diff --git a/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.TargetFrameworkInference.targets b/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.TargetFrameworkInference.targets
index b39881a1da1b..f07970633e3f 100644
--- a/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.TargetFrameworkInference.targets
+++ b/src/Tasks/Microsoft.NET.Build.Tasks/targets/Microsoft.NET.TargetFrameworkInference.targets
@@ -222,7 +222,8 @@ Copyright (c) .NET Foundation. All rights reserved.
     BeforeTargets="ProcessFrameworkReferences"
     Condition="'$(TargetPlatformVersion)' != '' and '$(TargetFrameworkIdentifier)' == '.NETCoreApp' and $([MSBuild]::VersionGreaterThanOrEquals($(TargetFrameworkVersion), 5.0)) and ('$(Language)' != 'C++' or '$(_EnablePackageReferencesInVCProjects)' == 'true')">
     <ItemGroup>
-      <_ValidTargetPlatformVersion Include="@(SdkSupportedTargetPlatformVersion)" Condition="'@(SdkSupportedTargetPlatformVersion)' != '' and $([MSBuild]::VersionEquals(%(Identity), $(TargetPlatformVersion)))" />
+      <_ApplicableTargetPlatformVersion Include="@(SdkSupportedTargetPlatformVersion)" Condition="'@(SdkSupportedTargetPlatformVersion)' != '' and '%(SdkSupportedTargetPlatformVersion.DefineConstantsOnly)' != 'true'" RemoveMetadata="DefineConstantsOnly" />
+      <_ValidTargetPlatformVersion Include="@(_ApplicableTargetPlatformVersion)" Condition="'@(_ApplicableTargetPlatformVersion)' != '' and $([MSBuild]::VersionEquals(%(Identity), $(TargetPlatformVersion)))" />
     </ItemGroup>
 
     <PropertyGroup>
@@ -236,8 +237,8 @@ Copyright (c) .NET Foundation. All rights reserved.
       Condition="'$(TargetPlatformVersion)' != '' and '$(TargetFrameworkIdentifier)' == '.NETCoreApp' and $([MSBuild]::VersionGreaterThanOrEquals($(TargetFrameworkVersion), 5.0)) and ('$(Language)' != 'C++' or '$(_EnablePackageReferencesInVCProjects)' == 'true')">
     <PropertyGroup>
       <TargetPlatformVersionSupported Condition="'$(TargetPlatformVersionSupported)' == '' and '@(_ValidTargetPlatformVersion)' != ''" >true</TargetPlatformVersionSupported>
-      <_ValidTargetPlatformVersions Condition="'@(SdkSupportedTargetPlatformVersion)' != ''" >@(SdkSupportedTargetPlatformVersion, '%0a')</_ValidTargetPlatformVersions>
-      <_ValidTargetPlatformVersions Condition="'@(SdkSupportedTargetPlatformVersion)' == ''" >None</_ValidTargetPlatformVersions>
+      <_ValidTargetPlatformVersions Condition="'@(_ApplicableTargetPlatformVersion)' != ''" >@(_ApplicableTargetPlatformVersion, '%0a')</_ValidTargetPlatformVersions>
+      <_ValidTargetPlatformVersions Condition="'@(_ApplicableTargetPlatformVersion)' == ''" >None</_ValidTargetPlatformVersions>
     </PropertyGroup>
 
     <NetSdkError Condition="'$(TargetPlatformVersionSupported)' != 'true'"
diff --git a/test/Microsoft.NET.Build.Tests/GivenThatWeWantToBuildWithATargetPlatform.cs b/test/Microsoft.NET.Build.Tests/GivenThatWeWantToBuildWithATargetPlatform.cs
index dff3696cb7e8..0ef98703ac67 100644
--- a/test/Microsoft.NET.Build.Tests/GivenThatWeWantToBuildWithATargetPlatform.cs
+++ b/test/Microsoft.NET.Build.Tests/GivenThatWeWantToBuildWithATargetPlatform.cs
@@ -1,6 +1,8 @@
 // Licensed to the .NET Foundation under one or more agreements.
 // The .NET Foundation licenses this file to you under the MIT license.
 
+using Microsoft.NET.Build.Tasks;
+
 namespace Microsoft.NET.Build.Tests
 {
     public class GivenThatWeWantToBuildWithATargetPlatform : SdkTest
@@ -90,5 +92,82 @@ public void It_fails_on_unsupported_os()
                 .And
                 .HaveStdOutContaining("NETSDK1139");
         }
+
+        [Fact]
+        public void It_fails_if_targetplatformversion_is_constant_only()
+        {
+            var testProject = new TestProject()
+            {
+                Name = "It_fails_if_targetplatformversion_is_constant_only",
+                TargetFrameworks = ToolsetInfo.CurrentTargetFramework,
+            };
+            var testAsset = _testAssetsManager.CreateTestProject(testProject);
+
+
+            string DirectoryBuildTargetsContent = $@"
+<Project>
+  <ItemGroup>
+    <SdkSupportedTargetPlatformVersion Include=""111.0"" DefineConstantsOnly=""true"" />
+    <SdkSupportedTargetPlatformVersion Include=""222.0"" />
+  </ItemGroup>
+  <PropertyGroup>
+    <TargetPlatformVersion>111.0</TargetPlatformVersion>
+    <TargetPlatformIdentifier>ios</TargetPlatformIdentifier>
+    <TargetPlatformSupported>true</TargetPlatformSupported>
+  </PropertyGroup>
+</Project>
+";
+
+            File.WriteAllText(Path.Combine(testAsset.TestRoot, "Directory.Build.targets"), DirectoryBuildTargetsContent);
+
+            var buildCommand = new BuildCommand(testAsset);
+            buildCommand.Execute()
+                .Should()
+                .Fail()
+                .And
+                .HaveStdOutContaining("NETSDK1140")
+                .And
+                .HaveStdOutContaining(string.Format(Strings.InvalidTargetPlatformVersion, "111.0", "ios", "222.0").Split ('\n', '\r') [0])
+                .And
+                .HaveStdOutContaining("222.0");
+        }
+
+        [Fact]
+        public void It_fails_if_targetplatformversion_is_invalid()
+        {
+            var testProject = new TestProject()
+            {
+                Name = "It_fails_if_targetplatformversion_is_invalid",
+                TargetFrameworks = ToolsetInfo.CurrentTargetFramework,
+            };
+            var testAsset = _testAssetsManager.CreateTestProject(testProject);
+
+
+            string DirectoryBuildTargetsContent = $@"
+<Project>
+  <ItemGroup>
+    <SdkSupportedTargetPlatformVersion Include=""222.0"" />
+  </ItemGroup>
+  <PropertyGroup>
+    <TargetPlatformVersion>111.0</TargetPlatformVersion>
+    <TargetPlatformIdentifier>ios</TargetPlatformIdentifier>
+    <TargetPlatformSupported>true</TargetPlatformSupported>
+  </PropertyGroup>
+</Project>
+";
+
+            File.WriteAllText(Path.Combine(testAsset.TestRoot, "Directory.Build.targets"), DirectoryBuildTargetsContent);
+
+            var buildCommand = new BuildCommand(testAsset);
+            buildCommand.Execute()
+                .Should()
+                .Fail()
+                .And
+                .HaveStdOutContaining("NETSDK1140")
+                .And
+                .HaveStdOutContaining(string.Format(Strings.InvalidTargetPlatformVersion, "111.0", "ios", "222.0").Split ('\n', '\r') [0])
+                .And
+                .HaveStdOutContaining("222.0");
+        }
     }
 }