diff --git a/eng/pipelines/coreclr/crossgen2.yml b/eng/pipelines/coreclr/crossgen2.yml
index 775928f7d3ffc2..6a187c7abbd51c 100644
--- a/eng/pipelines/coreclr/crossgen2.yml
+++ b/eng/pipelines/coreclr/crossgen2.yml
@@ -99,6 +99,30 @@ extends:
                   creator: dotnet-bot
                   testRunNamePrefixSuffix: TestReadyToRun_$(_BuildConfig)
 
+      - template: /eng/pipelines/common/platform-matrix.yml
+        parameters:
+          jobTemplate: /eng/pipelines/common/global-build-job.yml
+          helixQueuesTemplate: /eng/pipelines/libraries/helix-queues-setup.yml
+          buildConfig: Release
+          platforms:
+            - linux_x64
+            # - osx_x64 Not included to reduce pressure on osx_x64 machines
+            - windows_x64
+          jobParameters:
+            testGroup: innerloop
+            buildArgs: -s clr+libs+libs.tests
+                       -c $(_BuildConfig)
+                       /p:TestReadyToRun=true
+                       /p:UseRuntimeAsync=true
+                       /p:ArchiveTests=true
+            nameSuffix: TestReadyToRun_RuntimeAsync_Libraries
+            timeoutInMinutes: 360
+            postBuildSteps:
+              - template: /eng/pipelines/libraries/helix.yml
+                parameters:
+                  creator: dotnet-bot
+                  testRunNamePrefixSuffix: TestReadyToRun_RuntimeAsync_$(_BuildConfig)
+
       # Run pri0 tests with hot/cold splitting enabled (only supported on x64 at the moment)
       # TODO: test on arm64 once supported
       - template: /eng/pipelines/common/platform-matrix.yml
diff --git a/eng/testing/tests.targets b/eng/testing/tests.targets
index 6579ff2f0ba884..0eb0439d498836 100644
--- a/eng/testing/tests.targets
+++ b/eng/testing/tests.targets
@@ -2,7 +2,7 @@
   <!-- Enable runtime async for all .NET 11+ test projects. -->
   <PropertyGroup Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', 'net11.0'))
     and '$(TestNativeAot)' != 'true'
-    and '$(TestReadyToRun)' != 'true'
+    and ('$(TestReadyToRun)' != 'true' or '$(UseRuntimeAsync)' == 'true')
     and '$(UseNativeAOTRuntime)' != 'true'
     and '$(TargetOS)' != 'browser'
     and '$(TargetOS)' != 'wasi'