diff --git a/eng/native/tryrun.cmake b/eng/native/tryrun.cmake
index c0fe823dd78f1e..e5fb893778a3a0 100644
--- a/eng/native/tryrun.cmake
+++ b/eng/native/tryrun.cmake
@@ -45,6 +45,8 @@ elseif(EXISTS ${CROSS_ROOTFS}/etc/tizen-release)
 elseif(EXISTS ${CROSS_ROOTFS}/boot/system/develop/headers/config/HaikuConfig.h)
   set(HAIKU 1)
   set(CLR_CMAKE_TARGET_OS haiku)
+elseif(DEFINED ENV{DOTNET_RUNNING_UNDER_QEMU})
+  set(QEMU 1)
 endif()
 
 if(DARWIN)
@@ -124,5 +126,9 @@ else()
 endif()
 
 if(TARGET_ARCH_NAME MATCHES "^(x86|x64|s390x|armv6|loongarch64|riscv64|ppc64le)$")
-  set_cache_value(HAVE_FUNCTIONAL_PTHREAD_ROBUST_MUTEXES_EXITCODE 0)
+  if (QEMU)
+    set_cache_value(HAVE_FUNCTIONAL_PTHREAD_ROBUST_MUTEXES_EXITCODE 1)
+  else()
+    set_cache_value(HAVE_FUNCTIONAL_PTHREAD_ROBUST_MUTEXES_EXITCODE 0)
+  endif()
 endif()