diff --git a/src/coreclr/System.Private.CoreLib/src/System/Runtime/CompilerServices/CastHelpers.cs b/src/coreclr/System.Private.CoreLib/src/System/Runtime/CompilerServices/CastHelpers.cs
index a921099356ec3..486aeb72faddb 100644
--- a/src/coreclr/System.Private.CoreLib/src/System/Runtime/CompilerServices/CastHelpers.cs
+++ b/src/coreclr/System.Private.CoreLib/src/System/Runtime/CompilerServices/CastHelpers.cs
@@ -477,7 +477,12 @@ private static CastResult TryGet(nuint source, nuint target)
         private static object? ChkCastClassSpecial(void* toTypeHnd, object obj)
         {
             MethodTable* mt = RuntimeHelpers.GetMethodTable(obj);
-            Debug.Assert(mt != toTypeHnd, "The check for the trivial cases should be inlined by the JIT");
+
+            // Normally, this case is expected to be handled by JIT inline.
+            // However, with PGO data JIT might decide to check a different type instead
+            // so this one has to be always checked here
+            if (toTypeHnd == mt)
+                goto done;
 
             for (; ; )
             {
diff --git a/src/coreclr/jit/jitconfigvalues.h b/src/coreclr/jit/jitconfigvalues.h
index 33cf1d74f206e..569b030b95a84 100644
--- a/src/coreclr/jit/jitconfigvalues.h
+++ b/src/coreclr/jit/jitconfigvalues.h
@@ -548,7 +548,7 @@ CONFIG_INTEGER(JitMinimalJitProfiling, W("JitMinimalJitProfiling"), 1)
 CONFIG_INTEGER(JitMinimalPrejitProfiling, W("JitMinimalPrejitProfiling"), 0)
 
 CONFIG_INTEGER(JitProfileCasts, W("JitProfileCasts"), 0)                     // Profile castclass/isinst
-CONFIG_INTEGER(JitConsumeProfileForCasts, W("JitConsumeProfileForCasts"), 0) // Consume profile data (if any) for
+CONFIG_INTEGER(JitConsumeProfileForCasts, W("JitConsumeProfileForCasts"), 1) // Consume profile data (if any) for
                                                                              // castclass/isinst
 
 CONFIG_INTEGER(JitClassProfiling, W("JitClassProfiling"), 1)         // Profile virtual and interface calls