diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index b59a656853bbd..60d510014a613 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -915,6 +915,13 @@
         </ExcludeList>
     </ItemGroup>
 
+    <!-- Crossgen2 x86 specific excludes -->
+    <ItemGroup Condition="'$(XunitTestBinBase)' != '' and '$(TestBuildMode)' == 'crossgen2' and '$(RuntimeFlavor)' == 'coreclr' and '$(TargetArchitecture)' == 'x86'">
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/jit64/opt/cse/hugeexpr1/**">
+            <Issue>https://github.com/dotnet/runtime/issues/74555</Issue>
+        </ExcludeList>
+    </ItemGroup>
+
     <!-- Crossgen2 arm32 specific excludes -->
     <ItemGroup Condition="'$(XunitTestBinBase)' != '' and ('$(TestBuildMode)' == 'crossgen2' or '$(TestBuildMode)' == 'crossgen') and '$(RuntimeFlavor)' == 'coreclr' and ('$(TargetArchitecture)' == 'arm' or '$(AltJitArch)' == 'arm')">
         <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/Runtime_34170/Runtime_34170/*">