diff --git a/src/coreclr/jit/lowerxarch.cpp b/src/coreclr/jit/lowerxarch.cpp
index d68c3e0d2689a2..71b700ddd97ebf 100644
--- a/src/coreclr/jit/lowerxarch.cpp
+++ b/src/coreclr/jit/lowerxarch.cpp
@@ -6504,7 +6504,7 @@ void Lowering::ContainCheckStoreIndir(GenTreeStoreInd* node)
                 case NI_AVX2_ConvertToUInt32:
                 {
                     // These intrinsics are "ins reg/mem, xmm"
-                    isContainable = varTypeIsIntegral(simdBaseType);
+                    isContainable = varTypeIsIntegral(simdBaseType) && (genTypeSize(src) == genTypeSize(node));
                     break;
                 }
 
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_92349/Runtime_92349.cs b/src/tests/JIT/Regression/JitBlue/Runtime_92349/Runtime_92349.cs
new file mode 100644
index 00000000000000..5de0a28895b268
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_92349/Runtime_92349.cs
@@ -0,0 +1,29 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+using System;
+using System.Runtime.Intrinsics.X86;
+using System.Runtime.Intrinsics;
+using System.Runtime.CompilerServices;
+using System.Threading;
+using Xunit;
+
+public static class Runtime_92349
+{
+    [MethodImpl(MethodImplOptions.AggressiveOptimization)]
+    unsafe static void Test(byte* pValue)
+    {
+        *pValue = (byte)Sse2.ConvertToInt32(Vector128.Create(-10, 0, 0, 0));
+    }
+
+    [Fact]
+    public unsafe static void EntryPoint()
+    {
+        if (Sse2.IsSupported)
+        {
+            ulong value = 0;
+            Test((byte*)Unsafe.AsPointer(ref value));
+            Assert.True(value == 246);
+        }
+    }
+}
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_92349/Runtime_92349.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_92349/Runtime_92349.csproj
new file mode 100644
index 00000000000000..6bb210527e0797
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_92349/Runtime_92349.csproj
@@ -0,0 +1,9 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <Optimize>True</Optimize>
+    <AllowUnsafeBlocks>True</AllowUnsafeBlocks>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>
\ No newline at end of file