diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 944688f50c6c62..be21dbbb891514 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -296,7 +296,7 @@
     <ProjectExclusions Remove="$(MSBuildThisFileDirectory)System.Diagnostics.Process/tests/System.Diagnostics.Process.Tests.csproj" />
   </ItemGroup>
 
-  <ItemGroup Condition="('$(TargetOS)' == 'ios' or '$(TargetOS)' == 'iossimulator' or '$(TargetOS)' == 'tvos' or '$(TargetOS)' == 'tvossimulator' or '$(TargetOS)' == 'maccatalyst') and '$(RunDisablediOSTests)' != 'true'">
+  <ItemGroup Condition="'$(TargetsAppleMobile)' == 'true' and '$(RunDisablediOSTests)' != 'true'">
     <!-- PNSE -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Quic/tests/FunctionalTests/System.Net.Quic.Functional.Tests.csproj" />
     <!-- https://github.com/dotnet/runtime/issues/51414 -->
@@ -330,8 +330,8 @@
     <ProjectExclusions Include="$(RepoRoot)/src/tests/FunctionalTests/iOS/Simulator/LibraryMode/iOS.Simulator.LibraryMode.Test.csproj" />
   </ItemGroup>
 
-  <ItemGroup Condition="('$(TargetOS)' == 'iossimulator' or '$(TargetOS)' == 'tvossimulator') and ('$(RuntimeFlavor)' == 'Mono' or '$(UseNativeAOTRuntime)' == 'true') and '$(RunDisablediOSTests)' != 'true'">
-    <ProjectExclusions Include="$(RepoRoot)\src\tests\FunctionalTests\iOS\Simulator\CoreCLR.Interpreter\*.Test.csproj" />
+  <ItemGroup Condition="'$(TargetsAppleMobile)' == 'true' and ('$(RuntimeFlavor)' == 'Mono' or '$(UseNativeAOTRuntime)' == 'true') and '$(RunDisablediOSTests)' != 'true'">
+    <ProjectExclusions Include="$(RepoRoot)\src\tests\FunctionalTests\iOS\Simulator\CoreCLR\*.Test.csproj" />
   </ItemGroup>
 
   <ItemGroup Condition="'$(TargetOS)' == 'browser' and '$(RunDisabledWasmTests)' != 'true' and '$(RunAOTCompilation)' != 'true'">
@@ -629,9 +629,9 @@
     <ProjectExclusions Include="$(RepoRoot)\src\tests\FunctionalTests\Android\Device_Emulator\NativeAOT\*.Test.csproj" />
   </ItemGroup>
 
-  <ItemGroup Condition="('$(TargetOS)' == 'ios' or '$(TargetOS)' == 'iossimulator' or '$(TargetOS)' == 'tvos' or '$(TargetOS)' == 'tvossimulator' or '$(TargetOS)' == 'maccatalyst') and '$(RuntimeFlavor)' == 'CoreCLR' and '$(UseNativeAOTRuntime)' != 'true'">
+  <ItemGroup Condition="'$(TargetsAppleMobile)' == 'true' and '$(RuntimeFlavor)' == 'CoreCLR' and '$(UseNativeAOTRuntime)' != 'true'">
     <SmokeTestProject Remove="@(SmokeTestProject)" />
-    <SmokeTestProject Include="$(RepoRoot)\src\tests\FunctionalTests\iOS\Simulator\CoreCLR.Interpreter\*.Test.csproj"/>
+    <SmokeTestProject Include="$(RepoRoot)\src\tests\FunctionalTests\iOS\Simulator\CoreCLR\*.Test.csproj"/>
   </ItemGroup>
 
   <!--
diff --git a/src/mono/msbuild/apple/build/AppleBuild.InTree.targets b/src/mono/msbuild/apple/build/AppleBuild.InTree.targets
index 653c84a59739ae..37bc5fed8830e3 100644
--- a/src/mono/msbuild/apple/build/AppleBuild.InTree.targets
+++ b/src/mono/msbuild/apple/build/AppleBuild.InTree.targets
@@ -33,19 +33,4 @@
     </ItemGroup>
     <Message Text="Used runtime pack: %(ResolvedRuntimePack.PackageDirectory)" Importance="high" />
   </Target>
-
-  <!-- Override the ResolveReadyToRunCompilers target to use the in-build crossgen2.
-       This needs to be imported after SDK targets, so any project requiring this should set AfterMicrosoftNETSdkTargets -->
-  <Target Name="ResolveReadyToRunCompilers" Condition="'$(PublishReadyToRun)' == true" DependsOnTargets="ResolveRuntimeFilesFromLocalBuild">
-    <PropertyGroup>
-      <Crossgen2Path>$([MSBuild]::NormalizePath('$(Crossgen2InBuildDir)', 'crossgen2$(ExeSuffix)'))</Crossgen2Path>
-    </PropertyGroup>
-
-    <ItemGroup>
-      <Crossgen2Tool Include="$(Crossgen2Path)"
-                     TargetArch="$(TargetArchitecture)"
-                     TargetOS="$(TargetOS)"
-                     PerfmapFormatVersion="$(PublishReadyToRunPerfmapFormatVersion)"/>
-    </ItemGroup>
-  </Target>
 </Project>
diff --git a/src/mono/msbuild/apple/build/AppleBuild.ReadyToRun.targets b/src/mono/msbuild/apple/build/AppleBuild.ReadyToRun.targets
new file mode 100644
index 00000000000000..1bfe6b140f2ca5
--- /dev/null
+++ b/src/mono/msbuild/apple/build/AppleBuild.ReadyToRun.targets
@@ -0,0 +1,17 @@
+<Project>
+  <!-- Tracking issue: https://github.com/dotnet/runtime/issues/119006
+       Override the ResolveReadyToRunCompilers target to use the in-build crossgen2.
+       This needs to be imported after SDK targets, so any project requiring this should set AfterMicrosoftNETSdkTargets -->
+  <Target Name="ResolveReadyToRunCompilers" Condition="'$(PublishReadyToRun)' == true" DependsOnTargets="ResolveRuntimeFilesFromLocalBuild">
+    <PropertyGroup>
+      <Crossgen2Path>$([MSBuild]::NormalizePath('$(Crossgen2InBuildDir)', 'crossgen2$(ExeSuffix)'))</Crossgen2Path>
+    </PropertyGroup>
+
+    <ItemGroup>
+      <Crossgen2Tool Include="$(Crossgen2Path)"
+                     TargetArch="$(TargetArchitecture)"
+                     TargetOS="$(TargetOS)"
+                     PerfmapFormatVersion="$(PublishReadyToRunPerfmapFormatVersion)"/>
+    </ItemGroup>
+  </Target>
+</Project>
diff --git a/src/mono/msbuild/apple/build/AppleBuild.props b/src/mono/msbuild/apple/build/AppleBuild.props
index ba3ff16ac72337..f798429007f348 100644
--- a/src/mono/msbuild/apple/build/AppleBuild.props
+++ b/src/mono/msbuild/apple/build/AppleBuild.props
@@ -9,6 +9,24 @@
     <MonoForceInterpreter Condition="'$(MonoForceInterpreter)' == ''">true</MonoForceInterpreter>
   </PropertyGroup>
 
+  <PropertyGroup Condition="'$(PublishReadyToRun)' == 'true' and '$(UseMonoRuntime)' != 'true'">
+    <PublishReadyToRunComposite>true</PublishReadyToRunComposite>
+    <PublishReadyToRunContainerFormat>macho</PublishReadyToRunContainerFormat>
+  </PropertyGroup>
+
+  <ItemGroup Condition="'$(PublishReadyToRun)' != 'true' and '$(UseMonoRuntime)' != 'true'">
+    <EnvironmentVariables Include="DOTNET_ReadyToRun=0" />
+  </ItemGroup>
+
+  <!-- Tracking issue: https://github.com/dotnet/runtime/issues/119006
+       ReadyToRun settings for CoreCLR on Apple platforms.
+       This can be removed once we upstream Mach-O support in the targets to the SDK -->
+  <Import Project="$(Crossgen2SdkOverridePropsPath)" Condition="'$(PublishReadyToRun)' == 'true' and '$(UseMonoRuntime)' != 'true' and '$(Crossgen2SdkOverridePropsPath)' != ''" />
+  <PropertyGroup Condition="'$(PublishReadyToRun)' == 'true' and '$(UseMonoRuntime)' != 'true'">
+    <AfterMicrosoftNETSdkTargets Condition="'$(Crossgen2SdkOverrideTargetsPath)' != ''">$(AfterMicrosoftNETSdkTargets);$(Crossgen2SdkOverrideTargetsPath)</AfterMicrosoftNETSdkTargets>
+    <AfterMicrosoftNETSdkTargets>$(AfterMicrosoftNETSdkTargets);$(MonoProjectRoot)\msbuild\apple\build\AppleBuild.ReadyToRun.targets</AfterMicrosoftNETSdkTargets>
+  </PropertyGroup>
+
   <PropertyGroup>
     <iOSLikeDedup Condition="'$(iOSLikeDedup)' == '' and '$(RunAOTCompilation)' == 'true' and '$(MonoForceInterpreter)' != 'true'">true</iOSLikeDedup>
     <RuntimeIdentifier>$(TargetOS)-$(TargetArchitecture.ToLowerInvariant())</RuntimeIdentifier>
diff --git a/src/mono/sample/iOS/Program.csproj b/src/mono/sample/iOS/Program.csproj
index 667fcc709e9010..bc6143fe28ea18 100644
--- a/src/mono/sample/iOS/Program.csproj
+++ b/src/mono/sample/iOS/Program.csproj
@@ -26,24 +26,11 @@
     <BuildAppBundleDependsOnTargets Condition="'$(ArchiveTests)' == 'true'">Publish</BuildAppBundleDependsOnTargets>
   </PropertyGroup>
 
-  <PropertyGroup Condition="'$(PublishReadyToRun)' == 'true' and '$(UseMonoRuntime)' != 'true'">
-    <PublishReadyToRunComposite>true</PublishReadyToRunComposite>
-    <PublishReadyToRunContainerFormat>macho</PublishReadyToRunContainerFormat>
-  </PropertyGroup>
-
   <ItemGroup>
     <RuntimeComponents Condition="'$(DiagnosticPorts)' != ''" Include="diagnostics_tracing" />
   </ItemGroup>
 
-  <!-- Use the repo's CrossGen props/targets.
-       This can be removed once we upstream Mach-O support in the targets to the SDK -->
-  <Import Project="$(Crossgen2SdkOverridePropsPath)" Condition="'$(PublishReadyToRun)' == 'true' and '$(Crossgen2SdkOverridePropsPath)' != ''" />
   <Import Project="$(MonoProjectRoot)\msbuild\apple\build\AppleBuild.props" />
-  <PropertyGroup>
-    <!-- Import after SDK targets in order to override R2R-related targets in the SDK -->
-    <AfterMicrosoftNETSdkTargets Condition="'$(PublishReadyToRun)' == 'true' and '$(Crossgen2SdkOverrideTargetsPath)' != ''">$(Crossgen2SdkOverrideTargetsPath)</AfterMicrosoftNETSdkTargets>
-    <AfterMicrosoftNETSdkTargets>$(AfterMicrosoftNETSdkTargets);$(MonoProjectRoot)\msbuild\apple\build\AppleBuild.InTree.targets</AfterMicrosoftNETSdkTargets>
-  </PropertyGroup>
 
   <Target Name="BuildAppBundle" AfterTargets="$(BuildAppBundleAfterTargets)" DependsOnTargets="$(BuildAppBundleDependsOnTargets)"/>
   <Target Name="_SetAppleGenerateAppBundleProps" Condition="'$(TargetOS)' != 'ios' and '$(ArchiveTests)' != 'true'" BeforeTargets="_AppleGenerateAppBundle">
diff --git a/src/tests/FunctionalTests/iOS/Device/Directory.Build.props b/src/tests/FunctionalTests/iOS/Device/Directory.Build.props
index 680be4c0f552e9..efef1f3e3a4010 100644
--- a/src/tests/FunctionalTests/iOS/Device/Directory.Build.props
+++ b/src/tests/FunctionalTests/iOS/Device/Directory.Build.props
@@ -7,4 +7,4 @@
   </PropertyGroup>
 
   <Import Project="..\..\Directory.Build.props" />
-</Project>
\ No newline at end of file
+</Project>
diff --git a/src/tests/FunctionalTests/iOS/Simulator/CoreCLR.Interpreter/Program.cs b/src/tests/FunctionalTests/iOS/Simulator/CoreCLR/Program.cs
similarity index 100%
rename from src/tests/FunctionalTests/iOS/Simulator/CoreCLR.Interpreter/Program.cs
rename to src/tests/FunctionalTests/iOS/Simulator/CoreCLR/Program.cs
diff --git a/src/tests/FunctionalTests/iOS/Simulator/CoreCLR.Interpreter/iOS.Simulator.CoreCLR.Interpreter.Test.csproj b/src/tests/FunctionalTests/iOS/Simulator/CoreCLR/iOS.CoreCLR.Interpreter.Test.csproj
similarity index 76%
rename from src/tests/FunctionalTests/iOS/Simulator/CoreCLR.Interpreter/iOS.Simulator.CoreCLR.Interpreter.Test.csproj
rename to src/tests/FunctionalTests/iOS/Simulator/CoreCLR/iOS.CoreCLR.Interpreter.Test.csproj
index 23315975066cd6..072f8102f157b8 100644
--- a/src/tests/FunctionalTests/iOS/Simulator/CoreCLR.Interpreter/iOS.Simulator.CoreCLR.Interpreter.Test.csproj
+++ b/src/tests/FunctionalTests/iOS/Simulator/CoreCLR/iOS.CoreCLR.Interpreter.Test.csproj
@@ -7,15 +7,11 @@
     <TestRuntime>true</TestRuntime>
     <TargetFramework>$(NetCoreAppCurrent)</TargetFramework>
     <TargetOS Condition="'$(TargetOS)' == ''">iossimulator</TargetOS>
-    <MainLibraryFileName>iOS.Simulator.CoreCLR.Interpreter.Test.dll</MainLibraryFileName>
+    <MainLibraryFileName>iOS.CoreCLR.Interpreter.Test.dll</MainLibraryFileName>
     <IncludesTestRunner>false</IncludesTestRunner>
     <ExpectedExitCode>42</ExpectedExitCode>
   </PropertyGroup>
 
-  <ItemGroup>
-    <EnvironmentVariables Include="DOTNET_InterpMode=3" />
-  </ItemGroup>
-
   <ItemGroup>
     <Compile Include="Program.cs" />
   </ItemGroup>
diff --git a/src/tests/FunctionalTests/iOS/Simulator/CoreCLR/iOS.CoreCLR.R2R.Test.csproj b/src/tests/FunctionalTests/iOS/Simulator/CoreCLR/iOS.CoreCLR.R2R.Test.csproj
new file mode 100644
index 00000000000000..7afa3b15947766
--- /dev/null
+++ b/src/tests/FunctionalTests/iOS/Simulator/CoreCLR/iOS.CoreCLR.R2R.Test.csproj
@@ -0,0 +1,19 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+    <UseMonoRuntime>false</UseMonoRuntime>
+    <MonoForceInterpreter>false</MonoForceInterpreter>
+    <RunAOTCompilation>false</RunAOTCompilation>
+    <TestRuntime>true</TestRuntime>
+    <TargetFramework>$(NetCoreAppCurrent)</TargetFramework>
+    <TargetOS Condition="'$(TargetOS)' == ''">iossimulator</TargetOS>
+    <MainLibraryFileName>iOS.CoreCLR.R2R.Test.dll</MainLibraryFileName>
+    <IncludesTestRunner>false</IncludesTestRunner>
+    <ExpectedExitCode>42</ExpectedExitCode>
+    <PublishReadyToRun>true</PublishReadyToRun>
+  </PropertyGroup>
+
+  <ItemGroup>
+    <Compile Include="Program.cs" />
+  </ItemGroup>
+</Project>