diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_40607/Runtime_40607.cs b/src/tests/JIT/Regression/JitBlue/Runtime_40607/Runtime_40607.cs
new file mode 100644
index 0000000000000..5395a16b4a03b
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_40607/Runtime_40607.cs
@@ -0,0 +1,69 @@
+using System;
+using System.Runtime.CompilerServices;
+
+namespace Runtime_40607
+{
+    class Program
+    {
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        static bool WillBeInlined(out bool shouldBeFalse)
+        {
+            shouldBeFalse = false;
+            return true;
+        }
+
+        [MethodImpl(MethodImplOptions.NoInlining)]
+        [SkipLocalsInit]
+        static int DependsOnUnInitValue()
+        {
+            int retVal = 1;
+            bool shouldBeFalse;
+
+            while (WillBeInlined(out shouldBeFalse))
+            {
+                if (shouldBeFalse)
+                {
+                    retVal = 0;
+                }
+                break;
+            }
+
+            return retVal;
+        }
+
+        [MethodImpl(MethodImplOptions.NoInlining)]
+        static unsafe int PoisonStackWith(uint fillValue)
+        {
+            int retVal = 1;
+            bool shouldBeFalse;
+
+            *(uint*)&shouldBeFalse = fillValue;
+
+            while (WillBeInlined(out shouldBeFalse))
+            {
+                if (shouldBeFalse)
+                {
+                    retVal = 0;
+                }
+                break;
+            }
+
+            return retVal;
+        }
+
+        static int Main(string[] args)
+        {
+            PoisonStackWith(0xdeadbeef);
+
+            const int expected = 1;
+            int actual = DependsOnUnInitValue();
+
+            if (expected != actual)
+            {
+                return 0;
+            }
+
+            return 100;
+        }
+    }
+}
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_40607/Runtime_40607.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_40607/Runtime_40607.csproj
new file mode 100644
index 0000000000000..2ab2ec62439f7
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_40607/Runtime_40607.csproj
@@ -0,0 +1,11 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <OutputType>Exe</OutputType>
+    <DebugType />
+    <Optimize>True</Optimize>
+    <AllowUnsafeBlocks>True</AllowUnsafeBlocks>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>