diff --git a/CHANGELOG.md b/CHANGELOG.md
index cb8800c858a..aa34da715c0 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -70,6 +70,7 @@ Ref: https://keepachangelog.com/en/1.0.0/
 
 ### State Machine Breaking
 
+* (27-interchain-accounts) [\#2580](https://github.com/cosmos/ibc-go/issues/2580) Removing port prefix requirement from the ICA host channel handshake
 * (transfer) [\#2377](https://github.com/cosmos/ibc-go/pull/2377) Adding `sequence` to `MsgTransferResponse`.
 * (light-clients/07-tendermint) [\#2554](https://github.com/cosmos/ibc-go/pull/2554) Forbid negative values for `TrustingPeriod`, `UnbondingPeriod` and `MaxClockDrift` (as specified in ICS-07).
 
diff --git a/modules/apps/27-interchain-accounts/host/keeper/handshake.go b/modules/apps/27-interchain-accounts/host/keeper/handshake.go
index c4f2b6c4547..e1c5ec7a6cc 100644
--- a/modules/apps/27-interchain-accounts/host/keeper/handshake.go
+++ b/modules/apps/27-interchain-accounts/host/keeper/handshake.go
@@ -2,7 +2,6 @@ package keeper
 
 import (
 	"fmt"
-	"strings"
 
 	sdk "github.com/cosmos/cosmos-sdk/types"
 	sdkerrors "github.com/cosmos/cosmos-sdk/types/errors"
@@ -35,10 +34,6 @@ func (k Keeper) OnChanOpenTry(
 		return "", sdkerrors.Wrapf(icatypes.ErrInvalidHostPort, "expected %s, got %s", icatypes.HostPortID, portID)
 	}
 
-	if !strings.HasPrefix(counterparty.PortId, icatypes.ControllerPortPrefix) {
-		return "", sdkerrors.Wrapf(icatypes.ErrInvalidControllerPort, "expected %s{owner-account-address}, got %s", icatypes.ControllerPortPrefix, counterparty.PortId)
-	}
-
 	var metadata icatypes.Metadata
 	if err := icatypes.ModuleCdc.UnmarshalJSON([]byte(counterpartyVersion), &metadata); err != nil {
 		return "", sdkerrors.Wrapf(icatypes.ErrUnknownDataType, "cannot unmarshal ICS-27 interchain accounts metadata")
diff --git a/modules/apps/27-interchain-accounts/host/keeper/handshake_test.go b/modules/apps/27-interchain-accounts/host/keeper/handshake_test.go
index a473bcd8cf3..1aa18e20933 100644
--- a/modules/apps/27-interchain-accounts/host/keeper/handshake_test.go
+++ b/modules/apps/27-interchain-accounts/host/keeper/handshake_test.go
@@ -171,13 +171,6 @@ func (suite *KeeperTestSuite) TestOnChanOpenTry() {
 			},
 			false,
 		},
-		{
-			"invalid counterparty port ID",
-			func() {
-				channel.Counterparty.PortId = "invalid-port-id"
-			},
-			false,
-		},
 		{
 			"connection not found",
 			func() {