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\usepackage{selnolig} % disable illegal ligatures -\fi -\usepackage{bookmark} - -\IfFileExists{xurl.sty}{\usepackage{xurl}}{} % add URL line breaks if available -\urlstyle{same} % disable monospaced font for URLs -\hypersetup{ - pdftitle={Sample size estimation for task-related functional MRI studies using Bayesian updating}, - pdfauthor={Eduard T. Klapwijk; Joran Jongerling; Herbert Hoijtink; Eveline A. Crone}, - pdfkeywords={power analysis, region of interest, effect size, R -package, sample sizes, Bayesian updating}, - colorlinks=true, - linkcolor={blue}, - filecolor={Maroon}, - citecolor={Blue}, - urlcolor={Blue}, - pdfcreator={LaTeX via pandoc}} - -\title{Sample size estimation for task-related functional MRI studies -using Bayesian updating} -\author{Eduard T. Klapwijk \and Joran Jongerling \and Herbert -Hoijtink \and Eveline A. Crone} -\date{2024-06-13} - -\begin{document} -\maketitle -\begin{abstract} -Task-related functional MRI (fMRI) studies need to be properly powered -with an adequate sample size to reliably detect effects of interest. But -for most fMRI studies, it is not straightforward to determine a proper -sample size using power calculations based on published effect sizes. -Here, we present an alternative approach of sample size estimation with -empirical Bayesian updating. First, this method provides an estimate of -the required sample size using existing data from a similar task and -similar region of interest. Using this estimate researchers can plan -their research project, and report empirically determined sample size -estimations in their research proposal or pre-registration. Second, -researchers can expand the sample size estimations with new data. We -illustrate this approach using four existing fMRI data sets where -Cohen's d is the effect size of interest for the hemodynamic response in -the task condition of interest versus a control condition, and where a -Pearson correlation between task effect and age is the covariate of -interest. We show that sample sizes to reliably detect effects differ -between various tasks and regions of interest. We provide an R package -to allow researchers to use Bayesian updating with other task-related -fMRI studies. -\end{abstract} - -\section{Introduction}\label{introduction} - -Since the emergence of functional magnetic resonance imaging (fMRI), -these techniques have provided unprecedented opportunities to study -functional brain development during childhood and adolescence by -scanning children from the age of four years onward. There is great -progression in the assessment of neural functional growth using -cross-sectional and longitudinal assessments of cognitive, social and -affective processes across the full range of childhood to adulthood. -Despite the advancements in the ability to study the developing brain in -vivo using fMRI, recent years have seen an increased concern about the -replicability of scientific findings in general and particularly in -psychology and cognitive neuroscience (Bishop 2019; E. T. Klapwijk et -al. 2021; Munafò et al. 2017; Poldrack et al. 2017; see Marek et al. -2022 for a similar concern for resting-state functional connectivity and -structural MRI data sets). - -Low statistical power due to small sample sizes is arguably one of the -main reasons for lower than desired replicability of study results. -Statistical power is the probability that a study will reject the null -hypothesis when it is false, that is, when there is a non-zero effect -(e.g., Cohen's d or Pearson's correlation) in the population of -interest. Power is determined by the size of the effect, the alpha level -chosen, and the size of the sample (Cohen 1992). The smaller each of -effect size, alpha level, and sample size are, the lower the power. -Since many psychological phenomena consist of relatively subtle, small -effects (Funder and Ozer 2019; Gignac and Szodorai 2016; Yarkoni 2009), -the main source for increasing power, and over which researchers have a -reasonable degree of control, is the sample size (given limited -flexibility of the alpha level). Despite the need for well-powered -studies to reliably detect effects of interest, empirical reports have -shown that most cognitive neuroscience and fMRI studies are underpowered -due to small sample sizes (Button et al. 2013; Maxwell 2004; Nord et al. -2017; Poldrack et al. 2017; Szucs and Ioannidis 2017; Turner et al. -2018). With developmental populations, sufficiently large sample sizes -might be even harder to establish because of the challenges in -recruitment and testing of young participants (Achterberg and Meulen -2019; E. T. Klapwijk et al. 2021). - -Recently, well-coordinated efforts and funding have led to several -large-scale projects that collect developmental task-related fMRI data -with larger sample sizes. These projects have the potential to resolve -the problem of power with sample sizes in the thousands, such as the -IMAGEN study (\(N ≈ 2,000\)) (Schumann et al. 2010), the Philadelphia -Neurodevelopmental Cohort (\(N ≈ 1,000\)) (Satterthwaite et al. 2016), -the Human Connectome Project in Development (HCP-D; \(N ≈ 1,300\)) -(Somerville et al. 2018), and the Adolescent Brain Cognitive Development -(ABCD) study (\(N ≈ 11,000\)) (Casey et al. 2018). The leap forward made -with this wealth of high-powered, mostly publicly available data can -hardly be overstated, given that they provide an important open research -tool for researchers across the globe. - -However, most fMRI studies are carried out by individual research groups -in much smaller samples, which have more opportunities to pursue new -scientific questions, for example using novel paradigms. It is also -vital that the findings of such studies are replicable and meaningful, -meaning that these studies should be properly powered, also without -sample sizes in the range of large multi-lab studies. The main issue -with power analysis is that the effect size in the population of -interest is unknown. One option is to use effect sizes reported in the -literature of the research area at hand. But these effect sizes are -often inflated due to publication bias (Gelman and Carlin 2014; -Ioannidis 2005; Open Science Collaboration 2015; Wicherts et al. 2016; -Yarkoni 2009). Therefore, calculating power based on published effect -sizes usually underestimates the sample size needed to reliably detect -an effect. - -This paper will present a novel method to determine the required sample -size for fMRI studies based on existing (i.e., already collected) data -using Bayesian updating (Rouder 2014). Specifically, the approach will -determine the proportion of the already collected data that is needed to -get a desired credible interval (the Bayesian counterpart of the -confidence interval). This will provide an estimate of the percentage of -cases for which the credible interval is expected to be in the desired -range (e.g., the interval should \emph{not} contain the value 0 for the -parameter of interest). This in turn gives us an estimate of the sample -size needed for a certain level of power. The current paper will provide -examples (including an R package) for two effect sizes: Cohen's d and -Pearson's correlation. The sample size determined using existing data is -valuable when designing a new research project and when justifying -sample sizes in a pre-registration or in proposals send to a (medical) -ethical committee. - -We will illustrate sample size determination using existing data sets -and tasks that are currently widely used in the developmental fMRI -literature, specifically cognitive control, reward activity, and -social-cognitive processing (see Table~\ref{tbl-1} for an overview) -based on existing data from our own lab. It will be determined how large -the sample size should be to detect Cohen's d, such that 95\% does not -contain the value zero for a specific condition effect (e.g., brain -activity during feedback processing versus rule application). Most prior -developmental fMRI studies addressed the question whether an effect -linearly increases or decreases with age (Crone and Steinbeis 2017). We -therefore also determine the sample size needed to detect a Pearson -correlation of an effect with linear age that is larger than zero. In -the next sections, we will first introduce Bayesian updating, the -highest density credible interval, and sample size determination. Next, -we will provide examples using existing data from four fMRI studies -(Braams et al. 2014; Peters and Crone 2017; Spaans et al. 2023; Cruijsen -et al. 2023), and illustrate sample size determination using these -examples. - -\subsection{Bayesian updating}\label{bayesian-updating} - -Bayesian updating can be used to determine the sample size required to -estimate Cohen's d or Pearson's correlation with a certain precision. -Precision is presented in the form of a 95\% highest density credible -interval (HDCI), that is, the narrowest possible interval that is -believed to contain the true value of the parameter of interest with a -probability of .95\footnote{In statistical terms: the HDCI contains 95\% - of the marginal posterior density of the parameter which is a function - of the information in the data and prior knowledge with respect to the - parameter.}. The narrower this interval, the higher the precision with -which the parameter is estimated. - -Bayesian updating as implemented here relies on the assumption that a -priori, that is, before collecting the data, each possible value of the -parameter of interest is equally likely. This has two implications. -First, the HDCI is completely determined by the data and not by prior -information. Secondly, the numerical values of the estimate and -endpoints of the HDCI are equal to the estimate and endpoints of the -classical confidence interval. - -Bayesian updating can be used to determine the smallest sample size for -which the resulting HDCI does not contain the value zero. Bayesian -updating consists of four steps: - -\begin{enumerate} -\def\labelenumi{\arabic{enumi}.} -\item - Determine the maximum achievable size of the sample. -\item - Collect the data for an initial number of participants and then - compute the estimate and HDCI. The actual number chosen is irrelevant, - but with 20 participants the estimate and HDCI will usually give a - first impression of the size of Cohen's d or Pearson's correlation - that is not totally determined by sample fluctuations and/or outliers. -\item - Add several participants to the sample (updating) and recompute the - estimate and HDCI. -\item - If the HDCI still contains the value zero and the maximum achievable - sample size has not been obtained, return to the previous step. - Otherwise, the updating is finished and estimates and corresponding - HDCI's are reported. -\end{enumerate} - -\subsubsection{The highest density credible interval -(HDCI)}\label{the-highest-density-credible-interval-hdci} - -It is important to highlight that the HDCI is not a confidence interval. -If many data sets are sampled from the population of interest and each -data set is used to compute the 95\% confidence interval for the -parameter of interest, then it holds that 95\% of the intervals contain -the true value. However, in contrast to HDCIs, confidence intervals -cannot be updated because their coverage level will become smaller than -95\%. This will be illustrated using a simple example. - -Imagine many researchers want to show that Cohen's d is unequal to zero. -Each of them samples a data set with \(n = 20\) for each group from the -population of interest (in which Cohen's d happens to equal zero). About -5\% of the 95\% confidence intervals do not contain the value 0. These -researchers will not continue their efforts; they have ``shown'' that -``their'' effect is not zero. At this stage the Type I error rate is -.05. However, the 95\% remaining researchers increase their power by -updating their data with another 10 persons per group and recompute -their 95\% confidence intervals of which about 2.8\% (number determined -using simulation) does not contain the value 0. Therefore, the Type I -error rate is increased to 5\% + 2.8\% = 7.8\%, that is, the updating -rendered 92.2\% confidence intervals and not 95\% confidence intervals. - -A HDCI should therefore not be interpreted in the context of many -hypothetical data sets sampled from the population of interest. The HDCI -is computed using the observed data at hand and is the shortest interval -that is believed to contain the true value of Cohen's d with a -probability of .95. When updating, the size of the data at hand becomes -larger, the information with respect to Cohen's d increases, and -therefore the width of the HDCI becomes smaller. The HDCI summarizes the -evidence in the data at hand with respect to the size of Cohen's d, -which is different from a confidence interval which aims to control -error rates under (hypothetical) repeated sampling from the same -population. - -\subsection{Sample Size Determination}\label{sample-size-determination} - -The procedure elaborated in this paper is Bayesian (because HDCIs are -used) empirical (because existing data are used) sample size -determination. We use an existing dataset of a certain size, and for all -sample sizes between a minimum (e.g., \(n = 20\)) and maximum sample -size of the sample at hand we compute the HDCI. To account for the -arbitrary order of the participant in a data set, this is done for a set -number of permutations, e.g., 1000, of the participants in the data set. -For each sample size, we then calculate the average HDCI of all -permutations. Considering both the average HDCI and the HDCI's resulting -from the different permutations, will provide an estimate sample size -needed to obtain a 95\% HDCI . The 95\% HDCI for Cohen's d was -established through non-parametric bootstrapping (Efron and Tibshirani -1994). Specifically, we resampled the current subset of data 100 times -and calculated Cohen's d for the difference between variable x and -variable y each time. We then calculated the mean and standard -deviations of Cohen's d across the 100 resampled values. The 95\% CI was -determined by subtracting 1.96 times the standard deviation of the -Cohen's d values from the mean Cohen's d value, and by adding 1.96 times -the standard deviation of the Cohen's d values to the mean Cohen's d -value. - -To illustrate the current method, we can take a preview at -Figure~\ref{fig-1} C in the Results section. The dataset used to -construct HDCI's for Cohen's d consists of 149 participants from the -self-evaluation versus control contrast in the medial prefrontal cortex -during a self-evaluation task. In Figure~\ref{fig-1} C the first 20 -participants in each of 1000 permuted data sets are used to compute the -HDCI for Cohen's d.~Ten of these intervals are displayed in blue. As can -be seen, of the ten (of 1000) HDCIs displayed, four include the value -zero. Consequently, fluctuations in the order in which participants are -sampled determine whether the HDCI contains the value zero. This is -summarized in Figure~\ref{fig-2} C which shows that the probability that -one of the 1000 HDCIs does not contain the value zero is about 0.6 for -\(n = 20\). In Figure~\ref{fig-1} C, it is shown in the first interval -displayed in purple that the average of the 1000 HDCI's does not contain -the value zero. Therefore, although the average interval does not -contain the value zero, we can learn from the permutations that when -using 20 participants it is still rather likely that the resulting -interval will include the value zero. This becomes much less likely for -the samples of 46 and 72 participants. With these sample sizes neither -the HDCIs nor the average interval contain the value zero (see -Figure~\ref{fig-1} C). Additionally, the probability that an interval -does not contain the value zero equals 100\% for 72 participants (see -Figure~\ref{fig-2} C). Therefore, a sample size of 72 and higher will -usually render intervals that do not contain the value zero. - -An issue that sample size determination has in common with power -analysis, is that the effect size in the existing data set will very -likely differ from the effect size in the population that will be -addressed in the study being designed. However, sample size -determination does not suffer from the fact that effect sizes reported -in the literature tend to be inflated (like power analysis) because -effect sizes are straightforwardly computed from actual data. The -determined sample size is therefore an estimate of the required sample -size. This estimate is valuable because it allows researchers to plan -their research project, can be reported in their research proposal or -pre-registration, and it may lead to the conclusion that the sample size -needed cannot be achieved with the resources that you have at your -disposal. - -In the next section Bayesian empirical sample size determination will be -exemplified and discussed using different fMRI tasks from the BrainTime -(Braams et al. 2014; Peters and Crone 2017) and Self-Concept (Spaans et -al. 2023; Cruijsen et al. 2023) data sets. - -\subsection{\texorpdfstring{\emph{neuroUp} R -package}{neuroUp R package}}\label{neuroup-r-package} - -The code for Bayesian updating in this manuscript is implemented in the -R language for statistical computing (R Core Team, 2022). We currently -provide the \emph{neuroUp} package at the following location: -\url{https://github.com/eduardklap/neuroUp} (E. Klapwijk, Hoijtink, and -Jongerling 2024). This package is built on several packages from the -tidyverse (Wickham et al. 2019), most notably \emph{ggplot2}. The -package can be installed using the R commands: -\texttt{library(devtools)} and -\texttt{install\_github("eduardklap/neuroUp")}. All data used in the -current manuscript is also available within the \emph{neuroUp} package, -in this way all figures in the manuscript can be reproduced using the R -package. For a more elaborate introduction to \emph{neuroUp} and its -functions, please refer to -\url{https://eduardklap.github.io/neuroUp/articles/neuroUp.html}. To -cite package neuroUp in publications use E. Klapwijk, Hoijtink, and -Jongerling (2024). - -\section{Method \& Materials}\label{method-materials} - -We focus on sample size estimation for regions of interest from four -different fMRI tasks in two different samples (see Table~\ref{tbl-1}). -We re-used data that has been processed with SPM8 or SPM12 and derived -summary statistics for individual participants for regions and task -conditions of interest (see fMRI processing). - -\begin{longtable}[]{@{} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1284}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.2635}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.2365}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.0338}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.0743}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1284}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1351}}@{}} -\caption{Overview of tasks processed in the current -study.}\label{tbl-1}\tabularnewline -\toprule\noalign{} -\begin{minipage}[b]{\linewidth}\raggedright -task -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -source -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -associated papers -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -N -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -age range -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -cognitive process -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -region of interest -\end{minipage} \\ -\midrule\noalign{} -\endfirsthead -\toprule\noalign{} -\begin{minipage}[b]{\linewidth}\raggedright -task -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -source -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -associated papers -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -N -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -age range -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -cognitive process -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -region of interest -\end{minipage} \\ -\midrule\noalign{} -\endhead -\bottomrule\noalign{} -\endlastfoot -Feedback & BrainTime study, Leiden University & (Peters and Crone 2017; -Crone, Duijvenvoorde, and Peper 2016) & 271 & 8-25 yrs & feedback -learning & DLPFC \\ -Gambling & BrainTime study, Leiden University & (Braams et al. 2014; -Crone, Duijvenvoorde, and Peper 2016) & 221 & 12-28 yrs & -reward-processing & NAcc \\ -Self-evaluations & Self-Concept study, Leiden University & (Cruijsen et -al. 2023; Crone et al. 2022) & 149 & 11-21 yrs & self processing & -mPFC \\ -Vicarious charity & Self-Concept study, Leiden University & (Spaans et -al. 2023; Crone et al. 2022) & 156 & 11-21 yrs & vicarious rewards & -NAcc \\ -\end{longtable} - -\subsection{Data and processing}\label{data-and-processing} - -\subsubsection{BrainTime study}\label{braintime-study} - -The BrainTime study is an accelerated longitudinal research project of -normative development. A total of 299 participants between ages 8 and 25 -years took part in MRI scanning at the first time point. At the second -time point approximately 2 years later, 254 participants were scanned -(most dropout was due to braces, \(n = 33\)). At time point 3, -approximately 2 years after time point 2, 243 participants were scanned -(dropout due to braces: \(n = 11\)). The same Philips 3T MRI scanner and -settings were used for all time points. The following settings were -used: TR = \(2200 ms\), TE = \(30 ms\), sequential acquisition, 38 -slices, slice thickness = \(2.75 mm\), field of view (FOV) = -\(220 × 220 × 114.68 mm\). A high-resolution 3D T1 anatomical scan was -acquired (TR = \(9.76 ms\), TE = \(4.59 ms\), 140 slices, voxel size = -\(0.875 × 0.875 × 1.2 mm\), FOV = \(224 × 177 × 168 mm\)). - -\paragraph{Feedback task}\label{feedback-task} - -For the feedback task (Peters et al. 2014) we included 271 participants -at time point 1 from which region of interest data was available. We use -the same data and processing as reported in (Peters and Crone 2017). -During the task, on each trial participants viewed three squares with a -stimulus presented underneath. Participants were instructed to use -performance feedback to determine which stimulus belonged to which -square. After each choice, feedback was presented to the participant: a -minus sign for negative feedback or a plus sign for positive feedback. -After 12 trials, or when a criterion was reached (placing each of the -three stimuli in the correct box at least two times), a new sequence -with three new stimuli was presented. This criterion was used to strike -a balance between the number of trials in the learning and the -application phase. There were 15 sequences in total, resulting in a -maximum of \(15 x 12 = 180\) trials per participant. For the current -study, we focused on the learning \textgreater{} application contrast, -which compares feedback early in the learning process with feedback for -associations that were already learned (i.e.~application phase). -Individual trial-by-trial analyses were used to determine the learning -and application phase (see Peters and Crone (2017) for details). - -\paragraph{Gambling task}\label{gambling-task} - -For the Gambling task (Braams et al. 2014), we used data from 221 -participant at time point 3 (we went for the largest sample size and -this was the time point with the most data available for the contrasts -of interest). We use the same data and processing as reported in -Schreuders et al. (2018). In the Gambling task, participants could -choose heads or tails and win money when the computer selected the -chosen side of the coin or lose money when the opposite side was -selected. Chances of winning were 50\%. To keep participants engaged, -the number of coins that could be won or lost on varied across trials. -Participants were explained that the coins won in the task would -translate to real money, to be paid out at the end of the experiment. -Gambling was performed in two different conditions: participants played -23 trials for themselves, and 22 trials for their best friend. For the -current study, we focused on reward processing by analysing the winning -for self \textgreater{} losing for self contrast. - -\subsubsection{Self-Concept study}\label{self-concept-study} - -The Self-Concept study is a cohort-sequential longitudinal study in -which 160 adolescents from 11 to 21 years old took part at the first -time point (see \url{https://osf.io/h7u46} for study overview). MRI -scans were acquired on a Philips 3T MRI scanner with the following -settings: TR = \(2200 ms\), TE = \(30 ms\), sequential acquisition, 37 -slices, slice thickness = \(2.75 mm\), FOV = \(220 × 220 × 111.65 mm\). -A high-resolution 3D T1 anatomical scan was acquired (TR = \(9.8 ms\), -TE = \(4.6 ms\), 140 slices, voxel size = \(0.875 × 0.875 × 1.2 mm\), -FOV = \(224 × 178.5 × 168 mm\)). - -\paragraph{Self-evaluations task}\label{self-evaluations-task} - -For the Self-evaluation task we used the same data and processing as -reported in Cruijsen et al. (2023). In this task, participants read 60 -short sentences describing positive or negative traits in the academic, -physical, or prosocial domain (20 per domain; 10 with a positive valence -and 10 with a negative valence). Here we focus on the direct -self-evaluation condition, in which participants had to indicate to what -extent the trait sentences applied to them on a scale of 1 (`not at -all') to 4 (`completely'). In the control condition, participants had to -categorize 20 other trait sentences according to four categories: (1) -school, (2) social, (3) appearance, or (4) I don't know. For the current -study, we focused on the direct self-evaluation versus control contrast. -Eleven participants were excluded due to excessive motion during -scanning (\(\>3 mm, n = 8\)), not completing the scan (\(n = 1\)), and a -technical error (\(n = 2\)), resulting in a total sample of \(N = 149\). - -\paragraph{Vicarious Charity task}\label{vicarious-charity-task} - -For the Vicarious Charity task, we used the same data and processing as -reported in Spaans et al. (2023). In this task, participants could earn -money for themselves and for a self-chosen charity they selected before -scanning. On every trial, participants could choose one of two curtains -to open. After their button press, the chosen curtain opened to show the -division of the stake between themselves and the charity. The overall -outcome was a division of either €4 or €2 between parties. Unknown to -the participant, every outcome condition occurred 15 times during the -task. Participants were informed beforehand that they received extra -money based on the average of three random outcomes at the end of the -research visit. Here we focus on the self-gain \textgreater{} -both-no-gain contrast. This contrast compares the 30 trials in which -participants gained the full €4 or €2 themselves (i.e., €0 for charity) -against 15 baseline trials in which no money was gained in total (i.e., -€0 for self and €0 for charity). Two participants were excluded from the -analysis due to excessive movement during scanning (\(>3 mm\)), one due -to signal dropout in the SPM mask including the ventral striatum (this -was assessed by visual inspection of all individual SPM masks), and one -due to a technical error, resulting in a total of \(N = 156\). - -\subsubsection{fMRI analysis}\label{fmri-analysis} - -FMRI analyses for all four tasks were performed using SPM (Wellcome -Department of Cognitive Neurology, London); SPM8 was used for the -BrainTime data and SPM12 for the Self-Concept data. The following -preprocessing steps were used: slice timing correction, realignment -(motion correction), normalization, and smoothing (6 mm full-width at -half maximum isotropic Gaussian kernel). T1 templates were based on the -MNI305 stereotaxic space. All tasks have an event-related design and -events were time-locked with 0 duration to the moment of feedback -presentation. Six motion regressors were added to the model. All other -trials (i.e., trials that did not result in learning in the Feedback -task or too-late trials) were modeled as events of no interest. These -events were used as covariates in a general linear model together with a -set of cosine functions that high-pass filtered the data. The -least-squares parameter estimates of height of the best-fitting -canonical hemodynamic response function (HRF) for each condition were -used in pair-wise contrasts. The contrast images were submitted to -higher-level group analyses. Region of interest analyses were performed -with the MarsBaR toolbox (Brett et al. 2002). - -\paragraph{Regions of interest}\label{regions-of-interest} - -For the Feedback task, the atlas-based middle frontal gyrus was used as -a region of interest (Harvard-Oxford cortical atlas; thresholded at -50\%; center-of-mass coordinates \(x = -4, y = 22, z = 43\)). Extracted -parameter estimates for this region were obtained in tabular format from -the authors of Peters and Crone (2017), with one value for the mean -activation during learning and one value for the mean activation during -application for all participants. For the Gambling task, the anatomical -mask of the left nucleus accumbens was used as a region of interest -(Harvard-Oxford subcortical atlas; thresholded at 40\%; 28 voxels -included). Extracted parameter estimates for this region were obtained -in tabular format from the authors of Schreuders et al. (2018), with one -value for the mean activation during winning and one value for the mean -activation during losing for all participants. - -For the Self-evaluation task, the region of interest used was a mask of -the left medial prefrontal cortex (\(x = −6, y = 50, z = 4\)) based on a -meta-analysis by Denny et al. (2012). Extracted parameter estimates for -this region were obtained in tabular format from the authors of Cruijsen -et al. (2023), with one value for the mean activation during -self-evaluation and one value for the mean activation during the control -condition for all participants. For the Vicarious Charity task, the -anatomical mask of the left nucleus accumbens was used as a region of -interest (Harvard-Oxford subcortical atlas; thresholded at 40\%; -center-of-mass coordinates \(x = −10, y = 12, z = −7\); 28 voxels -included). Extracted parameter estimates for this region were obtained -in tabular format from the authors of Spaans et al. (2023), with one -value for the mean activation during gaining for self and one value for -the mean activation during no-gain for self and charity for all -participants. - -\section{Results}\label{results} - -\subsection{Task effects using Cohen's -d}\label{task-effects-using-cohens-d} - -The average HDCI was used to determine the optimal sample size for the -four fMRI tasks used. For each task and brain region of interest, we -estimated the sample size required to obtain an average HDCI for Cohen's -d not containing the value zero (Figure~\ref{fig-1} and -Figure~\ref{fig-2}; Table~\ref{tbl-2}). Additionally, we also -established whether it was also the case that a majority of the 1000 -underlying HDCIs did not contain the value zero. - -In Figure~\ref{fig-1} A, an estimate of the required sample size for -feedback learning processing in the DLPFC (middle frontal gyrus) is -presented. Five groups of HDCI's are presented for sample sizes of 20, -70, 120, 170, and 271 persons, in which 271 is the total group sample -size of the existing data set. As can be seen, already with a sample of -20 participants neither of the 10 permuted HDCIs displayed nor the -average of the 1000 HDCI's contain the value zero. In Figure 2A it can -be seen that the proportion of HDCI's not containing the value zero is -equal to 1.0. This is due to the huge effect size of Cohen's d equal to -about 1.9 (see Table~\ref{tbl-2}). Therefore, already with a sample size -of 20 participants, an effect bigger than zero will be detected for this -task and brain region. - -For the task effect of gambling (winning for self \textgreater{} losing -for self contrast) in the NAcc, we can see the results in -Figure~\ref{fig-1} B. Here, with a sample of 20 participants the average -of the 1000 HDCIs does not contain the value zero but some of the 10 -HDCI's displayed do. The proportion of HDCI's not containing the value -zero is bigger than 0.8 for 20 participants, but with 60 or more -participants none of the 1000 HDCI's contain zero anymore (Figure 2B). -This is related to the large effect size of Cohen's d equal to about 0.7 -(see Table~\ref{tbl-2}). Thus, for this task and brain region, already -with a sample size of 20 participants chances are high that an effect -bigger than zero will be detected. Using sample sizes of 60 or more -participants from this existing data set increases the chances of -detection to 100\%. - -In Figure~\ref{fig-1} C, results are plotted for the self-evaluation -task in the mPFC. We see that at a sample size of 20 some of the 10 -HDCI's displayed still contain the value 0, but not the average of the -1000 HDCI's. The proportion of HDCI's not containing the value 0 is also -below 1.0, around 0.5, for this task at \(N=20\) (Figure 2C). At the -next step that is plotted for this task (\(n = 46\)), we see that the -proportion of HDCI's not containing the value 0 is only a little below -1.0. Thus, for this task and brain region, at a sample size at 46 -participants chances are high that an effect bigger than zero will be -detected. - -The results of gaining for self in the NAcc are plotted in -Figure~\ref{fig-1} D. With a sample of 20 participants the average of -the 1000 HDCI's does not contain the value zero but some of the 10 -HDCI's displayed do. The proportion of HDCI's not containing the value -zero is around 0.75 (Figure 2D), but at \(n = 47\) the proportion of -HDCI's not containing the value 0 is almost 1.0. Therefore, using 20 -participants it is still likely that the resulting interval will include -the value zero. This becomes much less likely for the samples of 47 and -74 persons. With these sample sizes neither the HDCIs nor the average -interval contain the value zero. Additionally, the probability that an -interval does not contain the value zero almost reaches 100\%. -Therefore, for this task and brain region, a sample size of 47 and -higher will usually render intervals that do not contain the value zero. - -\begin{figure} - -\centering{ - -\includegraphics{figures/fig01_cohensd_estimates.png} - -} - -\caption{\label{fig-1}Estimates of task effects for five different -sample sizes (starting with \(N=20\), then 1/5th parts of the total -dataset). For each sample size 10 randomly chosen HDCI's out of the 1000 -HDCI's computed are displayed (in light blue, permutation numbers used -are displayed to the right of each subfigure). The average estimate with -credible interval summarizing the 1000 HDCI's for each sample size are -plotted in reddish purple. DLPFC = dorsolateral prefrontal cortex; mPFC -= medial prefrontal cortex; NAcc = nucleus accumbens.} - -\end{figure}% - -\begin{longtable}[]{@{} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.0933}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.0933}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1244}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1658}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1710}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1710}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1813}}@{}} -\caption{Mean estimates (with credible interval in brackets) of Cohen's -d for five different sample sizes (starting with n=20, then 1/5th parts -of the total dataset) of the 1000 HDCI's. DLPFC = dorsolateral -prefrontal cortex; mPFC = medial prefrontal cortex; NAcc = nucleus -accumbens.}\label{tbl-2}\tabularnewline -\toprule\noalign{} -\begin{minipage}[b]{\linewidth}\raggedright -\textbf{task} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{brain region} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 20} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 2/5} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 3/5} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 4/5} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{N = total} -\end{minipage} \\ -\midrule\noalign{} -\endfirsthead -\toprule\noalign{} -\begin{minipage}[b]{\linewidth}\raggedright -\textbf{task} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{brain region} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 20} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 2/5} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 3/5} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{n = 4/5} -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -\textbf{N = total} -\end{minipage} \\ -\midrule\noalign{} -\endhead -\bottomrule\noalign{} -\endlastfoot -Feedback & DLPFC & \textbf{2.03} (1.29, 2.76 ) & \textbf{1.89} (1.54, -2.25 ), n = 70 & \textbf{1.88} (1.62, 2.15 ), n = 120 & \textbf{1.87} -(1.65, 2.1 ), n = 170 & \textbf{1.87} (1.69, 2.04 ), \emph{N} = 271 \\ -Gambling & NAcc & \textbf{0.8} (0.25, 1.34 ) & \textbf{0.74} (0.45, 1.03 -), n = 60 & \textbf{0.73} (0.51, 0.96 ), n = 100 & \textbf{0.73} (0.54, -0.92 ), n = 140 & \textbf{0.73} (0.58, 0.88 ), \emph{N} = 221 \\ -Self-evaluations & mPFC & \textbf{0.5} (0.02, 0.98 ) & \textbf{0.47} -(0.17, 0.77 ), n = 46 & \textbf{0.46} (0.22, 0.7 ), n = 72 & -\textbf{0.46} (0.26, 0.66 ), n = 98 & \textbf{0.46} (0.29, 0.62 ), n = -149 \\ -Gaining self & NAcc & \textbf{0.64} (0.14, 1.14 ) & \textbf{0.59} (0.27, -0.91 ), n = 47 & \textbf{0.58} (0.32, 0.84 ), n = 74 & \textbf{0.58} -(0.36, 0.8 ), n = 101 & \textbf{0.57} (0.39, 0.75 ), \emph{N} = 156 \\ -\end{longtable} - -\begin{figure} - -\centering{ - -\includegraphics{figures/fig02_cohensd_nozero.png} - -} - -\caption{\label{fig-2}For each task, for five different sample sizes -(starting with \(n=20\), then 1/5th parts of the total dataset), the -proportion of intervals not containing the value 0 is plotted in reddish -purple.} - -\end{figure}% - -\subsection{Pearson correlations between task effects and -age}\label{pearson-correlations-between-task-effects-and-age} - -For each task and brain region of interest we also estimated the sample -size required to obtain an average HDCI for Pearson's correlation -between regional fMRI task responses and age not containing the value -zero (Figure~\ref{fig-3} and Figure~\ref{fig-4}; Table~\ref{tbl-3}) for -which a large proportion of the 1000 HDCI's does not contain the value -zero. - -In Figure~\ref{fig-3} A the results are shown for the Pearson's -correlation between age (children and adolescents aged 8-25 years) and -feedback learning processing in the DLPFC. As can be seen, with a sample -of 20 persons the average HDCI contains the value 0. Increasing the -sample size to 70 results in neither of the 10 HDCI's displayed nor the -average of the 1000 HDCI's containing the value 0. We can also see that -the proportion of HDCI's not containing the value zero is less than 0.5 -for 20 participants but equal to 1.0 for 70 participants -(Figure~\ref{fig-4} A). Therefore, for a reliable estimate of the -correlation between feedback processing in the DLPFC and age, sample -sizes bigger than 20 are needed. - -For the correlation between age and gambling in the NAcc, we can see the -results in Figure~\ref{fig-3} B. Here, for all plotted sample sizes both -the average of the HDCI's and all of the 10 HDCI's displayed do contain -the value zero. The proportion of HDCI's not containing the value zero -is below 0.1 for 20 participants, but with more participants almost all -of the 1000 HDCI's contain the value zero (Figure~\ref{fig-4} B). This -is related to the very small correlation equal to about -0.04 (see -Table~\ref{tbl-3}). Thus, for this task and brain region, it is unlikely -that an effect larger than zero will be detected for a correlation with -age, even with the total sample size of 221 participants. - -In Figure~\ref{fig-3} C, results are plotted for the correlation between -age and self-evaluation processing in the mPFC. We see that for all -plotted sample sizes both the average of the 1000 HDCI's and most of the -10 HDCI's displayed do contain the value zero. In Figure~\ref{fig-4} C, -we also see that the proportion of HDCI's not containing the value 0 is -well below 1.0 for all sample sizes shown. Thus, for this task and brain -region, with all available sample sizes the chances are high there will -be no effect detected that is larger than zero. The average Pearson -correlation is also small with a value around 0.13 (Table~\ref{tbl-3}). -The results for the correlation between age and gaining for self in the -NAcc are plotted in Figure 3D. We see that up to 104 participants both -the average of the 1000 HDCI's and most of the 10 HDCI's displayed do -contain the value zero. The proportion of HDCI's not containing the -value zero increases with bigger sample sizes (Figure~\ref{fig-4} A) but -is still below 0.5 for 104 participants. Therefore, with 104 -participants it is still likely that the resulting interval will include -the value zero. Therefore, for this task and brain region, with all -available sample sizes the chances are high there will be no effect -detected that is larger than zero. The average Pearson correlation is -also relatively small with a value around -0.18 (Table~\ref{tbl-3}). If -correlations of about -0.18 are considered relevant, the conclusion -might be that one could strive for a sample larger than 160. - -\begin{figure} - -\centering{ - -\includegraphics{figures/fig03_correlation_estimates.png} - -} - -\caption{\label{fig-3}Estimates of Pearson's correlation between age and -the task effect for five different sample sizes (starting with \(N=20\), -then 1/5th parts of the total dataset). For each sample size 10 randomly -chosen HDCI's out of the 1000 HDCI's computed are displayed (in green, -permutation numbers used are displayed to the right of each subfigure). -The average estimate with credible interval summarizing the 1000 HDCI's -for each sample size are plotted in orange. DLPFC = dorsolateral -prefrontal cortex; mPFC = medial prefrontal cortex; NAcc = nucleus -accumbens. Age is modeled as linearly increasing or decreasing.} - -\end{figure}% - -\begin{longtable}[]{@{} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.0874}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.0680}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1262}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1748}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1796}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1796}} - >{\raggedright\arraybackslash}p{(\columnwidth - 12\tabcolsep) * \real{0.1845}}@{}} -\caption{Mean estimates (with credible interval in brackets) of -Pearson's correlation between age and the task effect for five different -sample sizes (starting with N=20, then 1/5th parts of the total dataset) -of the 1000 HDCI's. DLPFC = dorsolateral prefrontal cortex; mPFC = -medial prefrontal cortex; NAcc = nucleus -accumbens.}\label{tbl-3}\tabularnewline -\toprule\noalign{} -\begin{minipage}[b]{\linewidth}\raggedright -task -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -brain region -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 20 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 2/5 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 3/5 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 4/5 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -N = total -\end{minipage} \\ -\midrule\noalign{} -\endfirsthead -\toprule\noalign{} -\begin{minipage}[b]{\linewidth}\raggedright -task -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -brain region -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 20 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 2/5 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 3/5 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -n = 4/5 -\end{minipage} & \begin{minipage}[b]{\linewidth}\raggedright -N = total -\end{minipage} \\ -\midrule\noalign{} -\endhead -\bottomrule\noalign{} -\endlastfoot -Feedback & DLPFC & \textbf{0.38} (-0.06, 0.69 ) & \textbf{0.38} (0.16, -0.56 ), \emph{N} = 70 & \textbf{0.37} (0.21, 0.52 ), \emph{N} = 120 & -\textbf{0.38} (0.24, 0.5 ), \emph{N} = 170 & \textbf{0.38} (0.27, 0.47 -), \emph{N} = 271 \\ -Gambling & NAcc & \textbf{-0.02} (-0.44, 0.4 ) & \textbf{-0.04} (-0.29, -0.21 ), \emph{N} = 60 & \textbf{-0.04} (-0.23, 0.16 ), \emph{N} = 100 & -\textbf{-0.04} (-0.2, 0.13 ), \emph{N} = 140 & \textbf{-0.04} (-0.17, -0.09 ), \emph{N} = 221 \\ -Self-evaluations & mPFC & \textbf{0.07} (-0.36, 0.48 ) & \textbf{0.06} -(-0.23, 0.34 ), \emph{N} = 46 & \textbf{0.06} (-0.17, 0.29 ), \emph{N} = -72 & \textbf{0.06} (-0.14, 0.25 ), \emph{N} = 98 & \textbf{0.06} (-0.1, -0.22 ), \emph{N} = 149 \\ -Gaining self & NAcc & \textbf{-0.18} (-0.56, 0.26 ) & \textbf{-0.17} -(-0.44, 0.11 ), \emph{N} = 47 & \textbf{-0.17} (-0.38, 0.06 ), \emph{N} -= 74 & \textbf{-0.17} (-0.35, 0.03 ), \emph{N} = 101 & \textbf{-0.17} -(-0.31, -0.01 ), \emph{N} = 156 \\ -\end{longtable} - -\begin{figure} - -\centering{ - -\includegraphics{figures/fig04_correlation_nozero.png} - -} - -\caption{\label{fig-4}For each task, for five different sample sizes -(starting with \(N=20\), then 1/5th parts of the total dataset), the -proportion of intervals not containing the value 0 is plotted inorange. -Age is modeled as linearly increasing or decreasing.} - -\end{figure}% - -\section{Discussion}\label{discussion} - -In this paper we tested how existing data can be used to approximately -determine the sample size that is required for a new study that is being -planned. The approach presented has been illustrated using four existing -fMRI studies where Cohen's d is the effect size of interest and four -studies where a Pearson correlation for linear age is of interest. -Additionally, it has been elaborated that Bayesian updating can be used -to deal with the fact that the required sample size can only -approximately be determined. Our results show that calculating and -plotting HDCI's can be helpful in determining at what sample sizes task -effects become more stable. We illustrated with four examples how -researchers can get an indication of the required sample size if they -plan to execute a study that uses feedback learning, reward-processing -(two examples), or self-processing. For all effects under study, the -width of the HDCI became smaller with larger sample sizes, showing that -the precision of the estimation increased with more data. At what sample -size estimations seemed to stabilize for general contrasts (e.g., -feedback processing versus rule application; reward versus loss) -differed per task and region of interest. For example, the effects in -the middle frontal gyrus during feedback processing were the strongest -of the effects studied here. There, even for sample sizes of 20 -participants, task effects clearly differed from zero for the middle -frontal gyrus. But even for such a strong effect, at higher sample sizes -the results became more stable (i.e., less variability in subsamples of -the total dataset). For the other three tasks, the HDCI's still -contained the value zero with 20 participants but at higher sample sizes -of 40-60 participants chances are very high that an effect larger than -zero will be detected. In this paper we tested how existing data can be -used to approximately determine the sample size that is required for a -new study that is being planned. The approach presented has been -illustrated using four existing fMRI studies where Cohen's d is the -effect size of interest and four studies where a Pearson correlation for -linear age is of interest. Additionally, it has been elaborated that -Bayesian updating can be used to deal with the fact that the required -sample size can only approximately be determined. - -Our results show that calculating and plotting HDCI's can be helpful in -determining at what sample sizes task effects become more stable. We -illustrated with four examples how researchers can get an indication of -the required sample size if they plan to execute a study that uses -feedback learning, reward-processing (two examples), or self-processing. -For all effects under study, the width of the HDCI became smaller with -larger sample sizes, showing that the precision of the estimation -increased with more data. At what sample size estimations seemed to -stabilize for general contrasts (e.g., feedback processing versus rule -application; reward versus loss) differed per task and region of -interest. For example, the effects in the middle frontal gyrus during -feedback processing were the strongest of the effects studied here. -There, even for sample sizes of 20 participants, task effects clearly -differed from zero for the middle frontal gyrus. But even for such a -strong effect, at higher sample sizes the results became more stable -(i.e., less variability in subsamples of the total dataset). For the -other three tasks, the HDCI's still contained the value zero with 20 -participants but at higher sample sizes of 40-60 participants chances -are very high that an effect larger than zero will be detected. - -The results are different for the Pearson correlation between linear age -and task effects, as can be seen in Figure~\ref{fig-3} and -Figure~\ref{fig-4}. Here again the results of the middle frontal gyrus -during feedback processing were the strongest. But even for such a -strong effect, the sample size needed to estimate the correlation with -age is much higher than the sample size needed to find a stable task -effect. For the Pearson correlation, only at a sample size of \(N=70\) -or more the lower bound of the credible is above zero, suggesting that -one can be confident that there is a positive Pearson correlation. - -For the correlation between linear age (between 12-28 years) and -reward-processing in the NAcc, the results were dependent on the -specific task context. In a gambling task with the contrast reward -versus loss, even with a sample size of 221 the average HDCI contains -the value zero when testing for linear age effects. We found that the -average Pearson correlation is -.04 for this effect, which is so small -that it is likely irrelevant. In contrast, for rewards in a vicarious -reward context with the contrast reward versus no reward, probability of -a positive Pearson correlation with negative age increased with larger -sample sizes and the average CI did just not contain zero using the full -sample size of 156 (\(M = -0.17; 95\% CI [-0.31, -0.01]\)). Note that we -only tested for linear age effects, whereas prior studies reported that -reward processing may be best described by non-linear effects (Braams et -al. 2014); which should be tested in future extensions of the approach -illustrated here. The results described for the linear age effects are -in line with simulation studies suggesting that typically in psychology -relatively large sample sizes of \(N=150\) to \(N=250\) (Schönbrodt and -Perugini 2013) are needed to obtain a study that is sufficiently powered -to evaluate a Pearson correlation with age or psychological variables. - -There are different ways in which the methods described here could be -put to practice. When planning to use an existing task for follow-up or -replication research, existing data can be used to provide an educated -guess of the sample size that is needed in the new study (given that the -new samples resemble the existing sample). In this way new task-related -fMRI studies will likely be properly powered, even if these are -small-scale studies from individual labs. Even in the current era of -large-scale consortium studies, there remains the need to conduct -studies with more modest sample sizes. Such studies can help to balance -between methodological robustness of well-established experiments and -experimental design novelty. These data sets could complement large, -public data sets with more idiosyncratic tasks and specific samples. -Furthermore, sample size determination using existing data can be -combined with Bayesian updating when collecting new data for a new -research project. The following steps can be used: - -\begin{enumerate} -\def\labelenumi{\arabic{enumi}.} -\item - Execute Bayesian empirical sample size determination. This will render - an estimate of the sample size needed for an adequately powered study. -\item - Execute the planned study with the sample size determined in the - previous step. -\item - Compute the effect size of interest (e.g., Cohen's d or Pearson's - correlation) and the corresponding HDCI. -\item - Evaluate the HDCI: - - \begin{enumerate} - \def\labelenumii{\alph{enumii}.} - \item - If the HDCI does not contain the value zero, your study is finished. - \item - If the HDCI does contain the value zero, there are two options: - - \begin{enumerate} - \def\labelenumiii{\roman{enumiii}.} - \item - If the estimate of the effect size is close to zero, the effect - size is small. Adding more data (updating) may (or may not) render - an HDCI that does not contain the value but will very likely still - render an effect size that is so small that it is irrelevant. - \item - If the estimated effect size is relevant in the context of the - study being executed, it may very well be (but there is no - certainty) that collecting additional data (updating) will render - a HDCI that does not contain the value zero. If you have the - resources, it may be worthwhile to collect additional data and - return to Step 3). If you do not have the resources, your study is - finished. - \end{enumerate} - \end{enumerate} -\end{enumerate} - -In this paper the focus was on Cohen's d and the Pearson correlation, -however, the approach presented can straightforwardly be generalized to -other statistical models and effect size measures. A relatively simple -example is quadratic regression with either Spearman's correlation or -the multiple correlation as the effect size measure, but generalizations -to more involved statistical models are conceivable. Arguably, in more -complex statistical models our approach may succeed where classical -power analysis may very well fail. The reason for the latter is that in -power analysis ``the effect size'' has to be specified. In, for example, -structural equation models, this implies that factor loadings, -regression coefficients and (co)variances have to be specified. Doing -this such that the specification represents a certain ``effect size'' is -at least difficult and maybe even impossible. In our approach effect -sizes do not have to be specified but are straightforwardly estimated -using existing data. The latter is usually easy and straightforward. -Therefore, in an era of open science in which data sets are increasingly -available for re-use (also for sample size determination) there is a lot -of potential for the approach presented in this paper. - -\subsubsection{Practical -recommendations}\label{practical-recommendations} - -When calculating HDCI's using existing data, we should keep in mind that -the determined sample size is only an indication of the sample size -required for the new study. In the new study the unknown effect size -(Cohen's d or Pearson's correlation) may be smaller or larger than in -the existing study and therefore a somewhat smaller or larger sample -size may be required. As elaborated earlier, this can be accommodated -using Bayesian updating using the determined sample size as the point of -departure. It is also important to consider how one can determine the -resemblance of a ``to be planned study'' to the existing study. Although -this is a subjective evaluation, it is probably wise to be mindful of -different factors that can influence the strength of the effect, such as -task domain, number of trials, region of interest, and modality (e.g., -visual versus verbal) (Bennett and Miller 2013; Elliott et al. 2020; -Herting et al. 2018). This is also important for cases where the -ultimate consequence of the sample size estimation might be that one -should not execute the planned study. For example, if a study resembles -study B in Figure 3, it is to be expected that the effect size for -linear correlations with age (if one expects a linear and not a -non-linear effect) is so small that either it is irrelevant, or -unrealistic large sample sizes are required to obtain an average HDCI -that does not contain zero. But even in this situation, it depends on -the context whether something is a meaningful small effect or a -negligible small effect (see for further discussions Dick et al. (2021) -and Funder and Ozer (2019)). One might still decide to continue the -study when there is evidence that the effect at hand is meaningful -because cumulatively it can lead to larger effects. If the effect is yet -deemed irrelevant, one could choose not to collect new data, or one -could alternatively take a bet to pilot a novel version of a similar -task might lead to a stronger effect. Bayesian updating can then be used -to estimate the HDCI's again after a small number of participants. If -the average effect is still close to zero it is probably better to abort -the study. - -\section{Acknowledgments}\label{acknowledgments} - -This study was funded by the NWO Spinoza prize awarded to Eveline A. -Crone. 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J. and Guroglu, B.}, - year = {2018}, - month = {01}, - date = {2018-01-09}, - journal = {Cogn Affect Behav Neurosci}, - doi = {10.3758/s13415-017-0557-1} -} diff --git a/_manuscript/figures/fig01_cohensd_estimates.png b/_manuscript/figures/fig01_cohensd_estimates.png deleted file mode 100644 index 901e9f8..0000000 Binary files a/_manuscript/figures/fig01_cohensd_estimates.png and /dev/null differ diff --git a/_manuscript/figures/fig02_cohensd_nozero.png b/_manuscript/figures/fig02_cohensd_nozero.png deleted file mode 100644 index 9818446..0000000 Binary files a/_manuscript/figures/fig02_cohensd_nozero.png and /dev/null differ diff --git a/_manuscript/figures/fig03_correlation_estimates.png b/_manuscript/figures/fig03_correlation_estimates.png deleted file mode 100644 index 5217e41..0000000 Binary files a/_manuscript/figures/fig03_correlation_estimates.png and /dev/null differ diff --git a/_manuscript/figures/fig04_correlation_nozero.png b/_manuscript/figures/fig04_correlation_nozero.png deleted file mode 100644 index 06ae761..0000000 Binary files a/_manuscript/figures/fig04_correlation_nozero.png and /dev/null differ diff --git a/_manuscript/index.docx b/_manuscript/index.docx deleted file mode 100644 index 942aa6d..0000000 Binary files a/_manuscript/index.docx and /dev/null differ diff --git a/_manuscript/index.html b/_manuscript/index.html deleted file mode 100644 index 3f4b1d6..0000000 --- a/_manuscript/index.html +++ /dev/null @@ -1,1259 +0,0 @@ - - - - - - - - - - - - - - - -Sample size estimation for task-related functional MRI studies using Bayesian updating - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
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Sample size estimation for task-related functional MRI studies using Bayesian updating

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Authors
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Eduard T. Klapwijk

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- Erasmus University Rotterdam, Netherlands -

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Joran Jongerling

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- Tilburg University, Netherlands -

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Herbert Hoijtink

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- Utrecht University, Netherlands -

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Eveline A. Crone

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- Erasmus University Rotterdam, Netherlands -

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- Leiden University, Netherlands -

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June 13, 2024

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Abstract
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Task-related functional MRI (fMRI) studies need to be properly powered with an adequate sample size to reliably detect effects of interest. But for most fMRI studies, it is not straightforward to determine a proper sample size using power calculations based on published effect sizes. Here, we present an alternative approach of sample size estimation with empirical Bayesian updating. First, this method provides an estimate of the required sample size using existing data from a similar task and similar region of interest. Using this estimate researchers can plan their research project, and report empirically determined sample size estimations in their research proposal or pre-registration. Second, researchers can expand the sample size estimations with new data. We illustrate this approach using four existing fMRI data sets where Cohen’s d is the effect size of interest for the hemodynamic response in the task condition of interest versus a control condition, and where a Pearson correlation between task effect and age is the covariate of interest. We show that sample sizes to reliably detect effects differ between various tasks and regions of interest. We provide an R package to allow researchers to use Bayesian updating with other task-related fMRI studies.

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Keywords
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power analysis, region of interest, effect size, R package, sample sizes, Bayesian updating

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1 Introduction

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Since the emergence of functional magnetic resonance imaging (fMRI), these techniques have provided unprecedented opportunities to study functional brain development during childhood and adolescence by scanning children from the age of four years onward. There is great progression in the assessment of neural functional growth using cross-sectional and longitudinal assessments of cognitive, social and affective processes across the full range of childhood to adulthood. Despite the advancements in the ability to study the developing brain in vivo using fMRI, recent years have seen an increased concern about the replicability of scientific findings in general and particularly in psychology and cognitive neuroscience (Bishop 2019; E. T. Klapwijk et al. 2021; Munafò et al. 2017; Poldrack et al. 2017; see Marek et al. 2022 for a similar concern for resting-state functional connectivity and structural MRI data sets).

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Low statistical power due to small sample sizes is arguably one of the main reasons for lower than desired replicability of study results. Statistical power is the probability that a study will reject the null hypothesis when it is false, that is, when there is a non-zero effect (e.g., Cohen’s d or Pearson’s correlation) in the population of interest. Power is determined by the size of the effect, the alpha level chosen, and the size of the sample (Cohen 1992). The smaller each of effect size, alpha level, and sample size are, the lower the power. Since many psychological phenomena consist of relatively subtle, small effects (Funder and Ozer 2019; Gignac and Szodorai 2016; Yarkoni 2009), the main source for increasing power, and over which researchers have a reasonable degree of control, is the sample size (given limited flexibility of the alpha level). Despite the need for well-powered studies to reliably detect effects of interest, empirical reports have shown that most cognitive neuroscience and fMRI studies are underpowered due to small sample sizes (Button et al. 2013; Maxwell 2004; Nord et al. 2017; Poldrack et al. 2017; Szucs and Ioannidis 2017; Turner et al. 2018). With developmental populations, sufficiently large sample sizes might be even harder to establish because of the challenges in recruitment and testing of young participants (Achterberg and Meulen 2019; E. T. Klapwijk et al. 2021).

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Recently, well-coordinated efforts and funding have led to several large-scale projects that collect developmental task-related fMRI data with larger sample sizes. These projects have the potential to resolve the problem of power with sample sizes in the thousands, such as the IMAGEN study (\(N ≈ 2,000\)) (Schumann et al. 2010), the Philadelphia Neurodevelopmental Cohort (\(N ≈ 1,000\)) (Satterthwaite et al. 2016), the Human Connectome Project in Development (HCP-D; \(N ≈ 1,300\)) (Somerville et al. 2018), and the Adolescent Brain Cognitive Development (ABCD) study (\(N ≈ 11,000\)) (Casey et al. 2018). The leap forward made with this wealth of high-powered, mostly publicly available data can hardly be overstated, given that they provide an important open research tool for researchers across the globe.

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However, most fMRI studies are carried out by individual research groups in much smaller samples, which have more opportunities to pursue new scientific questions, for example using novel paradigms. It is also vital that the findings of such studies are replicable and meaningful, meaning that these studies should be properly powered, also without sample sizes in the range of large multi-lab studies. The main issue with power analysis is that the effect size in the population of interest is unknown. One option is to use effect sizes reported in the literature of the research area at hand. But these effect sizes are often inflated due to publication bias (Gelman and Carlin 2014; Ioannidis 2005; Open Science Collaboration 2015; Wicherts et al. 2016; Yarkoni 2009). Therefore, calculating power based on published effect sizes usually underestimates the sample size needed to reliably detect an effect.

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This paper will present a novel method to determine the required sample size for fMRI studies based on existing (i.e., already collected) data using Bayesian updating (Rouder 2014). Specifically, the approach will determine the proportion of the already collected data that is needed to get a desired credible interval (the Bayesian counterpart of the confidence interval). This will provide an estimate of the percentage of cases for which the credible interval is expected to be in the desired range (e.g., the interval should not contain the value 0 for the parameter of interest). This in turn gives us an estimate of the sample size needed for a certain level of power. The current paper will provide examples (including an R package) for two effect sizes: Cohen’s d and Pearson’s correlation. The sample size determined using existing data is valuable when designing a new research project and when justifying sample sizes in a pre-registration or in proposals send to a (medical) ethical committee.

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We will illustrate sample size determination using existing data sets and tasks that are currently widely used in the developmental fMRI literature, specifically cognitive control, reward activity, and social-cognitive processing (see Table 1 for an overview) based on existing data from our own lab. It will be determined how large the sample size should be to detect Cohen’s d, such that 95% does not contain the value zero for a specific condition effect (e.g., brain activity during feedback processing versus rule application). Most prior developmental fMRI studies addressed the question whether an effect linearly increases or decreases with age (Crone and Steinbeis 2017). We therefore also determine the sample size needed to detect a Pearson correlation of an effect with linear age that is larger than zero. In the next sections, we will first introduce Bayesian updating, the highest density credible interval, and sample size determination. Next, we will provide examples using existing data from four fMRI studies (Braams et al. 2014; Peters and Crone 2017; Spaans et al. 2023; Cruijsen et al. 2023), and illustrate sample size determination using these examples.

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1.1 Bayesian updating

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Bayesian updating can be used to determine the sample size required to estimate Cohen’s d or Pearson’s correlation with a certain precision. Precision is presented in the form of a 95% highest density credible interval (HDCI), that is, the narrowest possible interval that is believed to contain the true value of the parameter of interest with a probability of .951. The narrower this interval, the higher the precision with which the parameter is estimated.

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Bayesian updating as implemented here relies on the assumption that a priori, that is, before collecting the data, each possible value of the parameter of interest is equally likely. This has two implications. First, the HDCI is completely determined by the data and not by prior information. Secondly, the numerical values of the estimate and endpoints of the HDCI are equal to the estimate and endpoints of the classical confidence interval.

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Bayesian updating can be used to determine the smallest sample size for which the resulting HDCI does not contain the value zero. Bayesian updating consists of four steps:

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  1. Determine the maximum achievable size of the sample.

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  2. Collect the data for an initial number of participants and then compute the estimate and HDCI. The actual number chosen is irrelevant, but with 20 participants the estimate and HDCI will usually give a first impression of the size of Cohen’s d or Pearson’s correlation that is not totally determined by sample fluctuations and/or outliers.

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  3. Add several participants to the sample (updating) and recompute the estimate and HDCI.

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  4. If the HDCI still contains the value zero and the maximum achievable sample size has not been obtained, return to the previous step. Otherwise, the updating is finished and estimates and corresponding HDCI’s are reported.

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1.1.1 The highest density credible interval (HDCI)

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It is important to highlight that the HDCI is not a confidence interval. If many data sets are sampled from the population of interest and each data set is used to compute the 95% confidence interval for the parameter of interest, then it holds that 95% of the intervals contain the true value. However, in contrast to HDCIs, confidence intervals cannot be updated because their coverage level will become smaller than 95%. This will be illustrated using a simple example.

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Imagine many researchers want to show that Cohen’s d is unequal to zero. Each of them samples a data set with \(n = 20\) for each group from the population of interest (in which Cohen’s d happens to equal zero). About 5% of the 95% confidence intervals do not contain the value 0. These researchers will not continue their efforts; they have “shown” that “their” effect is not zero. At this stage the Type I error rate is .05. However, the 95% remaining researchers increase their power by updating their data with another 10 persons per group and recompute their 95% confidence intervals of which about 2.8% (number determined using simulation) does not contain the value 0. Therefore, the Type I error rate is increased to 5% + 2.8% = 7.8%, that is, the updating rendered 92.2% confidence intervals and not 95% confidence intervals.

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A HDCI should therefore not be interpreted in the context of many hypothetical data sets sampled from the population of interest. The HDCI is computed using the observed data at hand and is the shortest interval that is believed to contain the true value of Cohen’s d with a probability of .95. When updating, the size of the data at hand becomes larger, the information with respect to Cohen’s d increases, and therefore the width of the HDCI becomes smaller. The HDCI summarizes the evidence in the data at hand with respect to the size of Cohen’s d, which is different from a confidence interval which aims to control error rates under (hypothetical) repeated sampling from the same population.

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1.2 Sample Size Determination

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The procedure elaborated in this paper is Bayesian (because HDCIs are used) empirical (because existing data are used) sample size determination. We use an existing dataset of a certain size, and for all sample sizes between a minimum (e.g., \(n = 20\)) and maximum sample size of the sample at hand we compute the HDCI. To account for the arbitrary order of the participant in a data set, this is done for a set number of permutations, e.g., 1000, of the participants in the data set. For each sample size, we then calculate the average HDCI of all permutations. Considering both the average HDCI and the HDCI’s resulting from the different permutations, will provide an estimate sample size needed to obtain a 95% HDCI . The 95% HDCI for Cohen’s d was established through non-parametric bootstrapping (Efron and Tibshirani 1994). Specifically, we resampled the current subset of data 100 times and calculated Cohen’s d for the difference between variable x and variable y each time. We then calculated the mean and standard deviations of Cohen’s d across the 100 resampled values. The 95% CI was determined by subtracting 1.96 times the standard deviation of the Cohen’s d values from the mean Cohen’s d value, and by adding 1.96 times the standard deviation of the Cohen’s d values to the mean Cohen’s d value.

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To illustrate the current method, we can take a preview at Figure 1 C in the Results section. The dataset used to construct HDCI’s for Cohen’s d consists of 149 participants from the self-evaluation versus control contrast in the medial prefrontal cortex during a self-evaluation task. In Figure 1 C the first 20 participants in each of 1000 permuted data sets are used to compute the HDCI for Cohen’s d. Ten of these intervals are displayed in blue. As can be seen, of the ten (of 1000) HDCIs displayed, four include the value zero. Consequently, fluctuations in the order in which participants are sampled determine whether the HDCI contains the value zero. This is summarized in Figure 2 C which shows that the probability that one of the 1000 HDCIs does not contain the value zero is about 0.6 for \(n = 20\). In Figure 1 C, it is shown in the first interval displayed in purple that the average of the 1000 HDCI’s does not contain the value zero. Therefore, although the average interval does not contain the value zero, we can learn from the permutations that when using 20 participants it is still rather likely that the resulting interval will include the value zero. This becomes much less likely for the samples of 46 and 72 participants. With these sample sizes neither the HDCIs nor the average interval contain the value zero (see Figure 1 C). Additionally, the probability that an interval does not contain the value zero equals 100% for 72 participants (see Figure 2 C). Therefore, a sample size of 72 and higher will usually render intervals that do not contain the value zero.

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An issue that sample size determination has in common with power analysis, is that the effect size in the existing data set will very likely differ from the effect size in the population that will be addressed in the study being designed. However, sample size determination does not suffer from the fact that effect sizes reported in the literature tend to be inflated (like power analysis) because effect sizes are straightforwardly computed from actual data. The determined sample size is therefore an estimate of the required sample size. This estimate is valuable because it allows researchers to plan their research project, can be reported in their research proposal or pre-registration, and it may lead to the conclusion that the sample size needed cannot be achieved with the resources that you have at your disposal.

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In the next section Bayesian empirical sample size determination will be exemplified and discussed using different fMRI tasks from the BrainTime (Braams et al. 2014; Peters and Crone 2017) and Self-Concept (Spaans et al. 2023; Cruijsen et al. 2023) data sets.

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1.3 neuroUp R package

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The code for Bayesian updating in this manuscript is implemented in the R language for statistical computing (R Core Team, 2022). We currently provide the neuroUp package at the following location: https://github.com/eduardklap/neuroUp (E. Klapwijk, Hoijtink, and Jongerling 2024). This package is built on several packages from the tidyverse (Wickham et al. 2019), most notably ggplot2. The package can be installed using the R commands: library(devtools) and install_github("eduardklap/neuroUp"). All data used in the current manuscript is also available within the neuroUp package, in this way all figures in the manuscript can be reproduced using the R package. For a more elaborate introduction to neuroUp and its functions, please refer to https://eduardklap.github.io/neuroUp/articles/neuroUp.html. To cite package neuroUp in publications use E. Klapwijk, Hoijtink, and Jongerling (2024).

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2 Method & Materials

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We focus on sample size estimation for regions of interest from four different fMRI tasks in two different samples (see Table 1). We re-used data that has been processed with SPM8 or SPM12 and derived summary statistics for individual participants for regions and task conditions of interest (see fMRI processing).

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-Table 1: Overview of tasks processed in the current study. -
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tasksourceassociated papersNage rangecognitive processregion of interest
FeedbackBrainTime study, Leiden University(Peters and Crone 2017; Crone, Duijvenvoorde, and Peper 2016)2718-25 yrsfeedback learningDLPFC
GamblingBrainTime study, Leiden University(Braams et al. 2014; Crone, Duijvenvoorde, and Peper 2016)22112-28 yrsreward-processingNAcc
Self-evaluationsSelf-Concept study, Leiden University(Cruijsen et al. 2023; Crone et al. 2022)14911-21 yrsself processingmPFC
Vicarious charitySelf-Concept study, Leiden University(Spaans et al. 2023; Crone et al. 2022)15611-21 yrsvicarious rewardsNAcc
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2.1 Data and processing

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2.1.1 BrainTime study

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The BrainTime study is an accelerated longitudinal research project of normative development. A total of 299 participants between ages 8 and 25 years took part in MRI scanning at the first time point. At the second time point approximately 2 years later, 254 participants were scanned (most dropout was due to braces, \(n = 33\)). At time point 3, approximately 2 years after time point 2, 243 participants were scanned (dropout due to braces: \(n = 11\)). The same Philips 3T MRI scanner and settings were used for all time points. The following settings were used: TR = \(2200 ms\), TE = \(30 ms\), sequential acquisition, 38 slices, slice thickness = \(2.75 mm\), field of view (FOV) = \(220 × 220 × 114.68 mm\). A high-resolution 3D T1 anatomical scan was acquired (TR = \(9.76 ms\), TE = \(4.59 ms\), 140 slices, voxel size = \(0.875 × 0.875 × 1.2 mm\), FOV = \(224 × 177 × 168 mm\)).

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2.1.1.1 Feedback task

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For the feedback task (Peters et al. 2014) we included 271 participants at time point 1 from which region of interest data was available. We use the same data and processing as reported in (Peters and Crone 2017). During the task, on each trial participants viewed three squares with a stimulus presented underneath. Participants were instructed to use performance feedback to determine which stimulus belonged to which square. After each choice, feedback was presented to the participant: a minus sign for negative feedback or a plus sign for positive feedback. After 12 trials, or when a criterion was reached (placing each of the three stimuli in the correct box at least two times), a new sequence with three new stimuli was presented. This criterion was used to strike a balance between the number of trials in the learning and the application phase. There were 15 sequences in total, resulting in a maximum of \(15 x 12 = 180\) trials per participant. For the current study, we focused on the learning > application contrast, which compares feedback early in the learning process with feedback for associations that were already learned (i.e. application phase). Individual trial-by-trial analyses were used to determine the learning and application phase (see Peters and Crone (2017) for details).

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2.1.1.2 Gambling task

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For the Gambling task (Braams et al. 2014), we used data from 221 participant at time point 3 (we went for the largest sample size and this was the time point with the most data available for the contrasts of interest). We use the same data and processing as reported in Schreuders et al. (2018). In the Gambling task, participants could choose heads or tails and win money when the computer selected the chosen side of the coin or lose money when the opposite side was selected. Chances of winning were 50%. To keep participants engaged, the number of coins that could be won or lost on varied across trials. Participants were explained that the coins won in the task would translate to real money, to be paid out at the end of the experiment. Gambling was performed in two different conditions: participants played 23 trials for themselves, and 22 trials for their best friend. For the current study, we focused on reward processing by analysing the winning for self > losing for self contrast.

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2.1.2 Self-Concept study

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The Self-Concept study is a cohort-sequential longitudinal study in which 160 adolescents from 11 to 21 years old took part at the first time point (see https://osf.io/h7u46 for study overview). MRI scans were acquired on a Philips 3T MRI scanner with the following settings: TR = \(2200 ms\), TE = \(30 ms\), sequential acquisition, 37 slices, slice thickness = \(2.75 mm\), FOV = \(220 × 220 × 111.65 mm\). A high-resolution 3D T1 anatomical scan was acquired (TR = \(9.8 ms\), TE = \(4.6 ms\), 140 slices, voxel size = \(0.875 × 0.875 × 1.2 mm\), FOV = \(224 × 178.5 × 168 mm\)).

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2.1.2.1 Self-evaluations task

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For the Self-evaluation task we used the same data and processing as reported in Cruijsen et al. (2023). In this task, participants read 60 short sentences describing positive or negative traits in the academic, physical, or prosocial domain (20 per domain; 10 with a positive valence and 10 with a negative valence). Here we focus on the direct self-evaluation condition, in which participants had to indicate to what extent the trait sentences applied to them on a scale of 1 (‘not at all’) to 4 (‘completely’). In the control condition, participants had to categorize 20 other trait sentences according to four categories: (1) school, (2) social, (3) appearance, or (4) I don’t know. For the current study, we focused on the direct self-evaluation versus control contrast. Eleven participants were excluded due to excessive motion during scanning (\(\>3 mm, n = 8\)), not completing the scan (\(n = 1\)), and a technical error (\(n = 2\)), resulting in a total sample of \(N = 149\).

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2.1.2.2 Vicarious Charity task

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For the Vicarious Charity task, we used the same data and processing as reported in Spaans et al. (2023). In this task, participants could earn money for themselves and for a self-chosen charity they selected before scanning. On every trial, participants could choose one of two curtains to open. After their button press, the chosen curtain opened to show the division of the stake between themselves and the charity. The overall outcome was a division of either €4 or €2 between parties. Unknown to the participant, every outcome condition occurred 15 times during the task. Participants were informed beforehand that they received extra money based on the average of three random outcomes at the end of the research visit. Here we focus on the self-gain > both-no-gain contrast. This contrast compares the 30 trials in which participants gained the full €4 or €2 themselves (i.e., €0 for charity) against 15 baseline trials in which no money was gained in total (i.e., €0 for self and €0 for charity). Two participants were excluded from the analysis due to excessive movement during scanning (\(>3 mm\)), one due to signal dropout in the SPM mask including the ventral striatum (this was assessed by visual inspection of all individual SPM masks), and one due to a technical error, resulting in a total of \(N = 156\).

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2.1.3 fMRI analysis

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FMRI analyses for all four tasks were performed using SPM (Wellcome Department of Cognitive Neurology, London); SPM8 was used for the BrainTime data and SPM12 for the Self-Concept data. The following preprocessing steps were used: slice timing correction, realignment (motion correction), normalization, and smoothing (6 mm full-width at half maximum isotropic Gaussian kernel). T1 templates were based on the MNI305 stereotaxic space. All tasks have an event-related design and events were time-locked with 0 duration to the moment of feedback presentation. Six motion regressors were added to the model. All other trials (i.e., trials that did not result in learning in the Feedback task or too-late trials) were modeled as events of no interest. These events were used as covariates in a general linear model together with a set of cosine functions that high-pass filtered the data. The least-squares parameter estimates of height of the best-fitting canonical hemodynamic response function (HRF) for each condition were used in pair-wise contrasts. The contrast images were submitted to higher-level group analyses. Region of interest analyses were performed with the MarsBaR toolbox (Brett et al. 2002).

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2.1.3.1 Regions of interest

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For the Feedback task, the atlas-based middle frontal gyrus was used as a region of interest (Harvard-Oxford cortical atlas; thresholded at 50%; center-of-mass coordinates \(x = -4, y = 22, z = 43\)). Extracted parameter estimates for this region were obtained in tabular format from the authors of Peters and Crone (2017), with one value for the mean activation during learning and one value for the mean activation during application for all participants. For the Gambling task, the anatomical mask of the left nucleus accumbens was used as a region of interest (Harvard-Oxford subcortical atlas; thresholded at 40%; 28 voxels included). Extracted parameter estimates for this region were obtained in tabular format from the authors of Schreuders et al. (2018), with one value for the mean activation during winning and one value for the mean activation during losing for all participants.

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For the Self-evaluation task, the region of interest used was a mask of the left medial prefrontal cortex (\(x = −6, y = 50, z = 4\)) based on a meta-analysis by Denny et al. (2012). Extracted parameter estimates for this region were obtained in tabular format from the authors of Cruijsen et al. (2023), with one value for the mean activation during self-evaluation and one value for the mean activation during the control condition for all participants. For the Vicarious Charity task, the anatomical mask of the left nucleus accumbens was used as a region of interest (Harvard-Oxford subcortical atlas; thresholded at 40%; center-of-mass coordinates \(x = −10, y = 12, z = −7\); 28 voxels included). Extracted parameter estimates for this region were obtained in tabular format from the authors of Spaans et al. (2023), with one value for the mean activation during gaining for self and one value for the mean activation during no-gain for self and charity for all participants.

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3 Results

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3.1 Task effects using Cohen’s d

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The average HDCI was used to determine the optimal sample size for the four fMRI tasks used. For each task and brain region of interest, we estimated the sample size required to obtain an average HDCI for Cohen’s d not containing the value zero (Figure 1 and Figure 2; Table 2). Additionally, we also established whether it was also the case that a majority of the 1000 underlying HDCIs did not contain the value zero.

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In Figure 1 A, an estimate of the required sample size for feedback learning processing in the DLPFC (middle frontal gyrus) is presented. Five groups of HDCI’s are presented for sample sizes of 20, 70, 120, 170, and 271 persons, in which 271 is the total group sample size of the existing data set. As can be seen, already with a sample of 20 participants neither of the 10 permuted HDCIs displayed nor the average of the 1000 HDCI’s contain the value zero. In Figure 2A it can be seen that the proportion of HDCI’s not containing the value zero is equal to 1.0. This is due to the huge effect size of Cohen’s d equal to about 1.9 (see Table 2). Therefore, already with a sample size of 20 participants, an effect bigger than zero will be detected for this task and brain region.

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For the task effect of gambling (winning for self > losing for self contrast) in the NAcc, we can see the results in Figure 1 B. Here, with a sample of 20 participants the average of the 1000 HDCIs does not contain the value zero but some of the 10 HDCI’s displayed do. The proportion of HDCI’s not containing the value zero is bigger than 0.8 for 20 participants, but with 60 or more participants none of the 1000 HDCI’s contain zero anymore (Figure 2B). This is related to the large effect size of Cohen’s d equal to about 0.7 (see Table 2). Thus, for this task and brain region, already with a sample size of 20 participants chances are high that an effect bigger than zero will be detected. Using sample sizes of 60 or more participants from this existing data set increases the chances of detection to 100%.

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In Figure 1 C, results are plotted for the self-evaluation task in the mPFC. We see that at a sample size of 20 some of the 10 HDCI’s displayed still contain the value 0, but not the average of the 1000 HDCI’s. The proportion of HDCI’s not containing the value 0 is also below 1.0, around 0.5, for this task at \(N=20\) (Figure 2C). At the next step that is plotted for this task (\(n = 46\)), we see that the proportion of HDCI’s not containing the value 0 is only a little below 1.0. Thus, for this task and brain region, at a sample size at 46 participants chances are high that an effect bigger than zero will be detected.

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The results of gaining for self in the NAcc are plotted in Figure 1 D. With a sample of 20 participants the average of the 1000 HDCI’s does not contain the value zero but some of the 10 HDCI’s displayed do. The proportion of HDCI’s not containing the value zero is around 0.75 (Figure 2D), but at \(n = 47\) the proportion of HDCI’s not containing the value 0 is almost 1.0. Therefore, using 20 participants it is still likely that the resulting interval will include the value zero. This becomes much less likely for the samples of 47 and 74 persons. With these sample sizes neither the HDCIs nor the average interval contain the value zero. Additionally, the probability that an interval does not contain the value zero almost reaches 100%. Therefore, for this task and brain region, a sample size of 47 and higher will usually render intervals that do not contain the value zero.

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-Figure 1: Estimates of task effects for five different sample sizes (starting with \(N=20\), then 1/5th parts of the total dataset). For each sample size 10 randomly chosen HDCI’s out of the 1000 HDCI’s computed are displayed (in light blue, permutation numbers used are displayed to the right of each subfigure). The average estimate with credible interval summarizing the 1000 HDCI’s for each sample size are plotted in reddish purple. DLPFC = dorsolateral prefrontal cortex; mPFC = medial prefrontal cortex; NAcc = nucleus accumbens. -
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-Table 2: Mean estimates (with credible interval in brackets) of Cohen’s d for five different sample sizes (starting with n=20, then 1/5th parts of the total dataset) of the 1000 HDCI’s. DLPFC = dorsolateral prefrontal cortex; mPFC = medial prefrontal cortex; NAcc = nucleus accumbens. -
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taskbrain regionn = 20n = 2/5n = 3/5n = 4/5N = total
FeedbackDLPFC2.03 (1.29, 2.76 )1.89 (1.54, 2.25 ), n = 701.88 (1.62, 2.15 ), n = 1201.87 (1.65, 2.1 ), n = 1701.87 (1.69, 2.04 ), N = 271
GamblingNAcc0.8 (0.25, 1.34 )0.74 (0.45, 1.03 ), n = 600.73 (0.51, 0.96 ), n = 1000.73 (0.54, 0.92 ), n = 1400.73 (0.58, 0.88 ), N = 221
Self-evaluationsmPFC0.5 (0.02, 0.98 )0.47 (0.17, 0.77 ), n = 460.46 (0.22, 0.7 ), n = 720.46 (0.26, 0.66 ), n = 980.46 (0.29, 0.62 ), n = 149
Gaining selfNAcc0.64 (0.14, 1.14 )0.59 (0.27, 0.91 ), n = 470.58 (0.32, 0.84 ), n = 740.58 (0.36, 0.8 ), n = 1010.57 (0.39, 0.75 ), N = 156
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-Figure 2: For each task, for five different sample sizes (starting with \(n=20\), then 1/5th parts of the total dataset), the proportion of intervals not containing the value 0 is plotted in reddish purple. -
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3.2 Pearson correlations between task effects and age

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For each task and brain region of interest we also estimated the sample size required to obtain an average HDCI for Pearson’s correlation between regional fMRI task responses and age not containing the value zero (Figure 3 and Figure 4; Table 3) for which a large proportion of the 1000 HDCI’s does not contain the value zero.

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In Figure 3 A the results are shown for the Pearson’s correlation between age (children and adolescents aged 8-25 years) and feedback learning processing in the DLPFC. As can be seen, with a sample of 20 persons the average HDCI contains the value 0. Increasing the sample size to 70 results in neither of the 10 HDCI’s displayed nor the average of the 1000 HDCI’s containing the value 0. We can also see that the proportion of HDCI’s not containing the value zero is less than 0.5 for 20 participants but equal to 1.0 for 70 participants (Figure 4 A). Therefore, for a reliable estimate of the correlation between feedback processing in the DLPFC and age, sample sizes bigger than 20 are needed.

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For the correlation between age and gambling in the NAcc, we can see the results in Figure 3 B. Here, for all plotted sample sizes both the average of the HDCI’s and all of the 10 HDCI’s displayed do contain the value zero. The proportion of HDCI’s not containing the value zero is below 0.1 for 20 participants, but with more participants almost all of the 1000 HDCI’s contain the value zero (Figure 4 B). This is related to the very small correlation equal to about -0.04 (see Table 3). Thus, for this task and brain region, it is unlikely that an effect larger than zero will be detected for a correlation with age, even with the total sample size of 221 participants.

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In Figure 3 C, results are plotted for the correlation between age and self-evaluation processing in the mPFC. We see that for all plotted sample sizes both the average of the 1000 HDCI’s and most of the 10 HDCI’s displayed do contain the value zero. In Figure 4 C, we also see that the proportion of HDCI’s not containing the value 0 is well below 1.0 for all sample sizes shown. Thus, for this task and brain region, with all available sample sizes the chances are high there will be no effect detected that is larger than zero. The average Pearson correlation is also small with a value around 0.13 (Table 3). The results for the correlation between age and gaining for self in the NAcc are plotted in Figure 3D. We see that up to 104 participants both the average of the 1000 HDCI’s and most of the 10 HDCI’s displayed do contain the value zero. The proportion of HDCI’s not containing the value zero increases with bigger sample sizes (Figure 4 A) but is still below 0.5 for 104 participants. Therefore, with 104 participants it is still likely that the resulting interval will include the value zero. Therefore, for this task and brain region, with all available sample sizes the chances are high there will be no effect detected that is larger than zero. The average Pearson correlation is also relatively small with a value around -0.18 (Table 3). If correlations of about -0.18 are considered relevant, the conclusion might be that one could strive for a sample larger than 160.

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-Figure 3: Estimates of Pearson’s correlation between age and the task effect for five different sample sizes (starting with \(N=20\), then 1/5th parts of the total dataset). For each sample size 10 randomly chosen HDCI’s out of the 1000 HDCI’s computed are displayed (in green, permutation numbers used are displayed to the right of each subfigure). The average estimate with credible interval summarizing the 1000 HDCI’s for each sample size are plotted in orange. DLPFC = dorsolateral prefrontal cortex; mPFC = medial prefrontal cortex; NAcc = nucleus accumbens. Age is modeled as linearly increasing or decreasing. -
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-Table 3: Mean estimates (with credible interval in brackets) of Pearson’s correlation between age and the task effect for five different sample sizes (starting with N=20, then 1/5th parts of the total dataset) of the 1000 HDCI’s. DLPFC = dorsolateral prefrontal cortex; mPFC = medial prefrontal cortex; NAcc = nucleus accumbens. -
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taskbrain regionn = 20n = 2/5n = 3/5n = 4/5N = total
FeedbackDLPFC0.38 (-0.06, 0.69 )0.38 (0.16, 0.56 ), N = 700.37 (0.21, 0.52 ), N = 1200.38 (0.24, 0.5 ), N = 1700.38 (0.27, 0.47 ), N = 271
GamblingNAcc-0.02 (-0.44, 0.4 )-0.04 (-0.29, 0.21 ), N = 60-0.04 (-0.23, 0.16 ), N = 100-0.04 (-0.2, 0.13 ), N = 140-0.04 (-0.17, 0.09 ), N = 221
Self-evaluationsmPFC0.07 (-0.36, 0.48 )0.06 (-0.23, 0.34 ), N = 460.06 (-0.17, 0.29 ), N = 720.06 (-0.14, 0.25 ), N = 980.06 (-0.1, 0.22 ), N = 149
Gaining selfNAcc-0.18 (-0.56, 0.26 )-0.17 (-0.44, 0.11 ), N = 47-0.17 (-0.38, 0.06 ), N = 74-0.17 (-0.35, 0.03 ), N = 101-0.17 (-0.31, -0.01 ), N = 156
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-Figure 4: For each task, for five different sample sizes (starting with \(N=20\), then 1/5th parts of the total dataset), the proportion of intervals not containing the value 0 is plotted inorange. Age is modeled as linearly increasing or decreasing. -
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4 Discussion

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In this paper we tested how existing data can be used to approximately determine the sample size that is required for a new study that is being planned. The approach presented has been illustrated using four existing fMRI studies where Cohen’s d is the effect size of interest and four studies where a Pearson correlation for linear age is of interest. Additionally, it has been elaborated that Bayesian updating can be used to deal with the fact that the required sample size can only approximately be determined. Our results show that calculating and plotting HDCI’s can be helpful in determining at what sample sizes task effects become more stable. We illustrated with four examples how researchers can get an indication of the required sample size if they plan to execute a study that uses feedback learning, reward-processing (two examples), or self-processing. For all effects under study, the width of the HDCI became smaller with larger sample sizes, showing that the precision of the estimation increased with more data. At what sample size estimations seemed to stabilize for general contrasts (e.g., feedback processing versus rule application; reward versus loss) differed per task and region of interest. For example, the effects in the middle frontal gyrus during feedback processing were the strongest of the effects studied here. There, even for sample sizes of 20 participants, task effects clearly differed from zero for the middle frontal gyrus. But even for such a strong effect, at higher sample sizes the results became more stable (i.e., less variability in subsamples of the total dataset). For the other three tasks, the HDCI’s still contained the value zero with 20 participants but at higher sample sizes of 40-60 participants chances are very high that an effect larger than zero will be detected. In this paper we tested how existing data can be used to approximately determine the sample size that is required for a new study that is being planned. The approach presented has been illustrated using four existing fMRI studies where Cohen’s d is the effect size of interest and four studies where a Pearson correlation for linear age is of interest. Additionally, it has been elaborated that Bayesian updating can be used to deal with the fact that the required sample size can only approximately be determined.

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Our results show that calculating and plotting HDCI’s can be helpful in determining at what sample sizes task effects become more stable. We illustrated with four examples how researchers can get an indication of the required sample size if they plan to execute a study that uses feedback learning, reward-processing (two examples), or self-processing. For all effects under study, the width of the HDCI became smaller with larger sample sizes, showing that the precision of the estimation increased with more data. At what sample size estimations seemed to stabilize for general contrasts (e.g., feedback processing versus rule application; reward versus loss) differed per task and region of interest. For example, the effects in the middle frontal gyrus during feedback processing were the strongest of the effects studied here. There, even for sample sizes of 20 participants, task effects clearly differed from zero for the middle frontal gyrus. But even for such a strong effect, at higher sample sizes the results became more stable (i.e., less variability in subsamples of the total dataset). For the other three tasks, the HDCI’s still contained the value zero with 20 participants but at higher sample sizes of 40-60 participants chances are very high that an effect larger than zero will be detected.

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The results are different for the Pearson correlation between linear age and task effects, as can be seen in Figure 3 and Figure 4. Here again the results of the middle frontal gyrus during feedback processing were the strongest. But even for such a strong effect, the sample size needed to estimate the correlation with age is much higher than the sample size needed to find a stable task effect. For the Pearson correlation, only at a sample size of \(N=70\) or more the lower bound of the credible is above zero, suggesting that one can be confident that there is a positive Pearson correlation.

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For the correlation between linear age (between 12-28 years) and reward-processing in the NAcc, the results were dependent on the specific task context. In a gambling task with the contrast reward versus loss, even with a sample size of 221 the average HDCI contains the value zero when testing for linear age effects. We found that the average Pearson correlation is -.04 for this effect, which is so small that it is likely irrelevant. In contrast, for rewards in a vicarious reward context with the contrast reward versus no reward, probability of a positive Pearson correlation with negative age increased with larger sample sizes and the average CI did just not contain zero using the full sample size of 156 (\(M = -0.17; 95\% CI [-0.31, -0.01]\)). Note that we only tested for linear age effects, whereas prior studies reported that reward processing may be best described by non-linear effects (Braams et al. 2014); which should be tested in future extensions of the approach illustrated here. The results described for the linear age effects are in line with simulation studies suggesting that typically in psychology relatively large sample sizes of \(N=150\) to \(N=250\) (Schönbrodt and Perugini 2013) are needed to obtain a study that is sufficiently powered to evaluate a Pearson correlation with age or psychological variables.

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There are different ways in which the methods described here could be put to practice. When planning to use an existing task for follow-up or replication research, existing data can be used to provide an educated guess of the sample size that is needed in the new study (given that the new samples resemble the existing sample). In this way new task-related fMRI studies will likely be properly powered, even if these are small-scale studies from individual labs. Even in the current era of large-scale consortium studies, there remains the need to conduct studies with more modest sample sizes. Such studies can help to balance between methodological robustness of well-established experiments and experimental design novelty. These data sets could complement large, public data sets with more idiosyncratic tasks and specific samples. Furthermore, sample size determination using existing data can be combined with Bayesian updating when collecting new data for a new research project. The following steps can be used:

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  1. Execute Bayesian empirical sample size determination. This will render an estimate of the sample size needed for an adequately powered study.

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  2. Execute the planned study with the sample size determined in the previous step.

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  3. Compute the effect size of interest (e.g., Cohen’s d or Pearson’s correlation) and the corresponding HDCI.

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  4. Evaluate the HDCI:

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    1. If the HDCI does not contain the value zero, your study is finished.

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    2. If the HDCI does contain the value zero, there are two options:

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      1. If the estimate of the effect size is close to zero, the effect size is small. Adding more data (updating) may (or may not) render an HDCI that does not contain the value but will very likely still render an effect size that is so small that it is irrelevant.

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      2. If the estimated effect size is relevant in the context of the study being executed, it may very well be (but there is no certainty) that collecting additional data (updating) will render a HDCI that does not contain the value zero. If you have the resources, it may be worthwhile to collect additional data and return to Step 3). If you do not have the resources, your study is finished.

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In this paper the focus was on Cohen’s d and the Pearson correlation, however, the approach presented can straightforwardly be generalized to other statistical models and effect size measures. A relatively simple example is quadratic regression with either Spearman’s correlation or the multiple correlation as the effect size measure, but generalizations to more involved statistical models are conceivable. Arguably, in more complex statistical models our approach may succeed where classical power analysis may very well fail. The reason for the latter is that in power analysis “the effect size” has to be specified. In, for example, structural equation models, this implies that factor loadings, regression coefficients and (co)variances have to be specified. Doing this such that the specification represents a certain “effect size” is at least difficult and maybe even impossible. In our approach effect sizes do not have to be specified but are straightforwardly estimated using existing data. The latter is usually easy and straightforward. Therefore, in an era of open science in which data sets are increasingly available for re-use (also for sample size determination) there is a lot of potential for the approach presented in this paper.

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4.0.1 Practical recommendations

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When calculating HDCI’s using existing data, we should keep in mind that the determined sample size is only an indication of the sample size required for the new study. In the new study the unknown effect size (Cohen’s d or Pearson’s correlation) may be smaller or larger than in the existing study and therefore a somewhat smaller or larger sample size may be required. As elaborated earlier, this can be accommodated using Bayesian updating using the determined sample size as the point of departure. It is also important to consider how one can determine the resemblance of a “to be planned study” to the existing study. Although this is a subjective evaluation, it is probably wise to be mindful of different factors that can influence the strength of the effect, such as task domain, number of trials, region of interest, and modality (e.g., visual versus verbal) (Bennett and Miller 2013; Elliott et al. 2020; Herting et al. 2018). This is also important for cases where the ultimate consequence of the sample size estimation might be that one should not execute the planned study. For example, if a study resembles study B in Figure 3, it is to be expected that the effect size for linear correlations with age (if one expects a linear and not a non-linear effect) is so small that either it is irrelevant, or unrealistic large sample sizes are required to obtain an average HDCI that does not contain zero. But even in this situation, it depends on the context whether something is a meaningful small effect or a negligible small effect (see for further discussions Dick et al. (2021) and Funder and Ozer (2019)). One might still decide to continue the study when there is evidence that the effect at hand is meaningful because cumulatively it can lead to larger effects. If the effect is yet deemed irrelevant, one could choose not to collect new data, or one could alternatively take a bet to pilot a novel version of a similar task might lead to a stronger effect. Bayesian updating can then be used to estimate the HDCI’s again after a small number of participants. If the average effect is still close to zero it is probably better to abort the study.

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5 Acknowledgments

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This study was funded by the NWO Spinoza prize awarded to Eveline A. Crone. The authors thank Sabine Peters, Lisa Schreuders, Jochem Spaans, and Renske van der Cruijsen for providing the ROI data files used in the paper.

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-Rouder, Jeffrey N. 2014. “Optional Stopping: No Problem for Bayesians.” Psychonomic Bulletin & Review 21 (2): 301–8. https://doi.org/10.3758/s13423-014-0595-4. -
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-Satterthwaite, Theodore D., John J. Connolly, Kosha Ruparel, Monica E. Calkins, Chad Jackson, Mark A. Elliott, David R. Roalf, et al. 2016. “The Philadelphia Neurodevelopmental Cohort: A Publicly Available Resource for the Study of Normal and Abnormal Brain Development in Youth.” NeuroImage, Sharing the wealth: Brain Imaging Repositories in 2015, 124 (January): 1115–19. https://doi.org/10.1016/j.neuroimage.2015.03.056. -
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-Schönbrodt, Felix D., and Marco Perugini. 2013. “At What Sample Size Do Correlations Stabilize?” Journal of Research in Personality 47 (5): 609–12. https://doi.org/10.1016/j.jrp.2013.05.009. -
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-Schreuders, E., E. T. Klapwijk, G. J. Will, and B. Guroglu. 2018. “Friend Versus Foe: Neural Correlates of Prosocial Decisions for Liked and Disliked Peers.” Cogn Affect Behav Neurosci, January. https://doi.org/10.3758/s13415-017-0557-1. -
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-Schumann, G., E. Loth, T. Banaschewski, A. Barbot, G. Barker, C. Büchel, P. J. Conrod, et al. 2010. “The IMAGEN Study: Reinforcement-Related Behaviour in Normal Brain Function and Psychopathology.” Molecular Psychiatry 15 (12): 1128–39. https://doi.org/10.1038/mp.2010.4. -
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-Somerville, Leah H., Susan Y. Bookheimer, Randy L. Buckner, Gregory C. Burgess, Sandra W. Curtiss, Mirella Dapretto, Jennifer Stine Elam, et al. 2018. “The Lifespan Human Connectome Project in Development: A Large-Scale Study of Brain Connectivity Development in 521 Year Olds.” NeuroImage 183 (December): 456–68. https://doi.org/10.1016/j.neuroimage.2018.08.050. -
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-Spaans, Jochem, Sabine Peters, Andrik Becht, Renske van der Cruijsen, Suzanne van de Groep, and Eveline A. Crone. 2023. “Longitudinal Neural and Behavioral Trajectories of Charity Contributions Across Adolescence.” Journal of Research on Adolescence 33 (2): 480–95. https://doi.org/10.1111/jora.12820. -
-
-Szucs, Denes, and John P. A. Ioannidis. 2017. “Empirical Assessment of Published Effect Sizes and Power in the Recent Cognitive Neuroscience and Psychology Literature.” PLOS Biology 15 (3): e2000797. https://doi.org/10.1371/journal.pbio.2000797. -
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-Turner, Benjamin O., Erick J. Paul, Michael B. Miller, and Aron K. Barbey. 2018. “Small Sample Sizes Reduce the Replicability of Task-Based fMRI Studies.” Communications Biology 1 (1). https://doi.org/10.1038/s42003-018-0073-z. -
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-Wicherts, Jelte M., Coosje L. S. Veldkamp, Hilde E. M. Augusteijn, Marjan Bakker, Robbie C. M. van Aert, and Marcel A. L. M. van Assen. 2016. “Degrees of Freedom in Planning, Running, Analyzing, and Reporting Psychological Studies: A Checklist to Avoid p-Hacking.” Frontiers in Psychology 7. https://www.frontiersin.org/articles/10.3389/fpsyg.2016.01832. -
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-Wickham, Hadley, Mara Averick, Jennifer Bryan, Winston Chang, Lucy D’Agostino McGowan, Romain François, Garrett Grolemund, et al. 2019. “Welcome to the Tidyverse.” Journal of Open Source Software 4 (43): 1686. https://doi.org/10.21105/joss.01686. -
-
-Yarkoni, Tal. 2009. “Big Correlations in Little Studies: Inflated fMRI Correlations Reflect Low Statistical PowerCommentary on Vul Et Al. (2009).” Perspectives on Psychological Science 4 (3): 294–98. https://doi.org/10.1111/j.1745-6924.2009.01127.x. -
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Footnotes

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  1. In statistical terms: the HDCI contains 95% of the marginal posterior density of the parameter which is a function of the information in the data and prior knowledge with respect to the parameter.↩︎

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- - - - - - \ No newline at end of file diff --git a/_manuscript/index.pdf b/_manuscript/index.pdf deleted file mode 100644 index bc5f109..0000000 Binary files a/_manuscript/index.pdf and /dev/null differ diff --git a/_manuscript/notebooks/figures-cohens_d-preview.html b/_manuscript/notebooks/figures-cohens_d-preview.html deleted file mode 100644 index 97c4c66..0000000 --- a/_manuscript/notebooks/figures-cohens_d-preview.html +++ /dev/null @@ -1,711 +0,0 @@ - - - - - - - - - - - Code for Figures 1-2 based on Cohen’s d - - - - - - - - - - - - -
- - Back to Article -
Code to create Figures 1 and 2
- - Download Source -
- -
- - -
-
-
-

Code for Figures 1-2 based on Cohen’s d

-
- - -
-
- -
- -
-
Author
-
-

Eduard Klapwijk

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Load libraries to produce figures:

-
-
# load libraries
-library(dplyr)
-library(patchwork)
-# load devtools library and load neuro-up package from github repo
-library(devtools)
-install_github("eduardklap/neuroUp")
-library(neuroUp)
-
-

Set seed and create Figure 1A for the Feedback task DLPFC ROI:

-
-
# set seed
-set.seed(1234)
-
-# Estimate differences (unstandardized and Cohen's d)
-Fig1a <- estim_diff(data = feedback,
-                    vars_of_interest = c("mfg_learning", 
-                                         "mfg_application"),
-                    sample_size = 20:271, 
-                    k = 1000, 
-                    name = "A. Feedback DLPFC")
-
-

Set seed and create Figure 1B for the Gambling task NAcc ROI:

-
-
# set seed
-set.seed(1234)
-
-# Estimate differences (unstandardized and Cohen's d)
-Fig1b <- estim_diff(data = gambling, 
-                    vars_of_interest = c("lnacc_self_win", 
-                                         "lnacc_self_loss"), 
-                    sample_size = 20:221, 
-                    k = 1000, 
-                    name = "B. Gambling NAcc")
-
-

Set seed and create Figure 1C for the Self-evaluations task mPFC ROI:

-
-
# set seed
-set.seed(1234)
-
-# Estimate differences (unstandardized and Cohen's d)
-Fig1c <- estim_diff(data = self_eval, 
-                    vars_of_interest = c("mpfc_self", 
-                                         "mpfc_control"),
-                    sample_size = 20:149, 
-                    k = 10, 
-                    name = "C. Self-evaluations mPFC")
-
-

Set seed and create Figure 1D for the Gaining for self task NAcc ROI:

-
-
# set seed
-set.seed(1234)
-
-# Estimate differences (unstandardized and Cohen's d)
-Fig1d <- estim_diff(data = vicar_char, 
-                    vars_of_interest = c("nacc_selfgain", 
-                                         "nacc_bothnogain"),
-                    sample_size = 20:156, 
-                    k = 10, 
-                    name = "D. Gaining self NAcc")
-
-

Combine figures 1A-D in one figure for Cohen’s d estimates:

-
-
Fig1a$fig_cohens_d + Fig1b$fig_cohens_d + Fig1c$fig_cohens_d + Fig1d$fig_cohens_d
-
-

Combine figures 1A-D in one figure for the proportion of intervals not containing the value 0:

-
-
Fig1a$fig_d_nozero + Fig1b$fig_d_nozero + Fig1c$fig_d_nozero + Fig1d$fig_d_nozero
-
-

Extract numbers to make table 2:

-
-
# first extract tibble from results (select mean only)
-feedback <- as_tibble(Fig1a$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-gambling <- as_tibble(Fig1b$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-selfeval <- as_tibble(Fig1c$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-gaining <- as_tibble(Fig1d$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-
-# use numbers to make a table in text
-
-
-
- - \ No newline at end of file diff --git a/_manuscript/notebooks/figures-cohens_d.out.ipynb b/_manuscript/notebooks/figures-cohens_d.out.ipynb deleted file mode 100644 index 3fe02b3..0000000 --- a/_manuscript/notebooks/figures-cohens_d.out.ipynb +++ /dev/null @@ -1,207 +0,0 @@ -{ - "cells": [ - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "# Code for Figures 1-2 based on Cohen’s d\n", - "\n", - "Eduard Klapwijk\n", - "\n", - "Load libraries to produce figures:" - ], - "id": "1662e68a-53f7-4246-935d-44578c796bf9" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "# load libraries\n", - "library(dplyr)\n", - "library(patchwork)\n", - "# load devtools library and load neuro-up package from github repo\n", - "library(devtools)\n", - "install_github(\"eduardklap/neuroUp\")\n", - "library(neuroUp)\n" - ], - "id": "7e8e2d25-eaf3-4117-bffc-12906ae89403" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Set seed and create Figure 1A for the Feedback task DLPFC ROI:" - ], - "id": "b9105184-9df1-483b-bfce-61781f1ba2e4" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "# set seed\n", - "set.seed(1234)\n", - "\n", - "# Estimate differences (unstandardized and Cohen's d)\n", - "Fig1a <- estim_diff(data = feedback,\n", - " vars_of_interest = c(\"mfg_learning\", \n", - " \"mfg_application\"),\n", - " sample_size = 20:271, \n", - " k = 1000, \n", - " name = \"A. Feedback DLPFC\")\n" - ], - "id": "c0b75a36-05ed-4ad7-b859-58d15025edf5" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Set seed and create Figure 1B for the Gambling task NAcc ROI:" - ], - "id": "e4550ae0-28c9-41c6-81fc-57e1429f537c" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "# set seed\n", - "set.seed(1234)\n", - "\n", - "# Estimate differences (unstandardized and Cohen's d)\n", - "Fig1b <- estim_diff(data = gambling, \n", - " vars_of_interest = c(\"lnacc_self_win\", \n", - " \"lnacc_self_loss\"), \n", - " sample_size = 20:221, \n", - " k = 1000, \n", - " name = \"B. Gambling NAcc\")\n" - ], - "id": "c2914db0-3080-40cf-814e-1995a252a5f3" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Set seed and create Figure 1C for the Self-evaluations task mPFC ROI:" - ], - "id": "fbdad508-b3b6-42fa-8fa4-2098818cc951" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "# set seed\n", - "set.seed(1234)\n", - "\n", - "# Estimate differences (unstandardized and Cohen's d)\n", - "Fig1c <- estim_diff(data = self_eval, \n", - " vars_of_interest = c(\"mpfc_self\", \n", - " \"mpfc_control\"),\n", - " sample_size = 20:149, \n", - " k = 10, \n", - " name = \"C. Self-evaluations mPFC\")\n" - ], - "id": "1cebea64-1d2f-4c61-98ec-95612f3b6013" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Set seed and create Figure 1D for the Gaining for self task NAcc ROI:" - ], - "id": "1227a47c-68ac-4833-b1be-feb106030930" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "# set seed\n", - "set.seed(1234)\n", - "\n", - "# Estimate differences (unstandardized and Cohen's d)\n", - "Fig1d <- estim_diff(data = vicar_char, \n", - " vars_of_interest = c(\"nacc_selfgain\", \n", - " \"nacc_bothnogain\"),\n", - " sample_size = 20:156, \n", - " k = 10, \n", - " name = \"D. Gaining self NAcc\")\n" - ], - "id": "8fb3262b-9e3d-4c11-abec-afddbfd4e2db" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Combine figures 1A-D in one figure for Cohen’s d estimates:" - ], - "id": "289091a9-a407-45a9-b20a-592f93b0b539" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "Fig1a$fig_cohens_d + Fig1b$fig_cohens_d + Fig1c$fig_cohens_d + Fig1d$fig_cohens_d\n" - ], - "id": "8c9dff54-346e-469e-b885-e613de3f7d0b" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Combine figures 1A-D in one figure for the proportion of intervals not containing the value 0:" - ], - "id": "994738d8-957f-4921-9f12-199ff897681a" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "Fig1a$fig_d_nozero + Fig1b$fig_d_nozero + Fig1c$fig_d_nozero + Fig1d$fig_d_nozero\n" - ], - "id": "21fe72e0-0cf6-487d-b353-c5677da0fb06" - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "Extract numbers to make table 2:" - ], - "id": "2c428ba4-42a9-4de9-a86b-34bd792850ff" - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "# first extract tibble from results (select mean only)\n", - "feedback <- as_tibble(Fig1a$tbl_select) %>%\n", - " dplyr::filter(permutation == \"Overall\")\n", - "gambling <- as_tibble(Fig1b$tbl_select) %>%\n", - " dplyr::filter(permutation == \"Overall\")\n", - "selfeval <- as_tibble(Fig1c$tbl_select) %>%\n", - " dplyr::filter(permutation == \"Overall\")\n", - "gaining <- as_tibble(Fig1d$tbl_select) %>%\n", - " dplyr::filter(permutation == \"Overall\")\n", - "\n", - "# use numbers to make a table in text\n" - ], - "id": "07541f4c-ed8c-40e2-9d12-8821a60bc653" - } - ], - "nbformat": 4, - "nbformat_minor": 5, - "metadata": {} -} diff --git a/_manuscript/notebooks/figures-cohens_d.qmd b/_manuscript/notebooks/figures-cohens_d.qmd deleted file mode 100644 index fb71353..0000000 --- a/_manuscript/notebooks/figures-cohens_d.qmd +++ /dev/null @@ -1,116 +0,0 @@ ---- -title: "Code for Figures 1-2 based on Cohen's d" -author: "Eduard Klapwijk" ---- - -Load libraries to produce figures: - -```{r setup, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE} -# load libraries -library(dplyr) -library(patchwork) -# load devtools library and load neuro-up package from github repo -library(devtools) -install_github("eduardklap/neuroUp") -library(neuroUp) - -``` - -Set seed and create Figure 1A for the Feedback task DLPFC ROI: - -```{r Figure 1a, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE} -# set seed -set.seed(1234) - -# Estimate differences (unstandardized and Cohen's d) -Fig1a <- estim_diff(data = feedback, - vars_of_interest = c("mfg_learning", - "mfg_application"), - sample_size = 20:271, - k = 1000, - name = "A. Feedback DLPFC") - -``` - -Set seed and create Figure 1B for the Gambling task NAcc ROI: - -```{r Figure 1b, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE} -# set seed -set.seed(1234) - -# Estimate differences (unstandardized and Cohen's d) -Fig1b <- estim_diff(data = gambling, - vars_of_interest = c("lnacc_self_win", - "lnacc_self_loss"), - sample_size = 20:221, - k = 1000, - name = "B. Gambling NAcc") - -``` - -Set seed and create Figure 1C for the Self-evaluations task mPFC ROI: - -```{r Figure 1c, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE} -# set seed -set.seed(1234) - -# Estimate differences (unstandardized and Cohen's d) -Fig1c <- estim_diff(data = self_eval, - vars_of_interest = c("mpfc_self", - "mpfc_control"), - sample_size = 20:149, - k = 10, - name = "C. Self-evaluations mPFC") - -``` - -Set seed and create Figure 1D for the Gaining for self task NAcc ROI: - -```{r Figure 1d, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE} -# set seed -set.seed(1234) - -# Estimate differences (unstandardized and Cohen's d) -Fig1d <- estim_diff(data = vicar_char, - vars_of_interest = c("nacc_selfgain", - "nacc_bothnogain"), - sample_size = 20:156, - k = 10, - name = "D. Gaining self NAcc") - -``` - -Combine figures 1A-D in one figure for Cohen's d estimates: - -```{r Figure 1 combination, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE, fig.height = 6, fig.width = 10, } - -Fig1a$fig_cohens_d + Fig1b$fig_cohens_d + Fig1c$fig_cohens_d + Fig1d$fig_cohens_d - -``` - -Combine figures 1A-D in one figure for the proportion of intervals not containing the value 0: - -```{r Figure 2 combination, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE, fig.height = 6, fig.width = 10, } - -Fig1a$fig_d_nozero + Fig1b$fig_d_nozero + Fig1c$fig_d_nozero + Fig1d$fig_d_nozero - -``` - -Extract numbers to make table 2: - -```{r Results table Cohens d, eval = FALSE, echo = FALSE, message = FALSE, warning = FALSE} - -# first extract tibble from results (select mean only) -feedback <- as_tibble(Fig1a$tbl_select) %>% - dplyr::filter(permutation == "Overall") -gambling <- as_tibble(Fig1b$tbl_select) %>% - dplyr::filter(permutation == "Overall") -selfeval <- as_tibble(Fig1c$tbl_select) %>% - dplyr::filter(permutation == "Overall") -gaining <- as_tibble(Fig1d$tbl_select) %>% - dplyr::filter(permutation == "Overall") - -# use numbers to make a table in text - -``` - diff --git a/_manuscript/notebooks/figures-correlations-preview.html b/_manuscript/notebooks/figures-correlations-preview.html deleted file mode 100644 index 4a960c7..0000000 --- a/_manuscript/notebooks/figures-correlations-preview.html +++ /dev/null @@ -1,722 +0,0 @@ - - - - - - - - - - Code for Figures 3-4 based on Pearson’s correlations - - - - - - - - - - - - - - - - - - - - - - - -
- - Back to Article -
Code to create Figures 3 and 4
- - Download Source -
- -
-
-
-

Code for Figures 3-4 based on Pearson’s correlations

-
- - -
-
- -
- -
-
Author
-
-

Eduard Klapwijk

-
-
- - - -
-
-
-
-
- - - -
-
-
- - -
- -

Load libraries to produce figures:

-
In [1]:
-
# load libraries
-library(dplyr)
-library(patchwork)
-# load devtools library and load neuro-up package from github repo
-library(devtools)
-install_github("eduardklap/neuroUp")
-library(neuroUp)
-
-

Set seed and create Figure 3A for the Feedback task DLPFC ROI:

-
In [2]:
-
# set seed
-set.seed(1234)
-
-# calculate difference mfg_learning vs. mfg_application
-data_feedback <- feedback
-data_feedback$dif <- data_feedback$mfg_learning - data_feedback$mfg_application
-
-# Estimate correlations
-Fig3a <- estim_corr(data = data_feedback,
-                    vars_of_interest = c("dif", "age"),
-                    sample_size = 20:271, 
-                    k = 1000, 
-                    name = "A. Feedback DLPFC corr. with age")
-
-

Set seed and create Figure 3B for the Gambling task NAcc ROI:

-
In [3]:
-
# set seed
-set.seed(1234)
-
-# Estimate correlations
-Fig3b <- estim_corr(data = gambling, 
-                    vars_of_interest = c("lnacc_self_winvsloss", 
-                                         "age"), 
-                    sample_size = 20:221, 
-                    k = 1000, 
-                    name = "B. Gambling NAcc corr. with age")
-
-

Set seed and create Figure 3C for the Self-evaluations task mPFC ROI:

-
In [4]:
-
# set seed
-set.seed(1234)
-
-# calculate difference mpfc_self - mpfc_control
-data_self <- self_eval
-data_self$dif <- data_self$mpfc_self - data_self$mpfc_control
-
-# Estimate correlations
-Fig3c <- estim_corr(data = data_self,
-                    vars_of_interest = c("dif",
-                                         "age"),
-                    sample_size = 20:149, 
-                    k = 1000, 
-                    name = "C. Self-evaluations mPFC corr. with age")
-
-

Set seed and create Figure 3D for the Gaining for self task NAcc ROI:

-
In [5]:
-
# set seed
-set.seed(1234)
-
-# calculate difference nacc_selfgain vs. nacc_bothnogain
-data_vicar <- vicar_char
-data_vicar$dif <- data_vicar$nacc_selfgain - data_vicar$nacc_bothnogain
-
-# Estimate correlations
-Fig3d <- estim_corr(data = data_vicar, 
-                    vars_of_interest = c("diff", 
-                                         "age"),
-                    sample_size = 20:156, 
-                    k = 1000, 
-                    name = "D. Gaining self left NAcc corr. with age")
-
-

Combine figures 3A-D in one figure for Pearson’s correlations:

-
In [6]:
-
Fig3a$fig_corr + Fig3b$fig_corr + Fig3c$fig_corr + Fig3d$fig_corr
-
-

Combine figures 4A-D in one figure for the proportion of intervals not containing the value 0:

-
In [7]:
-
Fig3a$fig_corr_nozero + Fig3b$fig_corr_nozero + Fig3c$fig_corr_nozero + Fig3d$fig_corr_nozero
-
-

Extract numbers to make table 3:

-
In [8]:
-
# first extract tibble from results (select mean only)
-feedback <- as_tibble(Fig3a$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-gambling <- as_tibble(Fig3b$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-selfeval <- as_tibble(Fig3c$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-gaining <- as_tibble(Fig3d$tbl_select) %>%
-  dplyr::filter(permutation == "Overall")
-
-# use numbers to make a table in text
-
-
-
- - \ No newline at end of file diff --git a/_manuscript/site_libs/bootstrap/bootstrap-icons.css b/_manuscript/site_libs/bootstrap/bootstrap-icons.css deleted file mode 100644 index 285e444..0000000 --- a/_manuscript/site_libs/bootstrap/bootstrap-icons.css +++ /dev/null @@ -1,2078 +0,0 @@ -/*! - * Bootstrap Icons v1.11.1 (https://icons.getbootstrap.com/) - * Copyright 2019-2023 The Bootstrap Authors - * Licensed under MIT (https://github.com/twbs/icons/blob/main/LICENSE) - */ - -@font-face { - font-display: block; - font-family: "bootstrap-icons"; - src: -url("./bootstrap-icons.woff?2820a3852bdb9a5832199cc61cec4e65") format("woff"); -} - -.bi::before, -[class^="bi-"]::before, -[class*=" bi-"]::before { - display: inline-block; - font-family: bootstrap-icons !important; - font-style: normal; - font-weight: normal !important; - font-variant: normal; - text-transform: none; - line-height: 1; - vertical-align: -.125em; - -webkit-font-smoothing: antialiased; - -moz-osx-font-smoothing: 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content: "\f580"; } -.bi-spellcheck::before { content: "\f581"; } -.bi-square-fill::before { content: "\f582"; } -.bi-square-half::before { content: "\f583"; } -.bi-square::before { content: "\f584"; } -.bi-stack::before { content: "\f585"; } -.bi-star-fill::before { content: "\f586"; } -.bi-star-half::before { content: "\f587"; } -.bi-star::before { content: "\f588"; } -.bi-stars::before { content: "\f589"; } -.bi-stickies-fill::before { content: "\f58a"; } -.bi-stickies::before { content: "\f58b"; } -.bi-sticky-fill::before { content: "\f58c"; } -.bi-sticky::before { content: "\f58d"; } -.bi-stop-btn-fill::before { content: "\f58e"; } -.bi-stop-btn::before { content: "\f58f"; } -.bi-stop-circle-fill::before { content: "\f590"; } -.bi-stop-circle::before { content: "\f591"; } -.bi-stop-fill::before { content: "\f592"; } -.bi-stop::before { content: "\f593"; } -.bi-stoplights-fill::before { content: "\f594"; } -.bi-stoplights::before { content: "\f595"; } -.bi-stopwatch-fill::before { 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6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #a2c1f6;--bs-accordion-btn-focus-box-shadow: 0 0 0 0.25rem rgba(69, 130, 236, 0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: #1c345e;--bs-accordion-active-bg: #dae6fb}.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1.1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;border-radius:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media(prefers-reduced-motion: reduce){.accordion-button{transition:none}}.accordion-button:not(.collapsed){color:var(--bs-accordion-active-color);background-color:var(--bs-accordion-active-bg);box-shadow:inset 0 calc(-1*var(--bs-accordion-border-width)) 0 var(--bs-accordion-border-color)}.accordion-button:not(.collapsed)::after{background-image:var(--bs-accordion-btn-active-icon);transform:var(--bs-accordion-btn-icon-transform)}.accordion-button::after{flex-shrink:0;-webkit-flex-shrink:0;width:var(--bs-accordion-btn-icon-width);height:var(--bs-accordion-btn-icon-width);margin-left:auto;content:"";background-image:var(--bs-accordion-btn-icon);background-repeat:no-repeat;background-size:var(--bs-accordion-btn-icon-width);transition:var(--bs-accordion-btn-icon-transition)}@media(prefers-reduced-motion: reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme=dark] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%238fb4f4'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%238fb4f4'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e")}.breadcrumb{--bs-breadcrumb-padding-x: 0;--bs-breadcrumb-padding-y: 0;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: ;--bs-breadcrumb-divider-color: rgba(52, 58, 64, 0.75);--bs-breadcrumb-item-padding-x: 0.5rem;--bs-breadcrumb-item-active-color: rgba(52, 58, 64, 0.75);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, ">") /* rtl: var(--bs-breadcrumb-divider, ">") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: 0.75rem;--bs-pagination-padding-y: 0.375rem;--bs-pagination-font-size:1.1rem;--bs-pagination-color: #4582ec;--bs-pagination-bg: #fff;--bs-pagination-border-width: 1px;--bs-pagination-border-color: #ddd;--bs-pagination-border-radius: 0.375rem;--bs-pagination-hover-color: #3768bd;--bs-pagination-hover-bg: #f8f9fa;--bs-pagination-hover-border-color: #ddd;--bs-pagination-focus-color: #3768bd;--bs-pagination-focus-bg: #e9ecef;--bs-pagination-focus-box-shadow: 0 0 0 0.25rem rgba(69, 130, 236, 0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #4582ec;--bs-pagination-active-border-color: #4582ec;--bs-pagination-disabled-color: rgba(52, 58, 64, 0.75);--bs-pagination-disabled-bg: #e9ecef;--bs-pagination-disabled-border-color: #ddd;display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color .15s ease-in-out,background-color .15s ease-in-out,border-color .15s ease-in-out,box-shadow .15s ease-in-out}@media(prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(1px*-1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: 0.75rem;--bs-pagination-font-size:calc(1.2625rem + 0.15vw);--bs-pagination-border-radius: 0.5rem}@media(min-width: 1200px){.pagination-lg{--bs-pagination-font-size:1.375rem}}.pagination-sm{--bs-pagination-padding-x: 0.5rem;--bs-pagination-padding-y: 0.25rem;--bs-pagination-font-size:0.9625rem;--bs-pagination-border-radius: 0.25rem}.badge{--bs-badge-padding-x: 1.2em;--bs-badge-padding-y: 0.6em;--bs-badge-font-size:0.75em;--bs-badge-font-weight: 400;--bs-badge-color: #fff;--bs-badge-border-radius: 0.375rem;display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: 0 solid var(--bs-alert-border-color);--bs-alert-border-radius: 0.375rem;--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:0.825rem;--bs-progress-bg: #e9ecef;--bs-progress-border-radius: 0.375rem;--bs-progress-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.075);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #4582ec;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media(prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media(prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: #343a40;--bs-list-group-bg: #fff;--bs-list-group-border-color: #ddd;--bs-list-group-border-width: 1px;--bs-list-group-border-radius: 0.375rem;--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: 0.5rem;--bs-list-group-action-color: rgba(52, 58, 64, 0.75);--bs-list-group-action-hover-color: #000;--bs-list-group-action-hover-bg: #f8f9fa;--bs-list-group-action-active-color: #343a40;--bs-list-group-action-active-bg: #e9ecef;--bs-list-group-disabled-color: rgba(52, 58, 64, 0.75);--bs-list-group-disabled-bg: #fff;--bs-list-group-active-color: #fff;--bs-list-group-active-bg: #4582ec;--bs-list-group-active-border-color: #4582ec;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") ". ";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1*var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media(min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 1400px){.list-group-horizontal-xxl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xxl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xxl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xxl>.list-group-item.active{margin-top:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}.list-group-flush{border-radius:0}.list-group-flush>.list-group-item{border-width:0 0 var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-primary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-primary-border-subtle);--bs-list-group-active-color: var(--bs-primary-bg-subtle);--bs-list-group-active-bg: var(--bs-primary-text-emphasis);--bs-list-group-active-border-color: var(--bs-primary-text-emphasis)}.list-group-item-secondary{--bs-list-group-color: var(--bs-secondary-text-emphasis);--bs-list-group-bg: var(--bs-secondary-bg-subtle);--bs-list-group-border-color: var(--bs-secondary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-secondary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-secondary-border-subtle);--bs-list-group-active-color: var(--bs-secondary-bg-subtle);--bs-list-group-active-bg: var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e");--bs-btn-close-opacity: 0.5;--bs-btn-close-hover-opacity: 0.75;--bs-btn-close-focus-shadow: 0 0 0 0.25rem rgba(69, 130, 236, 0.25);--bs-btn-close-focus-opacity: 1;--bs-btn-close-disabled-opacity: 0.25;--bs-btn-close-white-filter: invert(1) grayscale(100%) brightness(200%);box-sizing:content-box;width:1em;height:1em;padding:.25em .25em;color:var(--bs-btn-close-color);background:rgba(0,0,0,0) var(--bs-btn-close-bg) center/1em auto no-repeat;border:0;border-radius:.375rem;opacity:var(--bs-btn-close-opacity)}.btn-close:hover{color:var(--bs-btn-close-color);text-decoration:none;opacity:var(--bs-btn-close-hover-opacity)}.btn-close:focus{outline:0;box-shadow:var(--bs-btn-close-focus-shadow);opacity:var(--bs-btn-close-focus-opacity)}.btn-close:disabled,.btn-close.disabled{pointer-events:none;user-select:none;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;opacity:var(--bs-btn-close-disabled-opacity)}.btn-close-white{filter:var(--bs-btn-close-white-filter)}[data-bs-theme=dark] .btn-close{filter:var(--bs-btn-close-white-filter)}.toast{--bs-toast-zindex: 1090;--bs-toast-padding-x: 0.75rem;--bs-toast-padding-y: 0.5rem;--bs-toast-spacing: 1.5rem;--bs-toast-max-width: 350px;--bs-toast-font-size:0.875rem;--bs-toast-color: ;--bs-toast-bg: rgba(255, 255, 255, 0.85);--bs-toast-border-width: 1px;--bs-toast-border-color: rgba(0, 0, 0, 0.175);--bs-toast-border-radius: 0.375rem;--bs-toast-box-shadow: 0 0.5rem 1rem rgba(0, 0, 0, 0.15);--bs-toast-header-color: rgba(52, 58, 64, 0.75);--bs-toast-header-bg: rgba(255, 255, 255, 0.85);--bs-toast-header-border-color: rgba(0, 0, 0, 0.175);width:var(--bs-toast-max-width);max-width:100%;font-size:var(--bs-toast-font-size);color:var(--bs-toast-color);pointer-events:auto;background-color:var(--bs-toast-bg);background-clip:padding-box;border:var(--bs-toast-border-width) solid var(--bs-toast-border-color);box-shadow:var(--bs-toast-box-shadow);border-radius:var(--bs-toast-border-radius)}.toast.showing{opacity:0}.toast:not(.show){display:none}.toast-container{--bs-toast-zindex: 1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color);border-top-left-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width));border-top-right-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width))}.toast-header .btn-close{margin-right:calc(-0.5*var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: 0.5rem;--bs-modal-color: ;--bs-modal-bg: #fff;--bs-modal-border-color: rgba(0, 0, 0, 0.175);--bs-modal-border-width: 1px;--bs-modal-border-radius: 0.5rem;--bs-modal-box-shadow: 0 0.125rem 0.25rem rgba(0, 0, 0, 0.075);--bs-modal-inner-border-radius: calc(0.5rem - 1px);--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1rem 1rem;--bs-modal-header-border-color: #ddd;--bs-modal-header-border-width: 1px;--bs-modal-title-line-height: 1.5;--bs-modal-footer-gap: 0.5rem;--bs-modal-footer-bg: ;--bs-modal-footer-border-color: #ddd;--bs-modal-footer-border-width: 1px;position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin);pointer-events:none}.modal.fade .modal-dialog{transition:transform .3s ease-out;transform:translate(0, -50px)}@media(prefers-reduced-motion: reduce){.modal.fade .modal-dialog{transition:none}}.modal.show .modal-dialog{transform:none}.modal.modal-static .modal-dialog{transform:scale(1.02)}.modal-dialog-scrollable{height:calc(100% - var(--bs-modal-margin)*2)}.modal-dialog-scrollable .modal-content{max-height:100%;overflow:hidden}.modal-dialog-scrollable .modal-body{overflow-y:auto}.modal-dialog-centered{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;min-height:calc(100% - var(--bs-modal-margin)*2)}.modal-content{position:relative;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;width:100%;color:var(--bs-modal-color);pointer-events:auto;background-color:var(--bs-modal-bg);background-clip:padding-box;border:var(--bs-modal-border-width) solid var(--bs-modal-border-color);border-radius:var(--bs-modal-border-radius);outline:0}.modal-backdrop{--bs-backdrop-zindex: 1050;--bs-backdrop-bg: #000;--bs-backdrop-opacity: 0.5;position:fixed;top:0;left:0;z-index:var(--bs-backdrop-zindex);width:100vw;height:100vh;background-color:var(--bs-backdrop-bg)}.modal-backdrop.fade{opacity:0}.modal-backdrop.show{opacity:var(--bs-backdrop-opacity)}.modal-header{display:flex;display:-webkit-flex;flex-shrink:0;-webkit-flex-shrink:0;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-modal-header-padding);border-bottom:var(--bs-modal-header-border-width) solid 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var(--bg-gradient-start, 36%), #02b875 var(--bg-gradient-end, 180%)) #0fab9d;color:#fff}.bg-gradient-cyan-teal{--bslib-color-fg: #fff;--bslib-color-bg: #1bb2ab;background:linear-gradient(var(--bg-gradient-deg, 140deg), #17a2b8 var(--bg-gradient-start, 36%), #20c997 var(--bg-gradient-end, 180%)) #1bb2ab;color:#fff}:root{--bslib-value-box-shadow: none;--bslib-value-box-border-width-auto-yes: var(--bslib-value-box-border-width-baseline);--bslib-value-box-border-width-auto-no: 0;--bslib-value-box-border-width-baseline: 1px}.bslib-value-box{border-width:var(--bslib-value-box-border-width-auto-no, var(--bslib-value-box-border-width-baseline));container-name:bslib-value-box;container-type:inline-size}.bslib-value-box.card{box-shadow:var(--bslib-value-box-shadow)}.bslib-value-box.border-auto{border-width:var(--bslib-value-box-border-width-auto-yes, var(--bslib-value-box-border-width-baseline))}.bslib-value-box.default{--bslib-value-box-bg-default: var(--bs-card-bg, #fff);--bslib-value-box-border-color-default: var(--bs-card-border-color, rgba(0, 0, 0, 0.175));color:var(--bslib-value-box-color);background-color:var(--bslib-value-box-bg, var(--bslib-value-box-bg-default));border-color:var(--bslib-value-box-border-color, var(--bslib-value-box-border-color-default))}.bslib-value-box .value-box-grid{display:grid;grid-template-areas:"left right";align-items:center;overflow:hidden}.bslib-value-box .value-box-showcase{height:100%;max-height:var(---bslib-value-box-showcase-max-h, 100%)}.bslib-value-box .value-box-showcase,.bslib-value-box .value-box-showcase>.html-fill-item{width:100%}.bslib-value-box[data-full-screen=true] .value-box-showcase{max-height:var(---bslib-value-box-showcase-max-h-fs, 100%)}@media screen and (min-width: 575.98px){@container bslib-value-box (max-width: 300px){.bslib-value-box:not(.showcase-bottom) .value-box-grid{grid-template-columns:1fr !important;grid-template-rows:auto auto;grid-template-areas:"top" 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t}))){T=O,E=!1;break}A.set(O,N)}if(E)for(var P=function(t){var e=v.find((function(e){var i=A.get(e);if(i)return i.slice(0,t).every((function(t){return t}))}));if(e)return T=e,"break"},M=p?3:1;M>0&&"break"!==P(M);M--);e.placement!==T&&(e.modifiersData[n]._skip=!0,e.placement=T,e.reset=!0)}},requiresIfExists:["offset"],data:{_skip:!1}};function oi(t,e,i){return void 0===i&&(i={x:0,y:0}),{top:t.top-e.height-i.y,right:t.right-e.width+i.x,bottom:t.bottom-e.height+i.y,left:t.left-e.width-i.x}}function ri(t){return[zt,qt,Rt,Vt].some((function(e){return t[e]>=0}))}const ai={name:"hide",enabled:!0,phase:"main",requiresIfExists:["preventOverflow"],fn:function(t){var 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m?m(Object.assign({},e.rects,{placement:e.placement})):m,O="number"==typeof C?{mainAxis:C,altAxis:C}:Object.assign({mainAxis:0,altAxis:0},C),x=e.modifiersData.offset?e.modifiersData.offset[e.placement]:null,k={x:0,y:0};if(A){if(o){var L,S="y"===y?zt:Vt,D="y"===y?Rt:qt,$="y"===y?"height":"width",I=A[y],N=I+g[S],P=I-g[D],M=f?-T[$]/2:0,j=b===Xt?E[$]:T[$],F=b===Xt?-T[$]:-E[$],H=e.elements.arrow,W=f&&H?Ce(H):{width:0,height:0},B=e.modifiersData["arrow#persistent"]?e.modifiersData["arrow#persistent"].padding:{top:0,right:0,bottom:0,left:0},z=B[S],R=B[D],q=Ne(0,E[$],W[$]),V=v?E[$]/2-M-q-z-O.mainAxis:j-q-z-O.mainAxis,K=v?-E[$]/2+M+q+R+O.mainAxis:F+q+R+O.mainAxis,Q=e.elements.arrow&&$e(e.elements.arrow),X=Q?"y"===y?Q.clientTop||0:Q.clientLeft||0:0,Y=null!=(L=null==x?void 0:x[y])?L:0,U=I+K-Y,G=Ne(f?ye(N,I+V-Y-X):N,I,f?ve(P,U):P);A[y]=G,k[y]=G-I}if(a){var J,Z="x"===y?zt:Vt,tt="x"===y?Rt:qt,et=A[w],it="y"===w?"height":"width",nt=et+g[Z],st=et-g[tt],ot=-1!==[zt,Vt].indexOf(_),rt=null!=(J=null==x?void 0:x[w])?J:0,at=ot?nt:et-E[it]-T[it]-rt+O.altAxis,lt=ot?et+E[it]+T[it]-rt-O.altAxis:st,ct=f&&ot?function(t,e,i){var n=Ne(t,e,i);return n>i?i:n}(at,et,lt):Ne(f?at:nt,et,f?lt:st);A[w]=ct,k[w]=ct-et}e.modifiersData[n]=k}},requiresIfExists:["offset"]};function di(t,e,i){void 0===i&&(i=!1);var n,s,o=me(e),r=me(e)&&function(t){var e=t.getBoundingClientRect(),i=we(e.width)/t.offsetWidth||1,n=we(e.height)/t.offsetHeight||1;return 1!==i||1!==n}(e),a=Le(e),l=Te(t,r,i),c={scrollLeft:0,scrollTop:0},h={x:0,y:0};return(o||!o&&!i)&&(("body"!==ue(e)||Ue(a))&&(c=(n=e)!==fe(n)&&me(n)?{scrollLeft:(s=n).scrollLeft,scrollTop:s.scrollTop}:Xe(n)),me(e)?((h=Te(e,!0)).x+=e.clientLeft,h.y+=e.clientTop):a&&(h.x=Ye(a))),{x:l.left+c.scrollLeft-h.x,y:l.top+c.scrollTop-h.y,width:l.width,height:l.height}}function ui(t){var e=new Map,i=new Set,n=[];function s(t){i.add(t.name),[].concat(t.requires||[],t.requiresIfExists||[]).forEach((function(t){if(!i.has(t)){var n=e.get(t);n&&s(n)}})),n.push(t)}return t.forEach((function(t){e.set(t.name,t)})),t.forEach((function(t){i.has(t.name)||s(t)})),n}var fi={placement:"bottom",modifiers:[],strategy:"absolute"};function pi(){for(var t=arguments.length,e=new Array(t),i=0;iNumber.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return(this._inNavbar||"static"===this._config.display)&&(F.setDataAttribute(this._menu,"popper","static"),t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,...g(this._config.popperConfig,[t])}}_selectMenuItem({key:t,target:e}){const i=z.find(".dropdown-menu 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e=/input|textarea/i.test(t.target.tagName),i="Escape"===t.key,n=[Ei,Ti].includes(t.key);if(!n&&!i)return;if(e&&!i)return;t.preventDefault();const s=this.matches(Ii)?this:z.prev(this,Ii)[0]||z.next(this,Ii)[0]||z.findOne(Ii,t.delegateTarget.parentNode),o=qi.getOrCreateInstance(s);if(n)return t.stopPropagation(),o.show(),void o._selectMenuItem(t);o._isShown()&&(t.stopPropagation(),o.hide(),s.focus())}}N.on(document,Si,Ii,qi.dataApiKeydownHandler),N.on(document,Si,Pi,qi.dataApiKeydownHandler),N.on(document,Li,qi.clearMenus),N.on(document,Di,qi.clearMenus),N.on(document,Li,Ii,(function(t){t.preventDefault(),qi.getOrCreateInstance(this).toggle()})),m(qi);const Vi="backdrop",Ki="show",Qi=`mousedown.bs.${Vi}`,Xi={className:"modal-backdrop",clickCallback:null,isAnimated:!1,isVisible:!0,rootElement:"body"},Yi={className:"string",clickCallback:"(function|null)",isAnimated:"boolean",isVisible:"boolean",rootElement:"(element|string)"};class Ui extends H{constructor(t){super(),this._config=this._getConfig(t),this._isAppended=!1,this._element=null}static get Default(){return Xi}static get DefaultType(){return Yi}static get NAME(){return Vi}show(t){if(!this._config.isVisible)return void g(t);this._append();const e=this._getElement();this._config.isAnimated&&d(e),e.classList.add(Ki),this._emulateAnimation((()=>{g(t)}))}hide(t){this._config.isVisible?(this._getElement().classList.remove(Ki),this._emulateAnimation((()=>{this.dispose(),g(t)}))):g(t)}dispose(){this._isAppended&&(N.off(this._element,Qi),this._element.remove(),this._isAppended=!1)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_configAfterMerge(t){return t.rootElement=r(t.rootElement),t}_append(){if(this._isAppended)return;const t=this._getElement();this._config.rootElement.append(t),N.on(t,Qi,(()=>{g(this._config.clickCallback)})),this._isAppended=!0}_emulateAnimation(t){_(t,this._getElement(),this._config.isAnimated)}}const Gi=".bs.focustrap",Ji=`focusin${Gi}`,Zi=`keydown.tab${Gi}`,tn="backward",en={autofocus:!0,trapElement:null},nn={autofocus:"boolean",trapElement:"element"};class sn extends H{constructor(t){super(),this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}static get Default(){return en}static get DefaultType(){return nn}static get NAME(){return"focustrap"}activate(){this._isActive||(this._config.autofocus&&this._config.trapElement.focus(),N.off(document,Gi),N.on(document,Ji,(t=>this._handleFocusin(t))),N.on(document,Zi,(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,N.off(document,Gi))}_handleFocusin(t){const{trapElement:e}=this._config;if(t.target===document||t.target===e||e.contains(t.target))return;const i=z.focusableChildren(e);0===i.length?e.focus():this._lastTabNavDirection===tn?i[i.length-1].focus():i[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?tn:"forward")}}const on=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",rn=".sticky-top",an="padding-right",ln="margin-right";class cn{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,an,(e=>e+t)),this._setElementAttributes(on,an,(e=>e+t)),this._setElementAttributes(rn,ln,(e=>e-t))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,an),this._resetElementAttributes(on,an),this._resetElementAttributes(rn,ln)}isOverflowing(){return this.getWidth()>0}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t).getPropertyValue(e);t.style.setProperty(e,`${i(Number.parseFloat(s))}px`)}))}_saveInitialAttribute(t,e){const i=t.style.getPropertyValue(e);i&&F.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=F.getDataAttribute(t,e);null!==i?(F.removeDataAttribute(t,e),t.style.setProperty(e,i)):t.style.removeProperty(e)}))}_applyManipulationCallback(t,e){if(o(t))e(t);else for(const i of z.find(t,this._element))e(i)}}const hn=".bs.modal",dn=`hide${hn}`,un=`hidePrevented${hn}`,fn=`hidden${hn}`,pn=`show${hn}`,mn=`shown${hn}`,gn=`resize${hn}`,_n=`click.dismiss${hn}`,bn=`mousedown.dismiss${hn}`,vn=`keydown.dismiss${hn}`,yn=`click${hn}.data-api`,wn="modal-open",An="show",En="modal-static",Tn={backdrop:!0,focus:!0,keyboard:!0},Cn={backdrop:"(boolean|string)",focus:"boolean",keyboard:"boolean"};class On extends W{constructor(t,e){super(t,e),this._dialog=z.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._isTransitioning=!1,this._scrollBar=new cn,this._addEventListeners()}static get Default(){return Tn}static get DefaultType(){return Cn}static get NAME(){return"modal"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||N.trigger(this._element,pn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isTransitioning=!0,this._scrollBar.hide(),document.body.classList.add(wn),this._adjustDialog(),this._backdrop.show((()=>this._showElement(t))))}hide(){this._isShown&&!this._isTransitioning&&(N.trigger(this._element,dn).defaultPrevented||(this._isShown=!1,this._isTransitioning=!0,this._focustrap.deactivate(),this._element.classList.remove(An),this._queueCallback((()=>this._hideModal()),this._element,this._isAnimated())))}dispose(){N.off(window,hn),N.off(this._dialog,hn),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new Ui({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_showElement(t){document.body.contains(this._element)||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0;const e=z.findOne(".modal-body",this._dialog);e&&(e.scrollTop=0),d(this._element),this._element.classList.add(An),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,N.trigger(this._element,mn,{relatedTarget:t})}),this._dialog,this._isAnimated())}_addEventListeners(){N.on(this._element,vn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():this._triggerBackdropTransition())})),N.on(window,gn,(()=>{this._isShown&&!this._isTransitioning&&this._adjustDialog()})),N.on(this._element,bn,(t=>{N.one(this._element,_n,(e=>{this._element===t.target&&this._element===e.target&&("static"!==this._config.backdrop?this._config.backdrop&&this.hide():this._triggerBackdropTransition())}))}))}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(wn),this._resetAdjustments(),this._scrollBar.reset(),N.trigger(this._element,fn)}))}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(N.trigger(this._element,un).defaultPrevented)return;const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._element.style.overflowY;"hidden"===e||this._element.classList.contains(En)||(t||(this._element.style.overflowY="hidden"),this._element.classList.add(En),this._queueCallback((()=>{this._element.classList.remove(En),this._queueCallback((()=>{this._element.style.overflowY=e}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;if(i&&!t){const t=p()?"paddingLeft":"paddingRight";this._element.style[t]=`${e}px`}if(!i&&t){const t=p()?"paddingRight":"paddingLeft";this._element.style[t]=`${e}px`}}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const 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W{constructor(t,e){super(t,e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get Default(){return zn}static get DefaultType(){return Rn}static get NAME(){return"offcanvas"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||N.trigger(this._element,Nn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._backdrop.show(),this._config.scroll||(new cn).hide(),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add(Dn),this._queueCallback((()=>{this._config.scroll&&!this._config.backdrop||this._focustrap.activate(),this._element.classList.add(Sn),this._element.classList.remove(Dn),N.trigger(this._element,Pn,{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(N.trigger(this._element,Mn).defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.add($n),this._backdrop.hide(),this._queueCallback((()=>{this._element.classList.remove(Sn,$n),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._config.scroll||(new cn).reset(),N.trigger(this._element,Fn)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_initializeBackDrop(){const t=Boolean(this._config.backdrop);return new Ui({className:"offcanvas-backdrop",isVisible:t,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:t?()=>{"static"!==this._config.backdrop?this.hide():N.trigger(this._element,jn)}:null})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_addEventListeners(){N.on(this._element,Bn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():N.trigger(this._element,jn))}))}static jQueryInterface(t){return this.each((function(){const e=qn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}N.on(document,Wn,'[data-bs-toggle="offcanvas"]',(function(t){const e=z.getElementFromSelector(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this))return;N.one(e,Fn,(()=>{a(this)&&this.focus()}));const i=z.findOne(In);i&&i!==e&&qn.getInstance(i).hide(),qn.getOrCreateInstance(e).toggle(this)})),N.on(window,Ln,(()=>{for(const t of z.find(In))qn.getOrCreateInstance(t).show()})),N.on(window,Hn,(()=>{for(const t of z.find("[aria-modal][class*=show][class*=offcanvas-]"))"fixed"!==getComputedStyle(t).position&&qn.getOrCreateInstance(t).hide()})),R(qn),m(qn);const Vn={"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},Kn=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Qn=/^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i,Xn=(t,e)=>{const i=t.nodeName.toLowerCase();return e.includes(i)?!Kn.has(i)||Boolean(Qn.test(t.nodeValue)):e.filter((t=>t instanceof RegExp)).some((t=>t.test(i)))},Yn={allowList:Vn,content:{},extraClass:"",html:!1,sanitize:!0,sanitizeFn:null,template:"
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")),e}_typeCheckConfig(t){super._typeCheckConfig(t),this._checkContent(t.content)}_checkContent(t){for(const[e,i]of Object.entries(t))super._typeCheckConfig({selector:e,entry:i},Gn)}_setContent(t,e,i){const n=z.findOne(i,t);n&&((e=this._resolvePossibleFunction(e))?o(e)?this._putElementInTemplate(r(e),n):this._config.html?n.innerHTML=this._maybeSanitize(e):n.textContent=e:n.remove())}_maybeSanitize(t){return this._config.sanitize?function(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(const t of s){const i=t.nodeName.toLowerCase();if(!Object.keys(e).includes(i)){t.remove();continue}const n=[].concat(...t.attributes),s=[].concat(e["*"]||[],e[i]||[]);for(const e of n)Xn(e,s)||t.removeAttribute(e.nodeName)}return n.body.innerHTML}(t,this._config.allowList,this._config.sanitizeFn):t}_resolvePossibleFunction(t){return g(t,[this])}_putElementInTemplate(t,e){if(this._config.html)return e.innerHTML="",void e.append(t);e.textContent=t.textContent}}const Zn=new Set(["sanitize","allowList","sanitizeFn"]),ts="fade",es="show",is=".modal",ns="hide.bs.modal",ss="hover",os="focus",rs={AUTO:"auto",TOP:"top",RIGHT:p()?"left":"right",BOTTOM:"bottom",LEFT:p()?"right":"left"},as={allowList:Vn,animation:!0,boundary:"clippingParents",container:!1,customClass:"",delay:0,fallbackPlacements:["top","right","bottom","left"],html:!1,offset:[0,6],placement:"top",popperConfig:null,sanitize:!0,sanitizeFn:null,selector:!1,template:'',title:"",trigger:"hover focus"},ls={allowList:"object",animation:"boolean",boundary:"(string|element)",container:"(string|element|boolean)",customClass:"(string|function)",delay:"(number|object)",fallbackPlacements:"array",html:"boolean",offset:"(array|string|function)",placement:"(string|function)",popperConfig:"(null|object|function)",sanitize:"boolean",sanitizeFn:"(null|function)",selector:"(string|boolean)",template:"string",title:"(string|element|function)",trigger:"string"};class cs extends W{constructor(t,e){if(void 0===vi)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t,e),this._isEnabled=!0,this._timeout=0,this._isHovered=null,this._activeTrigger={},this._popper=null,this._templateFactory=null,this._newContent=null,this.tip=null,this._setListeners(),this._config.selector||this._fixTitle()}static get Default(){return as}static get DefaultType(){return ls}static get NAME(){return"tooltip"}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(){this._isEnabled&&(this._activeTrigger.click=!this._activeTrigger.click,this._isShown()?this._leave():this._enter())}dispose(){clearTimeout(this._timeout),N.off(this._element.closest(is),ns,this._hideModalHandler),this._element.getAttribute("data-bs-original-title")&&this._element.setAttribute("title",this._element.getAttribute("data-bs-original-title")),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this._isWithContent()||!this._isEnabled)return;const t=N.trigger(this._element,this.constructor.eventName("show")),e=(c(this._element)||this._element.ownerDocument.documentElement).contains(this._element);if(t.defaultPrevented||!e)return;this._disposePopper();const i=this._getTipElement();this._element.setAttribute("aria-describedby",i.getAttribute("id"));const{container:n}=this._config;if(this._element.ownerDocument.documentElement.contains(this.tip)||(n.append(i),N.trigger(this._element,this.constructor.eventName("inserted"))),this._popper=this._createPopper(i),i.classList.add(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._queueCallback((()=>{N.trigger(this._element,this.constructor.eventName("shown")),!1===this._isHovered&&this._leave(),this._isHovered=!1}),this.tip,this._isAnimated())}hide(){if(this._isShown()&&!N.trigger(this._element,this.constructor.eventName("hide")).defaultPrevented){if(this._getTipElement().classList.remove(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._activeTrigger.click=!1,this._activeTrigger[os]=!1,this._activeTrigger[ss]=!1,this._isHovered=null,this._queueCallback((()=>{this._isWithActiveTrigger()||(this._isHovered||this._disposePopper(),this._element.removeAttribute("aria-describedby"),N.trigger(this._element,this.constructor.eventName("hidden")))}),this.tip,this._isAnimated())}}update(){this._popper&&this._popper.update()}_isWithContent(){return Boolean(this._getTitle())}_getTipElement(){return this.tip||(this.tip=this._createTipElement(this._newContent||this._getContentForTemplate())),this.tip}_createTipElement(t){const e=this._getTemplateFactory(t).toHtml();if(!e)return null;e.classList.remove(ts,es),e.classList.add(`bs-${this.constructor.NAME}-auto`);const i=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME).toString();return e.setAttribute("id",i),this._isAnimated()&&e.classList.add(ts),e}setContent(t){this._newContent=t,this._isShown()&&(this._disposePopper(),this.show())}_getTemplateFactory(t){return this._templateFactory?this._templateFactory.changeContent(t):this._templateFactory=new Jn({...this._config,content:t,extraClass:this._resolvePossibleFunction(this._config.customClass)}),this._templateFactory}_getContentForTemplate(){return{".tooltip-inner":this._getTitle()}}_getTitle(){return this._resolvePossibleFunction(this._config.title)||this._element.getAttribute("data-bs-original-title")}_initializeOnDelegatedTarget(t){return this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_isAnimated(){return this._config.animation||this.tip&&this.tip.classList.contains(ts)}_isShown(){return this.tip&&this.tip.classList.contains(es)}_createPopper(t){const e=g(this._config.placement,[this,t,this._element]),i=rs[e.toUpperCase()];return bi(this._element,t,this._getPopperConfig(i))}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return g(t,[this._element])}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"preSetPlacement",enabled:!0,phase:"beforeMain",fn:t=>{this._getTipElement().setAttribute("data-popper-placement",t.state.placement)}}]};return{...e,...g(this._config.popperConfig,[e])}}_setListeners(){const t=this._config.trigger.split(" ");for(const e of t)if("click"===e)N.on(this._element,this.constructor.eventName("click"),this._config.selector,(t=>{this._initializeOnDelegatedTarget(t).toggle()}));else if("manual"!==e){const t=e===ss?this.constructor.eventName("mouseenter"):this.constructor.eventName("focusin"),i=e===ss?this.constructor.eventName("mouseleave"):this.constructor.eventName("focusout");N.on(this._element,t,this._config.selector,(t=>{const e=this._initializeOnDelegatedTarget(t);e._activeTrigger["focusin"===t.type?os:ss]=!0,e._enter()})),N.on(this._element,i,this._config.selector,(t=>{const e=this._initializeOnDelegatedTarget(t);e._activeTrigger["focusout"===t.type?os:ss]=e._element.contains(t.relatedTarget),e._leave()}))}this._hideModalHandler=()=>{this._element&&this.hide()},N.on(this._element.closest(is),ns,this._hideModalHandler)}_fixTitle(){const t=this._element.getAttribute("title");t&&(this._element.getAttribute("aria-label")||this._element.textContent.trim()||this._element.setAttribute("aria-label",t),this._element.setAttribute("data-bs-original-title",t),this._element.removeAttribute("title"))}_enter(){this._isShown()||this._isHovered?this._isHovered=!0:(this._isHovered=!0,this._setTimeout((()=>{this._isHovered&&this.show()}),this._config.delay.show))}_leave(){this._isWithActiveTrigger()||(this._isHovered=!1,this._setTimeout((()=>{this._isHovered||this.hide()}),this._config.delay.hide))}_setTimeout(t,e){clearTimeout(this._timeout),this._timeout=setTimeout(t,e)}_isWithActiveTrigger(){return Object.values(this._activeTrigger).includes(!0)}_getConfig(t){const e=F.getDataAttributes(this._element);for(const t of Object.keys(e))Zn.has(t)&&delete e[t];return t={...e,..."object"==typeof t&&t?t:{}},t=this._mergeConfigObj(t),t=this._configAfterMerge(t),this._typeCheckConfig(t),t}_configAfterMerge(t){return t.container=!1===t.container?document.body:r(t.container),"number"==typeof t.delay&&(t.delay={show:t.delay,hide:t.delay}),"number"==typeof t.title&&(t.title=t.title.toString()),"number"==typeof t.content&&(t.content=t.content.toString()),t}_getDelegateConfig(){const t={};for(const[e,i]of Object.entries(this._config))this.constructor.Default[e]!==i&&(t[e]=i);return t.selector=!1,t.trigger="manual",t}_disposePopper(){this._popper&&(this._popper.destroy(),this._popper=null),this.tip&&(this.tip.remove(),this.tip=null)}static jQueryInterface(t){return this.each((function(){const e=cs.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}m(cs);const hs={...cs.Default,content:"",offset:[0,8],placement:"right",template:'',trigger:"click"},ds={...cs.DefaultType,content:"(null|string|element|function)"};class us extends cs{static get Default(){return hs}static get DefaultType(){return ds}static get 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e=this._observableSections.get(t.target.hash);if(e){t.preventDefault();const i=this._rootElement||window,n=e.offsetTop-this._element.offsetTop;if(i.scrollTo)return void i.scrollTo({top:n,behavior:"smooth"});i.scrollTop=n}})))}_getNewObserver(){const t={root:this._rootElement,threshold:this._config.threshold,rootMargin:this._config.rootMargin};return new IntersectionObserver((t=>this._observerCallback(t)),t)}_observerCallback(t){const e=t=>this._targetLinks.get(`#${t.target.id}`),i=t=>{this._previousScrollData.visibleEntryTop=t.target.offsetTop,this._process(e(t))},n=(this._rootElement||document.documentElement).scrollTop,s=n>=this._previousScrollData.parentScrollTop;this._previousScrollData.parentScrollTop=n;for(const o of t){if(!o.isIntersecting){this._activeTarget=null,this._clearActiveClass(e(o));continue}const t=o.target.offsetTop>=this._previousScrollData.visibleEntryTop;if(s&&t){if(i(o),!n)return}else s||t||i(o)}}_initializeTargetsAndObservables(){this._targetLinks=new Map,this._observableSections=new Map;const t=z.find(bs,this._config.target);for(const e of t){if(!e.hash||l(e))continue;const t=z.findOne(decodeURI(e.hash),this._element);a(t)&&(this._targetLinks.set(decodeURI(e.hash),e),this._observableSections.set(e.hash,t))}}_process(t){this._activeTarget!==t&&(this._clearActiveClass(this._config.target),this._activeTarget=t,t.classList.add(_s),this._activateParents(t),N.trigger(this._element,ps,{relatedTarget:t}))}_activateParents(t){if(t.classList.contains("dropdown-item"))z.findOne(".dropdown-toggle",t.closest(".dropdown")).classList.add(_s);else for(const e of z.parents(t,".nav, .list-group"))for(const t of z.prev(e,ys))t.classList.add(_s)}_clearActiveClass(t){t.classList.remove(_s);const e=z.find(`${bs}.${_s}`,t);for(const t of e)t.classList.remove(_s)}static jQueryInterface(t){return this.each((function(){const e=Es.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t]()}}))}}N.on(window,gs,(()=>{for(const t of z.find('[data-bs-spy="scroll"]'))Es.getOrCreateInstance(t)})),m(Es);const Ts=".bs.tab",Cs=`hide${Ts}`,Os=`hidden${Ts}`,xs=`show${Ts}`,ks=`shown${Ts}`,Ls=`click${Ts}`,Ss=`keydown${Ts}`,Ds=`load${Ts}`,$s="ArrowLeft",Is="ArrowRight",Ns="ArrowUp",Ps="ArrowDown",Ms="Home",js="End",Fs="active",Hs="fade",Ws="show",Bs=":not(.dropdown-toggle)",zs='[data-bs-toggle="tab"], [data-bs-toggle="pill"], [data-bs-toggle="list"]',Rs=`.nav-link${Bs}, .list-group-item${Bs}, [role="tab"]${Bs}, ${zs}`,qs=`.${Fs}[data-bs-toggle="tab"], .${Fs}[data-bs-toggle="pill"], .${Fs}[data-bs-toggle="list"]`;class Vs extends W{constructor(t){super(t),this._parent=this._element.closest('.list-group, .nav, [role="tablist"]'),this._parent&&(this._setInitialAttributes(this._parent,this._getChildren()),N.on(this._element,Ss,(t=>this._keydown(t))))}static get NAME(){return"tab"}show(){const t=this._element;if(this._elemIsActive(t))return;const e=this._getActiveElem(),i=e?N.trigger(e,Cs,{relatedTarget:t}):null;N.trigger(t,xs,{relatedTarget:e}).defaultPrevented||i&&i.defaultPrevented||(this._deactivate(e,t),this._activate(t,e))}_activate(t,e){t&&(t.classList.add(Fs),this._activate(z.getElementFromSelector(t)),this._queueCallback((()=>{"tab"===t.getAttribute("role")?(t.removeAttribute("tabindex"),t.setAttribute("aria-selected",!0),this._toggleDropDown(t,!0),N.trigger(t,ks,{relatedTarget:e})):t.classList.add(Ws)}),t,t.classList.contains(Hs)))}_deactivate(t,e){t&&(t.classList.remove(Fs),t.blur(),this._deactivate(z.getElementFromSelector(t)),this._queueCallback((()=>{"tab"===t.getAttribute("role")?(t.setAttribute("aria-selected",!1),t.setAttribute("tabindex","-1"),this._toggleDropDown(t,!1),N.trigger(t,Os,{relatedTarget:e})):t.classList.remove(Ws)}),t,t.classList.contains(Hs)))}_keydown(t){if(![$s,Is,Ns,Ps,Ms,js].includes(t.key))return;t.stopPropagation(),t.preventDefault();const e=this._getChildren().filter((t=>!l(t)));let i;if([Ms,js].includes(t.key))i=e[t.key===Ms?0:e.length-1];else{const n=[Is,Ps].includes(t.key);i=b(e,t.target,n,!0)}i&&(i.focus({preventScroll:!0}),Vs.getOrCreateInstance(i).show())}_getChildren(){return z.find(Rs,this._parent)}_getActiveElem(){return this._getChildren().find((t=>this._elemIsActive(t)))||null}_setInitialAttributes(t,e){this._setAttributeIfNotExists(t,"role","tablist");for(const t of e)this._setInitialAttributesOnChild(t)}_setInitialAttributesOnChild(t){t=this._getInnerElement(t);const e=this._elemIsActive(t),i=this._getOuterElement(t);t.setAttribute("aria-selected",e),i!==t&&this._setAttributeIfNotExists(i,"role","presentation"),e||t.setAttribute("tabindex","-1"),this._setAttributeIfNotExists(t,"role","tab"),this._setInitialAttributesOnTargetPanel(t)}_setInitialAttributesOnTargetPanel(t){const 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"${t}"`);e[t]()}}))}}N.on(document,Ls,zs,(function(t){["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this)||Vs.getOrCreateInstance(this).show()})),N.on(window,Ds,(()=>{for(const t of z.find(qs))Vs.getOrCreateInstance(t)})),m(Vs);const Ks=".bs.toast",Qs=`mouseover${Ks}`,Xs=`mouseout${Ks}`,Ys=`focusin${Ks}`,Us=`focusout${Ks}`,Gs=`hide${Ks}`,Js=`hidden${Ks}`,Zs=`show${Ks}`,to=`shown${Ks}`,eo="hide",io="show",no="showing",so={animation:"boolean",autohide:"boolean",delay:"number"},oo={animation:!0,autohide:!0,delay:5e3};class ro extends W{constructor(t,e){super(t,e),this._timeout=null,this._hasMouseInteraction=!1,this._hasKeyboardInteraction=!1,this._setListeners()}static get Default(){return oo}static get DefaultType(){return so}static get 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t=this;e.preventDefault(),this.initialX=this.currentX,this.initialY=this.currentY,this.active=!1,setTimeout((function(){t.dragging=!1,t.img.isDragging=!1,t.img.classList.remove("dragging")}),100)}},{key:"drag",value:function(e){this.active&&(e.preventDefault(),"touchmove"===e.type?(this.currentX=e.touches[0].clientX-this.initialX,this.currentY=e.touches[0].clientY-this.initialY):(this.currentX=e.clientX-this.initialX,this.currentY=e.clientY-this.initialY),this.xOffset=this.currentX,this.yOffset=this.currentY,this.img.isDragging=!0,this.dragging=!0,this.setTranslate(this.img,this.currentX,this.currentY))}},{key:"onMove",value:function(e){if(this.zoomedIn){var t=e.clientX-this.img.naturalWidth/2,i=e.clientY-this.img.naturalHeight/2;this.setTranslate(this.img,t,i)}}},{key:"setTranslate",value:function(e,t,i){e.style.transform="translate3d("+t+"px, "+i+"px, 0)"}},{key:"widowWidth",value:function(){return 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n(e,[{key:"dragStart",value:function(e){if(this.slide.classList.contains("zoomed"))this.active=!1;else{"touchstart"===e.type?(this.initialX=e.touches[0].clientX-this.xOffset,this.initialY=e.touches[0].clientY-this.yOffset):(this.initialX=e.clientX-this.xOffset,this.initialY=e.clientY-this.yOffset);var t=e.target.nodeName.toLowerCase();e.target.classList.contains("nodrag")||u(e.target,".nodrag")||-1!==["input","select","textarea","button","a"].indexOf(t)?this.active=!1:(e.preventDefault(),(e.target===this.el||"img"!==t&&u(e.target,".gslide-inline"))&&(this.active=!0,this.el.classList.add("dragging"),this.dragContainer=u(e.target,".ginner-container")))}}},{key:"dragEnd",value:function(e){var t=this;e&&e.preventDefault(),this.initialX=0,this.initialY=0,this.currentX=null,this.currentY=null,this.initialX=null,this.initialY=null,this.xOffset=0,this.yOffset=0,this.active=!1,this.doSlideChange&&(this.instance.preventOutsideClick=!0,"right"==this.doSlideChange&&this.instance.prevSlide(),"left"==this.doSlideChange&&this.instance.nextSlide()),this.doSlideClose&&this.instance.close(),this.toleranceReached||this.setTranslate(this.dragContainer,0,0,!0),setTimeout((function(){t.instance.preventOutsideClick=!1,t.toleranceReached=!1,t.lastDirection=null,t.dragging=!1,t.el.isDragging=!1,t.el.classList.remove("dragging"),t.slide.classList.remove("dragging-nav"),t.dragContainer.style.transform="",t.dragContainer.style.transition=""}),100)}},{key:"drag",value:function(e){if(this.active){e.preventDefault(),this.slide.classList.add("dragging-nav"),"touchmove"===e.type?(this.currentX=e.touches[0].clientX-this.initialX,this.currentY=e.touches[0].clientY-this.initialY):(this.currentX=e.clientX-this.initialX,this.currentY=e.clientY-this.initialY),this.xOffset=this.currentX,this.yOffset=this.currentY,this.el.isDragging=!0,this.dragging=!0,this.doSlideChange=!1,this.doSlideClose=!1;var t=Math.abs(this.currentX),i=Math.abs(this.currentY);if(t>0&&t>=Math.abs(this.currentY)&&(!this.lastDirection||"x"==this.lastDirection)){this.yOffset=0,this.lastDirection="x",this.setTranslate(this.dragContainer,this.currentX,0);var n=this.shouldChange();if(!this.instance.settings.dragAutoSnap&&n&&(this.doSlideChange=n),this.instance.settings.dragAutoSnap&&n)return this.instance.preventOutsideClick=!0,this.toleranceReached=!0,this.active=!1,this.instance.preventOutsideClick=!0,this.dragEnd(null),"right"==n&&this.instance.prevSlide(),void("left"==n&&this.instance.nextSlide())}if(this.toleranceY>0&&i>0&&i>=t&&(!this.lastDirection||"y"==this.lastDirection)){this.xOffset=0,this.lastDirection="y",this.setTranslate(this.dragContainer,0,this.currentY);var s=this.shouldClose();return!this.instance.settings.dragAutoSnap&&s&&(this.doSlideClose=!0),void(this.instance.settings.dragAutoSnap&&s&&this.instance.close())}}}},{key:"shouldChange",value:function(){var e=!1;if(Math.abs(this.currentX)>=this.toleranceX){var t=this.currentX>0?"right":"left";("left"==t&&this.slide!==this.slide.parentNode.lastChild||"right"==t&&this.slide!==this.slide.parentNode.firstChild)&&(e=t)}return e}},{key:"shouldClose",value:function(){var e=!1;return Math.abs(this.currentY)>=this.toleranceY&&(e=!0),e}},{key:"setTranslate",value:function(e,t,i){var n=arguments.length>3&&void 0!==arguments[3]&&arguments[3];e.style.transition=n?"all .2s ease":"",e.style.transform="translate3d(".concat(t,"px, ").concat(i,"px, 0)")}}]),e}();function j(e,t,i,n){var s=e.querySelector(".gslide-media"),l=new Image,o="gSlideTitle_"+i,r="gSlideDesc_"+i;l.addEventListener("load",(function(){T(n)&&n()}),!1),l.src=t.href,""!=t.sizes&&""!=t.srcset&&(l.sizes=t.sizes,l.srcset=t.srcset),l.alt="",I(t.alt)||""===t.alt||(l.alt=t.alt),""!==t.title&&l.setAttribute("aria-labelledby",o),""!==t.description&&l.setAttribute("aria-describedby",r),t.hasOwnProperty("_hasCustomWidth")&&t._hasCustomWidth&&(l.style.width=t.width),t.hasOwnProperty("_hasCustomHeight")&&t._hasCustomHeight&&(l.style.height=t.height),s.insertBefore(l,s.firstChild)}function F(e,t,i,n){var s=this,l=e.querySelector(".ginner-container"),o="gvideo"+i,r=e.querySelector(".gslide-media"),a=this.getAllPlayers();h(l,"gvideo-container"),r.insertBefore(m('
'),r.firstChild);var d=e.querySelector(".gvideo-wrapper");S(this.settings.plyr.css,"Plyr");var c=t.href,u=null==t?void 0:t.videoProvider,g=!1;r.style.maxWidth=t.width,S(this.settings.plyr.js,"Plyr",(function(){if(!u&&c.match(/vimeo\.com\/([0-9]*)/)&&(u="vimeo"),!u&&(c.match(/(youtube\.com|youtube-nocookie\.com)\/watch\?v=([a-zA-Z0-9\-_]+)/)||c.match(/youtu\.be\/([a-zA-Z0-9\-_]+)/)||c.match(/(youtube\.com|youtube-nocookie\.com)\/embed\/([a-zA-Z0-9\-_]+)/))&&(u="youtube"),"local"===u||!u){u="local";var l='")}var r=g||m('
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'.concat(d,"
"))),k(d))){"none"==d.style.display&&(d.style.display="block");var c=document.createElement("div");c.className="ginlined-content",c.appendChild(d),s=c}if(r){var u=document.getElementById(r);if(!u)return!1;var g=u.cloneNode(!0);g.style.height=t.height,g.style.maxWidth=t.width,h(g,"ginlined-content"),s=g}if(!s)return console.error("Unable to append inline slide content",t),!1;o.style.height=t.height,o.style.width=t.width,o.appendChild(s),this.events["inlineclose"+r]=a("click",{onElement:o.querySelectorAll(".gtrigger-close"),withCallback:function(e){e.preventDefault(),l.close()}}),T(n)&&n()}function Z(e,t,i,n){var s=e.querySelector(".gslide-media"),l=function(e){var t=e.url,i=e.allow,n=e.callback,s=e.appendTo,l=document.createElement("iframe");return l.className="vimeo-video gvideo",l.src=t,l.style.width="100%",l.style.height="100%",i&&l.setAttribute("allow",i),l.onload=function(){l.onload=null,h(l,"node-ready"),T(n)&&n()},s&&s.appendChild(l),l}({url:t.href,callback:n});s.parentNode.style.maxWidth=t.width,s.parentNode.style.height=t.height,s.appendChild(l)}var U=function(){function e(){var i=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};t(this,e),this.defaults={href:"",sizes:"",srcset:"",title:"",type:"",videoProvider:"",description:"",alt:"",descPosition:"bottom",effect:"",width:"",height:"",content:!1,zoomable:!0,draggable:!0},L(i)&&(this.defaults=l(this.defaults,i))}return n(e,[{key:"sourceType",value:function(e){var t=e;if(null!==(e=e.toLowerCase()).match(/\.(jpeg|jpg|jpe|gif|png|apn|webp|avif|svg)/))return"image";if(e.match(/(youtube\.com|youtube-nocookie\.com)\/watch\?v=([a-zA-Z0-9\-_]+)/)||e.match(/youtu\.be\/([a-zA-Z0-9\-_]+)/)||e.match(/(youtube\.com|youtube-nocookie\.com)\/embed\/([a-zA-Z0-9\-_]+)/))return"video";if(e.match(/vimeo\.com\/([0-9]*)/))return"video";if(null!==e.match(/\.(mp4|ogg|webm|mov)/))return"video";if(null!==e.match(/\.(mp3|wav|wma|aac|ogg)/))return"audio";if(e.indexOf("#")>-1&&""!==t.split("#").pop().trim())return"inline";return e.indexOf("goajax=true")>-1?"ajax":"external"}},{key:"parseConfig",value:function(e,t){var i=this,n=l({descPosition:t.descPosition},this.defaults);if(L(e)&&!k(e)){O(e,"type")||(O(e,"content")&&e.content?e.type="inline":O(e,"href")&&(e.type=this.sourceType(e.href)));var s=l(n,e);return this.setSize(s,t),s}var r="",a=e.getAttribute("data-glightbox"),h=e.nodeName.toLowerCase();if("a"===h&&(r=e.href),"img"===h&&(r=e.src,n.alt=e.alt),n.href=r,o(n,(function(s,l){O(t,l)&&"width"!==l&&(n[l]=t[l]);var o=e.dataset[l];I(o)||(n[l]=i.sanitizeValue(o))})),n.content&&(n.type="inline"),!n.type&&r&&(n.type=this.sourceType(r)),I(a)){if(!n.title&&"a"==h){var d=e.title;I(d)||""===d||(n.title=d)}if(!n.title&&"img"==h){var c=e.alt;I(c)||""===c||(n.title=c)}}else{var u=[];o(n,(function(e,t){u.push(";\\s?"+t)})),u=u.join("\\s?:|"),""!==a.trim()&&o(n,(function(e,t){var s=a,l=new RegExp("s?"+t+"s?:s?(.*?)("+u+"s?:|$)"),o=s.match(l);if(o&&o.length&&o[1]){var r=o[1].trim().replace(/;\s*$/,"");n[t]=i.sanitizeValue(r)}}))}if(n.description&&"."===n.description.substring(0,1)){var g;try{g=document.querySelector(n.description).innerHTML}catch(e){if(!(e instanceof DOMException))throw e}g&&(n.description=g)}if(!n.description){var v=e.querySelector(".glightbox-desc");v&&(n.description=v.innerHTML)}return this.setSize(n,t,e),this.slideConfig=n,n}},{key:"setSize",value:function(e,t){var i=arguments.length>2&&void 0!==arguments[2]?arguments[2]:null,n="video"==e.type?this.checkSize(t.videosWidth):this.checkSize(t.width),s=this.checkSize(t.height);return e.width=O(e,"width")&&""!==e.width?this.checkSize(e.width):n,e.height=O(e,"height")&&""!==e.height?this.checkSize(e.height):s,i&&"image"==e.type&&(e._hasCustomWidth=!!i.dataset.width,e._hasCustomHeight=!!i.dataset.height),e}},{key:"checkSize",value:function(e){return M(e)?"".concat(e,"px"):e}},{key:"sanitizeValue",value:function(e){return"true"!==e&&"false"!==e?e:"true"===e}}]),e}(),$=function(){function e(i,n,s){t(this,e),this.element=i,this.instance=n,this.index=s}return n(e,[{key:"setContent",value:function(){var e=this,t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:null,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(c(t,"loaded"))return!1;var n=this.instance.settings,s=this.slideConfig,l=w();T(n.beforeSlideLoad)&&n.beforeSlideLoad({index:this.index,slide:t,player:!1});var o=s.type,r=s.descPosition,a=t.querySelector(".gslide-media"),d=t.querySelector(".gslide-title"),u=t.querySelector(".gslide-desc"),g=t.querySelector(".gdesc-inner"),v=i,f="gSlideTitle_"+this.index,p="gSlideDesc_"+this.index;if(T(n.afterSlideLoad)&&(v=function(){T(i)&&i(),n.afterSlideLoad({index:e.index,slide:t,player:e.instance.getSlidePlayerInstance(e.index)})}),""==s.title&&""==s.description?g&&g.parentNode.parentNode.removeChild(g.parentNode):(d&&""!==s.title?(d.id=f,d.innerHTML=s.title):d.parentNode.removeChild(d),u&&""!==s.description?(u.id=p,l&&n.moreLength>0?(s.smallDescription=this.slideShortDesc(s.description,n.moreLength,n.moreText),u.innerHTML=s.smallDescription,this.descriptionEvents(u,s)):u.innerHTML=s.description):u.parentNode.removeChild(u),h(a.parentNode,"desc-".concat(r)),h(g.parentNode,"description-".concat(r))),h(a,"gslide-".concat(o)),h(t,"loaded"),"video"!==o){if("external"!==o)return"inline"===o?(G.apply(this.instance,[t,s,this.index,v]),void(s.draggable&&new V({dragEl:t.querySelector(".gslide-inline"),toleranceX:n.dragToleranceX,toleranceY:n.dragToleranceY,slide:t,instance:this.instance}))):void("image"!==o?T(v)&&v():j(t,s,this.index,(function(){var i=t.querySelector("img");s.draggable&&new V({dragEl:i,toleranceX:n.dragToleranceX,toleranceY:n.dragToleranceY,slide:t,instance:e.instance}),s.zoomable&&i.naturalWidth>i.offsetWidth&&(h(i,"zoomable"),new H(i,t,(function(){e.instance.resize()}))),T(v)&&v()})));Z.apply(this,[t,s,this.index,v])}else F.apply(this.instance,[t,s,this.index,v])}},{key:"slideShortDesc",value:function(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:50,i=arguments.length>2&&void 0!==arguments[2]&&arguments[2],n=document.createElement("div");n.innerHTML=e;var s=n.innerText,l=i;if((e=s.trim()).length<=t)return e;var o=e.substr(0,t-1);return l?(n=null,o+'... '+i+""):o}},{key:"descriptionEvents",value:function(e,t){var i=this,n=e.querySelector(".desc-more");if(!n)return!1;a("click",{onElement:n,withCallback:function(e,n){e.preventDefault();var s=document.body,l=u(n,".gslide-desc");if(!l)return!1;l.innerHTML=t.description,h(s,"gdesc-open");var o=a("click",{onElement:[s,u(l,".gslide-description")],withCallback:function(e,n){"a"!==e.target.nodeName.toLowerCase()&&(d(s,"gdesc-open"),h(s,"gdesc-closed"),l.innerHTML=t.smallDescription,i.descriptionEvents(l,t),setTimeout((function(){d(s,"gdesc-closed")}),400),o.destroy())}})}})}},{key:"create",value:function(){return m(this.instance.settings.slideHTML)}},{key:"getConfig",value:function(){k(this.element)||this.element.hasOwnProperty("draggable")||(this.element.draggable=this.instance.settings.draggable);var e=new U(this.instance.settings.slideExtraAttributes);return this.slideConfig=e.parseConfig(this.element,this.instance.settings),this.slideConfig}}]),e}(),J=w(),K=null!==w()||void 0!==document.createTouch||"ontouchstart"in window||"onmsgesturechange"in window||navigator.msMaxTouchPoints,Q=document.getElementsByTagName("html")[0],ee={selector:".glightbox",elements:null,skin:"clean",theme:"clean",closeButton:!0,startAt:null,autoplayVideos:!0,autofocusVideos:!0,descPosition:"bottom",width:"900px",height:"506px",videosWidth:"960px",beforeSlideChange:null,afterSlideChange:null,beforeSlideLoad:null,afterSlideLoad:null,slideInserted:null,slideRemoved:null,slideExtraAttributes:null,onOpen:null,onClose:null,loop:!1,zoomable:!0,draggable:!0,dragAutoSnap:!1,dragToleranceX:40,dragToleranceY:65,preload:!0,oneSlidePerOpen:!1,touchNavigation:!0,touchFollowAxis:!0,keyboardNavigation:!0,closeOnOutsideClick:!0,plugins:!1,plyr:{css:"https://cdn.plyr.io/3.6.12/plyr.css",js:"https://cdn.plyr.io/3.6.12/plyr.js",config:{ratio:"16:9",fullscreen:{enabled:!0,iosNative:!0},youtube:{noCookie:!0,rel:0,showinfo:0,iv_load_policy:3},vimeo:{byline:!1,portrait:!1,title:!1,transparent:!1}}},openEffect:"zoom",closeEffect:"zoom",slideEffect:"slide",moreText:"See more",moreLength:60,cssEfects:{fade:{in:"fadeIn",out:"fadeOut"},zoom:{in:"zoomIn",out:"zoomOut"},slide:{in:"slideInRight",out:"slideOutLeft"},slideBack:{in:"slideInLeft",out:"slideOutRight"},none:{in:"none",out:"none"}},svg:{close:'',next:' ',prev:''},slideHTML:'
\n
\n
\n
\n
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\n
\n

\n
\n
\n
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',lightboxHTML:''},te=function(){function e(){var i=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};t(this,e),this.customOptions=i,this.settings=l(ee,i),this.effectsClasses=this.getAnimationClasses(),this.videoPlayers={},this.apiEvents=[],this.fullElementsList=!1}return n(e,[{key:"init",value:function(){var e=this,t=this.getSelector();t&&(this.baseEvents=a("click",{onElement:t,withCallback:function(t,i){t.preventDefault(),e.open(i)}})),this.elements=this.getElements()}},{key:"open",value:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:null,t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:null;if(0===this.elements.length)return!1;this.activeSlide=null,this.prevActiveSlideIndex=null,this.prevActiveSlide=null;var i=M(t)?t:this.settings.startAt;if(k(e)){var n=e.getAttribute("data-gallery");n&&(this.fullElementsList=this.elements,this.elements=this.getGalleryElements(this.elements,n)),I(i)&&(i=this.getElementIndex(e))<0&&(i=0)}M(i)||(i=0),this.build(),g(this.overlay,"none"===this.settings.openEffect?"none":this.settings.cssEfects.fade.in);var s=document.body,l=window.innerWidth-document.documentElement.clientWidth;if(l>0){var o=document.createElement("style");o.type="text/css",o.className="gcss-styles",o.innerText=".gscrollbar-fixer {margin-right: ".concat(l,"px}"),document.head.appendChild(o),h(s,"gscrollbar-fixer")}h(s,"glightbox-open"),h(Q,"glightbox-open"),J&&(h(document.body,"glightbox-mobile"),this.settings.slideEffect="slide"),this.showSlide(i,!0),1===this.elements.length?(h(this.prevButton,"glightbox-button-hidden"),h(this.nextButton,"glightbox-button-hidden")):(d(this.prevButton,"glightbox-button-hidden"),d(this.nextButton,"glightbox-button-hidden")),this.lightboxOpen=!0,this.trigger("open"),T(this.settings.onOpen)&&this.settings.onOpen(),K&&this.settings.touchNavigation&&B(this),this.settings.keyboardNavigation&&X(this)}},{key:"openAt",value:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:0;this.open(null,e)}},{key:"showSlide",value:function(){var e=this,t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:0,i=arguments.length>1&&void 0!==arguments[1]&&arguments[1];f(this.loader),this.index=parseInt(t);var n=this.slidesContainer.querySelector(".current");n&&d(n,"current"),this.slideAnimateOut();var s=this.slidesContainer.querySelectorAll(".gslide")[t];if(c(s,"loaded"))this.slideAnimateIn(s,i),p(this.loader);else{f(this.loader);var l=this.elements[t],o={index:this.index,slide:s,slideNode:s,slideConfig:l.slideConfig,slideIndex:this.index,trigger:l.node,player:null};this.trigger("slide_before_load",o),l.instance.setContent(s,(function(){p(e.loader),e.resize(),e.slideAnimateIn(s,i),e.trigger("slide_after_load",o)}))}this.slideDescription=s.querySelector(".gslide-description"),this.slideDescriptionContained=this.slideDescription&&c(this.slideDescription.parentNode,"gslide-media"),this.settings.preload&&(this.preloadSlide(t+1),this.preloadSlide(t-1)),this.updateNavigationClasses(),this.activeSlide=s}},{key:"preloadSlide",value:function(e){var t=this;if(e<0||e>this.elements.length-1)return!1;if(I(this.elements[e]))return!1;var i=this.slidesContainer.querySelectorAll(".gslide")[e];if(c(i,"loaded"))return!1;var n=this.elements[e],s=n.type,l={index:e,slide:i,slideNode:i,slideConfig:n.slideConfig,slideIndex:e,trigger:n.node,player:null};this.trigger("slide_before_load",l),"video"===s||"external"===s?setTimeout((function(){n.instance.setContent(i,(function(){t.trigger("slide_after_load",l)}))}),200):n.instance.setContent(i,(function(){t.trigger("slide_after_load",l)}))}},{key:"prevSlide",value:function(){this.goToSlide(this.index-1)}},{key:"nextSlide",value:function(){this.goToSlide(this.index+1)}},{key:"goToSlide",value:function(){var e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(this.prevActiveSlide=this.activeSlide,this.prevActiveSlideIndex=this.index,!this.loop()&&(e<0||e>this.elements.length-1))return!1;e<0?e=this.elements.length-1:e>=this.elements.length&&(e=0),this.showSlide(e)}},{key:"insertSlide",value:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:-1;t<0&&(t=this.elements.length);var i=new $(e,this,t),n=i.getConfig(),s=l({},n),o=i.create(),r=this.elements.length-1;s.index=t,s.node=!1,s.instance=i,s.slideConfig=n,this.elements.splice(t,0,s);var a=null,h=null;if(this.slidesContainer){if(t>r)this.slidesContainer.appendChild(o);else{var d=this.slidesContainer.querySelectorAll(".gslide")[t];this.slidesContainer.insertBefore(o,d)}(this.settings.preload&&0==this.index&&0==t||this.index-1==t||this.index+1==t)&&this.preloadSlide(t),0===this.index&&0===t&&(this.index=1),this.updateNavigationClasses(),a=this.slidesContainer.querySelectorAll(".gslide")[t],h=this.getSlidePlayerInstance(t),s.slideNode=a}this.trigger("slide_inserted",{index:t,slide:a,slideNode:a,slideConfig:n,slideIndex:t,trigger:null,player:h}),T(this.settings.slideInserted)&&this.settings.slideInserted({index:t,slide:a,player:h})}},{key:"removeSlide",value:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:-1;if(e<0||e>this.elements.length-1)return!1;var t=this.slidesContainer&&this.slidesContainer.querySelectorAll(".gslide")[e];t&&(this.getActiveSlideIndex()==e&&(e==this.elements.length-1?this.prevSlide():this.nextSlide()),t.parentNode.removeChild(t)),this.elements.splice(e,1),this.trigger("slide_removed",e),T(this.settings.slideRemoved)&&this.settings.slideRemoved(e)}},{key:"slideAnimateIn",value:function(e,t){var i=this,n=e.querySelector(".gslide-media"),s=e.querySelector(".gslide-description"),l={index:this.prevActiveSlideIndex,slide:this.prevActiveSlide,slideNode:this.prevActiveSlide,slideIndex:this.prevActiveSlide,slideConfig:I(this.prevActiveSlideIndex)?null:this.elements[this.prevActiveSlideIndex].slideConfig,trigger:I(this.prevActiveSlideIndex)?null:this.elements[this.prevActiveSlideIndex].node,player:this.getSlidePlayerInstance(this.prevActiveSlideIndex)},o={index:this.index,slide:this.activeSlide,slideNode:this.activeSlide,slideConfig:this.elements[this.index].slideConfig,slideIndex:this.index,trigger:this.elements[this.index].node,player:this.getSlidePlayerInstance(this.index)};if(n.offsetWidth>0&&s&&(p(s),s.style.display=""),d(e,this.effectsClasses),t)g(e,this.settings.cssEfects[this.settings.openEffect].in,(function(){i.settings.autoplayVideos&&i.slidePlayerPlay(e),i.trigger("slide_changed",{prev:l,current:o}),T(i.settings.afterSlideChange)&&i.settings.afterSlideChange.apply(i,[l,o])}));else{var r=this.settings.slideEffect,a="none"!==r?this.settings.cssEfects[r].in:r;this.prevActiveSlideIndex>this.index&&"slide"==this.settings.slideEffect&&(a=this.settings.cssEfects.slideBack.in),g(e,a,(function(){i.settings.autoplayVideos&&i.slidePlayerPlay(e),i.trigger("slide_changed",{prev:l,current:o}),T(i.settings.afterSlideChange)&&i.settings.afterSlideChange.apply(i,[l,o])}))}setTimeout((function(){i.resize(e)}),100),h(e,"current")}},{key:"slideAnimateOut",value:function(){if(!this.prevActiveSlide)return!1;var e=this.prevActiveSlide;d(e,this.effectsClasses),h(e,"prev");var t=this.settings.slideEffect,i="none"!==t?this.settings.cssEfects[t].out:t;this.slidePlayerPause(e),this.trigger("slide_before_change",{prev:{index:this.prevActiveSlideIndex,slide:this.prevActiveSlide,slideNode:this.prevActiveSlide,slideIndex:this.prevActiveSlideIndex,slideConfig:I(this.prevActiveSlideIndex)?null:this.elements[this.prevActiveSlideIndex].slideConfig,trigger:I(this.prevActiveSlideIndex)?null:this.elements[this.prevActiveSlideIndex].node,player:this.getSlidePlayerInstance(this.prevActiveSlideIndex)},current:{index:this.index,slide:this.activeSlide,slideNode:this.activeSlide,slideIndex:this.index,slideConfig:this.elements[this.index].slideConfig,trigger:this.elements[this.index].node,player:this.getSlidePlayerInstance(this.index)}}),T(this.settings.beforeSlideChange)&&this.settings.beforeSlideChange.apply(this,[{index:this.prevActiveSlideIndex,slide:this.prevActiveSlide,player:this.getSlidePlayerInstance(this.prevActiveSlideIndex)},{index:this.index,slide:this.activeSlide,player:this.getSlidePlayerInstance(this.index)}]),this.prevActiveSlideIndex>this.index&&"slide"==this.settings.slideEffect&&(i=this.settings.cssEfects.slideBack.out),g(e,i,(function(){var t=e.querySelector(".ginner-container"),i=e.querySelector(".gslide-media"),n=e.querySelector(".gslide-description");t.style.transform="",i.style.transform="",d(i,"greset"),i.style.opacity="",n&&(n.style.opacity=""),d(e,"prev")}))}},{key:"getAllPlayers",value:function(){return this.videoPlayers}},{key:"getSlidePlayerInstance",value:function(e){var t="gvideo"+e,i=this.getAllPlayers();return!(!O(i,t)||!i[t])&&i[t]}},{key:"stopSlideVideo",value:function(e){if(k(e)){var t=e.querySelector(".gvideo-wrapper");t&&(e=t.getAttribute("data-index"))}console.log("stopSlideVideo is deprecated, use slidePlayerPause");var i=this.getSlidePlayerInstance(e);i&&i.playing&&i.pause()}},{key:"slidePlayerPause",value:function(e){if(k(e)){var t=e.querySelector(".gvideo-wrapper");t&&(e=t.getAttribute("data-index"))}var i=this.getSlidePlayerInstance(e);i&&i.playing&&i.pause()}},{key:"playSlideVideo",value:function(e){if(k(e)){var t=e.querySelector(".gvideo-wrapper");t&&(e=t.getAttribute("data-index"))}console.log("playSlideVideo is deprecated, use slidePlayerPlay");var i=this.getSlidePlayerInstance(e);i&&!i.playing&&i.play()}},{key:"slidePlayerPlay",value:function(e){var t;if(!J||null!==(t=this.settings.plyr.config)&&void 0!==t&&t.muted){if(k(e)){var i=e.querySelector(".gvideo-wrapper");i&&(e=i.getAttribute("data-index"))}var n=this.getSlidePlayerInstance(e);n&&!n.playing&&(n.play(),this.settings.autofocusVideos&&n.elements.container.focus())}}},{key:"setElements",value:function(e){var t=this;this.settings.elements=!1;var i=[];e&&e.length&&o(e,(function(e,n){var s=new $(e,t,n),o=s.getConfig(),r=l({},o);r.slideConfig=o,r.instance=s,r.index=n,i.push(r)})),this.elements=i,this.lightboxOpen&&(this.slidesContainer.innerHTML="",this.elements.length&&(o(this.elements,(function(){var e=m(t.settings.slideHTML);t.slidesContainer.appendChild(e)})),this.showSlide(0,!0)))}},{key:"getElementIndex",value:function(e){var t=!1;return o(this.elements,(function(i,n){if(O(i,"node")&&i.node==e)return t=n,!0})),t}},{key:"getElements",value:function(){var e=this,t=[];this.elements=this.elements?this.elements:[],!I(this.settings.elements)&&E(this.settings.elements)&&this.settings.elements.length&&o(this.settings.elements,(function(i,n){var s=new $(i,e,n),o=s.getConfig(),r=l({},o);r.node=!1,r.index=n,r.instance=s,r.slideConfig=o,t.push(r)}));var i=!1;return this.getSelector()&&(i=document.querySelectorAll(this.getSelector())),i?(o(i,(function(i,n){var s=new $(i,e,n),o=s.getConfig(),r=l({},o);r.node=i,r.index=n,r.instance=s,r.slideConfig=o,r.gallery=i.getAttribute("data-gallery"),t.push(r)})),t):t}},{key:"getGalleryElements",value:function(e,t){return e.filter((function(e){return e.gallery==t}))}},{key:"getSelector",value:function(){return!this.settings.elements&&(this.settings.selector&&"data-"==this.settings.selector.substring(0,5)?"*[".concat(this.settings.selector,"]"):this.settings.selector)}},{key:"getActiveSlide",value:function(){return this.slidesContainer.querySelectorAll(".gslide")[this.index]}},{key:"getActiveSlideIndex",value:function(){return this.index}},{key:"getAnimationClasses",value:function(){var e=[];for(var t in this.settings.cssEfects)if(this.settings.cssEfects.hasOwnProperty(t)){var i=this.settings.cssEfects[t];e.push("g".concat(i.in)),e.push("g".concat(i.out))}return e.join(" ")}},{key:"build",value:function(){var e=this;if(this.built)return!1;var t=document.body.childNodes,i=[];o(t,(function(e){e.parentNode==document.body&&"#"!==e.nodeName.charAt(0)&&e.hasAttribute&&!e.hasAttribute("aria-hidden")&&(i.push(e),e.setAttribute("aria-hidden","true"))}));var n=O(this.settings.svg,"next")?this.settings.svg.next:"",s=O(this.settings.svg,"prev")?this.settings.svg.prev:"",l=O(this.settings.svg,"close")?this.settings.svg.close:"",r=this.settings.lightboxHTML;r=m(r=(r=(r=r.replace(/{nextSVG}/g,n)).replace(/{prevSVG}/g,s)).replace(/{closeSVG}/g,l)),document.body.appendChild(r);var d=document.getElementById("glightbox-body");this.modal=d;var g=d.querySelector(".gclose");this.prevButton=d.querySelector(".gprev"),this.nextButton=d.querySelector(".gnext"),this.overlay=d.querySelector(".goverlay"),this.loader=d.querySelector(".gloader"),this.slidesContainer=document.getElementById("glightbox-slider"),this.bodyHiddenChildElms=i,this.events={},h(this.modal,"glightbox-"+this.settings.skin),this.settings.closeButton&&g&&(this.events.close=a("click",{onElement:g,withCallback:function(t,i){t.preventDefault(),e.close()}})),g&&!this.settings.closeButton&&g.parentNode.removeChild(g),this.nextButton&&(this.events.next=a("click",{onElement:this.nextButton,withCallback:function(t,i){t.preventDefault(),e.nextSlide()}})),this.prevButton&&(this.events.prev=a("click",{onElement:this.prevButton,withCallback:function(t,i){t.preventDefault(),e.prevSlide()}})),this.settings.closeOnOutsideClick&&(this.events.outClose=a("click",{onElement:d,withCallback:function(t,i){e.preventOutsideClick||c(document.body,"glightbox-mobile")||u(t.target,".ginner-container")||u(t.target,".gbtn")||c(t.target,"gnext")||c(t.target,"gprev")||e.close()}})),o(this.elements,(function(t,i){e.slidesContainer.appendChild(t.instance.create()),t.slideNode=e.slidesContainer.querySelectorAll(".gslide")[i]})),K&&h(document.body,"glightbox-touch"),this.events.resize=a("resize",{onElement:window,withCallback:function(){e.resize()}}),this.built=!0}},{key:"resize",value:function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:null;if((e=e||this.activeSlide)&&!c(e,"zoomed")){var t=y(),i=e.querySelector(".gvideo-wrapper"),n=e.querySelector(".gslide-image"),s=this.slideDescription,l=t.width,o=t.height;if(l<=768?h(document.body,"glightbox-mobile"):d(document.body,"glightbox-mobile"),i||n){var r=!1;if(s&&(c(s,"description-bottom")||c(s,"description-top"))&&!c(s,"gabsolute")&&(r=!0),n)if(l<=768)n.querySelector("img");else if(r){var a=s.offsetHeight,u=n.querySelector("img");u.setAttribute("style","max-height: calc(100vh - ".concat(a,"px)")),s.setAttribute("style","max-width: ".concat(u.offsetWidth,"px;"))}if(i){var g=O(this.settings.plyr.config,"ratio")?this.settings.plyr.config.ratio:"";if(!g){var v=i.clientWidth,f=i.clientHeight,p=v/f;g="".concat(v/p,":").concat(f/p)}var m=g.split(":"),x=this.settings.videosWidth,b=this.settings.videosWidth,S=(b=M(x)||-1!==x.indexOf("px")?parseInt(x):-1!==x.indexOf("vw")?l*parseInt(x)/100:-1!==x.indexOf("vh")?o*parseInt(x)/100:-1!==x.indexOf("%")?l*parseInt(x)/100:parseInt(i.clientWidth))/(parseInt(m[0])/parseInt(m[1]));if(S=Math.floor(S),r&&(o-=s.offsetHeight),b>l||S>o||ob){var w=i.offsetWidth,T=i.offsetHeight,C=o/T,k={width:w*C,height:T*C};i.parentNode.setAttribute("style","max-width: ".concat(k.width,"px")),r&&s.setAttribute("style","max-width: ".concat(k.width,"px;"))}else i.parentNode.style.maxWidth="".concat(x),r&&s.setAttribute("style","max-width: ".concat(x,";"))}}}}},{key:"reload",value:function(){this.init()}},{key:"updateNavigationClasses",value:function(){var e=this.loop();d(this.nextButton,"disabled"),d(this.prevButton,"disabled"),0==this.index&&this.elements.length-1==0?(h(this.prevButton,"disabled"),h(this.nextButton,"disabled")):0!==this.index||e?this.index!==this.elements.length-1||e||h(this.nextButton,"disabled"):h(this.prevButton,"disabled")}},{key:"loop",value:function(){var e=O(this.settings,"loopAtEnd")?this.settings.loopAtEnd:null;return e=O(this.settings,"loop")?this.settings.loop:e,e}},{key:"close",value:function(){var e=this;if(!this.lightboxOpen){if(this.events){for(var t in this.events)this.events.hasOwnProperty(t)&&this.events[t].destroy();this.events=null}return!1}if(this.closing)return!1;this.closing=!0,this.slidePlayerPause(this.activeSlide),this.fullElementsList&&(this.elements=this.fullElementsList),this.bodyHiddenChildElms.length&&o(this.bodyHiddenChildElms,(function(e){e.removeAttribute("aria-hidden")})),h(this.modal,"glightbox-closing"),g(this.overlay,"none"==this.settings.openEffect?"none":this.settings.cssEfects.fade.out),g(this.activeSlide,this.settings.cssEfects[this.settings.closeEffect].out,(function(){if(e.activeSlide=null,e.prevActiveSlideIndex=null,e.prevActiveSlide=null,e.built=!1,e.events){for(var t in e.events)e.events.hasOwnProperty(t)&&e.events[t].destroy();e.events=null}var i=document.body;d(Q,"glightbox-open"),d(i,"glightbox-open touching gdesc-open glightbox-touch glightbox-mobile gscrollbar-fixer"),e.modal.parentNode.removeChild(e.modal),e.trigger("close"),T(e.settings.onClose)&&e.settings.onClose();var n=document.querySelector(".gcss-styles");n&&n.parentNode.removeChild(n),e.lightboxOpen=!1,e.closing=null}))}},{key:"destroy",value:function(){this.close(),this.clearAllEvents(),this.baseEvents&&this.baseEvents.destroy()}},{key:"on",value:function(e,t){var i=arguments.length>2&&void 0!==arguments[2]&&arguments[2];if(!e||!T(t))throw new TypeError("Event name and callback must be defined");this.apiEvents.push({evt:e,once:i,callback:t})}},{key:"once",value:function(e,t){this.on(e,t,!0)}},{key:"trigger",value:function(e){var t=this,i=arguments.length>1&&void 0!==arguments[1]?arguments[1]:null,n=[];o(this.apiEvents,(function(t,s){var l=t.evt,o=t.once,r=t.callback;l==e&&(r(i),o&&n.push(s))})),n.length&&o(n,(function(e){return t.apiEvents.splice(e,1)}))}},{key:"clearAllEvents",value:function(){this.apiEvents.splice(0,this.apiEvents.length)}},{key:"version",value:function(){return"3.1.0"}}]),e}();return function(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},t=new te(e);return t.init(),t}})); \ No newline at end of file diff --git a/_manuscript/site_libs/quarto-contrib/glightbox/lightbox.css b/_manuscript/site_libs/quarto-contrib/glightbox/lightbox.css deleted file mode 100644 index 2c29fe1..0000000 --- a/_manuscript/site_libs/quarto-contrib/glightbox/lightbox.css +++ /dev/null @@ -1,22 +0,0 @@ -body:not(.glightbox-mobile) div.gslide div.gslide-description, -body:not(.glightbox-mobile) div.gslide-description .gslide-title, -body:not(.glightbox-mobile) div.gslide-description .gslide-desc { - color: var(--quarto-body-color); - background-color: var(--quarto-body-bg); -} - -.goverlay { - background: rgba(0, 0, 0, 0.7); -} - -div.gslide-description .gslide-title { - margin-top: 0.25em; - margin-bottom: 0.25em; - font-weight: 500; - font-family: inherit; -} - -div.gslide-description .gslide-desc { - padding-bottom: 0.5em; - font-family: inherit; -} diff --git a/_manuscript/site_libs/quarto-html/anchor.min.js b/_manuscript/site_libs/quarto-html/anchor.min.js deleted file mode 100644 index 5ac814d..0000000 --- a/_manuscript/site_libs/quarto-html/anchor.min.js +++ /dev/null @@ -1,9 +0,0 @@ -// @license magnet:?xt=urn:btih:d3d9a9a6595521f9666a5e94cc830dab83b65699&dn=expat.txt Expat -// -// AnchorJS - v5.0.0 - 2023-01-18 -// https://www.bryanbraun.com/anchorjs/ -// Copyright (c) 2023 Bryan Braun; Licensed MIT -// -// @license magnet:?xt=urn:btih:d3d9a9a6595521f9666a5e94cc830dab83b65699&dn=expat.txt Expat -!function(A,e){"use strict";"function"==typeof define&&define.amd?define([],e):"object"==typeof module&&module.exports?module.exports=e():(A.AnchorJS=e(),A.anchors=new A.AnchorJS)}(globalThis,function(){"use strict";return function(A){function u(A){A.icon=Object.prototype.hasOwnProperty.call(A,"icon")?A.icon:"",A.visible=Object.prototype.hasOwnProperty.call(A,"visible")?A.visible:"hover",A.placement=Object.prototype.hasOwnProperty.call(A,"placement")?A.placement:"right",A.ariaLabel=Object.prototype.hasOwnProperty.call(A,"ariaLabel")?A.ariaLabel:"Anchor",A.class=Object.prototype.hasOwnProperty.call(A,"class")?A.class:"",A.base=Object.prototype.hasOwnProperty.call(A,"base")?A.base:"",A.truncate=Object.prototype.hasOwnProperty.call(A,"truncate")?Math.floor(A.truncate):64,A.titleText=Object.prototype.hasOwnProperty.call(A,"titleText")?A.titleText:""}function d(A){var e;if("string"==typeof A||A instanceof String)e=[].slice.call(document.querySelectorAll(A));else{if(!(Array.isArray(A)||A instanceof NodeList))throw new TypeError("The selector provided to AnchorJS was invalid.");e=[].slice.call(A)}return e}this.options=A||{},this.elements=[],u(this.options),this.add=function(A){var e,t,o,i,n,s,a,r,l,c,h,p=[];if(u(this.options),0!==(e=d(A=A||"h2, h3, h4, h5, h6")).length){for(null===document.head.querySelector("style.anchorjs")&&((A=document.createElement("style")).className="anchorjs",A.appendChild(document.createTextNode("")),void 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343d2f8..0000000 --- a/_manuscript/site_libs/quarto-html/quarto-syntax-highlighting-dark.css +++ /dev/null @@ -1,189 +0,0 @@ -/* quarto syntax highlight colors */ -:root { - --quarto-hl-al-color: #f07178; - --quarto-hl-an-color: #d4d0ab; - --quarto-hl-at-color: #00e0e0; - --quarto-hl-bn-color: #d4d0ab; - --quarto-hl-bu-color: #abe338; - --quarto-hl-ch-color: #abe338; - --quarto-hl-co-color: #f8f8f2; - --quarto-hl-cv-color: #ffd700; - --quarto-hl-cn-color: #ffd700; - --quarto-hl-cf-color: #ffa07a; - --quarto-hl-dt-color: #ffa07a; - --quarto-hl-dv-color: #d4d0ab; - --quarto-hl-do-color: #f8f8f2; - --quarto-hl-er-color: #f07178; - --quarto-hl-ex-color: #00e0e0; - --quarto-hl-fl-color: #d4d0ab; - --quarto-hl-fu-color: #ffa07a; - --quarto-hl-im-color: #abe338; - --quarto-hl-in-color: #d4d0ab; - --quarto-hl-kw-color: #ffa07a; - --quarto-hl-op-color: #ffa07a; - --quarto-hl-ot-color: #00e0e0; - --quarto-hl-pp-color: #dcc6e0; - --quarto-hl-re-color: #00e0e0; - --quarto-hl-sc-color: #abe338; - --quarto-hl-ss-color: #abe338; - --quarto-hl-st-color: #abe338; - --quarto-hl-va-color: #00e0e0; - --quarto-hl-vs-color: #abe338; - --quarto-hl-wa-color: #dcc6e0; -} - -/* other quarto variables */ -:root { - --quarto-font-monospace: SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace; -} - -code span.al { - background-color: #2a0f15; - font-weight: bold; - color: #f07178; -} - -code span.an { - color: #d4d0ab; -} - -code span.at { - color: #00e0e0; -} - -code span.bn { - color: #d4d0ab; -} - -code span.bu { - color: #abe338; -} - -code span.ch { - color: #abe338; -} - -code span.co { - font-style: italic; - color: #f8f8f2; -} - -code span.cv { - color: #ffd700; -} - -code span.cn { - color: #ffd700; -} - -code span.cf { - font-weight: bold; - color: #ffa07a; -} - -code span.dt { - color: #ffa07a; -} - -code span.dv { - color: #d4d0ab; -} - -code span.do { - color: #f8f8f2; -} - -code span.er { - color: #f07178; - text-decoration: underline; -} - -code span.ex { - font-weight: bold; - color: #00e0e0; -} - -code span.fl { - color: #d4d0ab; -} - -code span.fu { - color: #ffa07a; -} - -code span.im { - color: #abe338; -} - -code span.in { - color: #d4d0ab; -} - -code span.kw { - font-weight: bold; - color: #ffa07a; -} - -pre > code.sourceCode > span { - color: #f8f8f2; -} - -code span { - color: #f8f8f2; -} - -code.sourceCode > span { - color: #f8f8f2; -} - -div.sourceCode, -div.sourceCode pre.sourceCode { - color: #f8f8f2; -} - -code span.op { - color: #ffa07a; -} - -code span.ot { - color: #00e0e0; -} - -code span.pp { - color: #dcc6e0; -} - -code span.re { - background-color: #f8f8f2; - color: #00e0e0; -} - -code span.sc { - color: #abe338; -} - -code span.ss { - color: #abe338; -} - -code span.st { - color: #abe338; -} - -code span.va { - color: #00e0e0; -} - -code span.vs { - color: #abe338; -} - -code span.wa { - color: #dcc6e0; -} - -.prevent-inlining { - content: " code.sourceCode > span { - color: #003B4F; -} - -code span { - color: #003B4F; -} - -code.sourceCode > span { - color: #003B4F; -} - -div.sourceCode, -div.sourceCode pre.sourceCode { - color: #003B4F; -} - -code span.ot { - color: #003B4F; - font-style: inherit; -} - -code span.at { - color: #657422; - font-style: inherit; -} - -code span.ss { - color: #20794D; - font-style: inherit; -} - -code span.an { - color: #5E5E5E; - font-style: inherit; -} - -code span.fu { - color: #4758AB; - font-style: inherit; -} - -code span.st { - color: #20794D; - font-style: inherit; -} - -code span.cf { - color: #003B4F; - font-style: inherit; -} - -code span.op { - color: #5E5E5E; - font-style: inherit; -} - -code span.er { - color: #AD0000; - font-style: inherit; -} - -code span.bn { - color: #AD0000; - font-style: inherit; -} - -code span.al { - color: #AD0000; - font-style: inherit; -} - -code span.va { - color: #111111; - font-style: inherit; -} - -code span.bu { - font-style: inherit; -} - -code span.ex { - font-style: inherit; -} - -code span.pp { - color: #AD0000; - font-style: inherit; -} - -code span.in { - color: #5E5E5E; - font-style: inherit; -} - -code span.vs { - color: #20794D; - font-style: inherit; -} - -code span.wa { - color: #5E5E5E; - font-style: italic; -} - -code span.do { - color: #5E5E5E; - font-style: italic; -} - -code span.im { - color: #00769E; - font-style: inherit; -} - -code span.ch { - color: #20794D; - font-style: inherit; -} - -code span.dt { - color: #AD0000; - font-style: inherit; -} - -code span.fl { - color: #AD0000; - font-style: inherit; -} - -code span.co { - color: #5E5E5E; - font-style: inherit; -} - -code span.cv { - color: #5E5E5E; - font-style: italic; -} - -code span.cn { - color: #8f5902; - font-style: inherit; -} - -code span.sc { - color: #5E5E5E; - font-style: inherit; -} - -code span.dv { - color: #AD0000; - font-style: inherit; -} - -code span.kw { - color: #003B4F; - font-style: inherit; -} - -.prevent-inlining { - content: " { - // Find any conflicting margin elements and add margins to the - // top to prevent overlap - const marginChildren = window.document.querySelectorAll( - ".column-margin.column-container > *, .margin-caption, .aside" - ); - - let lastBottom = 0; - for (const marginChild of marginChildren) { - if (marginChild.offsetParent !== null) { - // clear the top margin so we recompute it - marginChild.style.marginTop = null; - const top = marginChild.getBoundingClientRect().top + window.scrollY; - if (top < lastBottom) { - const marginChildStyle = window.getComputedStyle(marginChild); - const marginBottom = parseFloat(marginChildStyle["marginBottom"]); - const margin = lastBottom - top + marginBottom; - marginChild.style.marginTop = `${margin}px`; - } - const styles = window.getComputedStyle(marginChild); - const marginTop = parseFloat(styles["marginTop"]); - lastBottom = top + marginChild.getBoundingClientRect().height + marginTop; - } - } -}; - -window.document.addEventListener("DOMContentLoaded", function (_event) { - // Recompute the position of margin elements anytime the body size changes - if (window.ResizeObserver) { - const resizeObserver = new window.ResizeObserver( - throttle(() => { - layoutMarginEls(); - if ( - window.document.body.getBoundingClientRect().width < 990 && - isReaderMode() - ) { - quartoToggleReader(); - } - }, 50) - ); - resizeObserver.observe(window.document.body); - } - - const tocEl = window.document.querySelector('nav.toc-active[role="doc-toc"]'); - const sidebarEl = window.document.getElementById("quarto-sidebar"); - const leftTocEl = window.document.getElementById("quarto-sidebar-toc-left"); - const marginSidebarEl = window.document.getElementById( - "quarto-margin-sidebar" - ); - // function to determine whether the element has a previous sibling that is active - const prevSiblingIsActiveLink = (el) => { - const sibling = el.previousElementSibling; - if (sibling && sibling.tagName === "A") { - return sibling.classList.contains("active"); - } else { - return false; - } - }; - - // fire slideEnter for bootstrap tab activations (for htmlwidget resize behavior) - function fireSlideEnter(e) { - const event = window.document.createEvent("Event"); - event.initEvent("slideenter", true, true); - window.document.dispatchEvent(event); - } - const tabs = window.document.querySelectorAll('a[data-bs-toggle="tab"]'); - tabs.forEach((tab) => { - tab.addEventListener("shown.bs.tab", fireSlideEnter); - }); - - // fire slideEnter for tabby tab activations (for htmlwidget resize behavior) - document.addEventListener("tabby", fireSlideEnter, false); - - // Track scrolling and mark TOC links as active - // get table of contents and sidebar (bail if we don't have at least one) - const tocLinks = tocEl - ? [...tocEl.querySelectorAll("a[data-scroll-target]")] - : []; - const makeActive = (link) => tocLinks[link].classList.add("active"); - const removeActive = (link) => tocLinks[link].classList.remove("active"); - const removeAllActive = () => - [...Array(tocLinks.length).keys()].forEach((link) => removeActive(link)); - - // activate the anchor for a section associated with this TOC entry - tocLinks.forEach((link) => { - link.addEventListener("click", () => { - if (link.href.indexOf("#") !== -1) { - const anchor = link.href.split("#")[1]; - const heading = window.document.querySelector( - `[data-anchor-id=${anchor}]` - ); - if (heading) { - // Add the class - heading.classList.add("reveal-anchorjs-link"); - - // function to show the anchor - const handleMouseout = () => { - heading.classList.remove("reveal-anchorjs-link"); - heading.removeEventListener("mouseout", handleMouseout); - }; - - // add a function to clear the anchor when the user mouses out of it - heading.addEventListener("mouseout", handleMouseout); - } - } - }); - }); - - const sections = tocLinks.map((link) => { - const target = link.getAttribute("data-scroll-target"); - if (target.startsWith("#")) { - return window.document.getElementById(decodeURI(`${target.slice(1)}`)); - } else { - return window.document.querySelector(decodeURI(`${target}`)); - } - }); - - const sectionMargin = 200; - let currentActive = 0; - // track whether we've initialized state the first time - let init = false; - - const updateActiveLink = () => { - // The index from bottom to top (e.g. reversed list) - let sectionIndex = -1; - if ( - window.innerHeight + window.pageYOffset >= - window.document.body.offsetHeight - ) { - sectionIndex = 0; - } else { - sectionIndex = [...sections].reverse().findIndex((section) => { - if (section) { - return window.pageYOffset >= section.offsetTop - sectionMargin; - } else { - return false; - } - }); - } - if (sectionIndex > -1) { - const current = sections.length - sectionIndex - 1; - if (current !== currentActive) { - removeAllActive(); - currentActive = current; - makeActive(current); - if (init) { - window.dispatchEvent(sectionChanged); - } - init = true; - } - } - }; - - const inHiddenRegion = (top, bottom, hiddenRegions) => { - for (const region of hiddenRegions) { - if (top <= region.bottom && bottom >= region.top) { - return true; - } - } - return false; - }; - - const categorySelector = "header.quarto-title-block .quarto-category"; - const activateCategories = (href) => { - // Find any categories - // Surround them with a link pointing back to: - // #category=Authoring - try { - const categoryEls = window.document.querySelectorAll(categorySelector); - for (const categoryEl of categoryEls) { - const categoryText = categoryEl.textContent; - if (categoryText) { - const link = `${href}#category=${encodeURIComponent(categoryText)}`; - const linkEl = window.document.createElement("a"); - linkEl.setAttribute("href", link); - for (const child of categoryEl.childNodes) { - linkEl.append(child); - } - categoryEl.appendChild(linkEl); - } - } - } catch { - // Ignore errors - } - }; - function hasTitleCategories() { - return window.document.querySelector(categorySelector) !== null; - } - - function offsetRelativeUrl(url) { - const offset = getMeta("quarto:offset"); - return offset ? offset + url : url; - } - - function offsetAbsoluteUrl(url) { - const offset = getMeta("quarto:offset"); - const baseUrl = new URL(offset, window.location); - - const projRelativeUrl = url.replace(baseUrl, ""); - if (projRelativeUrl.startsWith("/")) { - return projRelativeUrl; - } else { - return "/" + projRelativeUrl; - } - } - - // read a meta tag value - function getMeta(metaName) { - const metas = window.document.getElementsByTagName("meta"); - for (let i = 0; i < metas.length; i++) { - if (metas[i].getAttribute("name") === metaName) { - return metas[i].getAttribute("content"); - } - } - return ""; - } - - async function findAndActivateCategories() { - const currentPagePath = offsetAbsoluteUrl(window.location.href); - const response = await fetch(offsetRelativeUrl("listings.json")); - if (response.status == 200) { - return response.json().then(function (listingPaths) { - const listingHrefs = []; - for (const listingPath of listingPaths) { - const pathWithoutLeadingSlash = listingPath.listing.substring(1); - for (const item of listingPath.items) { - if ( - item === currentPagePath || - item === currentPagePath + "index.html" - ) { - // Resolve this path against the offset to be sure - // we already are using the correct path to the listing - // (this adjusts the listing urls to be rooted against - // whatever root the page is actually running against) - const relative = offsetRelativeUrl(pathWithoutLeadingSlash); - const baseUrl = window.location; - const resolvedPath = new URL(relative, baseUrl); - listingHrefs.push(resolvedPath.pathname); - break; - } - } - } - - // Look up the tree for a nearby linting and use that if we find one - const nearestListing = findNearestParentListing( - offsetAbsoluteUrl(window.location.pathname), - listingHrefs - ); - if (nearestListing) { - activateCategories(nearestListing); - } else { - // See if the referrer is a listing page for this item - const referredRelativePath = offsetAbsoluteUrl(document.referrer); - const referrerListing = listingHrefs.find((listingHref) => { - const isListingReferrer = - listingHref === referredRelativePath || - listingHref === referredRelativePath + "index.html"; - return isListingReferrer; - }); - - if (referrerListing) { - // Try to use the referrer if possible - activateCategories(referrerListing); - } else if (listingHrefs.length > 0) { - // Otherwise, just fall back to the first listing - activateCategories(listingHrefs[0]); - } - } - }); - } - } - if (hasTitleCategories()) { - findAndActivateCategories(); - } - - const findNearestParentListing = (href, listingHrefs) => { - if (!href || !listingHrefs) { - return undefined; - } - // Look up the tree for a nearby linting and use that if we find one - const relativeParts = href.substring(1).split("/"); - while (relativeParts.length > 0) { - const path = relativeParts.join("/"); - for (const listingHref of listingHrefs) { - if (listingHref.startsWith(path)) { - return listingHref; - } - } - relativeParts.pop(); - } - - return undefined; - }; - - const manageSidebarVisiblity = (el, placeholderDescriptor) => { - let isVisible = true; - let elRect; - - return (hiddenRegions) => { - if (el === null) { - return; - } - - // Find the last element of the TOC - const lastChildEl = el.lastElementChild; - - if (lastChildEl) { - // Converts the sidebar to a menu - const convertToMenu = () => { - for (const child of el.children) { - child.style.opacity = 0; - child.style.overflow = "hidden"; - } - - nexttick(() => { - const toggleContainer = window.document.createElement("div"); - toggleContainer.style.width = "100%"; - toggleContainer.classList.add("zindex-over-content"); - toggleContainer.classList.add("quarto-sidebar-toggle"); - toggleContainer.classList.add("headroom-target"); // Marks this to be managed by headeroom - toggleContainer.id = placeholderDescriptor.id; - toggleContainer.style.position = "fixed"; - - const toggleIcon = window.document.createElement("i"); - toggleIcon.classList.add("quarto-sidebar-toggle-icon"); - toggleIcon.classList.add("bi"); - toggleIcon.classList.add("bi-caret-down-fill"); - - const toggleTitle = window.document.createElement("div"); - const titleEl = window.document.body.querySelector( - placeholderDescriptor.titleSelector - ); - if (titleEl) { - toggleTitle.append( - titleEl.textContent || titleEl.innerText, - toggleIcon - ); - } - toggleTitle.classList.add("zindex-over-content"); - toggleTitle.classList.add("quarto-sidebar-toggle-title"); - toggleContainer.append(toggleTitle); - - const toggleContents = window.document.createElement("div"); - toggleContents.classList = el.classList; - toggleContents.classList.add("zindex-over-content"); - toggleContents.classList.add("quarto-sidebar-toggle-contents"); - for (const child of el.children) { - if (child.id === "toc-title") { - continue; - } - - const clone = child.cloneNode(true); - clone.style.opacity = 1; - clone.style.display = null; - toggleContents.append(clone); - } - toggleContents.style.height = "0px"; - const positionToggle = () => { - // position the element (top left of parent, same width as parent) - if (!elRect) { - elRect = el.getBoundingClientRect(); - } - toggleContainer.style.left = `${elRect.left}px`; - toggleContainer.style.top = `${elRect.top}px`; - toggleContainer.style.width = `${elRect.width}px`; - }; - positionToggle(); - - toggleContainer.append(toggleContents); - el.parentElement.prepend(toggleContainer); - - // Process clicks - let tocShowing = false; - // Allow the caller to control whether this is dismissed - // when it is clicked (e.g. sidebar navigation supports - // opening and closing the nav tree, so don't dismiss on click) - const clickEl = placeholderDescriptor.dismissOnClick - ? toggleContainer - : toggleTitle; - - const closeToggle = () => { - if (tocShowing) { - toggleContainer.classList.remove("expanded"); - toggleContents.style.height = "0px"; - tocShowing = false; - } - }; - - // Get rid of any expanded toggle if the user scrolls - window.document.addEventListener( - "scroll", - throttle(() => { - closeToggle(); - }, 50) - ); - - // Handle positioning of the toggle - window.addEventListener( - "resize", - throttle(() => { - elRect = undefined; - positionToggle(); - }, 50) - ); - - window.addEventListener("quarto-hrChanged", () => { - elRect = undefined; - }); - - // Process the click - clickEl.onclick = () => { - if (!tocShowing) { - toggleContainer.classList.add("expanded"); - toggleContents.style.height = null; - tocShowing = true; - } else { - closeToggle(); - } - }; - }); - }; - - // Converts a sidebar from a menu back to a sidebar - const convertToSidebar = () => { - for (const child of el.children) { - child.style.opacity = 1; - child.style.overflow = null; - } - - const placeholderEl = window.document.getElementById( - placeholderDescriptor.id - ); - if (placeholderEl) { - placeholderEl.remove(); - } - - el.classList.remove("rollup"); - }; - - if (isReaderMode()) { - convertToMenu(); - isVisible = false; - } else { - // Find the top and bottom o the element that is being managed - const elTop = el.offsetTop; - const elBottom = - elTop + lastChildEl.offsetTop + lastChildEl.offsetHeight; - - if (!isVisible) { - // If the element is current not visible reveal if there are - // no conflicts with overlay regions - if (!inHiddenRegion(elTop, elBottom, hiddenRegions)) { - convertToSidebar(); - isVisible = true; - } - } else { - // If the element is visible, hide it if it conflicts with overlay regions - // and insert a placeholder toggle (or if we're in reader mode) - if (inHiddenRegion(elTop, elBottom, hiddenRegions)) { - convertToMenu(); - isVisible = false; - } - } - } - } - }; - }; - - const tabEls = document.querySelectorAll('a[data-bs-toggle="tab"]'); - for (const tabEl of tabEls) { - const id = tabEl.getAttribute("data-bs-target"); - if (id) { - const columnEl = document.querySelector( - `${id} .column-margin, .tabset-margin-content` - ); - if (columnEl) - tabEl.addEventListener("shown.bs.tab", function (event) { - const el = event.srcElement; - if (el) { - const visibleCls = `${el.id}-margin-content`; - // walk up until we find a parent tabset - let panelTabsetEl = el.parentElement; - while (panelTabsetEl) { - if (panelTabsetEl.classList.contains("panel-tabset")) { - break; - } - panelTabsetEl = panelTabsetEl.parentElement; - } - - if (panelTabsetEl) { - const prevSib = panelTabsetEl.previousElementSibling; - if ( - prevSib && - prevSib.classList.contains("tabset-margin-container") - ) { - const childNodes = prevSib.querySelectorAll( - ".tabset-margin-content" - ); - for (const childEl of childNodes) { - if (childEl.classList.contains(visibleCls)) { - childEl.classList.remove("collapse"); - } else { - childEl.classList.add("collapse"); - } - } - } - } - } - - layoutMarginEls(); - }); - } - } - - // Manage the visibility of the toc and the sidebar - const marginScrollVisibility = manageSidebarVisiblity(marginSidebarEl, { - id: "quarto-toc-toggle", - titleSelector: "#toc-title", - dismissOnClick: true, - }); - const sidebarScrollVisiblity = manageSidebarVisiblity(sidebarEl, { - id: "quarto-sidebarnav-toggle", - titleSelector: ".title", - dismissOnClick: false, - }); - let tocLeftScrollVisibility; - if (leftTocEl) { - tocLeftScrollVisibility = manageSidebarVisiblity(leftTocEl, { - id: "quarto-lefttoc-toggle", - titleSelector: "#toc-title", - dismissOnClick: true, - }); - } - - // Find the first element that uses formatting in special columns - const conflictingEls = window.document.body.querySelectorAll( - '[class^="column-"], [class*=" column-"], aside, [class*="margin-caption"], [class*=" margin-caption"], [class*="margin-ref"], [class*=" margin-ref"]' - ); - - // Filter all the possibly conflicting elements into ones - // the do conflict on the left or ride side - const arrConflictingEls = Array.from(conflictingEls); - const leftSideConflictEls = arrConflictingEls.filter((el) => { - if (el.tagName === "ASIDE") { - return false; - } - return Array.from(el.classList).find((className) => { - return ( - className !== "column-body" && - className.startsWith("column-") && - !className.endsWith("right") && - !className.endsWith("container") && - className !== "column-margin" - ); - }); - }); - const rightSideConflictEls = arrConflictingEls.filter((el) => { - if (el.tagName === "ASIDE") { - return true; - } - - const hasMarginCaption = Array.from(el.classList).find((className) => { - return className == "margin-caption"; - }); - if (hasMarginCaption) { - return true; - } - - return Array.from(el.classList).find((className) => { - return ( - className !== "column-body" && - !className.endsWith("container") && - className.startsWith("column-") && - !className.endsWith("left") - ); - }); - }); - - const kOverlapPaddingSize = 10; - function toRegions(els) { - return els.map((el) => { - const boundRect = el.getBoundingClientRect(); - const top = - boundRect.top + - document.documentElement.scrollTop - - kOverlapPaddingSize; - return { - top, - bottom: top + el.scrollHeight + 2 * kOverlapPaddingSize, - }; - }); - } - - let hasObserved = false; - const visibleItemObserver = (els) => { - let visibleElements = [...els]; - const intersectionObserver = new IntersectionObserver( - (entries, _observer) => { - entries.forEach((entry) => { - if (entry.isIntersecting) { - if (visibleElements.indexOf(entry.target) === -1) { - visibleElements.push(entry.target); - } - } else { - visibleElements = visibleElements.filter((visibleEntry) => { - return visibleEntry !== entry; - }); - } - }); - - if (!hasObserved) { - hideOverlappedSidebars(); - } - hasObserved = true; - }, - {} - ); - els.forEach((el) => { - intersectionObserver.observe(el); - }); - - return { - getVisibleEntries: () => { - return visibleElements; - }, - }; - }; - - const rightElementObserver = visibleItemObserver(rightSideConflictEls); - const leftElementObserver = visibleItemObserver(leftSideConflictEls); - - const hideOverlappedSidebars = () => { - marginScrollVisibility(toRegions(rightElementObserver.getVisibleEntries())); - sidebarScrollVisiblity(toRegions(leftElementObserver.getVisibleEntries())); - if (tocLeftScrollVisibility) { - tocLeftScrollVisibility( - toRegions(leftElementObserver.getVisibleEntries()) - ); - } - }; - - window.quartoToggleReader = () => { - // Applies a slow class (or removes it) - // to update the transition speed - const slowTransition = (slow) => { - const manageTransition = (id, slow) => { - const el = document.getElementById(id); - if (el) { - if (slow) { - el.classList.add("slow"); - } else { - el.classList.remove("slow"); - } - } - }; - - manageTransition("TOC", slow); - manageTransition("quarto-sidebar", slow); - }; - const readerMode = !isReaderMode(); - setReaderModeValue(readerMode); - - // If we're entering reader mode, slow the transition - if (readerMode) { - slowTransition(readerMode); - } - highlightReaderToggle(readerMode); - hideOverlappedSidebars(); - - // If we're exiting reader mode, restore the non-slow transition - if (!readerMode) { - slowTransition(!readerMode); - } - }; - - const highlightReaderToggle = (readerMode) => { - const els = document.querySelectorAll(".quarto-reader-toggle"); - if (els) { - els.forEach((el) => { - if (readerMode) { - el.classList.add("reader"); - } else { - el.classList.remove("reader"); - } - }); - } - }; - - const setReaderModeValue = (val) => { - if (window.location.protocol !== "file:") { - window.localStorage.setItem("quarto-reader-mode", val); - } else { - localReaderMode = val; - } - }; - - const isReaderMode = () => { - if (window.location.protocol !== "file:") { - return window.localStorage.getItem("quarto-reader-mode") === "true"; - } else { - return localReaderMode; - } - }; - let localReaderMode = null; - - const tocOpenDepthStr = tocEl?.getAttribute("data-toc-expanded"); - const tocOpenDepth = tocOpenDepthStr ? Number(tocOpenDepthStr) : 1; - - // Walk the TOC and collapse/expand nodes - // Nodes are expanded if: - // - they are top level - // - they have children that are 'active' links - // - they are directly below an link that is 'active' - const walk = (el, depth) => { - // Tick depth when we enter a UL - if (el.tagName === "UL") { - depth = depth + 1; - } - - // It this is active link - let isActiveNode = false; - if (el.tagName === "A" && el.classList.contains("active")) { - isActiveNode = true; - } - - // See if there is an active child to this element - let hasActiveChild = false; - for (child of el.children) { - hasActiveChild = walk(child, depth) || hasActiveChild; - } - - // Process the collapse state if this is an UL - if (el.tagName === "UL") { - if (tocOpenDepth === -1 && depth > 1) { - el.classList.add("collapse"); - } else if ( - depth <= tocOpenDepth || - hasActiveChild || - prevSiblingIsActiveLink(el) - ) { - el.classList.remove("collapse"); - } else { - el.classList.add("collapse"); - } - - // untick depth when we leave a UL - depth = depth - 1; - } - return hasActiveChild || isActiveNode; - }; - - // walk the TOC and expand / collapse any items that should be shown - - if (tocEl) { - walk(tocEl, 0); - updateActiveLink(); - } - - // Throttle the scroll event and walk peridiocally - window.document.addEventListener( - "scroll", - throttle(() => { - if (tocEl) { - updateActiveLink(); - walk(tocEl, 0); - } - if (!isReaderMode()) { - hideOverlappedSidebars(); - } - }, 5) - ); - window.addEventListener( - "resize", - throttle(() => { - if (!isReaderMode()) { - hideOverlappedSidebars(); - } - }, 10) - ); - hideOverlappedSidebars(); - highlightReaderToggle(isReaderMode()); -}); - -// grouped tabsets -window.addEventListener("pageshow", (_event) => { - function getTabSettings() { - const data = localStorage.getItem("quarto-persistent-tabsets-data"); - if (!data) { - localStorage.setItem("quarto-persistent-tabsets-data", "{}"); - return {}; - 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