diff --git a/src/coreclr/src/vm/class.cpp b/src/coreclr/src/vm/class.cpp
index 0f398b93c6cce..e8b39c00b606d 100644
--- a/src/coreclr/src/vm/class.cpp
+++ b/src/coreclr/src/vm/class.cpp
@@ -1169,6 +1169,12 @@ void ClassLoader::ValidateMethodsWithCovariantReturnTypes(MethodTable* pMT)
             if (!pMD->RequiresCovariantReturnTypeChecking() && !pParentMD->RequiresCovariantReturnTypeChecking())
                 continue;
 
+            // Locate the MethodTable defining the pParentMD.
+            while (pParentMT->GetCanonicalMethodTable() != pParentMD->GetMethodTable())
+            {
+                pParentMT = pParentMT->GetParentMethodTable();
+            }
+
             SigTypeContext context1(pParentMT->GetInstantiation(), pMD->GetMethodInstantiation());
             MetaSig methodSig1(pParentMD);
             TypeHandle hType1 = methodSig1.GetReturnProps().GetTypeHandleThrowing(pParentMD->GetModule(), &context1, ClassLoader::LoadTypesFlag::LoadTypes, CLASS_LOAD_EXACTPARENTS);
diff --git a/src/tests/Regressions/coreclr/GitHub_45053/test45053.cs b/src/tests/Regressions/coreclr/GitHub_45053/test45053.cs
new file mode 100644
index 0000000000000..1c093f6ee2924
--- /dev/null
+++ b/src/tests/Regressions/coreclr/GitHub_45053/test45053.cs
@@ -0,0 +1,39 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+using System;
+using System.Collections.Generic;
+
+public abstract class T<TR>
+{
+    public abstract TR GetA();
+}
+
+// This abstract causes the error - not overriding the base method cause the runtime to crash
+public abstract class TA : T<A> { }
+
+// This works
+// public abstract class TA : T<A>
+// {
+//  // Overriding in between fixes the problem
+//    public override A GetA() => new ();
+// }
+
+    // Overriden here, in the grandson
+public class TB : TA
+{
+    public override B GetA() => new ();
+}
+public class A { }
+
+public class B : A { }
+
+class Program
+{
+    static int Main()
+    {
+        System.Console.WriteLine((new TB() as T<A>).GetA().GetType().FullName);
+
+        return 100;
+    }
+}
diff --git a/src/tests/Regressions/coreclr/GitHub_45053/test45053.csproj b/src/tests/Regressions/coreclr/GitHub_45053/test45053.csproj
new file mode 100644
index 0000000000000..89a08fc082a41
--- /dev/null
+++ b/src/tests/Regressions/coreclr/GitHub_45053/test45053.csproj
@@ -0,0 +1,10 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+    <CLRTestKind>BuildAndRun</CLRTestKind>
+    <CLRTestPriority>1</CLRTestPriority>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="test45053.cs" />
+  </ItemGroup>
+</Project>