diff --git a/src/coreclr/jit/morph.cpp b/src/coreclr/jit/morph.cpp
index 52454b0c8b731..153f9b8bba8a8 100644
--- a/src/coreclr/jit/morph.cpp
+++ b/src/coreclr/jit/morph.cpp
@@ -8919,6 +8919,14 @@ GenTree* Compiler::fgMorphSmpOp(GenTree* tree, MorphAddrContext* mac, bool* optA
             break;
 #endif
 
+        case GT_COMMA:
+            if (op2->OperIsStore() || (op2->OperGet() == GT_COMMA && op2->TypeGet() == TYP_VOID) || fgIsThrow(op2))
+            {
+                typ = tree->gtType = TYP_VOID;
+            }
+
+            break;
+
         default:
             break;
     }
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_91443/Runtime_91443.cs b/src/tests/JIT/Regression/JitBlue/Runtime_91443/Runtime_91443.cs
new file mode 100644
index 0000000000000..d3844b77271dd
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_91443/Runtime_91443.cs
@@ -0,0 +1,23 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+using System.Numerics;
+using System.Runtime.CompilerServices;
+using Xunit;
+
+public class Runtime_91443
+{
+    [Fact]
+    public static void TestEntryPoint()
+    {
+        new Runtime_91443().Method0();
+    }
+    
+    static Vector3 s;
+
+    [MethodImpl(MethodImplOptions.NoInlining)]
+    private void Method0()
+    {
+        Vector3.Cross(s, s);
+    }
+}
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_91443/Runtime_91443.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_91443/Runtime_91443.csproj
new file mode 100644
index 0000000000000..de6d5e08882e8
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_91443/Runtime_91443.csproj
@@ -0,0 +1,8 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <Optimize>True</Optimize>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>