diff --git a/temporalcli/commands.gen.go b/temporalcli/commands.gen.go
index 9ba527d2..2927646d 100644
--- a/temporalcli/commands.gen.go
+++ b/temporalcli/commands.gen.go
@@ -1250,6 +1250,7 @@ type TemporalServerStartDevCommand struct {
 	SqlitePragma       []string
 	DynamicConfigValue []string
 	LogConfig          bool
+	SearchAttribute    []string
 }
 
 func NewTemporalServerStartDevCommand(cctx *CommandContext, parent *TemporalServerCommand) *TemporalServerStartDevCommand {
@@ -1278,6 +1279,7 @@ func NewTemporalServerStartDevCommand(cctx *CommandContext, parent *TemporalServ
 	s.Command.Flags().StringArrayVar(&s.SqlitePragma, "sqlite-pragma", nil, "Specify SQLite pragma statements in pragma=value format.")
 	s.Command.Flags().StringArrayVar(&s.DynamicConfigValue, "dynamic-config-value", nil, "Dynamic config value, as KEY=JSON_VALUE (string values need quotes).")
 	s.Command.Flags().BoolVar(&s.LogConfig, "log-config", false, "Log the server config being used to stderr.")
+	s.Command.Flags().StringArrayVar(&s.SearchAttribute, "search-attribute", nil, "Search attributes to register, in key=type format.")
 	s.Command.Run = func(c *cobra.Command, args []string) {
 		if err := s.run(cctx, args); err != nil {
 			cctx.Options.Fail(err)
diff --git a/temporalcli/commands.server.go b/temporalcli/commands.server.go
index 927bb6f7..7f7559cd 100644
--- a/temporalcli/commands.server.go
+++ b/temporalcli/commands.server.go
@@ -3,11 +3,20 @@ package temporalcli
 import (
 	"encoding/json"
 	"fmt"
+	"strings"
 
 	"github.com/google/uuid"
 	"github.com/temporalio/cli/temporalcli/devserver"
+	"go.temporal.io/api/enums/v1"
+	"go.temporal.io/api/operatorservice/v1"
+	"google.golang.org/grpc"
+	"google.golang.org/grpc/credentials/insecure"
 )
 
+var defaultDynamicConfigValues = map[string]any{
+	"system.forceSearchAttributesCacheRefreshOnRead": true,
+}
+
 func (t *TemporalServerStartDevCommand) run(cctx *CommandContext, args []string) error {
 	// Have to assume "localhost" is 127.0.0.1 for server to work (it expects IP)
 	if t.Ip == "localhost" {
@@ -87,6 +96,22 @@ func (t *TemporalServerStartDevCommand) run(cctx *CommandContext, args []string)
 		}
 	}
 
+	// Apply set of default dynamic config values if not already present
+	for k, v := range defaultDynamicConfigValues {
+		if _, ok := opts.DynamicConfigValues[k]; !ok {
+			if opts.DynamicConfigValues == nil {
+				opts.DynamicConfigValues = map[string]any{}
+			}
+			opts.DynamicConfigValues[k] = v
+		}
+	}
+
+	// Prepare search attributes for adding before starting server
+	searchAttrs, err := t.prepareSearchAttributes()
+	if err != nil {
+		return err
+	}
+
 	// If not using DB file, set persistent cluster ID
 	if t.DbFilename == "" {
 		opts.ClusterID = persistentClusterID()
@@ -114,6 +139,11 @@ func (t *TemporalServerStartDevCommand) run(cctx *CommandContext, args []string)
 	}
 	defer s.Stop()
 
+	// Register search attributes
+	if err := t.registerSearchAttributes(cctx, searchAttrs, opts.Namespaces); err != nil {
+		return err
+	}
+
 	friendlyIP := t.Ip
 	if friendlyIP == "127.0.0.1" {
 		friendlyIP = "localhost"
@@ -147,3 +177,57 @@ func persistentClusterID() string {
 	_ = writeEnvConfigFile(file, map[string]map[string]string{"default": {"cluster-id": id}})
 	return id
 }
+
+func (t *TemporalServerStartDevCommand) prepareSearchAttributes() (map[string]enums.IndexedValueType, error) {
+	opts, err := stringKeysValues(t.SearchAttribute)
+	if err != nil {
+		return nil, fmt.Errorf("invalid search attributes: %w", err)
+	}
+	attrs := make(map[string]enums.IndexedValueType, len(opts))
+	for k, v := range opts {
+		// Case-insensitive index type lookup
+		var valType enums.IndexedValueType
+		for valTypeName, valTypeOrd := range enums.IndexedValueType_shorthandValue {
+			if strings.EqualFold(v, valTypeName) {
+				valType = enums.IndexedValueType(valTypeOrd)
+				break
+			}
+		}
+		if valType == 0 {
+			return nil, fmt.Errorf("invalid search attribute value type %q", v)
+		}
+		attrs[k] = valType
+	}
+	return attrs, nil
+}
+
+func (t *TemporalServerStartDevCommand) registerSearchAttributes(
+	cctx *CommandContext,
+	attrs map[string]enums.IndexedValueType,
+	namespaces []string,
+) error {
+	if len(attrs) == 0 {
+		return nil
+	}
+
+	conn, err := grpc.NewClient(
+		fmt.Sprintf("%v:%v", t.Ip, t.Port),
+		grpc.WithTransportCredentials(insecure.NewCredentials()),
+	)
+	if err != nil {
+		return fmt.Errorf("failed creating client to register search attributes: %w", err)
+	}
+	defer conn.Close()
+	client := operatorservice.NewOperatorServiceClient(conn)
+	// Call for each namespace
+	for _, ns := range namespaces {
+		_, err := client.AddSearchAttributes(cctx, &operatorservice.AddSearchAttributesRequest{
+			Namespace:        ns,
+			SearchAttributes: attrs,
+		})
+		if err != nil {
+			return fmt.Errorf("failed registering search attributes: %w", err)
+		}
+	}
+	return nil
+}
diff --git a/temporalcli/commands.server_test.go b/temporalcli/commands.server_test.go
index 72462c56..b32952e9 100644
--- a/temporalcli/commands.server_test.go
+++ b/temporalcli/commands.server_test.go
@@ -11,7 +11,9 @@ import (
 	"github.com/stretchr/testify/assert"
 	"github.com/stretchr/testify/require"
 	"github.com/temporalio/cli/temporalcli/devserver"
+	"go.temporal.io/api/operatorservice/v1"
 	"go.temporal.io/sdk/client"
+	"go.temporal.io/sdk/temporal"
 )
 
 // TODO(cretz): To test:
@@ -122,6 +124,82 @@ func TestServer_StartDev_ConcurrentStarts(t *testing.T) {
 	wg.Wait()
 }
 
+func TestServer_StartDev_WithSearchAttributes(t *testing.T) {
+	h := NewCommandHarness(t)
+	defer h.Close()
+
+	// Start in background, then wait for client to be able to connect
+	port := strconv.Itoa(devserver.MustGetFreePort("127.0.0.1"))
+	resCh := make(chan *CommandResult, 1)
+	go func() {
+		resCh <- h.Execute(
+			"server", "start-dev",
+			"-p", port,
+			"--headless",
+			"--search-attribute", "search-attr-1=Int",
+			"--search-attribute", "search-attr-2=kEyWoRdLiSt",
+		)
+	}()
+
+	// Try to connect for a bit while checking for error
+	var cl client.Client
+	h.EventuallyWithT(func(t *assert.CollectT) {
+		select {
+		case res := <-resCh:
+			if res.Err != nil {
+				panic(res.Err)
+			}
+		default:
+		}
+		var err error
+		cl, err = client.Dial(client.Options{HostPort: "127.0.0.1:" + port})
+		if !assert.NoError(t, err) {
+			return
+		}
+		// Confirm search attributes are present
+		resp, err := cl.OperatorService().ListSearchAttributes(
+			context.Background(), &operatorservice.ListSearchAttributesRequest{Namespace: "default"})
+		if !assert.NoError(t, err) {
+			return
+		}
+		assert.Contains(t, resp.CustomAttributes, "search-attr-1")
+		assert.Contains(t, resp.CustomAttributes, "search-attr-2")
+
+	}, 3*time.Second, 200*time.Millisecond)
+	defer cl.Close()
+
+	// Do a workflow start with the search attributes
+	run, err := cl.ExecuteWorkflow(
+		context.Background(),
+		client.StartWorkflowOptions{
+			TaskQueue: "my-task-queue",
+			TypedSearchAttributes: temporal.NewSearchAttributes(
+				temporal.NewSearchAttributeKeyInt64("search-attr-1").ValueSet(123),
+				temporal.NewSearchAttributeKeyKeywordList("search-attr-2").ValueSet([]string{"foo", "bar"}),
+			),
+		},
+		"MyWorkflow",
+	)
+	h.NoError(err)
+	h.NotEmpty(run.GetRunID())
+
+	// Check that they are there
+	desc, err := cl.DescribeWorkflowExecution(context.Background(), run.GetID(), "")
+	h.NoError(err)
+	sa := desc.WorkflowExecutionInfo.SearchAttributes.IndexedFields
+	h.JSONEq("123", string(sa["search-attr-1"].Data))
+	h.JSONEq(`["foo","bar"]`, string(sa["search-attr-2"].Data))
+
+	// Send an interrupt by cancelling context
+	h.CancelContext()
+	select {
+	case <-time.After(20 * time.Second):
+		h.Fail("didn't cleanup after 20 seconds")
+	case res := <-resCh:
+		h.NoError(res.Err)
+	}
+}
+
 type testLogger struct {
 	t *testing.T
 }
diff --git a/temporalcli/commandsmd/commands.md b/temporalcli/commandsmd/commands.md
index e858f04c..443ec9ed 100644
--- a/temporalcli/commandsmd/commands.md
+++ b/temporalcli/commandsmd/commands.md
@@ -602,6 +602,7 @@ To persist Workflows across runs, use:
 * `--sqlite-pragma` (string[]) - Specify SQLite pragma statements in pragma=value format.
 * `--dynamic-config-value` (string[]) - Dynamic config value, as KEY=JSON_VALUE (string values need quotes).
 * `--log-config` (bool) - Log the server config being used to stderr.
+* `--search-attribute` (string[]) - Search attributes to register, in key=type format.
 
 ### temporal task-queue: Manage Task Queues.