diff --git a/CMake/ctkMacroWrapPythonQtModuleInit.cpp.in b/CMake/ctkMacroWrapPythonQtModuleInit.cpp.in
index c74b6665cd..8f2bc84cb1 100644
--- a/CMake/ctkMacroWrapPythonQtModuleInit.cpp.in
+++ b/CMake/ctkMacroWrapPythonQtModuleInit.cpp.in
@@ -3,6 +3,8 @@
 #include <PythonQt.h>
 #include <Python.h>
 
+#include <QCoreApplication>
+
 //-----------------------------------------------------------------------------
 static PyMethodDef Py@TARGET_CONFIG@PythonQt_ClassMethods[] = {
 {NULL, NULL, 0, NULL}};
@@ -52,6 +54,12 @@ void copyAttributes(PyObject* orig_module, PyObject* dest_module)
 //-----------------------------------------------------------------------------
 void init@TARGET_CONFIG@PythonQt()
 {
+
+  if (!QCoreApplication::instance())
+    {
+    PythonQt::init(PythonQt::PythonAlreadyInitialized);
+    }
+
   static const char modulename[] = "@TARGET_CONFIG@PythonQt";
   PyObject *m;