diff --git a/recipes/opencv/4.x/conandata.yml b/recipes/opencv/4.x/conandata.yml
index 867bde99de61c..523e50b3b56b9 100644
--- a/recipes/opencv/4.x/conandata.yml
+++ b/recipes/opencv/4.x/conandata.yml
@@ -27,6 +27,9 @@ patches:
     - patch_file: "patches/4.5.5-0003-find-quirc.patch"
       patch_description: "Robust discovery & injection of quirc"
       patch_type: "conan"
+    - patch_file: "patches/4.8.1-0004-link-qt-targets.patch"
+      patch_description: "Link to Qt through CMake targets"
+      patch_type: "conan"
     - patch_file: "patches/4.8.1-0001-find-ade.patch"
       patch_description: "Robust discovery & injection of ade"
       patch_type: "conan"
diff --git a/recipes/opencv/4.x/conanfile.py b/recipes/opencv/4.x/conanfile.py
index 31a4382eaa728..2c4952f422304 100644
--- a/recipes/opencv/4.x/conanfile.py
+++ b/recipes/opencv/4.x/conanfile.py
@@ -1101,21 +1101,21 @@ def requirements(self):
         if self.options.get_safe("with_gtk"):
             self.requires("gtk/system")
         if self.options.get_safe("with_qt"):
-            self.requires("qt/5.15.11")
+            self.requires("qt/5.15.12")
         if self.options.get_safe("with_wayland"):
             self.requires("xkbcommon/1.6.0")
             self.requires("wayland/1.22.0")
         # imgcodecs module dependencies
         if self.options.get_safe("with_avif"):
-            self.requires("libavif/1.0.1")
+            self.requires("libavif/1.0.2")
         if self.options.get_safe("with_jpeg") == "libjpeg":
             self.requires("libjpeg/9e")
         elif self.options.get_safe("with_jpeg") == "libjpeg-turbo":
-            self.requires("libjpeg-turbo/3.0.0")
+            self.requires("libjpeg-turbo/3.0.1")
         elif self.options.get_safe("with_jpeg") == "mozjpeg":
-            self.requires("mozjpeg/4.1.3")
+            self.requires("mozjpeg/4.1.5")
         if self.options.get_safe("with_jpeg2000") == "jasper":
-            self.requires("jasper/4.0.0")
+            self.requires("jasper/4.1.0")
         elif self.options.get_safe("with_jpeg2000") == "openjpeg":
             self.requires("openjpeg/2.5.0")
         if self.options.get_safe("with_png"):
@@ -1139,11 +1139,11 @@ def requirements(self):
             self.requires("ffmpeg/4.4.4")
         # freetype module dependencies
         if self.options.freetype:
-            self.requires("freetype/2.13.0")
-            self.requires("harfbuzz/8.2.2")
+            self.requires("freetype/2.13.2")
+            self.requires("harfbuzz/8.3.0")
         # hdf module dependencies
         if self.options.hdf:
-            self.requires("hdf5/1.14.2")
+            self.requires("hdf5/1.14.3")
         # ovis module dependencies
         if self.options.ovis:
             self.requires("ogre/1.10.2")
@@ -1210,11 +1210,11 @@ def build_requirements(self):
             if not self._is_legacy_one_profile:
                 self.tool_requires("protobuf/<host_version>")
         if self.options.get_safe("with_wayland"):
-            self.tool_requires("wayland-protocols/1.31")
+            self.tool_requires("wayland-protocols/1.32")
             if not self._is_legacy_one_profile:
                 self.tool_requires("wayland/<host_version>")
             if not self.conf.get("tools.gnu:pkg_config", check_type=str):
-                self.tool_requires("pkgconf/2.0.3")
+                self.tool_requires("pkgconf/2.1.0")
 
     def source(self):
         get(self, **self.conan_data["sources"][self.version][0], strip_root=True)
@@ -1290,10 +1290,7 @@ def _patch_sources(self):
                 )
 
         ## Cleanup RPATH
-        if Version(self.version) < "4.1.2":
-            install_layout_file = os.path.join(self.source_folder, "CMakeLists.txt")
-        else:
-            install_layout_file = os.path.join(self.source_folder, "cmake", "OpenCVInstallLayout.cmake")
+        install_layout_file = os.path.join(self.source_folder, "cmake", "OpenCVInstallLayout.cmake")
         replace_in_file(self, install_layout_file,
                               "ocv_update(CMAKE_INSTALL_RPATH \"${CMAKE_INSTALL_PREFIX}/${OPENCV_LIB_INSTALL_PATH}\")",
                               "")
diff --git a/recipes/opencv/4.x/patches/4.8.1-0004-link-qt-targets.patch b/recipes/opencv/4.x/patches/4.8.1-0004-link-qt-targets.patch
new file mode 100644
index 0000000000000..d4ceb77155293
--- /dev/null
+++ b/recipes/opencv/4.x/patches/4.8.1-0004-link-qt-targets.patch
@@ -0,0 +1,22 @@
+--- a/contrib/modules/cvv/CMakeLists.txt
++++ b/contrib/modules/cvv/CMakeLists.txt
+@@ -18,7 +18,7 @@
+ set(CMAKE_AUTOMOC ON)
+ set(CMAKE_INCLUDE_CURRENT_DIR ON)
+ foreach(module ${CVV_QT_MODULES})
+-  list(APPEND CVV_LIBRARIES ${Qt${QT_VERSION_MAJOR}${module}_LIBRARIES})
++  list(APPEND CVV_LIBRARIES Qt${QT_VERSION_MAJOR}::${module})
+ endforeach()
+ 
+ ocv_glob_module_sources()
+--- a/modules/highgui/CMakeLists.txt
++++ b/modules/highgui/CMakeLists.txt
+@@ -116,7 +116,7 @@ if(HAVE_QT)
+     foreach(dt_dep ${qt_deps})
+       add_definitions(${Qt${QT_VERSION_MAJOR}${dt_dep}_DEFINITIONS})
+       include_directories(${Qt${QT_VERSION_MAJOR}${dt_dep}_INCLUDE_DIRS})
+-      list(APPEND HIGHGUI_LIBRARIES ${Qt${QT_VERSION_MAJOR}${dt_dep}_LIBRARIES})
++      list(APPEND HIGHGUI_LIBRARIES Qt${QT_VERSION_MAJOR}::${dt_dep})
+     endforeach()
+   else()
+     ocv_assert(QT_VERSION_MAJOR EQUAL 4)