diff --git a/CMakeLists.txt b/CMakeLists.txt
index 2349303a..0d1deb31 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -11,6 +11,39 @@ cmake_minimum_required(VERSION 2.8)
 project(PythonQt)
 #-----------------------------------------------------------------------------
 
+#----------------------------------------------------------------------------
+# Qt version
+
+# Sanity checks
+if(DEFINED Qt5_DIR AND DEFINED QT_QMAKE_EXECUTABLE)
+  message(FATAL_ERROR
+    "${PROJECT_NAME} shoult NOT be configured setting both Qt5_DIR and QT_QMAKE_EXECUTABLE options.
+To build with Qt4, specify QT_QMAKE_EXECUTABLE. To build with Qt5, specify  Qt5_DIR.")
+endif()
+
+# Set PythonQt_QT_VERSION
+if(DEFINED Qt5_DIR)
+  message(STATUS "${PROJECT_NAME}: Setting PythonQt_QT_VERSION to 5 because Qt5_DIR is defined.")
+  set(PythonQt_QT_VERSION 5)
+elseif(DEFINED QT_QMAKE_EXECUTABLE)
+  message(STATUS "${PROJECT_NAME}: Setting PythonQt_QT_VERSION to 4 because QT_QMAKE_EXECUTABLE is defined.")
+  set(PythonQt_QT_VERSION 4)
+else()
+  set(PythonQt_QT_VERSION 4 CACHE STRING "Pick a version of Qt to use: 4 or 5")
+  # Set the possible values of Qt version for cmake-gui
+  set_property(CACHE PythonQt_QT_VERSION PROPERTY STRINGS "4" "5")
+endif()
+
+# Requirements
+set(minimum_required_qt5_version "5.3.0")
+set(minimum_required_qt4_version "4.6.2")
+set(minimum_required_qt_version ${minimum_required_qt${PythonQt_QT_VERSION}_version})
+
+# Qt components
+set(qt5libs Core Widgets Network OpenGL Sql Svg UiTools WebKitWidgets Xml XmlPatterns)
+set(qt4libs core gui network opengl sql svg uitools webkit xml xmlpatterns)
+set(qtlibs ${qt${PythonQt_QT_VERSION}libs})
+
 #-----------------------------------------------------------------------------
 # Python libraries
 
@@ -40,17 +73,41 @@ if(NOT DEFINED PythonQt_INSTALL_INCLUDE_DIR)
   set(PythonQt_INSTALL_INCLUDE_DIR include/PythonQt)
 endif()
 
+# Since the Qt bindings sources used for both Qt4 and Qt5 are
+# grouped using Qt4 naming convention, qt_wrapped_libs variables are the
+# same for the two Qt versions.
+set(qt4_wrapped_libs ${qt4libs})
+set(qt5_wrapped_libs ${qt4libs})
+set(qt_wrapped_libs ${qt${PythonQt_QT_VERSION}_wrapped_libs})
+
+set(qt5_wrapped_lib_depends_gui Multimedia)
+
+set(qtlib_to_wraplib_Widgets gui)
+set(qtlib_to_wraplib_WebKitWidgets webkit)
+
+# Define PythonQt_Wrap_Qt* options
 option(PythonQt_Wrap_QtAll "Make all Qt components available in python" OFF)
+foreach(qtlib ${qt_wrapped_libs})
+  OPTION(PythonQt_Wrap_Qt${qtlib} "Make all of Qt${qtlib} available in python" OFF)
+endforeach()
 
-set(qtlibs core gui network opengl sql svg uitools webkit xml xmlpatterns)
+# Set qtlib_to_wraplib_* variables
 foreach(qtlib ${qtlibs})
-  OPTION(PythonQt_Wrap_Qt${qtlib} "Make all of Qt${qtlib} available in python" OFF)
+  string(TOLOWER ${qtlib} qtlib_lowercase)
+  if(DEFINED qtlib_to_wraplib_${qtlib})
+    set(qtlib_lowercase ${qtlib_to_wraplib_${qtlib}})
+  endif()
+  set(qtlib_to_wraplib_${qtlib} ${qtlib_lowercase})
 endforeach()
 
 # Force option if it applies
 if(PythonQt_Wrap_QtAll)
-  list(REMOVE_ITEM qtlibs xmlpatterns) # xmlpatterns wrapper does *NOT* build at all :(
-  foreach(qtlib ${qtlibs})
+  set(_qt_wrapped_libs ${qt_wrapped_libs})
+
+  # XXX xmlpatterns wrapper does *NOT* build at all :(
+  list(REMOVE_ITEM _qt_wrapped_libs xmlpatterns)
+
+  foreach(qtlib ${_qt_wrapped_libs})
     if(NOT ${PythonQt_Wrap_Qt${qtlib}})
       set(PythonQt_Wrap_Qt${qtlib} ON CACHE BOOL "Make all of Qt${qtlib} available in python" FORCE)
       message(STATUS "Enabling [PythonQt_Wrap_Qt${qtlib}] because of [PythonQt_Wrap_QtAll] evaluates to True")
@@ -68,40 +125,86 @@ endif()
 #-----------------------------------------------------------------------------
 # Setup Qt
 
-set(minimum_required_qt_version "4.6.2")
+if(PythonQt_QT_VERSION VERSION_GREATER "4")
+
+  # Required components
+  set(qt_required_components Core Widgets)
+  foreach(qtlib ${qtlibs})
+    set(qt_wrapped_lib ${qtlib_to_wraplib_${qtlib}})
+    if(${PythonQt_Wrap_Qt${qt_wrapped_lib}})
+      list(APPEND qt_required_components ${qtlib} ${qt${PythonQt_QT_VERSION}_wrapped_lib_depends_${qt_wrapped_lib}})
+    endif()
+  endforeach()
+  if(BUILD_TESTING)
+    list(APPEND qt_required_components Test)
+  endif()
+  list(REMOVE_DUPLICATES qt_required_components)
 
-find_package(Qt4)
+  message(STATUS "${PROJECT_NAME}: Required Qt components [${qt_required_components}]")
+  find_package(Qt5 ${minimum_required_qt_version} COMPONENTS ${qt_required_components} REQUIRED)
 
-if(QT4_FOUND)
+  set(QT_LIBRARIES )
+  foreach(qtlib ${qt_required_components})
+    include_directories(${Qt5${qtlib}_INCLUDE_DIRS})
+    add_definitions(${Qt5${qtlib}_DEFINITIONS})
+    list(APPEND QT_LIBRARIES ${Qt5${qtlib}_LIBRARIES})
+  endforeach()
 
-  set(found_qt_version ${QT_VERSION_MAJOR}.${QT_VERSION_MINOR}.${QT_VERSION_PATCH})
+  set(QT_VERSION_MAJOR ${Qt5Core_VERSION_MAJOR})
+  set(QT_VERSION_MINOR ${Qt5Core_VERSION_MINOR})
 
-  if(${found_qt_version} VERSION_LESS ${minimum_required_qt_version})
-      message(FATAL_ERROR "error: PythonQt requires Qt >= ${minimum_required_qt_version} -- you cannot use Qt ${found_qt_version}.")
-  endif()
+  macro(pythonqt_wrap_cpp)
+    qt5_wrap_cpp(${ARGV})
+  endmacro()
 
-  # Enable required qt module
-  foreach(qtlib network opengl sql svg uitools webkit xml xmlpatterns)
-    string(TOUPPER ${qtlib} qtlib_uppercase)
-    if (NOT ${QT_QT${qtlib_uppercase}_FOUND})
-      message(FATAL_ERROR "QT_QT${qtlib_uppercase} *not* FOUND - Try to disable PythonQt_Wrap_Qt${qtlib}")
+else()
+
+  find_package(Qt4)
+
+  if(QT4_FOUND)
+
+    set(found_qt_version ${QT_VERSION_MAJOR}.${QT_VERSION_MINOR}.${QT_VERSION_PATCH})
+
+    if(${found_qt_version} VERSION_LESS ${minimum_required_qt_version})
+      message(FATAL_ERROR "error: PythonQt requires Qt >= ${minimum_required_qt_version} -- you cannot use Qt ${found_qt_version}.")
     endif()
-    set(QT_USE_QT${qtlib_uppercase} ${PythonQt_Wrap_Qt${qtlib}})
-  endforeach()
 
-  set(QT_USE_QTTEST ${BUILD_TESTING})
+    # Enable required qt module
+    foreach(qtlib ${qt_wrapped_libs})
+      string(TOUPPER ${qtlib} qtlib_uppercase)
+      if (NOT ${QT_QT${qtlib_uppercase}_FOUND})
+        message(FATAL_ERROR "QT_QT${qtlib_uppercase} *not* FOUND - Try to disable PythonQt_Wrap_Qt${qtlib}")
+      endif()
+      set(QT_USE_QT${qtlib_uppercase} ${PythonQt_Wrap_Qt${qtlib}})
+    endforeach()
+
+    # Enable QtTest in Qt4 is the option BUILD_TESTING was activated
+    set(QT_USE_QTTEST ${BUILD_TESTING})
+
+    include(${QT_USE_FILE})
+  else()
+    message(FATAL_ERROR "error: Qt4 was not found on your system. You probably need to set the QT_QMAKE_EXECUTABLE variable")
+  endif()
+
+  macro(pythonqt_wrap_cpp)
+    qt4_wrap_cpp(${ARGV})
+  endmacro()
 
-  include(${QT_USE_FILE})
-else()
-  message(FATAL_ERROR "error: Qt4 was not found on your system. You probably need to set the QT_QMAKE_EXECUTABLE variable")
 endif()
 
 #-----------------------------------------------------------------------------
 # The variable "generated_cpp_suffix" allows to conditionnally compile the generated wrappers
 # associated with the Qt version being used.
+
+set(generated_cpp_suffix_46 _47)
+set(generated_cpp_suffix_52 _50)
+set(generated_cpp_suffix_51 _50)
+
 set(generated_cpp_suffix "_${QT_VERSION_MAJOR}${QT_VERSION_MINOR}")
-if("${generated_cpp_suffix}" STREQUAL "_46")
-  set(generated_cpp_suffix "_47") # Also use 4.7 wrappers for 4.6.x version
+if(DEFINED generated_cpp_suffix_${QT_VERSION_MAJOR}${QT_VERSION_MINOR})
+  set(generated_cpp_suffix "${generated_cpp_suffix_${QT_VERSION_MAJOR}${QT_VERSION_MINOR}}")
+elseif(${QT_VERSION_MAJOR}.${QT_VERSION_MINOR} VERSION_GREATER "5.4")
+  set(generated_cpp_suffix "_54")
 endif()
 
 #-----------------------------------------------------------------------------
@@ -181,7 +284,7 @@ set(moc_sources
 
 #-----------------------------------------------------------------------------
 # Add extra sources
-foreach(qtlib core gui network opengl sql svg uitools webkit xml xmlpatterns)
+foreach(qtlib ${qt_wrapped_libs})
 
   if (${PythonQt_Wrap_Qt${qtlib}})
 
@@ -189,7 +292,7 @@ foreach(qtlib core gui network opengl sql svg uitools webkit xml xmlpatterns)
 
     set(file_prefix generated_cpp${generated_cpp_suffix}/com_trolltech_qt_${qtlib}/com_trolltech_qt_${qtlib})
 
-    foreach(index RANGE 0 11)
+    foreach(index RANGE 0 12)
 
       # Source files
       if(EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/${file_prefix}${index}.cpp)
@@ -208,19 +311,9 @@ foreach(qtlib core gui network opengl sql svg uitools webkit xml xmlpatterns)
   endif()
 endforeach()
 
-#-----------------------------------------------------------------------------
-# UI files
-set(ui_sources )
-
-#-----------------------------------------------------------------------------
-# Resources
-set(qrc_sources )
-
 #-----------------------------------------------------------------------------
 # Do wrapping
-qt4_wrap_cpp(gen_moc_sources ${moc_sources})
-qt4_wrap_ui(gen_ui_sources ${ui_sources})
-qt4_add_resources(gen_qrc_sources ${qrc_sources})
+pythonqt_wrap_cpp(gen_moc_sources ${moc_sources})
 
 #-----------------------------------------------------------------------------
 # Build the library
@@ -232,8 +325,6 @@ include_directories(
 add_library(PythonQt SHARED
             ${sources}
             ${gen_moc_sources}
-            ${gen_ui_sources}
-            ${gen_qrc_sources}
   )
 set_target_properties(PythonQt PROPERTIES DEFINE_SYMBOL PYTHONQT_EXPORTS)
 
@@ -270,12 +361,14 @@ if(BUILD_TESTING)
     tests/PythonQtTestMain.cpp
     )
 
+  set_property(SOURCE tests/PythonQtTestMain.cpp PROPERTY COMPILE_DEFINITIONS "main=tests_PythonQtTestMain")
+
   list(APPEND test_sources
     tests/PythonQtTests.cpp
     tests/PythonQtTests.h
     )
 
-  QT4_WRAP_CPP(test_sources
+  pythonqt_wrap_cpp(test_sources
     tests/PythonQtTests.h
     )
 
@@ -286,12 +379,12 @@ if(BUILD_TESTING)
       tests/PythonQtTestCleanup.cpp
       tests/PythonQtTestCleanup.h
       )
-    QT4_WRAP_CPP(test_sources
+    pythonqt_wrap_cpp(test_sources
       tests/PythonQtTestCleanup.h
       )
-  endif()
 
-  set_property(SOURCE tests/PythonQtTestMain.cpp PROPERTY COMPILE_DEFINITIONS "main=tests_PythonQtTestMain")
+    set_property(SOURCE tests/PythonQtTestMain.cpp APPEND PROPERTY COMPILE_DEFINITIONS "PythonQt_Wrap_Qtcore")
+  endif()
 
   add_executable(PythonQtCppTests ${test_sources})
   target_link_libraries(PythonQtCppTests PythonQt)
diff --git a/generated_cpp_50/PythonQt_QtBindings.cpp b/generated_cpp_50/PythonQt_QtBindings.cpp
new file mode 100644
index 00000000..7ae1630a
--- /dev/null
+++ b/generated_cpp_50/PythonQt_QtBindings.cpp
@@ -0,0 +1,58 @@
+
+#include "PythonQt_QtBindings.h"
+
+#include "PythonQt.h"
+
+void PythonQt_init_QtGui(PyObject*);
+void PythonQt_init_QtSvg(PyObject*);
+void PythonQt_init_QtSql(PyObject*);
+void PythonQt_init_QtNetwork(PyObject*);
+void PythonQt_init_QtCore(PyObject*);
+void PythonQt_init_QtWebKit(PyObject*);
+void PythonQt_init_QtOpenGL(PyObject*);
+void PythonQt_init_QtXml(PyObject*);
+void PythonQt_init_QtXmlPatterns(PyObject*);
+void PythonQt_init_QtUiTools(PyObject*);
+
+PYTHONQT_EXPORT void PythonQt_init_QtBindings()
+  {
+  #ifdef PYTHONQT_WRAP_Qtcore
+  PythonQt_init_QtCore(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtgui
+  PythonQt_init_QtGui(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtnetwork
+  PythonQt_init_QtNetwork(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtopengl
+  PythonQt_init_QtOpenGL(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsql
+  PythonQt_init_QtSql(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsvg
+  PythonQt_init_QtSvg(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtuitools
+  PythonQt_init_QtUiTools(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtwebkit
+  PythonQt_init_QtWebKit(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxml
+  PythonQt_init_QtXml(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxmlpatterns
+  PythonQt_init_QtXmlPatterns(0);
+  #endif
+  };
diff --git a/generated_cpp_50/PythonQt_QtBindings.h b/generated_cpp_50/PythonQt_QtBindings.h
new file mode 100644
index 00000000..03e96aed
--- /dev/null
+++ b/generated_cpp_50/PythonQt_QtBindings.h
@@ -0,0 +1,10 @@
+#ifndef _PYTHONQT_QTBINDINGS_H
+#define _PYTHONQT_QTBINDINGS_H
+
+#include "PythonQtSystem.h"
+
+/// Initialize Qt bindings enabled at configuration time
+PYTHONQT_EXPORT void PythonQt_init_QtBindings();
+
+#endif
+
diff --git a/generated_cpp_53/PythonQt_QtBindings.cpp b/generated_cpp_53/PythonQt_QtBindings.cpp
new file mode 100644
index 00000000..7ae1630a
--- /dev/null
+++ b/generated_cpp_53/PythonQt_QtBindings.cpp
@@ -0,0 +1,58 @@
+
+#include "PythonQt_QtBindings.h"
+
+#include "PythonQt.h"
+
+void PythonQt_init_QtGui(PyObject*);
+void PythonQt_init_QtSvg(PyObject*);
+void PythonQt_init_QtSql(PyObject*);
+void PythonQt_init_QtNetwork(PyObject*);
+void PythonQt_init_QtCore(PyObject*);
+void PythonQt_init_QtWebKit(PyObject*);
+void PythonQt_init_QtOpenGL(PyObject*);
+void PythonQt_init_QtXml(PyObject*);
+void PythonQt_init_QtXmlPatterns(PyObject*);
+void PythonQt_init_QtUiTools(PyObject*);
+
+PYTHONQT_EXPORT void PythonQt_init_QtBindings()
+  {
+  #ifdef PYTHONQT_WRAP_Qtcore
+  PythonQt_init_QtCore(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtgui
+  PythonQt_init_QtGui(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtnetwork
+  PythonQt_init_QtNetwork(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtopengl
+  PythonQt_init_QtOpenGL(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsql
+  PythonQt_init_QtSql(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsvg
+  PythonQt_init_QtSvg(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtuitools
+  PythonQt_init_QtUiTools(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtwebkit
+  PythonQt_init_QtWebKit(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxml
+  PythonQt_init_QtXml(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxmlpatterns
+  PythonQt_init_QtXmlPatterns(0);
+  #endif
+  };
diff --git a/generated_cpp_53/PythonQt_QtBindings.h b/generated_cpp_53/PythonQt_QtBindings.h
new file mode 100644
index 00000000..03e96aed
--- /dev/null
+++ b/generated_cpp_53/PythonQt_QtBindings.h
@@ -0,0 +1,10 @@
+#ifndef _PYTHONQT_QTBINDINGS_H
+#define _PYTHONQT_QTBINDINGS_H
+
+#include "PythonQtSystem.h"
+
+/// Initialize Qt bindings enabled at configuration time
+PYTHONQT_EXPORT void PythonQt_init_QtBindings();
+
+#endif
+
diff --git a/generated_cpp_54/PythonQt_QtBindings.cpp b/generated_cpp_54/PythonQt_QtBindings.cpp
new file mode 100644
index 00000000..7ae1630a
--- /dev/null
+++ b/generated_cpp_54/PythonQt_QtBindings.cpp
@@ -0,0 +1,58 @@
+
+#include "PythonQt_QtBindings.h"
+
+#include "PythonQt.h"
+
+void PythonQt_init_QtGui(PyObject*);
+void PythonQt_init_QtSvg(PyObject*);
+void PythonQt_init_QtSql(PyObject*);
+void PythonQt_init_QtNetwork(PyObject*);
+void PythonQt_init_QtCore(PyObject*);
+void PythonQt_init_QtWebKit(PyObject*);
+void PythonQt_init_QtOpenGL(PyObject*);
+void PythonQt_init_QtXml(PyObject*);
+void PythonQt_init_QtXmlPatterns(PyObject*);
+void PythonQt_init_QtUiTools(PyObject*);
+
+PYTHONQT_EXPORT void PythonQt_init_QtBindings()
+  {
+  #ifdef PYTHONQT_WRAP_Qtcore
+  PythonQt_init_QtCore(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtgui
+  PythonQt_init_QtGui(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtnetwork
+  PythonQt_init_QtNetwork(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtopengl
+  PythonQt_init_QtOpenGL(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsql
+  PythonQt_init_QtSql(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtsvg
+  PythonQt_init_QtSvg(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtuitools
+  PythonQt_init_QtUiTools(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtwebkit
+  PythonQt_init_QtWebKit(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxml
+  PythonQt_init_QtXml(0);
+  #endif
+
+  #ifdef PYTHONQT_WRAP_Qtxmlpatterns
+  PythonQt_init_QtXmlPatterns(0);
+  #endif
+  };
diff --git a/generated_cpp_54/PythonQt_QtBindings.h b/generated_cpp_54/PythonQt_QtBindings.h
new file mode 100644
index 00000000..03e96aed
--- /dev/null
+++ b/generated_cpp_54/PythonQt_QtBindings.h
@@ -0,0 +1,10 @@
+#ifndef _PYTHONQT_QTBINDINGS_H
+#define _PYTHONQT_QTBINDINGS_H
+
+#include "PythonQtSystem.h"
+
+/// Initialize Qt bindings enabled at configuration time
+PYTHONQT_EXPORT void PythonQt_init_QtBindings();
+
+#endif
+
diff --git a/tests/PythonQtTestMain.cpp b/tests/PythonQtTestMain.cpp
index ac3a37d8..8b498ab4 100644
--- a/tests/PythonQtTestMain.cpp
+++ b/tests/PythonQtTestMain.cpp
@@ -65,6 +65,7 @@ int main(int argc, char *argv[])
     Py_Finalize();
   }
 
+#ifdef PythonQt_Wrap_Qtcore
   PythonQtTestCleanup cleanup;
   failCount += QTest::qExec(&cleanup, argc, argv);
 
@@ -73,6 +74,8 @@ int main(int argc, char *argv[])
   } else {
     std::cout << "All tests passed successfully." << std::endl;
   }
+#endif
+
   return failCount;
 }