch (CustomExceptionHandlerInterface $e) {
+            $returned = $e->renderResponse($this->request);
         }
 
         // If $returned is a string, then the controller output something,
diff --git a/system/Exceptions/CustomExceptionHandlerInterface.php b/system/Exceptions/CustomExceptionHandlerInterface.php
new file mode 100644
index 000000000000..50cbd9e8779a
--- /dev/null
+++ b/system/Exceptions/CustomExceptionHandlerInterface.php
@@ -0,0 +1,23 @@
+<?php
+
+/**
+ * This file is part of CodeIgniter 4 framework.
+ *
+ * (c) CodeIgniter Foundation <admin@codeigniter.com>
+ *
+ * For the full copyright and license information, please view
+ * the LICENSE file that was distributed with this source code.
+ */
+
+namespace CodeIgniter\Exceptions;
+
+use CodeIgniter\HTTP\RequestInterface;
+use CodeIgniter\HTTP\ResponseInterface;
+
+/**
+ * Interface for implementing a global custom exception handler
+ */
+interface CustomExceptionHandlerInterface
+{
+    public function renderResponse(RequestInterface $request): ResponseInterface;
+}
diff --git a/tests/_support/Controllers/Popcorn.php b/tests/_support/Controllers/Popcorn.php
index 71a316685a32..dd85c7cb7ef4 100644
--- a/tests/_support/Controllers/Popcorn.php
+++ b/tests/_support/Controllers/Popcorn.php
@@ -12,7 +12,12 @@
 namespace Tests\Support\Controllers;
 
 use CodeIgniter\API\ResponseTrait;
+use CodeIgniter\Config\Services;
 use CodeIgniter\Controller;
+use CodeIgniter\Exceptions\CustomExceptionHandlerInterface;
+use CodeIgniter\HTTP\RequestInterface;
+use CodeIgniter\HTTP\ResponseInterface;
+use Exception;
 use RuntimeException;
 
 /**
@@ -89,4 +94,16 @@ public function echoJson()
     {
         return $this->response->setJSON($this->request->getJSON());
     }
+
+    public function customException()
+    {
+        throw new class () extends Exception implements CustomExceptionHandlerInterface {
+            public function renderResponse(RequestInterface $request): ResponseInterface
+            {
+                return Services::response()
+                    ->setStatusCode(400)
+                    ->setBody('an exception thrown');
+            }
+        };
+    }
 }
diff --git a/tests/system/CodeIgniterTest.php b/tests/system/CodeIgniterTest.php
index f7838105af4d..833fd8773988 100644
--- a/tests/system/CodeIgniterTest.php
+++ b/tests/system/CodeIgniterTest.php
@@ -12,6 +12,7 @@
 namespace CodeIgniter;
 
 use CodeIgniter\Config\Services;
+use CodeIgniter\HTTP\ResponseInterface;
 use CodeIgniter\Router\RouteCollection;
 use CodeIgniter\Test\CIUnitTestCase;
 use CodeIgniter\Test\Mock\MockCodeIgniter;
@@ -425,4 +426,26 @@ public function testRunDefaultRoute()
 
         $this->assertStringContainsString('Welcome to CodeIgniter', $output);
     }
+
+    public function testCustomExceptionHandler()
+    {
+        $_SERVER['REQUEST_URI'] = '/exception';
+
+        // Inject mock router.
+        $routes = Services::routes(false);
+        $routes->add('exception', '\Tests\Support\Controllers\Popcorn::customException');
+
+        $router = Services::router($routes, Services::request(), false);
+        Services::injectMock('router', $router);
+
+        ob_start();
+        $this->codeigniter->useSafeOutput(true)->run();
+        ob_get_clean();
+
+        /** @var ResponseInterface $response */
+        $response = $this->getPrivateProperty($this->codeigniter, 'response');
+
+        $this->assertSame('an exception thrown', $response->getBody());
+        $this->assertSame(400, $response->getStatusCode());
+    }
 }
diff --git a/user_guide_src/source/general/errors.rst b/user_guide_src/source/general/errors.rst
index b7863b03010d..9abe5269c652 100644
--- a/user_guide_src/source/general/errors.rst
+++ b/user_guide_src/source/general/errors.rst
@@ -131,3 +131,33 @@ forcing a redirect to a specific route or URL::
 redirect code to use instead of the default (``302``, "temporary redirect")::
 
     throw new \CodeIgniter\Router\Exceptions\RedirectException($route, 301);
+
+
+Custom Exception Handler
+========================
+
+You can use your own exception handler which will be called globally.
+
+Your exception must implement ``\CodeIgniter\Exception\CustomExceptionHandlerInterface``::
+
+    namespace App\Exceptions;
+
+    use App\Config\Services;
+    use CodeIgniter\Exception\CustomExceptionHandlerInterface
+    use Exception;
+
+    class MyException extends Exception implements CustomExceptionHandlerInterface
+    {
+        public function renderResponse(RequestInterface $request): ResponseInterface
+        {
+            return Services::response()->setBody($this->getMessage());
+        }
+    }
+
+Now, if an exception is thrown in any part of the application, it will be handled.::
+
+    if (someCondition) {
+        throw new MyException('Something wrong')
+    }
+
+.. note:: Of course, if not caught by the try..catch block defined earlier.
\ No newline at end of file