diff --git a/eng/native/configurecompiler.cmake b/eng/native/configurecompiler.cmake
index 2957221d466617..e7c1a33ffe4125 100644
--- a/eng/native/configurecompiler.cmake
+++ b/eng/native/configurecompiler.cmake
@@ -529,7 +529,7 @@ endif ()
 #--------------------------------------
 # Compile Options
 #--------------------------------------
-if (CLR_CMAKE_HOST_UNIX)
+if (CLR_CMAKE_HOST_UNIX OR CLR_CMAKE_HOST_WASI)
   # Disable frame pointer optimizations so profilers can get better call stacks
   add_compile_options(-fno-omit-frame-pointer)
 
@@ -707,7 +707,7 @@ if (CLR_CMAKE_HOST_UNIX)
     endif()
   endif(CLR_CMAKE_HOST_MACCATALYST)
 
-endif(CLR_CMAKE_HOST_UNIX)
+endif(CLR_CMAKE_HOST_UNIX OR CLR_CMAKE_HOST_WASI)
 
 if(CLR_CMAKE_TARGET_UNIX)
   add_compile_definitions($<$<NOT:$<BOOL:$<TARGET_PROPERTY:IGNORE_DEFAULT_TARGET_OS>>>:TARGET_UNIX>)