diff --git a/src/backend/commands/async.c b/src/backend/commands/async.c
index 4b16fb56825..1d3e2602220 100644
--- a/src/backend/commands/async.c
+++ b/src/backend/commands/async.c
@@ -144,6 +144,9 @@
 #include "utils/snapmgr.h"
 #include "utils/timestamp.h"
 
+#ifdef EMSCRIPTEN
+#include <emscripten.h>
+#endif
 
 /*
  * Maximum size of a NOTIFY payload, including terminating NULL.  This
@@ -1676,6 +1679,12 @@ SignalBackends(void)
 	BackendId  *ids;
 	int			count;
 
+	#ifdef EMSCRIPTEN
+	// With PGlite we call HandleNotifyInterrupt() directly
+	HandleNotifyInterrupt();
+	return;
+	#endif
+
 	/*
 	 * Identify backends that we need to signal.  We don't want to send
 	 * signals while holding the NotifyQueueLock, so this loop just builds a