diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 772794aa47..22c5a0c30e 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -39,6 +39,14 @@ jobs:
             target: x86_64-unknown-linux-gnu
             variant: release
 
+          - os: ubuntu-16.04
+            target: x86_64-unknown-linux-musl
+            variant: debug
+
+          - os: ubuntu-16.04
+            target: x86_64-unknown-linux-musl
+            variant: release
+
           - os: windows-2019
             target: x86_64-pc-windows-msvc
             variant: release # Note: we do not support windows debug builds.
@@ -81,6 +89,15 @@ jobs:
           python-version: 2.7.x
           architecture: x64
 
+      - name: Install musl toolchain
+        if: matrix.config.target == 'x86_64-unknown-linux-musl'
+        run: |
+          rustup target add x86_64-unknown-linux-musl
+
+          sudo apt update
+          sudo apt install musl musl-dev musl-tools
+          sudo ld-musl-config
+
       - name: Install cross compilation toolchain
         if: matrix.config.target == 'aarch64-unknown-linux-gnu'
         run: |
diff --git a/build.rs b/build.rs
index bc47afc4a3..e7e84185fb 100644
--- a/build.rs
+++ b/build.rs
@@ -91,6 +91,11 @@ fn build_v8() {
     }
   }
 
+  if env::var("TARGET").unwrap() == "x86_64-unknown-linux-musl" {
+    gn_args.push("use_glib=false".to_string());
+    gn_args.push("use_gold=true".to_string());
+  };
+
   if env::var("TARGET").unwrap() == "aarch64-unknown-linux-gnu" {
     gn_args.push(r#"target_cpu="arm64""#.to_string());
     gn_args.push("use_sysroot=true".to_string());