diff --git a/docs/src/main/asciidoc/grpc-generation-reference.adoc b/docs/src/main/asciidoc/grpc-generation-reference.adoc
index 6d871816c3c33..48c732bcd5123 100644
--- a/docs/src/main/asciidoc/grpc-generation-reference.adoc
+++ b/docs/src/main/asciidoc/grpc-generation-reference.adoc
@@ -99,6 +99,21 @@ quarkus {
 }
 ----
 
+== Generating Descriptor Set
+Protocol Buffers do not contain descriptions of their own types. Thus, given only a raw message without the corresponding .proto file defining its type, it is difficult to extract any useful data. However, the contents of a .proto file can itself be https://protobuf.dev/programming-guides/techniques/#self-description[represented using protocol buffers].
+
+By default, Quarkus does not generate these descriptors. Quarkus does provide several configuration options for generating them. These would be added to your `application.properties` or `application.yml` file:
+
+* `quarkus.generate-code.grpc.descriptor-set.generate`
+** Set to `true` to enable generation
+* `quarkus.generate-code.grpc.descriptor-set.output-dir`
+** Set this to a value relative to the project's build directory (i.e. `target` for Maven, `build` for Gradle)
+** Maven default value: `target/generated-sources/grpc`
+** Gradle default value: `$buildDir/classes/java/quarkus-generated-sources/grpc`
+* `quarkus.generate-code.grpc.descriptor-set.name`
+** Name of the descriptor set file to generate
+** Default value: `descriptor_set.dsc`
+
 == Configuring gRPC code generation for dependencies
 
 You may have dependencies that contain `\*.proto` files you want to compile to Java sources.
diff --git a/extensions/grpc/codegen/src/main/java/io/quarkus/grpc/deployment/GrpcCodeGen.java b/extensions/grpc/codegen/src/main/java/io/quarkus/grpc/deployment/GrpcCodeGen.java
index 32a0ed9d06172..6c5417239d0a3 100644
--- a/extensions/grpc/codegen/src/main/java/io/quarkus/grpc/deployment/GrpcCodeGen.java
+++ b/extensions/grpc/codegen/src/main/java/io/quarkus/grpc/deployment/GrpcCodeGen.java
@@ -1,5 +1,6 @@
 package io.quarkus.grpc.deployment;
 
+import static java.lang.Boolean.FALSE;
 import static java.lang.Boolean.TRUE;
 import static java.util.Arrays.asList;
 
@@ -56,6 +57,9 @@ public class GrpcCodeGen implements CodeGenProvider {
     private static final String SCAN_FOR_IMPORTS = "quarkus.generate-code.grpc.scan-for-imports";
 
     private static final String POST_PROCESS_SKIP = "quarkus.generate.code.grpc-post-processing.skip";
+    private static final String GENERATE_DESCRIPTOR_SET = "quarkus.generate-code.grpc.descriptor-set.generate";
+    private static final String DESCRIPTOR_SET_OUTPUT_DIR = "quarkus.generate-code.grpc.descriptor-set.output-dir";
+    private static final String DESCRIPTOR_SET_FILENAME = "quarkus.generate-code.grpc.descriptor-set.name";
 
     private Executables executables;
     private String input;
@@ -149,6 +153,11 @@ public boolean trigger(CodeGenContext context) throws CodeGenException {
                         "--q-grpc_out=" + outDir,
                         "--grpc_out=" + outDir,
                         "--java_out=" + outDir));
+
+                if (shouldGenerateDescriptorSet(context.config())) {
+                    command.add(String.format("--descriptor_set_out=%s", getDescriptorSetOutputFile(context)));
+                }
+
                 command.addAll(protoFiles);
 
                 ProcessBuilder processBuilder = new ProcessBuilder(command);
@@ -262,6 +271,25 @@ private boolean isGeneratingFromAppDependenciesEnabled(Config config) {
                 .filter(value -> !"none".equals(value)).isPresent();
     }
 
+    private boolean shouldGenerateDescriptorSet(Config config) {
+        return config.getOptionalValue(GENERATE_DESCRIPTOR_SET, Boolean.class).orElse(FALSE);
+    }
+
+    private Path getDescriptorSetOutputFile(CodeGenContext context) throws IOException {
+        var dscOutputDir = context.config().getOptionalValue(DESCRIPTOR_SET_OUTPUT_DIR, String.class)
+                .map(context.workDir()::resolve)
+                .orElseGet(context::outDir);
+
+        if (Files.notExists(dscOutputDir)) {
+            Files.createDirectories(dscOutputDir);
+        }
+
+        var dscFilename = context.config().getOptionalValue(DESCRIPTOR_SET_FILENAME, String.class)
+                .orElse("descriptor_set.dsc");
+
+        return dscOutputDir.resolve(dscFilename).normalize();
+    }
+
     private Collection<String> gatherDirectoriesWithImports(Path workDir, CodeGenContext context) throws CodeGenException {
         Config properties = context.config();
 
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/build.gradle b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/build.gradle
new file mode 100644
index 0000000000000..57535418f2507
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/build.gradle
@@ -0,0 +1,33 @@
+plugins {
+    id 'java'
+    id 'io.quarkus'
+}
+
+repositories {
+    mavenLocal {
+        content {
+            includeGroupByRegex 'io.quarkus.*'
+            includeGroup 'org.hibernate.orm'
+        }
+    }
+    mavenCentral()
+    gradlePluginPortal()
+}
+
+dependencies {
+    implementation enforcedPlatform("${quarkusPlatformGroupId}:${quarkusPlatformArtifactId}:${quarkusPlatformVersion}")
+    implementation 'io.quarkus:quarkus-resteasy'
+    implementation 'io.quarkus:quarkus-grpc'
+}
+
+group 'org.acme'
+version '1.0.0-SNAPSHOT'
+
+java {
+    sourceCompatibility = JavaVersion.VERSION_11
+    targetCompatibility = JavaVersion.VERSION_11
+}
+
+test {
+    systemProperty "java.util.logging.manager", "org.jboss.logmanager.LogManager"
+}
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/gradle.properties b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/gradle.properties
new file mode 100644
index 0000000000000..ec2b6ef199c2c
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/gradle.properties
@@ -0,0 +1,2 @@
+quarkusPlatformArtifactId=quarkus-bom
+quarkusPlatformGroupId=io.quarkus
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/settings.gradle b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/settings.gradle
new file mode 100644
index 0000000000000..662c07020134c
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/settings.gradle
@@ -0,0 +1,16 @@
+pluginManagement {
+    repositories {
+        mavenLocal {
+            content {
+                includeGroupByRegex 'io.quarkus.*'
+                includeGroup 'org.hibernate.orm'
+            }
+        }
+        mavenCentral()
+        gradlePluginPortal()
+    }
+    plugins {
+        id 'io.quarkus' version "${quarkusPluginVersion}"
+    }
+}
+rootProject.name = 'grpc-descriptor-set-alternate-output-dir'
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/java/org/acme/quarkus/sample/HelloResource.java b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/java/org/acme/quarkus/sample/HelloResource.java
new file mode 100644
index 0000000000000..e5c864ff6be0e
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/java/org/acme/quarkus/sample/HelloResource.java
@@ -0,0 +1,21 @@
+package org.acme.quarkus.sample;
+
+import jakarta.inject.Inject;
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.Produces;
+import jakarta.ws.rs.core.MediaType;
+
+import io.quarkus.example.HelloMsg;
+
+@Path("/hello")
+public class HelloResource {
+
+    @GET
+    @Produces(MediaType.TEXT_PLAIN)
+    public String hello() {
+        Integer number = HelloMsg.Status.TEST_ONE.getNumber();
+        // return a thing from proto file (for devmode test)
+        return "hello " + number;
+    }
+}
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/proto/hello.proto b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/proto/hello.proto
new file mode 100644
index 0000000000000..4ebcaf36db77a
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/proto/hello.proto
@@ -0,0 +1,23 @@
+syntax = "proto3";
+package io.quarkus.example;
+
+option java_multiple_files = true;
+option java_package = "io.quarkus.example";
+
+import "google/protobuf/timestamp.proto";
+
+
+message HelloMsg {
+  enum Status {
+    UNKNOWN = 0;
+    NOT_SERVING = 1;
+    TEST_ONE = 2;
+  }
+  string message = 1;
+  google.protobuf.Timestamp date_time = 2;
+  Status status = 3;
+}
+
+service DevModeService {
+  rpc Check(HelloMsg) returns (HelloMsg);
+}
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/resources/application.properties b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/resources/application.properties
new file mode 100644
index 0000000000000..f4576b12d2123
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output-dir/src/main/resources/application.properties
@@ -0,0 +1,3 @@
+quarkus.generate-code.grpc.descriptor-set.generate=true
+quarkus.generate-code.grpc.descriptor-set.name=hello.dsc
+quarkus.generate-code.grpc.descriptor-set.output-dir=proto
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/build.gradle b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/build.gradle
new file mode 100644
index 0000000000000..57535418f2507
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/build.gradle
@@ -0,0 +1,33 @@
+plugins {
+    id 'java'
+    id 'io.quarkus'
+}
+
+repositories {
+    mavenLocal {
+        content {
+            includeGroupByRegex 'io.quarkus.*'
+            includeGroup 'org.hibernate.orm'
+        }
+    }
+    mavenCentral()
+    gradlePluginPortal()
+}
+
+dependencies {
+    implementation enforcedPlatform("${quarkusPlatformGroupId}:${quarkusPlatformArtifactId}:${quarkusPlatformVersion}")
+    implementation 'io.quarkus:quarkus-resteasy'
+    implementation 'io.quarkus:quarkus-grpc'
+}
+
+group 'org.acme'
+version '1.0.0-SNAPSHOT'
+
+java {
+    sourceCompatibility = JavaVersion.VERSION_11
+    targetCompatibility = JavaVersion.VERSION_11
+}
+
+test {
+    systemProperty "java.util.logging.manager", "org.jboss.logmanager.LogManager"
+}
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/gradle.properties b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/gradle.properties
new file mode 100644
index 0000000000000..ec2b6ef199c2c
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/gradle.properties
@@ -0,0 +1,2 @@
+quarkusPlatformArtifactId=quarkus-bom
+quarkusPlatformGroupId=io.quarkus
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/settings.gradle b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/settings.gradle
new file mode 100644
index 0000000000000..687590ad96980
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/settings.gradle
@@ -0,0 +1,16 @@
+pluginManagement {
+    repositories {
+        mavenLocal {
+            content {
+                includeGroupByRegex 'io.quarkus.*'
+                includeGroup 'org.hibernate.orm'
+            }
+        }
+        mavenCentral()
+        gradlePluginPortal()
+    }
+    plugins {
+        id 'io.quarkus' version "${quarkusPluginVersion}"
+    }
+}
+rootProject.name = 'grpc-descriptor-set-alternate-output'
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/java/org/acme/quarkus/sample/HelloResource.java b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/java/org/acme/quarkus/sample/HelloResource.java
new file mode 100644
index 0000000000000..e5c864ff6be0e
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/java/org/acme/quarkus/sample/HelloResource.java
@@ -0,0 +1,21 @@
+package org.acme.quarkus.sample;
+
+import jakarta.inject.Inject;
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.Produces;
+import jakarta.ws.rs.core.MediaType;
+
+import io.quarkus.example.HelloMsg;
+
+@Path("/hello")
+public class HelloResource {
+
+    @GET
+    @Produces(MediaType.TEXT_PLAIN)
+    public String hello() {
+        Integer number = HelloMsg.Status.TEST_ONE.getNumber();
+        // return a thing from proto file (for devmode test)
+        return "hello " + number;
+    }
+}
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/proto/hello.proto b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/proto/hello.proto
new file mode 100644
index 0000000000000..4ebcaf36db77a
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/proto/hello.proto
@@ -0,0 +1,23 @@
+syntax = "proto3";
+package io.quarkus.example;
+
+option java_multiple_files = true;
+option java_package = "io.quarkus.example";
+
+import "google/protobuf/timestamp.proto";
+
+
+message HelloMsg {
+  enum Status {
+    UNKNOWN = 0;
+    NOT_SERVING = 1;
+    TEST_ONE = 2;
+  }
+  string message = 1;
+  google.protobuf.Timestamp date_time = 2;
+  Status status = 3;
+}
+
+service DevModeService {
+  rpc Check(HelloMsg) returns (HelloMsg);
+}
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/resources/application.properties b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/resources/application.properties
new file mode 100644
index 0000000000000..8181681cb4951
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set-alternate-output/src/main/resources/application.properties
@@ -0,0 +1,2 @@
+quarkus.generate-code.grpc.descriptor-set.generate=true
+quarkus.generate-code.grpc.descriptor-set.name=hello.dsc
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set/build.gradle b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/build.gradle
new file mode 100644
index 0000000000000..57535418f2507
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/build.gradle
@@ -0,0 +1,33 @@
+plugins {
+    id 'java'
+    id 'io.quarkus'
+}
+
+repositories {
+    mavenLocal {
+        content {
+            includeGroupByRegex 'io.quarkus.*'
+            includeGroup 'org.hibernate.orm'
+        }
+    }
+    mavenCentral()
+    gradlePluginPortal()
+}
+
+dependencies {
+    implementation enforcedPlatform("${quarkusPlatformGroupId}:${quarkusPlatformArtifactId}:${quarkusPlatformVersion}")
+    implementation 'io.quarkus:quarkus-resteasy'
+    implementation 'io.quarkus:quarkus-grpc'
+}
+
+group 'org.acme'
+version '1.0.0-SNAPSHOT'
+
+java {
+    sourceCompatibility = JavaVersion.VERSION_11
+    targetCompatibility = JavaVersion.VERSION_11
+}
+
+test {
+    systemProperty "java.util.logging.manager", "org.jboss.logmanager.LogManager"
+}
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set/gradle.properties b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/gradle.properties
new file mode 100644
index 0000000000000..ec2b6ef199c2c
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/gradle.properties
@@ -0,0 +1,2 @@
+quarkusPlatformArtifactId=quarkus-bom
+quarkusPlatformGroupId=io.quarkus
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set/settings.gradle b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/settings.gradle
new file mode 100644
index 0000000000000..46dc110045b06
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/settings.gradle
@@ -0,0 +1,16 @@
+pluginManagement {
+    repositories {
+        mavenLocal {
+            content {
+                includeGroupByRegex 'io.quarkus.*'
+                includeGroup 'org.hibernate.orm'
+            }
+        }
+        mavenCentral()
+        gradlePluginPortal()
+    }
+    plugins {
+        id 'io.quarkus' version "${quarkusPluginVersion}"
+    }
+}
+rootProject.name = 'grpc-descriptor-set'
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/java/org/acme/quarkus/sample/HelloResource.java b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/java/org/acme/quarkus/sample/HelloResource.java
new file mode 100644
index 0000000000000..e5c864ff6be0e
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/java/org/acme/quarkus/sample/HelloResource.java
@@ -0,0 +1,21 @@
+package org.acme.quarkus.sample;
+
+import jakarta.inject.Inject;
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.Produces;
+import jakarta.ws.rs.core.MediaType;
+
+import io.quarkus.example.HelloMsg;
+
+@Path("/hello")
+public class HelloResource {
+
+    @GET
+    @Produces(MediaType.TEXT_PLAIN)
+    public String hello() {
+        Integer number = HelloMsg.Status.TEST_ONE.getNumber();
+        // return a thing from proto file (for devmode test)
+        return "hello " + number;
+    }
+}
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/proto/hello.proto b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/proto/hello.proto
new file mode 100644
index 0000000000000..4ebcaf36db77a
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/proto/hello.proto
@@ -0,0 +1,23 @@
+syntax = "proto3";
+package io.quarkus.example;
+
+option java_multiple_files = true;
+option java_package = "io.quarkus.example";
+
+import "google/protobuf/timestamp.proto";
+
+
+message HelloMsg {
+  enum Status {
+    UNKNOWN = 0;
+    NOT_SERVING = 1;
+    TEST_ONE = 2;
+  }
+  string message = 1;
+  google.protobuf.Timestamp date_time = 2;
+  Status status = 3;
+}
+
+service DevModeService {
+  rpc Check(HelloMsg) returns (HelloMsg);
+}
\ No newline at end of file
diff --git a/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/resources/application.properties b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/resources/application.properties
new file mode 100644
index 0000000000000..b39cd85e72737
--- /dev/null
+++ b/integration-tests/gradle/src/main/resources/grpc-descriptor-set/src/main/resources/application.properties
@@ -0,0 +1 @@
+quarkus.generate-code.grpc.descriptor-set.generate=true
\ No newline at end of file
diff --git a/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetAlternateOutputBuildTest.java b/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetAlternateOutputBuildTest.java
new file mode 100644
index 0000000000000..e108c207370d7
--- /dev/null
+++ b/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetAlternateOutputBuildTest.java
@@ -0,0 +1,27 @@
+package io.quarkus.gradle;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import org.junit.jupiter.api.Test;
+
+public class GrpcDescriptorSetAlternateOutputBuildTest extends QuarkusGradleWrapperTestBase {
+
+    @Test
+    public void testGrpcDescriptorSetAlternateOutput() throws Exception {
+        var projectDir = getProjectDir("grpc-descriptor-set-alternate-output");
+        var buildResult = runGradleWrapper(projectDir, "clean", "build");
+        assertThat(BuildResult.isSuccessful(buildResult.getTasks().get(":quarkusGenerateCode"))).isTrue();
+
+        var expectedOutputDir = projectDir.toPath()
+                .resolve("build")
+                .resolve("classes")
+                .resolve("java")
+                .resolve("quarkus-generated-sources")
+                .resolve("grpc");
+
+        assertThat(expectedOutputDir).exists();
+        assertThat(expectedOutputDir.resolve("hello.dsc"))
+                .exists()
+                .isNotEmptyFile();
+    }
+}
diff --git a/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetAlternateOutputDirBuildTest.java b/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetAlternateOutputDirBuildTest.java
new file mode 100644
index 0000000000000..579042e321d11
--- /dev/null
+++ b/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetAlternateOutputDirBuildTest.java
@@ -0,0 +1,24 @@
+package io.quarkus.gradle;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import org.junit.jupiter.api.Test;
+
+public class GrpcDescriptorSetAlternateOutputDirBuildTest extends QuarkusGradleWrapperTestBase {
+
+    @Test
+    public void testGrpcDescriptorSetAlternateOutputDir() throws Exception {
+        var projectDir = getProjectDir("grpc-descriptor-set-alternate-output-dir");
+        var buildResult = runGradleWrapper(projectDir, "clean", "build");
+        assertThat(BuildResult.isSuccessful(buildResult.getTasks().get(":quarkusGenerateCode"))).isTrue();
+
+        var expectedOutputDir = projectDir.toPath()
+                .resolve("build")
+                .resolve("proto");
+
+        assertThat(expectedOutputDir).exists();
+        assertThat(expectedOutputDir.resolve("hello.dsc"))
+                .exists()
+                .isNotEmptyFile();
+    }
+}
diff --git a/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetBuildTest.java b/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetBuildTest.java
new file mode 100644
index 0000000000000..c5506309e0bc8
--- /dev/null
+++ b/integration-tests/gradle/src/test/java/io/quarkus/gradle/GrpcDescriptorSetBuildTest.java
@@ -0,0 +1,27 @@
+package io.quarkus.gradle;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import org.junit.jupiter.api.Test;
+
+public class GrpcDescriptorSetBuildTest extends QuarkusGradleWrapperTestBase {
+
+    @Test
+    public void testGrpcDescriptorSet() throws Exception {
+        var projectDir = getProjectDir("grpc-descriptor-set");
+        var buildResult = runGradleWrapper(projectDir, "clean", "build");
+        assertThat(BuildResult.isSuccessful(buildResult.getTasks().get(":quarkusGenerateCode"))).isTrue();
+
+        var expectedOutputDir = projectDir.toPath()
+                .resolve("build")
+                .resolve("classes")
+                .resolve("java")
+                .resolve("quarkus-generated-sources")
+                .resolve("grpc");
+
+        assertThat(expectedOutputDir).exists();
+        assertThat(expectedOutputDir.resolve("descriptor_set.dsc"))
+                .exists()
+                .isNotEmptyFile();
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/pom.xml b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/pom.xml
new file mode 100644
index 0000000000000..8f819511f53e6
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/pom.xml
@@ -0,0 +1,28 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<project xmlns="http://maven.apache.org/POM/4.0.0"
+         xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+         xsi:schemaLocation="http://maven.apache.org/POM/4.0.0 http://maven.apache.org/xsd/maven-4.0.0.xsd">
+    <modelVersion>4.0.0</modelVersion>
+
+    <parent>
+        <artifactId>quarkus-integration-test-grpc-descriptor-sets-parent</artifactId>
+        <groupId>io.quarkus</groupId>
+        <version>999-SNAPSHOT</version>
+    </parent>
+
+    <artifactId>quarkus-integration-test-grpc-descriptor-sets-alternate-output-dir</artifactId>
+    <name>Quarkus - Integration Tests - gRPC - Descriptor Sets - Alternate Output Dir</name>
+
+        <build>
+        <plugins>
+            <plugin>
+                <artifactId>maven-surefire-plugin</artifactId>
+                <configuration>
+                    <systemPropertyVariables>
+                        <build.dir>${project.build.directory}</build.dir>
+                    </systemPropertyVariables>
+                </configuration>
+            </plugin>
+        </plugins>
+    </build>
+</project>
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java
new file mode 100644
index 0000000000000..4922f5e81e09e
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java
@@ -0,0 +1,41 @@
+package io.quarkus.grpc.examples.hello;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.PathParam;
+
+import examples.GreeterGrpc;
+import examples.HelloReply;
+import examples.HelloRequest;
+import examples.MutinyGreeterGrpc;
+import io.quarkus.grpc.GrpcClient;
+import io.smallrye.mutiny.Uni;
+
+@Path("/hello")
+public class HelloWorldEndpoint {
+
+    @GrpcClient("hello")
+    GreeterGrpc.GreeterBlockingStub blockingHelloService;
+
+    @GrpcClient("hello")
+    MutinyGreeterGrpc.MutinyGreeterStub mutinyHelloService;
+
+    @GET
+    @Path("/blocking/{name}")
+    public String helloBlocking(@PathParam("name") String name) {
+        HelloReply reply = blockingHelloService.sayHello(HelloRequest.newBuilder().setName(name).build());
+        return generateResponse(reply);
+
+    }
+
+    @GET
+    @Path("/mutiny/{name}")
+    public Uni<String> helloMutiny(@PathParam("name") String name) {
+        return mutinyHelloService.sayHello(HelloRequest.newBuilder().setName(name).build())
+                .onItem().transform((reply) -> generateResponse(reply));
+    }
+
+    public String generateResponse(HelloReply reply) {
+        return String.format("%s! HelloWorldService has been called %d number of times.", reply.getMessage(), reply.getCount());
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java
new file mode 100644
index 0000000000000..6b13fdf54462d
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java
@@ -0,0 +1,23 @@
+package io.quarkus.grpc.examples.hello;
+
+import java.util.concurrent.atomic.AtomicInteger;
+
+import examples.HelloReply;
+import examples.HelloRequest;
+import examples.MutinyGreeterGrpc;
+import io.quarkus.grpc.GrpcService;
+import io.smallrye.mutiny.Uni;
+
+@GrpcService
+public class HelloWorldService extends MutinyGreeterGrpc.GreeterImplBase {
+
+    AtomicInteger counter = new AtomicInteger();
+
+    @Override
+    public Uni<HelloReply> sayHello(HelloRequest request) {
+        int count = counter.incrementAndGet();
+        String name = request.getName();
+        return Uni.createFrom().item("Hello " + name)
+                .map(res -> HelloReply.newBuilder().setMessage(res).setCount(count).build());
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/proto/helloworld.proto b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/proto/helloworld.proto
new file mode 100644
index 0000000000000..c50ba71b3b4fa
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/proto/helloworld.proto
@@ -0,0 +1,21 @@
+syntax = "proto2";
+
+option java_multiple_files = true;
+option java_package = "examples";
+option java_outer_classname = "HelloWorldProto";
+option objc_class_prefix = "HLW";
+
+package helloworld;
+
+service Greeter {
+    rpc SayHello (HelloRequest) returns (HelloReply) {}
+}
+
+message HelloRequest {
+    required string name = 1;
+}
+
+message HelloReply {
+    required  string message = 1;
+    optional int32 count = 2;
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/resources/application.properties b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/resources/application.properties
new file mode 100644
index 0000000000000..214afae1821d5
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/main/resources/application.properties
@@ -0,0 +1,12 @@
+quarkus.generate-code.grpc.descriptor-set.generate=true
+quarkus.generate-code.grpc.descriptor-set.name=hello.dsc
+quarkus.generate-code.grpc.descriptor-set.output-dir=proto
+
+quarkus.grpc.server.port=9001
+
+quarkus.grpc.clients.hello.host=localhost
+quarkus.grpc.clients.hello.port=9001
+
+%vertx.quarkus.grpc.clients.hello.port=8081
+%vertx.quarkus.grpc.clients.hello.use-quarkus-grpc-client=true
+%vertx.quarkus.grpc.server.use-separate-server=false
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java
new file mode 100644
index 0000000000000..a982554fb6d75
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output-dir/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java
@@ -0,0 +1,21 @@
+package io.quarkus.grpc.examples.hello;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import java.nio.file.Path;
+
+import org.junit.jupiter.api.Test;
+
+public class DescriptorSetExistsTest {
+
+    @Test
+    public void descriptorSetExists() {
+        var expectedOutputDir = Path.of(System.getProperty("build.dir"))
+                .resolve("proto");
+
+        assertThat(expectedOutputDir).exists();
+        assertThat(expectedOutputDir.resolve("hello.dsc"))
+                .exists()
+                .isNotEmptyFile();
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/pom.xml b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/pom.xml
new file mode 100644
index 0000000000000..91203496badde
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/pom.xml
@@ -0,0 +1,28 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<project xmlns="http://maven.apache.org/POM/4.0.0"
+         xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+         xsi:schemaLocation="http://maven.apache.org/POM/4.0.0 http://maven.apache.org/xsd/maven-4.0.0.xsd">
+    <modelVersion>4.0.0</modelVersion>
+
+    <parent>
+        <artifactId>quarkus-integration-test-grpc-descriptor-sets-parent</artifactId>
+        <groupId>io.quarkus</groupId>
+        <version>999-SNAPSHOT</version>
+    </parent>
+
+    <artifactId>quarkus-integration-test-grpc-descriptor-sets-alternate-output</artifactId>
+    <name>Quarkus - Integration Tests - gRPC - Descriptor Sets - Alternate Output</name>
+
+    <build>
+        <plugins>
+            <plugin>
+                <artifactId>maven-surefire-plugin</artifactId>
+                <configuration>
+                    <systemPropertyVariables>
+                        <build.dir>${project.build.directory}</build.dir>
+                    </systemPropertyVariables>
+                </configuration>
+            </plugin>
+        </plugins>
+    </build>
+</project>
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java
new file mode 100644
index 0000000000000..4922f5e81e09e
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java
@@ -0,0 +1,41 @@
+package io.quarkus.grpc.examples.hello;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.PathParam;
+
+import examples.GreeterGrpc;
+import examples.HelloReply;
+import examples.HelloRequest;
+import examples.MutinyGreeterGrpc;
+import io.quarkus.grpc.GrpcClient;
+import io.smallrye.mutiny.Uni;
+
+@Path("/hello")
+public class HelloWorldEndpoint {
+
+    @GrpcClient("hello")
+    GreeterGrpc.GreeterBlockingStub blockingHelloService;
+
+    @GrpcClient("hello")
+    MutinyGreeterGrpc.MutinyGreeterStub mutinyHelloService;
+
+    @GET
+    @Path("/blocking/{name}")
+    public String helloBlocking(@PathParam("name") String name) {
+        HelloReply reply = blockingHelloService.sayHello(HelloRequest.newBuilder().setName(name).build());
+        return generateResponse(reply);
+
+    }
+
+    @GET
+    @Path("/mutiny/{name}")
+    public Uni<String> helloMutiny(@PathParam("name") String name) {
+        return mutinyHelloService.sayHello(HelloRequest.newBuilder().setName(name).build())
+                .onItem().transform((reply) -> generateResponse(reply));
+    }
+
+    public String generateResponse(HelloReply reply) {
+        return String.format("%s! HelloWorldService has been called %d number of times.", reply.getMessage(), reply.getCount());
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java
new file mode 100644
index 0000000000000..6b13fdf54462d
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java
@@ -0,0 +1,23 @@
+package io.quarkus.grpc.examples.hello;
+
+import java.util.concurrent.atomic.AtomicInteger;
+
+import examples.HelloReply;
+import examples.HelloRequest;
+import examples.MutinyGreeterGrpc;
+import io.quarkus.grpc.GrpcService;
+import io.smallrye.mutiny.Uni;
+
+@GrpcService
+public class HelloWorldService extends MutinyGreeterGrpc.GreeterImplBase {
+
+    AtomicInteger counter = new AtomicInteger();
+
+    @Override
+    public Uni<HelloReply> sayHello(HelloRequest request) {
+        int count = counter.incrementAndGet();
+        String name = request.getName();
+        return Uni.createFrom().item("Hello " + name)
+                .map(res -> HelloReply.newBuilder().setMessage(res).setCount(count).build());
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/proto/helloworld.proto b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/proto/helloworld.proto
new file mode 100644
index 0000000000000..c50ba71b3b4fa
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/proto/helloworld.proto
@@ -0,0 +1,21 @@
+syntax = "proto2";
+
+option java_multiple_files = true;
+option java_package = "examples";
+option java_outer_classname = "HelloWorldProto";
+option objc_class_prefix = "HLW";
+
+package helloworld;
+
+service Greeter {
+    rpc SayHello (HelloRequest) returns (HelloReply) {}
+}
+
+message HelloRequest {
+    required string name = 1;
+}
+
+message HelloReply {
+    required  string message = 1;
+    optional int32 count = 2;
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/resources/application.properties b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/resources/application.properties
new file mode 100644
index 0000000000000..20a1d5d62db45
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/main/resources/application.properties
@@ -0,0 +1,11 @@
+quarkus.generate-code.grpc.descriptor-set.generate=true
+quarkus.generate-code.grpc.descriptor-set.name=hello.dsc
+
+quarkus.grpc.server.port=9001
+
+quarkus.grpc.clients.hello.host=localhost
+quarkus.grpc.clients.hello.port=9001
+
+%vertx.quarkus.grpc.clients.hello.port=8081
+%vertx.quarkus.grpc.clients.hello.use-quarkus-grpc-client=true
+%vertx.quarkus.grpc.server.use-separate-server=false
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java
new file mode 100644
index 0000000000000..0c1a586f0ec38
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set-alternate-output/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java
@@ -0,0 +1,22 @@
+package io.quarkus.grpc.examples.hello;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import java.nio.file.Path;
+
+import org.junit.jupiter.api.Test;
+
+public class DescriptorSetExistsTest {
+
+    @Test
+    public void descriptorSetExists() {
+        var expectedOutputDir = Path.of(System.getProperty("build.dir"))
+                .resolve("generated-sources")
+                .resolve("grpc");
+
+        assertThat(expectedOutputDir).exists();
+        assertThat(expectedOutputDir.resolve("hello.dsc"))
+                .exists()
+                .isNotEmptyFile();
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/pom.xml b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/pom.xml
new file mode 100644
index 0000000000000..cc417c76e19b9
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/pom.xml
@@ -0,0 +1,28 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<project xmlns="http://maven.apache.org/POM/4.0.0"
+         xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+         xsi:schemaLocation="http://maven.apache.org/POM/4.0.0 http://maven.apache.org/xsd/maven-4.0.0.xsd">
+    <modelVersion>4.0.0</modelVersion>
+
+    <parent>
+        <artifactId>quarkus-integration-test-grpc-descriptor-sets-parent</artifactId>
+        <groupId>io.quarkus</groupId>
+        <version>999-SNAPSHOT</version>
+    </parent>
+
+    <artifactId>quarkus-integration-test-grpc-descriptor-sets-descriptor-set</artifactId>
+    <name>Quarkus - Integration Tests - gRPC - Descriptor Sets - Descriptor Set</name>
+
+    <build>
+        <plugins>
+            <plugin>
+                <artifactId>maven-surefire-plugin</artifactId>
+                <configuration>
+                    <systemPropertyVariables>
+                        <build.dir>${project.build.directory}</build.dir>
+                    </systemPropertyVariables>
+                </configuration>
+            </plugin>
+        </plugins>
+    </build>
+</project>
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java
new file mode 100644
index 0000000000000..4922f5e81e09e
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldEndpoint.java
@@ -0,0 +1,41 @@
+package io.quarkus.grpc.examples.hello;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.PathParam;
+
+import examples.GreeterGrpc;
+import examples.HelloReply;
+import examples.HelloRequest;
+import examples.MutinyGreeterGrpc;
+import io.quarkus.grpc.GrpcClient;
+import io.smallrye.mutiny.Uni;
+
+@Path("/hello")
+public class HelloWorldEndpoint {
+
+    @GrpcClient("hello")
+    GreeterGrpc.GreeterBlockingStub blockingHelloService;
+
+    @GrpcClient("hello")
+    MutinyGreeterGrpc.MutinyGreeterStub mutinyHelloService;
+
+    @GET
+    @Path("/blocking/{name}")
+    public String helloBlocking(@PathParam("name") String name) {
+        HelloReply reply = blockingHelloService.sayHello(HelloRequest.newBuilder().setName(name).build());
+        return generateResponse(reply);
+
+    }
+
+    @GET
+    @Path("/mutiny/{name}")
+    public Uni<String> helloMutiny(@PathParam("name") String name) {
+        return mutinyHelloService.sayHello(HelloRequest.newBuilder().setName(name).build())
+                .onItem().transform((reply) -> generateResponse(reply));
+    }
+
+    public String generateResponse(HelloReply reply) {
+        return String.format("%s! HelloWorldService has been called %d number of times.", reply.getMessage(), reply.getCount());
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java
new file mode 100644
index 0000000000000..6b13fdf54462d
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/java/io/quarkus/grpc/examples/hello/HelloWorldService.java
@@ -0,0 +1,23 @@
+package io.quarkus.grpc.examples.hello;
+
+import java.util.concurrent.atomic.AtomicInteger;
+
+import examples.HelloReply;
+import examples.HelloRequest;
+import examples.MutinyGreeterGrpc;
+import io.quarkus.grpc.GrpcService;
+import io.smallrye.mutiny.Uni;
+
+@GrpcService
+public class HelloWorldService extends MutinyGreeterGrpc.GreeterImplBase {
+
+    AtomicInteger counter = new AtomicInteger();
+
+    @Override
+    public Uni<HelloReply> sayHello(HelloRequest request) {
+        int count = counter.incrementAndGet();
+        String name = request.getName();
+        return Uni.createFrom().item("Hello " + name)
+                .map(res -> HelloReply.newBuilder().setMessage(res).setCount(count).build());
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/proto/helloworld.proto b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/proto/helloworld.proto
new file mode 100644
index 0000000000000..c50ba71b3b4fa
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/proto/helloworld.proto
@@ -0,0 +1,21 @@
+syntax = "proto2";
+
+option java_multiple_files = true;
+option java_package = "examples";
+option java_outer_classname = "HelloWorldProto";
+option objc_class_prefix = "HLW";
+
+package helloworld;
+
+service Greeter {
+    rpc SayHello (HelloRequest) returns (HelloReply) {}
+}
+
+message HelloRequest {
+    required string name = 1;
+}
+
+message HelloReply {
+    required  string message = 1;
+    optional int32 count = 2;
+}
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/resources/application.properties b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/resources/application.properties
new file mode 100644
index 0000000000000..b63c49d1fd261
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/main/resources/application.properties
@@ -0,0 +1,10 @@
+quarkus.generate-code.grpc.descriptor-set.generate=true
+
+quarkus.grpc.server.port=9001
+
+quarkus.grpc.clients.hello.host=localhost
+quarkus.grpc.clients.hello.port=9001
+
+%vertx.quarkus.grpc.clients.hello.port=8081
+%vertx.quarkus.grpc.clients.hello.use-quarkus-grpc-client=true
+%vertx.quarkus.grpc.server.use-separate-server=false
diff --git a/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java
new file mode 100644
index 0000000000000..4b64f9caccae6
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/grpc-descriptor-set/src/test/java/io/quarkus/grpc/examples/hello/DescriptorSetExistsTest.java
@@ -0,0 +1,22 @@
+package io.quarkus.grpc.examples.hello;
+
+import static org.assertj.core.api.Assertions.assertThat;
+
+import java.nio.file.Path;
+
+import org.junit.jupiter.api.Test;
+
+public class DescriptorSetExistsTest {
+
+    @Test
+    public void descriptorSetExists() {
+        var expectedOutputDir = Path.of(System.getProperty("build.dir"))
+                .resolve("generated-sources")
+                .resolve("grpc");
+
+        assertThat(expectedOutputDir).exists();
+        assertThat(expectedOutputDir.resolve("descriptor_set.dsc"))
+                .exists()
+                .isNotEmptyFile();
+    }
+}
diff --git a/integration-tests/grpc-descriptor-sets/pom.xml b/integration-tests/grpc-descriptor-sets/pom.xml
new file mode 100644
index 0000000000000..45a21572d641d
--- /dev/null
+++ b/integration-tests/grpc-descriptor-sets/pom.xml
@@ -0,0 +1,105 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<project xmlns="http://maven.apache.org/POM/4.0.0"
+         xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
+         xsi:schemaLocation="http://maven.apache.org/POM/4.0.0 http://maven.apache.org/xsd/maven-4.0.0.xsd">
+    <modelVersion>4.0.0</modelVersion>
+
+    <parent>
+        <artifactId>quarkus-integration-tests-parent</artifactId>
+        <groupId>io.quarkus</groupId>
+        <version>999-SNAPSHOT</version>
+    </parent>
+
+    <artifactId>quarkus-integration-test-grpc-descriptor-sets-parent</artifactId>
+    <name>Quarkus - Integration Tests - gRPC - Descriptor Sets - Parent</name>
+    <packaging>pom</packaging>
+
+    <modules>
+        <module>grpc-descriptor-set</module>
+        <module>grpc-descriptor-set-alternate-output</module>
+        <module>grpc-descriptor-set-alternate-output-dir</module>
+    </modules>
+
+    <dependencies>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-resteasy-reactive</artifactId>
+        </dependency>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-grpc</artifactId>
+        </dependency>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-junit5</artifactId>
+            <scope>test</scope>
+        </dependency>
+        <dependency>
+            <groupId>io.rest-assured</groupId>
+            <artifactId>rest-assured</artifactId>
+            <scope>test</scope>
+        </dependency>
+        <dependency>
+            <groupId>org.awaitility</groupId>
+            <artifactId>awaitility</artifactId>
+            <scope>test</scope>
+        </dependency>
+        <dependency>
+            <groupId>org.assertj</groupId>
+            <artifactId>assertj-core</artifactId>
+            <scope>test</scope>
+        </dependency>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-test-grpc</artifactId>
+            <version>${project.version}</version> <!--kept here to not pollute the BOM-->
+            <scope>test</scope>
+        </dependency>
+
+        <!-- Minimal test dependencies to *-deployment artifacts for consistent build order -->
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-grpc-deployment</artifactId>
+            <version>${project.version}</version>
+            <type>pom</type>
+            <scope>test</scope>
+            <exclusions>
+                <exclusion>
+                    <groupId>*</groupId>
+                    <artifactId>*</artifactId>
+                </exclusion>
+            </exclusions>
+        </dependency>
+        <dependency>
+            <groupId>io.quarkus</groupId>
+            <artifactId>quarkus-resteasy-reactive-deployment</artifactId>
+            <version>${project.version}</version>
+            <type>pom</type>
+            <scope>test</scope>
+            <exclusions>
+                <exclusion>
+                    <groupId>*</groupId>
+                    <artifactId>*</artifactId>
+                </exclusion>
+            </exclusions>
+        </dependency>
+    </dependencies>
+
+    <build>
+        <plugins>
+            <plugin>
+                <groupId>io.quarkus</groupId>
+                <artifactId>quarkus-maven-plugin</artifactId>
+                <executions>
+                    <execution>
+                        <goals>
+                            <goal>generate-code</goal>
+                            <goal>build</goal>
+                        </goals>
+                    </execution>
+                </executions>
+            </plugin>
+        </plugins>
+    </build>
+
+</project>
diff --git a/integration-tests/pom.xml b/integration-tests/pom.xml
index b623b32388ee6..ce18414ff5768 100644
--- a/integration-tests/pom.xml
+++ b/integration-tests/pom.xml
@@ -373,6 +373,7 @@
                 <module>locales</module>
                 <module>redis-devservices</module>
                 <!-- gRPC tests -->
+                <module>grpc-descriptor-sets</module>
                 <module>grpc-inprocess</module>
                 <module>grpc-vertx</module>
                 <module>grpc-tls</module>