diff --git a/.changes/1.17.46.json b/.changes/1.17.46.json
new file mode 100644
index 0000000000..629dd4e923
--- /dev/null
+++ b/.changes/1.17.46.json
@@ -0,0 +1,22 @@
+[
+  {
+    "category": "``ssm``", 
+    "description": "[``botocore``] Supports removing a label or labels from a parameter, enables ScheduledEndTime and ChangeDetails for StartChangeRequestExecution API, supports critical/security/other noncompliant count for patch API.", 
+    "type": "api-change"
+  }, 
+  {
+    "category": "``medialive``", 
+    "description": "[``botocore``] MediaLive VPC outputs update to include Availability Zones, Security groups, Elastic Network Interfaces, and Subnet Ids in channel response", 
+    "type": "api-change"
+  }, 
+  {
+    "category": "``ec2``", 
+    "description": "[``botocore``] This release adds support for storing EBS-backed AMIs in S3 and restoring them from S3 to enable cross-partition copying of AMIs", 
+    "type": "api-change"
+  }, 
+  {
+    "category": "``cloud9``", 
+    "description": "[``botocore``] Documentation updates for Cloud9", 
+    "type": "api-change"
+  }
+]
\ No newline at end of file
diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index fb386b1514..ed2ed12643 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -2,6 +2,15 @@
 CHANGELOG
 =========
 
+1.17.46
+=======
+
+* api-change:``ssm``: [``botocore``] Supports removing a label or labels from a parameter, enables ScheduledEndTime and ChangeDetails for StartChangeRequestExecution API, supports critical/security/other noncompliant count for patch API.
+* api-change:``medialive``: [``botocore``] MediaLive VPC outputs update to include Availability Zones, Security groups, Elastic Network Interfaces, and Subnet Ids in channel response
+* api-change:``ec2``: [``botocore``] This release adds support for storing EBS-backed AMIs in S3 and restoring them from S3 to enable cross-partition copying of AMIs
+* api-change:``cloud9``: [``botocore``] Documentation updates for Cloud9
+
+
 1.17.45
 =======
 
diff --git a/boto3/__init__.py b/boto3/__init__.py
index ec9fcb9c7d..ac1dd1613f 100644
--- a/boto3/__init__.py
+++ b/boto3/__init__.py
@@ -18,7 +18,7 @@
 
 
 __author__ = 'Amazon Web Services'
-__version__ = '1.17.45'
+__version__ = '1.17.46'
 
 
 # The default Boto3 session; autoloaded when needed.
diff --git a/setup.cfg b/setup.cfg
index c040effa37..fff7b46f97 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -3,6 +3,6 @@ universal = 1
 
 [metadata]
 requires_dist =
-    botocore>=1.20.45,<1.21.0
+    botocore>=1.20.46,<1.21.0
     jmespath>=0.7.1,<1.0.0
     s3transfer>=0.3.0,<0.4.0
diff --git a/setup.py b/setup.py
index a07c7c4b45..44e0bdf08e 100644
--- a/setup.py
+++ b/setup.py
@@ -14,7 +14,7 @@
 
 
 requires = [
-    'botocore>=1.20.45,<1.21.0',
+    'botocore>=1.20.46,<1.21.0',
     'jmespath>=0.7.1,<1.0.0',
     's3transfer>=0.3.0,<0.4.0'
 ]