diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index f9b1378fed..25c0207ac6 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -147,6 +147,20 @@ jobs:
       working-directory: python
       run: tox -e lint,mypy,doc,py3
 
+    - name: build deltachat-rpc-server
+      if: ${{ matrix.python }}
+      uses: actions-rs/cargo@v1
+      with:
+        command: build
+        args: -p deltachat-rpc-server
+
+    - name: run deltachat-rpc-client tests
+      if: ${{ matrix.python }}
+      env:
+        DCC_NEW_TMP_EMAIL: ${{ secrets.DCC_NEW_TMP_EMAIL }}
+      working-directory: deltachat-rpc-client
+      run: tox -e py3
+
     - name: install pypy
       if: ${{ matrix.python }}
       uses: actions/setup-python@v4
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7dba5780c3..ba1d01aa07 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,7 @@
 
 ### API-Changes
 - Add Python API to send reactions #3762
+- jsonrpc: Add async Python client #3734
 
 ### Fixes
 - Make sure malformed messsages will never block receiving further messages anymore #3771
diff --git a/deltachat-rpc-client/README.md b/deltachat-rpc-client/README.md
new file mode 100644
index 0000000000..6b38c361ab
--- /dev/null
+++ b/deltachat-rpc-client/README.md
@@ -0,0 +1,33 @@
+# Delta Chat RPC python client
+
+RPC client connects to standalone Delta Chat RPC server `deltachat-rpc-server`
+and provides asynchronous interface to it.
+
+## Getting started
+
+To use Delta Chat RPC client, first build a `deltachat-rpc-server` with `cargo build -p deltachat-rpc-server`.
+Install it anywhere in your `PATH`.
+
+## Testing
+
+1. Build `deltachat-rpc-server` with `cargo build -p deltachat-rpc-server`.
+2. Run `tox`.
+
+Additional arguments to `tox` are passed to pytest, e.g. `tox -- -s` does not capture test output.
+
+## Using in REPL
+
+It is recommended to use IPython, because it supports using `await` directly
+from the REPL.
+
+```
+PATH="../target/debug:$PATH" ipython
+...
+In  [1]: from deltachat_rpc_client import *
+In  [2]: dc = Deltachat(await start_rpc_server())
+In  [3]: await dc.get_all_accounts()
+Out [3]: []
+In  [4]: alice = await dc.add_account()
+In  [5]: (await alice.get_info())["journal_mode"]
+Out [5]: 'wal'
+```
diff --git a/deltachat-rpc-client/examples/echobot.py b/deltachat-rpc-client/examples/echobot.py
new file mode 100755
index 0000000000..a55ca91a4b
--- /dev/null
+++ b/deltachat-rpc-client/examples/echobot.py
@@ -0,0 +1,58 @@
+#!/usr/bin/env python3
+import asyncio
+import logging
+import sys
+
+import deltachat_rpc_client as dc
+
+
+async def main():
+    rpc = await dc.start_rpc_server()
+    deltachat = dc.Deltachat(rpc)
+    system_info = await deltachat.get_system_info()
+    logging.info("Running deltachat core %s", system_info["deltachat_core_version"])
+
+    accounts = await deltachat.get_all_accounts()
+    account = accounts[0] if accounts else await deltachat.add_account()
+
+    await account.set_config("bot", "1")
+    if not await account.is_configured():
+        logging.info("Account is not configured, configuring")
+        await account.set_config("addr", sys.argv[1])
+        await account.set_config("mail_pw", sys.argv[2])
+        await account.configure()
+        logging.info("Configured")
+    else:
+        logging.info("Account is already configured")
+        await deltachat.start_io()
+
+    async def process_messages():
+        fresh_messages = await account.get_fresh_messages()
+        fresh_message_snapshot_tasks = [
+            message.get_snapshot() for message in fresh_messages
+        ]
+        fresh_message_snapshots = await asyncio.gather(*fresh_message_snapshot_tasks)
+        for snapshot in reversed(fresh_message_snapshots):
+            if not snapshot.is_info:
+                await snapshot.chat.send_text(snapshot.text)
+            await snapshot.message.mark_seen()
+
+    # Process old messages.
+    await process_messages()
+
+    while True:
+        event = await account.wait_for_event()
+        if event["type"] == "Info":
+            logging.info("%s", event["msg"])
+        elif event["type"] == "Warning":
+            logging.warning("%s", event["msg"])
+        elif event["type"] == "Error":
+            logging.error("%s", event["msg"])
+        elif event["type"] == "IncomingMsg":
+            logging.info("Got an incoming message")
+            await process_messages()
+
+
+if __name__ == "__main__":
+    logging.basicConfig(level=logging.INFO)
+    asyncio.run(main())
diff --git a/deltachat-rpc-client/pyproject.toml b/deltachat-rpc-client/pyproject.toml
new file mode 100644
index 0000000000..cabcc848a6
--- /dev/null
+++ b/deltachat-rpc-client/pyproject.toml
@@ -0,0 +1,14 @@
+[build-system]
+requires = ["setuptools>=45", "setuptools_scm[toml]>=6.2"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "deltachat-rpc-client"
+description = "Python client for Delta Chat core JSON-RPC interface"
+dependencies = [
+    "aiohttp",
+    "aiodns"
+]
+dynamic = [
+    "version"
+]
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/__init__.py b/deltachat-rpc-client/src/deltachat_rpc_client/__init__.py
new file mode 100644
index 0000000000..720e1ebdbd
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/__init__.py
@@ -0,0 +1,5 @@
+from .account import Account
+from .contact import Contact
+from .deltachat import Deltachat
+from .message import Message
+from .rpc import Rpc, new_online_account, start_rpc_server
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/account.py b/deltachat-rpc-client/src/deltachat_rpc_client/account.py
new file mode 100644
index 0000000000..61e2395f12
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/account.py
@@ -0,0 +1,68 @@
+from typing import Optional
+
+from .chat import Chat
+from .contact import Contact
+from .message import Message
+
+
+class Account:
+    def __init__(self, rpc, account_id):
+        self.rpc = rpc
+        self.account_id = account_id
+
+    def __repr__(self):
+        return "<Account id={}>".format(self.account_id)
+
+    async def wait_for_event(self):
+        """Wait until the next event and return it."""
+        return await self.rpc.get_next_event(self.account_id)
+
+    async def remove(self) -> None:
+        """Remove the account."""
+        await self.rpc.remove_account(self.account_id)
+
+    async def start_io(self) -> None:
+        """Start the account I/O."""
+        await self.rpc.start_io(self.account_id)
+
+    async def stop_io(self) -> None:
+        """Stop the account I/O."""
+        await self.rpc.stop_io(self.account_id)
+
+    async def get_info(self):
+        return await self.rpc.get_info(self.account_id)
+
+    async def get_file_size(self):
+        return await self.rpc.get_account_file_size(self.account_id)
+
+    async def is_configured(self) -> bool:
+        """Return True for configured accounts."""
+        return await self.rpc.is_configured(self.account_id)
+
+    async def set_config(self, key: str, value: Optional[str]):
+        """Set the configuration value key pair."""
+        await self.rpc.set_config(self.account_id, key, value)
+
+    async def get_config(self, key: str) -> Optional[str]:
+        """Get the configuration value."""
+        return await self.rpc.get_config(self.account_id, key)
+
+    async def configure(self):
+        """Configure an account."""
+        await self.rpc.configure(self.account_id)
+
+    async def create_contact(self, address: str, name: Optional[str]) -> Contact:
+        """Create a contact with the given address and, optionally, a name."""
+        return Contact(
+            self.rpc,
+            self.account_id,
+            await self.rpc.create_contact(self.account_id, address, name),
+        )
+
+    async def secure_join(self, qr: str) -> Chat:
+        chat_id = await self.rpc.secure_join(self.account_id, qr)
+        return Chat(self.rpc, self.account_id, self.chat_id)
+
+    async def get_fresh_messages(self):
+        fresh_msg_ids = await self.rpc.get_fresh_msgs(self.account_id)
+        return [Message(self.rpc, self.account_id, msg_id) for msg_id in fresh_msg_ids]
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/chat.py b/deltachat-rpc-client/src/deltachat_rpc_client/chat.py
new file mode 100644
index 0000000000..6600bb8bc1
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/chat.py
@@ -0,0 +1,33 @@
+class Chat:
+    def __init__(self, rpc, account_id, chat_id):
+        self.rpc = rpc
+        self.account_id = account_id
+        self.chat_id = chat_id
+
+    async def block(self):
+        """Block the chat."""
+        await self.rpc.block_chat(self.account_id, self.chat_id)
+
+    async def accept(self):
+        """Accept the contact request."""
+        await self.rpc.accept_chat(self.account_id, self.chat_id)
+
+    async def delete(self):
+        await self.rpc.delete_chat(self.account_id, self.chat_id)
+
+    async def get_encryption_info(self):
+        await self.rpc.get_chat_encryption_info(self.account_id, self.chat_id)
+
+    async def send_text(self, text: str):
+        from .message import Message
+
+        msg_id = await self.rpc.misc_send_text_message(
+            self.account_id, self.chat_id, text
+        )
+        return Message(self.rpc, self.account_id, msg_id)
+
+    async def leave(self):
+        await self.rpc.leave_group(self.account_id, self.chat_id)
+
+    async def get_fresh_message_count() -> int:
+        await get_fresh_msg_cnt(self.account_id, self.chat_id)
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/contact.py b/deltachat-rpc-client/src/deltachat_rpc_client/contact.py
new file mode 100644
index 0000000000..8f60ad16f4
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/contact.py
@@ -0,0 +1,44 @@
+class Contact:
+    """
+    Contact API.
+
+    Essentially a wrapper for RPC, account ID and a contact ID.
+    """
+
+    def __init__(self, rpc, account_id, contact_id):
+        self.rpc = rpc
+        self.account_id = account_id
+        self.contact_id = contact_id
+
+    async def block(self):
+        """Block contact."""
+        await self.rpc.block_contact(self.account_id, self.contact_id)
+
+    async def unblock(self):
+        """Unblock contact."""
+        await self.rpc.unblock_contact(self.account_id, self.contact_id)
+
+    async def delete(self):
+        """Delete contact."""
+        await self.rpc.delete_contact(self.account_id, self.contact_id)
+
+    async def change_name(self, name: str):
+        await self.rpc.change_contact_name(self.account_id, self.contact_id, name)
+
+    async def get_encryption_info(self) -> str:
+        return await self.rpc.get_contact_encryption_info(
+            self.account_id, self.contact_id
+        )
+
+    async def get_dictionary(self):
+        """Returns a dictionary with a snapshot of all contact properties."""
+        return await self.rpc.get_contact(self.account_id, self.contact_id)
+
+    async def create_chat(self):
+        from .chat import Chat
+
+        return Chat(
+            self.rpc,
+            self.account_id,
+            await self.rpc.create_chat_by_contact_id(self.account_id, self.contact_id),
+        )
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/deltachat.py b/deltachat-rpc-client/src/deltachat_rpc_client/deltachat.py
new file mode 100644
index 0000000000..8b58494182
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/deltachat.py
@@ -0,0 +1,31 @@
+from .account import Account
+
+
+class Deltachat:
+    """
+    Delta Chat account manager.
+    This is the root of the object oriented API.
+    """
+
+    def __init__(self, rpc):
+        self.rpc = rpc
+
+    async def add_account(self):
+        account_id = await self.rpc.add_account()
+        return Account(self.rpc, account_id)
+
+    async def get_all_accounts(self):
+        account_ids = await self.rpc.get_all_account_ids()
+        return [Account(self.rpc, account_id) for account_id in account_ids]
+
+    async def start_io(self) -> None:
+        await self.rpc.start_io_for_all_accounts()
+
+    async def stop_io(self) -> None:
+        await self.rpc.stop_io_for_all_accounts()
+
+    async def maybe_network(self) -> None:
+        await self.rpc.maybe_network()
+
+    async def get_system_info(self):
+        return await self.rpc.get_system_info()
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/message.py b/deltachat-rpc-client/src/deltachat_rpc_client/message.py
new file mode 100644
index 0000000000..346c6e787e
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/message.py
@@ -0,0 +1,41 @@
+from dataclasses import dataclass
+from typing import Optional
+
+from .chat import Chat
+from .contact import Contact
+
+
+class Message:
+    def __init__(self, rpc, account_id, msg_id):
+        self.rpc = rpc
+        self.account_id = account_id
+        self.msg_id = msg_id
+
+    async def send_reaction(self, reactions):
+        msg_id = await self.rpc.send_reaction(self.account_id, self.msg_id, reactions)
+        return Message(self.rpc, self.account_id, msg_id)
+
+    async def get_snapshot(self):
+        message_object = await self.rpc.get_message(self.account_id, self.msg_id)
+        return MessageSnapshot(
+            message=self,
+            chat=Chat(self.rpc, self.account_id, message_object["chatId"]),
+            sender=Contact(self.rpc, self.account_id, message_object["fromId"]),
+            text=message_object["text"],
+            error=message_object.get("error"),
+            is_info=message_object["isInfo"],
+        )
+
+    async def mark_seen(self) -> None:
+        """Mark the message as seen."""
+        await self.rpc.markseen_msgs(self.account_id, [self.msg_id])
+
+
+@dataclass
+class MessageSnapshot:
+    message: Message
+    chat: Chat
+    sender: Contact
+    text: str
+    error: Optional[str]
+    is_info: bool
diff --git a/deltachat-rpc-client/src/deltachat_rpc_client/rpc.py b/deltachat-rpc-client/src/deltachat_rpc_client/rpc.py
new file mode 100644
index 0000000000..cffb0565ec
--- /dev/null
+++ b/deltachat-rpc-client/src/deltachat_rpc_client/rpc.py
@@ -0,0 +1,92 @@
+import asyncio
+import json
+import logging
+import os
+
+import aiohttp
+
+
+class JsonRpcError(Exception):
+    pass
+
+
+class Rpc:
+    def __init__(self, process):
+        self.process = process
+        self.event_queues = {}
+        self.id = 0
+        self.reader_task = asyncio.create_task(self.reader_loop())
+
+        # Map from request ID to `asyncio.Future` returning the response.
+        self.request_events = {}
+
+    async def reader_loop(self):
+        while True:
+            line = await self.process.stdout.readline()
+            response = json.loads(line)
+            if "id" in response:
+                fut = self.request_events.pop(response["id"])
+                fut.set_result(response)
+            elif response["method"] == "event":
+                # An event notification.
+                params = response["params"]
+                account_id = params["contextId"]
+                if account_id not in self.event_queues:
+                    self.event_queues[account_id] = asyncio.Queue()
+                await self.event_queues[account_id].put(params["event"])
+            else:
+                print(response)
+
+    async def wait_for_event(self, account_id):
+        """Returns next event."""
+        if account_id in self.event_queues:
+            return await self.event_queues[account_id].get()
+
+    def __getattr__(self, attr):
+        async def method(*args, **kwargs):
+            self.id += 1
+            request_id = self.id
+
+            params = args
+            if kwargs:
+                assert not args
+                params = kwargs
+
+            request = {
+                "jsonrpc": "2.0",
+                "method": attr,
+                "params": params,
+                "id": self.id,
+            }
+            data = (json.dumps(request) + "\n").encode()
+            self.process.stdin.write(data)
+            event = asyncio.Event()
+            loop = asyncio.get_running_loop()
+            fut = loop.create_future()
+            self.request_events[request_id] = fut
+            response = await fut
+            if "error" in response:
+                raise JsonRpcError(response["error"])
+            if "result" in response:
+                return response["result"]
+
+        return method
+
+
+async def start_rpc_server(*args, **kwargs):
+    proc = await asyncio.create_subprocess_exec(
+        "deltachat-rpc-server",
+        stdin=asyncio.subprocess.PIPE,
+        stdout=asyncio.subprocess.PIPE,
+        *args,
+        **kwargs
+    )
+    rpc = Rpc(proc)
+    return rpc
+
+
+async def new_online_account():
+    url = os.getenv("DCC_NEW_TMP_EMAIL")
+    async with aiohttp.ClientSession() as session:
+        async with session.post(url) as response:
+            return json.loads(await response.text())
diff --git a/deltachat-rpc-client/tests/test_something.py b/deltachat-rpc-client/tests/test_something.py
new file mode 100644
index 0000000000..1744f3de91
--- /dev/null
+++ b/deltachat-rpc-client/tests/test_something.py
@@ -0,0 +1,92 @@
+import asyncio
+import os
+
+import pytest
+import pytest_asyncio
+
+import deltachat_rpc_client
+from deltachat_rpc_client import Deltachat
+
+
+@pytest_asyncio.fixture
+async def rpc(tmp_path):
+    return await deltachat_rpc_client.start_rpc_server(
+        env={**os.environ, "DC_ACCOUNTS_PATH": str(tmp_path / "accounts")}
+    )
+
+
+@pytest.mark.asyncio
+async def test_system_info(rpc):
+    system_info = await rpc.get_system_info()
+    assert "arch" in system_info
+    assert "deltachat_core_version" in system_info
+
+
+@pytest.mark.asyncio
+async def test_email_address_validity(rpc):
+    valid_addresses = [
+        "email@example.com",
+        "36aa165ae3406424e0c61af17700f397cad3fe8ab83d682d0bddf3338a5dd52e@yggmail@yggmail",
+    ]
+    invalid_addresses = ["email@", "example.com", "emai221"]
+
+    for addr in valid_addresses:
+        assert await rpc.check_email_validity(addr)
+    for addr in invalid_addresses:
+        assert not await rpc.check_email_validity(addr)
+
+
+@pytest.mark.asyncio
+async def test_online_account(rpc):
+    account_json = await deltachat_rpc_client.new_online_account()
+
+    account_id = await rpc.add_account()
+    await rpc.set_config(account_id, "addr", account_json["email"])
+    await rpc.set_config(account_id, "mail_pw", account_json["password"])
+
+    await rpc.configure(account_id)
+    while True:
+        event = await rpc.wait_for_event(account_id)
+        if event["type"] == "ConfigureProgress":
+            # Progress 0 indicates error.
+            assert event["progress"] != 0
+
+            if event["progress"] == 1000:
+                # Success.
+                break
+        else:
+            print(event)
+    print("Successful configuration")
+
+
+@pytest.mark.asyncio
+async def test_object_account(rpc):
+    deltachat = Deltachat(rpc)
+
+    async def create_configured_account():
+        account = await deltachat.add_account()
+        assert not await account.is_configured()
+        account_json = await deltachat_rpc_client.new_online_account()
+        await account.set_config("addr", account_json["email"])
+        await account.set_config("mail_pw", account_json["password"])
+        await account.configure()
+        assert await account.is_configured()
+        return account
+
+    alice, bob = await asyncio.gather(
+        create_configured_account(), create_configured_account()
+    )
+
+    alice_contact_bob = await alice.create_contact(await bob.get_config("addr"), "Bob")
+    alice_chat_bob = await alice_contact_bob.create_chat()
+    await alice_chat_bob.send_text("Hello!")
+
+    while True:
+        event = await bob.wait_for_event()
+        if event["type"] == "IncomingMsg":
+            chat_id = event["chatId"]
+            msg_id = event["msgId"]
+            break
+
+    message = await rpc.get_message(bob.account_id, msg_id)
+    assert message["text"] == "Hello!"
diff --git a/deltachat-rpc-client/tox.ini b/deltachat-rpc-client/tox.ini
new file mode 100644
index 0000000000..20618227b9
--- /dev/null
+++ b/deltachat-rpc-client/tox.ini
@@ -0,0 +1,20 @@
+[tox]
+isolated_build = true
+envlist =
+    py3
+
+[testenv]
+commands =
+    pytest {posargs}
+setenv =
+# Avoid stack overflow when Rust core is built without optimizations.
+    RUST_MIN_STACK=8388608
+    PATH = {env:PATH}{:}{toxinidir}/../target/debug
+passenv =
+    DCC_NEW_TMP_EMAIL
+deps =
+    pytest
+    pytest-async
+    pytest-asyncio
+    aiohttp
+    aiodns