diff --git a/eng/targets/Helix.Common.props b/eng/targets/Helix.Common.props
index 0eb345b5755a..87efd43249d0 100644
--- a/eng/targets/Helix.Common.props
+++ b/eng/targets/Helix.Common.props
@@ -33,7 +33,7 @@
     <HelixAvailableTargetQueue Include="Debian.9.Amd64.Open" Platform="Linux" />
     <HelixAvailableTargetQueue Include="Redhat.7.Amd64.Open" Platform="Linux" />
     <HelixAvailableTargetQueue Include="(Fedora.28.Amd64.Open)Ubuntu.1604.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:fedora-28-helix-09ca40b-20190508143249" Platform="Linux" />
-  </ItemGroup>  
+  </ItemGroup>
   <ItemGroup Condition="'$(TargetArchitecture)' == 'x64' AND '$(IsHelixDaily)' == 'true'">
     <HelixAvailableTargetQueue Include="Windows.7.Amd64.Open" Platform="Windows" />
     <HelixAvailableTargetQueue Include="Windows.81.Amd64.Open" Platform="Windows" />
@@ -43,7 +43,7 @@
   <ItemGroup Condition="'$(TargetArchitecture)' == 'arm64' AND '$(IsHelixDaily)' == 'true' AND '$(IsWindowsOnlyTest)' != 'true'">
     <HelixAvailableTargetQueue Include="(Debian.9.Arm64.Open)Ubuntu.1804.Armarch.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-9-helix-arm64v8-a12566d-20190807161036" Platform="Linux" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetArchitecture)' == 'arm64' AND '$(IsHelixDaily)' == 'true'">
+  <ItemGroup Condition="'$(IsWindowsOnlyTest)' != 'true' AND '$(TargetArchitecture)' == 'arm64' AND '$(IsHelixDaily)' == 'true'">
     <HelixAvailableTargetQueue Include="Windows.10.Arm64.Open" Platform="Windows" />
   </ItemGroup>
 </Project>
diff --git a/src/DataProtection/Extensions/test/DataProtectionProviderTests.cs b/src/DataProtection/Extensions/test/DataProtectionProviderTests.cs
index 3d5c59419f5e..8fb700d452da 100644
--- a/src/DataProtection/Extensions/test/DataProtectionProviderTests.cs
+++ b/src/DataProtection/Extensions/test/DataProtectionProviderTests.cs
@@ -115,7 +115,7 @@ public void System_UsesProvidedDirectory_WithConfigurationCallback()
 
         [ConditionalFact]
         [X509StoreIsAvailable(StoreName.My, StoreLocation.CurrentUser)]
-        [SkipOnHelix("https://github.com/dotnet/aspnetcore/issues/6720", Queues = "All.OSX")]
+        [SkipOnHelix("https://github.com/dotnet/aspnetcore/issues/6720 and https://github.com/dotnet/aspnetcore/issues/26871", Queues = "All.OSX;Windows.10.Arm64.Open")]
         public void System_UsesProvidedDirectoryAndCertificate()
         {
             var filePath = Path.Combine(GetTestFilesPath(), "TestCert.pfx");
diff --git a/src/Security/Authentication/Negotiate/test/Negotiate.FunctionalTest/NegotiateHandlerFunctionalTests.cs b/src/Security/Authentication/Negotiate/test/Negotiate.FunctionalTest/NegotiateHandlerFunctionalTests.cs
index 1a1c8def5cce..87e22bde8a57 100644
--- a/src/Security/Authentication/Negotiate/test/Negotiate.FunctionalTest/NegotiateHandlerFunctionalTests.cs
+++ b/src/Security/Authentication/Negotiate/test/Negotiate.FunctionalTest/NegotiateHandlerFunctionalTests.cs
@@ -69,7 +69,7 @@ public async Task Anonymous_Challenge_401Negotiate_Win7()
 
         [ConditionalTheory]
         [MemberData(nameof(Http11And2))]
-        [MinimumOSVersion(OperatingSystems.Windows, WindowsVersions.Win81, SkipReason = "Windows only supports ALPN on 8.1 and later.")]
+        [MinimumOSVersion(OperatingSystems.Windows, WindowsVersions.Win10, SkipReason = "Windows only supports ALPN and required ciphers on 10 and later.")]
         public async Task Anonymous_NoChallenge_NoOps(Version version)
         {
             using var host = await CreateHostAsync();
@@ -84,7 +84,7 @@ public async Task Anonymous_NoChallenge_NoOps(Version version)
 
         [ConditionalTheory]
         [MemberData(nameof(Http11And2))]
-        [MinimumOSVersion(OperatingSystems.Windows, WindowsVersions.Win81, SkipReason = "Windows only supports ALPN on 8.1 and later.")]
+        [MinimumOSVersion(OperatingSystems.Windows, WindowsVersions.Win10, SkipReason = "Windows only supports ALPN and required ciphers on 10 and later.")]
         public async Task Anonymous_Challenge_401Negotiate(Version version)
         {
             using var host = await CreateHostAsync();
diff --git a/src/Servers/IIS/IIS/test/Common.FunctionalTests/RequestResponseTests.cs b/src/Servers/IIS/IIS/test/Common.FunctionalTests/RequestResponseTests.cs
index dba351a50645..a682908f06a6 100644
--- a/src/Servers/IIS/IIS/test/Common.FunctionalTests/RequestResponseTests.cs
+++ b/src/Servers/IIS/IIS/test/Common.FunctionalTests/RequestResponseTests.cs
@@ -666,6 +666,7 @@ await connection.Send(
 
         [ConditionalFact]
         [MaximumOSVersion(OperatingSystems.Windows, WindowsVersions.Win10_20H1, SkipReason = "Shutdown hangs https://github.com/dotnet/aspnetcore/issues/25107")]
+        [MinimumOSVersion(OperatingSystems.Windows, WindowsVersions.Win81, SkipReason = "NullReferenceException https://github.com/dotnet/aspnetcore/issues/26839")]
         public async Task ClientDisconnectStress()
         {
             var maxRequestSize = 1000;
diff --git a/src/Servers/Kestrel/test/InMemory.FunctionalTests/EventSourceTests.cs b/src/Servers/Kestrel/test/InMemory.FunctionalTests/EventSourceTests.cs
index 372362d720cd..9782539ba180 100644
--- a/src/Servers/Kestrel/test/InMemory.FunctionalTests/EventSourceTests.cs
+++ b/src/Servers/Kestrel/test/InMemory.FunctionalTests/EventSourceTests.cs
@@ -268,7 +268,8 @@ public async Task Http2_EmitsStartAndStopEventsWithActivityIds()
             Assert.Equal(eventIndex, events.Count);
         }
 
-        [Fact]
+        [ConditionalFact]
+        [MinimumOSVersion(OperatingSystems.Windows, WindowsVersions.Win8, SkipReason = "SslStream.AuthenticateAsServerAsync() doesn't throw on Win 7 when the client tries SSL 2.0.")]
         public async Task TlsHandshakeFailure_EmitsStartAndStopEventsWithActivityIds()
         {
             int port;
@@ -298,7 +299,7 @@ public async Task TlsHandshakeFailure_EmitsStartAndStopEventsWithActivityIds()
                 {
                     TargetHost = "localhost",
 
-                    // Only enabling SslProtocols.Ssl2 should cause a handshake failure on all platforms.
+                    // Only enabling SslProtocols.Ssl2 should cause a handshake failure on most platforms.
 #pragma warning disable CS0618 // Type or member is obsolete
                     EnabledSslProtocols = SslProtocols.Ssl2,
 #pragma warning restore CS0618 // Type or member is obsolete