diff --git a/.github/workflows/mkosi.yml b/.github/workflows/mkosi.yml
index 9488e5ed2e18f..c990a6acf0ed4 100644
--- a/.github/workflows/mkosi.yml
+++ b/.github/workflows/mkosi.yml
@@ -117,14 +117,12 @@ jobs:
                 WITH_DEBUG=1
                 # Enabling optimizations significantly speeds up integration tests.
                 OPTIMIZATION=g
-                SANITIZERS=address,undefined
 
         [Host]
         ToolsTree=default
         ToolsTreeDistribution=fedora
         # TODO: Drop once https://bugs.launchpad.net/ubuntu/+source/linux/+bug/2038777 is fixed in Github Actions
         QemuFirmware=uefi
-        QemuMem=4G
         # We build with debuginfo so there's no point in mounting the sources into the machine.
         RuntimeBuildSources=no
         EOF
diff --git a/mkosi.conf b/mkosi.conf
index 8ad0cb0d0f062..2da8804a7ef05 100644
--- a/mkosi.conf
+++ b/mkosi.conf
@@ -10,9 +10,13 @@ MinimumVersion=23~devel
 @CacheDirectory=build/mkosi.cache
 
 [Content]
-# The kernel versions in CentOS Stream 9 and Ubuntu 22.04 don't support orphan_file, but later
-# versions of mkfs.ext4 enabled it by default, so we disable it explicitly.
-Environment=SYSTEMD_REPART_MKFS_OPTIONS_EXT4="-O ^orphan_file"
+# Prevent ASAN warnings when building the image and ship the real ASAN options prefixed with MKOSI_.
+Environment=ASAN_OPTIONS=verify_asan_link_order=false
+            MKOSI_ASAN_OPTIONS=strict_string_checks=1:detect_stack_use_after_return=1:check_initialization_order=1:strict_init_order=1:disable_coredump=0:use_madv_dontdump=1
+            MKOSI_UBSAN_OPTIONS=print_stacktrace=1:print_summary=1:halt_on_error=1
+            # The kernel versions in CentOS Stream 9 and Ubuntu 22.04 don't support orphan_file, but later
+            # versions of mkfs.ext4 enabled it by default, so we disable it explicitly.
+            SYSTEMD_REPART_MKFS_OPTIONS_EXT4="-O ^orphan_file"
 @SELinuxRelabel=no
 BuildSourcesEphemeral=yes
 
diff --git a/mkosi.conf.d/20-sanitizers.conf b/mkosi.conf.d/20-sanitizers.conf
deleted file mode 100644
index 235b233e1ad0e..0000000000000
--- a/mkosi.conf.d/20-sanitizers.conf
+++ /dev/null
@@ -1,19 +0,0 @@
-# SPDX-License-Identifier: LGPL-2.1-or-later
-
-[Match]
-Environment=SANITIZERS
-
-[Content]
-# Set verify_asan_link_order=0 to prevent ASAN warnings when building the image and make sure the real ASAN
-# options are set when booting the image.
-# Set intercept_tls_get_addr=0 to work around leak sanitizer segmentation fault in test-dlopen-so on CentOS
-# Stream 9.
-# TODO: Drop intercept_tls_get_addr=0 when we remove CentOS Stream 9 builds.
-Environment=ASAN_OPTIONS=verify_asan_link_order=0:intercept_tls_get_addr=0
-KernelCommandLine=
-        ASAN_OPTIONS=strict_string_checks=1:detect_stack_use_after_return=1:check_initialization_order=1:strict_init_order=1:disable_coredump=0:use_madv_dontdump=1
-        systemd.setenv=ASAN_OPTIONS=strict_string_checks=1:detect_stack_use_after_return=1:check_initialization_order=1:strict_init_order=1:disable_coredump=0:use_madv_dontdump=1
-        UBSAN_OPTIONS=print_stacktrace=1:print_summary=1:halt_on_error=1
-        systemd.setenv=UBSAN_OPTIONS=print_stacktrace=1:print_summary=1:halt_on_error=1
-        LSAN_OPTIONS=suppressions=/usr/lib/systemd/leak-sanitizer-suppressions
-        systemd.setenv=LSAN_OPTIONS=suppressions=/usr/lib/systemd/leak-sanitizer-suppressions
diff --git a/mkosi.images/exitrd/mkosi.conf.d/10-arch.conf b/mkosi.images/exitrd/mkosi.conf.d/10-arch.conf
index c8b1904f6f432..25d20887ffa39 100644
--- a/mkosi.images/exitrd/mkosi.conf.d/10-arch.conf
+++ b/mkosi.images/exitrd/mkosi.conf.d/10-arch.conf
@@ -15,6 +15,11 @@ RemoveFiles=
         /usr/lib/libgomp.so*
         /usr/lib/libgphobos.so*
         /usr/lib/libobjc.so*
+        /usr/lib/libasan.so*
+        /usr/lib/libtsan.so*
+        /usr/lib/liblsan.so*
+        /usr/lib/libubsan.so*
+        /usr/lib/libstdc++.so*
         /usr/lib/libgdruntime.so*
 
         # Remove all files that are only required for development.
diff --git a/mkosi.images/minimal-base/mkosi.conf.d/10-arch.conf b/mkosi.images/minimal-base/mkosi.conf.d/10-arch.conf
index 9b033975d64c2..30e8fda59e013 100644
--- a/mkosi.images/minimal-base/mkosi.conf.d/10-arch.conf
+++ b/mkosi.images/minimal-base/mkosi.conf.d/10-arch.conf
@@ -17,6 +17,11 @@ RemoveFiles=
         /usr/lib/libgomp.so*
         /usr/lib/libgphobos.so*
         /usr/lib/libobjc.so*
+        /usr/lib/libasan.so*
+        /usr/lib/libtsan.so*
+        /usr/lib/liblsan.so*
+        /usr/lib/libubsan.so*
+        /usr/lib/libstdc++.so*
         /usr/lib/libgdruntime.so*
 
         # Remove all files that are only required for development.
diff --git a/mkosi.images/system/initrd/mkosi.conf b/mkosi.images/system/initrd/mkosi.conf
deleted file mode 100644
index c54d1a24ee8a7..0000000000000
--- a/mkosi.images/system/initrd/mkosi.conf
+++ /dev/null
@@ -1,4 +0,0 @@
-# SPDX-License-Identifier: LGPL-2.1-or-later
-
-[Content]
-PostInstallationScripts=../mkosi.sanitizers.chroot
diff --git a/mkosi.images/system/mkosi.conf b/mkosi.images/system/mkosi.conf
index 1c2e0c553be3a..f543b6410f345 100644
--- a/mkosi.images/system/mkosi.conf
+++ b/mkosi.images/system/mkosi.conf
@@ -27,13 +27,6 @@ ExtraTrees=
         %O/minimal-base:/usr/share/TEST-13-NSPAWN-container-template
         %O/exitrd:/exitrd
 
-PostInstallationScripts=mkosi.sanitizers.chroot
-
-InitrdPackages=
-        findutils
-        grep
-        sed
-
 Packages=
         acl
         attr
diff --git a/mkosi.images/system/mkosi.conf.d/10-opensuse/mkosi.build.chroot b/mkosi.images/system/mkosi.conf.d/10-opensuse/mkosi.build.chroot
index 4e8f982176c5b..8b6fc7ab13ced 100755
--- a/mkosi.images/system/mkosi.conf.d/10-opensuse/mkosi.build.chroot
+++ b/mkosi.images/system/mkosi.conf.d/10-opensuse/mkosi.build.chroot
@@ -49,8 +49,6 @@ build() {
     IFS=
     # TODO: Replace meson_build and meson_install overrides with "--undefine __meson_verbose" once
     # https://github.com/mesonbuild/meson/pull/12835 is available.
-    # TODO: Replace __meson_auto_features override with meson_extra_configure_options once the suse spec
-    # starts to use it.
     # shellcheck disable=SC2046
     rpmbuild \
         -bb \
@@ -71,7 +69,7 @@ build() {
         --define "build_cflags $(rpm --eval %build_cflags) $EXTRA_CFLAGS" \
         --define "meson_build %{shrink:%{__meson} compile -C %{_vpath_builddir} -j %{_smp_build_ncpus} %{nil}}" \
         --define "meson_install %{shrink:DESTDIR=%{buildroot} %{__meson} install -C %{_vpath_builddir} --no-rebuild --quiet %{nil}}" \
-        --define "__meson_auto_features auto -D mode=developer -D b_sanitize=${SANITIZERS:-none}" \
+        --define "meson_extra_configure_options -D mode=developer -D b_sanitize=${SANITIZERS:-none}" \
         --define "__os_install_post /usr/lib/rpm/brp-suse %{nil}" \
         --define "__elf_exclude_path ^/usr/lib/systemd/tests/unit-tests/.*$" \
         --define "__script_requires %{nil}" \
diff --git a/mkosi.images/system/mkosi.extra/usr/lib/systemd/leak-sanitizer-suppressions b/mkosi.images/system/mkosi.extra/usr/lib/systemd/leak-sanitizer-suppressions
deleted file mode 100644
index 639abb8f3f9f4..0000000000000
--- a/mkosi.images/system/mkosi.extra/usr/lib/systemd/leak-sanitizer-suppressions
+++ /dev/null
@@ -1 +0,0 @@
-leak:libselinux
diff --git a/mkosi.images/system/mkosi.extra/usr/lib/systemd/system/iscsi-init.service.d/asan.conf b/mkosi.images/system/mkosi.extra/usr/lib/systemd/system/iscsi-init.service.d/asan.conf
deleted file mode 100644
index ebf7899a789ff..0000000000000
--- a/mkosi.images/system/mkosi.extra/usr/lib/systemd/system/iscsi-init.service.d/asan.conf
+++ /dev/null
@@ -1,7 +0,0 @@
-# SPDX-License-Identifier: LGPL-2.1-or-later
-
-# The iscsi-init.service calls `sh` which might, in certain circumstances, pull in instrumented systemd NSS
-# modules causing `sh` to fail. Avoid the issue by setting LD_PRELOAD to load the sanitizer libraries if
-# needed.
-[Service]
-EnvironmentFile=-/usr/lib/systemd/systemd-asan-env
diff --git a/mkosi.images/system/mkosi.postinst.chroot b/mkosi.images/system/mkosi.postinst.chroot
index 397884b72027d..15f268a20aea9 100755
--- a/mkosi.images/system/mkosi.postinst.chroot
+++ b/mkosi.images/system/mkosi.postinst.chroot
@@ -2,6 +2,48 @@
 # SPDX-License-Identifier: LGPL-2.1-or-later
 set -e
 
+if [ -n "$SANITIZERS" ]; then
+    LD_PRELOAD=$(ldd /usr/lib/systemd/systemd | grep libasan.so | awk '{print $3}')
+
+    mkdir -p /etc/systemd/system.conf.d
+
+    cat >/etc/systemd/system.conf.d/10-asan.conf <<EOF
+[Manager]
+ManagerEnvironment=ASAN_OPTIONS=$MKOSI_ASAN_OPTIONS\\
+                   UBSAN_OPTIONS=$MKOSI_UBSAN_OPTIONS\\
+                   LD_PRELOAD=$LD_PRELOAD
+DefaultEnvironment=ASAN_OPTIONS=$MKOSI_ASAN_OPTIONS\\
+                   UBSAN_OPTIONS=$MKOSI_UBSAN_OPTIONS\\
+                   LD_PRELOAD=$LD_PRELOAD
+EOF
+
+    # ASAN logs to stderr by default. However, journald's stderr is connected to /dev/null, so we lose
+    # all the ASAN logs. To rectify that, let's connect journald's stdout to the console so that any
+    # sanitizer failures appear directly on the user's console.
+    mkdir -p /etc/systemd/system/systemd-journald.service.d
+    cat >/etc/systemd/system/systemd-journald.service.d/10-stdout-tty.conf <<EOF
+[Service]
+StandardOutput=tty
+EOF
+
+    # Both systemd and util-linux's login call vhangup() on /dev/console which disconnects all users.
+    # This means systemd-journald can't log to /dev/console even if we configure `StandardOutput=tty`. As
+    # a workaround, we modify console-getty.service to disable systemd's vhangup() and disallow login
+    # from calling vhangup() so that journald's ASAN logs correctly end up in the console.
+
+    mkdir -p /etc/systemd/system/console-getty.service.d
+    cat >/etc/systemd/system/console-getty.service.d/10-no-vhangup.conf <<EOF
+[Service]
+TTYVHangup=no
+CapabilityBoundingSet=~CAP_SYS_TTY_CONFIG
+EOF
+    # ASAN and syscall filters aren't compatible with each other.
+    find /usr /etc -name '*.service' -type f -exec sed -i 's/^\(MemoryDeny\|SystemCall\)/# \1/' {} +
+
+    # `systemd-hwdb update` takes > 50s when built with sanitizers so let's not run it by default.
+    systemctl mask systemd-hwdb-update.service
+fi
+
 if command -v authselect >/dev/null; then
     # authselect 1.5.0 renamed the minimal profile to the local profile without keeping backwards compat so
     # let's use the new name if it exists.
diff --git a/mkosi.images/system/mkosi.sanitizers.chroot b/mkosi.images/system/mkosi.sanitizers.chroot
deleted file mode 100755
index 48c5d147aa598..0000000000000
--- a/mkosi.images/system/mkosi.sanitizers.chroot
+++ /dev/null
@@ -1,130 +0,0 @@
-#!/bin/bash
-# SPDX-License-Identifier: LGPL-2.1-or-later
-set -e
-
-if [[ -z "$SANITIZERS" ]]; then
-    exit 0
-fi
-
-# Sanitizers log to stderr by default. However, journald's stderr is connected to /dev/null, so we lose
-# all the sanitizer logs. To rectify that, let's connect journald's stdout to kmsg so that the sanitizer
-# failures end up in the journal.
-mkdir -p /etc/systemd/system/systemd-journald.service.d
-cat >/etc/systemd/system/systemd-journald.service.d/10-stdout-tty.conf <<EOF
-[Service]
-StandardOutput=kmsg
-EOF
-
-# ASAN and syscall filters aren't compatible with each other.
-find /usr /etc -name '*.service' -type f -exec sed -i 's/^\(MemoryDeny\|SystemCall\)/# \1/' {} +
-
-# `systemd-hwdb update` takes > 50s when built with sanitizers so let's not run it by default.
-systemctl mask systemd-hwdb-update.service
-
-ASAN_RT_PATH="$(grep libasan.so < <(ldd /usr/lib/systemd/systemd) | cut -d ' ' -f 3)"
-if [[ -z "$ASAN_RT_PATH" ]]; then
-    ASAN_RT_PATH="$(grep libclang_rt.asan < <(ldd /usr/lib/systemd/systemd) | cut -d ' ' -f 3)"
-
-    # As clang's ASan DSO is usually in a non-standard path, let's check if
-    # the environment is set accordingly. If not, warn the user and exit.
-    # We're not setting the LD_LIBRARY_PATH automagically here, because
-    # user should encounter (and fix) the same issue when running the unit
-    # tests (meson test)
-    if ldd /usr/lib/systemd/systemd | grep -q "libclang_rt.asan.*not found"; then
-        echo >&2 "clang's ASan DSO libclang_rt.asan is not present in the runtime library path"
-        exit 1
-    fi
-fi
-if [[ -z "$ASAN_RT_PATH" ]]; then
-    echo >&2 "systemd is not linked against the ASan DSO"
-    echo >&2 "gcc does this by default, for clang compile with -shared-libasan"
-    exit 1
-fi
-
-wrap=(
-    /usr/lib/polkit-1/polkitd
-    /usr/libexec/polkit-1/polkitd
-    agetty
-    btrfs
-    capsh
-    chgrp
-    chown
-    cryptsetup
-    curl
-    dbus-broker-launch
-    dbus-daemon
-    delv
-    dhcpd
-    dig
-    dmsetup
-    dnsmasq
-    findmnt
-    getent
-    getfacl
-    id
-    integritysetup
-    iscsid
-    kpartx
-    logger
-    login
-    ls
-    lsblk
-    lvm
-    mdadm
-    mkfs.btrfs
-    mkfs.erofs
-    mkfs.ext4
-    mkfs.vfat
-    mkfs.xfs
-    mksquashfs
-    mkswap
-    multipath
-    multipathd
-    nvme
-    p11-kit
-    pkill
-    ps
-    setfacl
-    setpriv
-    sshd
-    stat
-    su
-    tar
-    tgtd
-    useradd
-    userdel
-    veritysetup
-)
-
-for bin in "${wrap[@]}"; do
-    if ! command -v "$bin" >/dev/null; then
-        continue
-    fi
-
-    if [[ "$bin" == getent ]]; then
-        enable_lsan=1
-    else
-        enable_lsan=0
-    fi
-
-    target="$(command -v "$bin")"
-
-    mv "$target" "$target.orig"
-
-    cat >"$target" <<EOF
-#!/bin/bash
-# Preload the ASan runtime DSO, otherwise ASAn will complain
-export LD_PRELOAD="$ASAN_RT_PATH"
-# Disable LSan to speed things up, since we don't care about leak reports
-# from 'external' binaries
-export ASAN_OPTIONS=detect_leaks=$enable_lsan
-# Set argv[0] to the original binary name without the ".orig" suffix
-exec -a "\$0" -- "${target}.orig" "\$@"
-EOF
-    chmod +x "$target"
-done
-
-cat >/usr/lib/systemd/systemd-asan-env <<EOF
-LD_PRELOAD=$ASAN_RT_PATH
-LSAN_OPTIONS=detect_leaks=0
-EOF