diff --git a/enable/wx/base_window.py b/enable/wx/base_window.py
index f53106007..0fe74adf6 100644
--- a/enable/wx/base_window.py
+++ b/enable/wx/base_window.py
@@ -177,6 +177,10 @@ def __init__(self, parent, wid=-1, pos=wx.DefaultPosition,
         # Create the delegate:
         self.control = control = self._create_control(parent, wid, pos, size)
 
+        # Figure out the pixel scale factor
+        if self.high_resolution:
+            self.base_pixel_scale = self.control.GetContentScaleFactor()
+
         # Set up the 'erase background' event handler:
         control.Bind(wx.EVT_ERASE_BACKGROUND, self._on_erase_background)
 
@@ -263,7 +267,8 @@ def _on_close(self, event):
     def _flip_y(self, y):
         """ Convert from a Kiva to a wxPython y coordinate
         """
-        return int(self._size[1] - 1 - y)
+        # Handle the device pixel ratio adjustment here
+        return int(self._size[1] / self.base_pixel_scale - 1 - y)
 
     def _on_erase_background(self, event):
         pass
@@ -325,7 +330,7 @@ def _create_key_event(self, event_type, event):
 
         if focus_owner is not None:
             if event_type == "character":
-                key = chr(event.GetUniChar())
+                key = chr(event.GetUnicodeKey())
                 if not key:
                     return None
             else:
@@ -333,7 +338,7 @@ def _create_key_event(self, event_type, event):
                 if key_code in KEY_MAP:
                     key = KEY_MAP.get(key_code)
                 else:
-                    key = chr(event.GetUniChar()).lower()
+                    key = chr(event.GetUnicodeKey()).lower()
 
             # Use the last-seen mouse coordinates instead of GetX/GetY due
             # to wx bug.
@@ -439,7 +444,7 @@ def _get_control_size(self):
         """
         result = None
         if self.control:
-            result = self.control.GetSize()
+            result = self.control.GetSize() * self.base_pixel_scale
         return result
 
     def _window_paint(self, event):
@@ -451,8 +456,8 @@ def set_pointer(self, pointer):
         """ Set the current pointer (i.e. cursor) shape
         """
         ptr = POINTER_MAP[pointer]
-        if type(ptr) is int:
-            POINTER_MAP[pointer] = ptr = wx.StockCursor(ptr)
+        if isinstance(ptr, type(wx.CURSOR_ARROW)):
+            POINTER_MAP[pointer] = ptr = wx.Cursor(ptr)
         self.control.SetCursor(ptr)
 
     def set_tooltip(self, tooltip):
diff --git a/enable/wx/cairo.py b/enable/wx/cairo.py
index 299e6cbfb..135de251b 100644
--- a/enable/wx/cairo.py
+++ b/enable/wx/cairo.py
@@ -22,7 +22,10 @@
 class Window(BaseWindow):
     def _create_gc(self, size, pix_format="bgra32"):
         "Create a Kiva graphics context of a specified size"
-        gc = GraphicsContext((size[0] + 1, size[1] + 1))
+        gc = GraphicsContext(
+            (size[0] + 1, size[1] + 1),
+            base_pixel_scale=self.base_pixel_scale,
+        )
         gc.translate_ctm(0.5, 0.5)
         return gc
 
diff --git a/enable/wx/gl.py b/enable/wx/gl.py
index dab2e45a1..4eecf94ec 100644
--- a/enable/wx/gl.py
+++ b/enable/wx/gl.py
@@ -43,7 +43,10 @@ def _create_control(self, parent, wid, pos=wx.DefaultPosition,
     def _create_gc(self, size, pix_format=None):
         """ Create a GraphicsContext instance.
         """
-        gc = GraphicsContext((size[0] + 1, size[1] + 1))
+        gc = GraphicsContext(
+            (size[0] + 1, size[1] + 1),
+            base_pixel_scale=self.base_pixel_scale,
+        )
         if self._pyglet_gl_context is None:
             self._pyglet_gl_context = FakePygletContext()
         gc.gl_init()
diff --git a/enable/wx/image.py b/enable/wx/image.py
index bb38f97ef..e8a52af50 100644
--- a/enable/wx/image.py
+++ b/enable/wx/image.py
@@ -28,7 +28,7 @@ def _wx_bitmap_from_buffer(buf, width, height):
     copy[..., 1::4] = arr[..., 1::4]
     copy[..., 2::4] = arr[..., 0::4]
     copy[..., 3::4] = arr[..., 3::4]
-    return wx.BitmapFromBufferRGBA(width, height, np.ravel(copy))
+    return wx.Bitmap.FromBufferRGBA(width, height, np.ravel(copy))
 
 
 class Window(BaseWindow):
@@ -41,6 +41,7 @@ def _create_gc(self, size, pix_format="bgra32"):
         gc = GraphicsContext(
             (size[0] + 1, size[1] + 1),
             pix_format=pix_format,
+            base_pixel_scale=self.base_pixel_scale,
             bottom_up=bottom_up,
         )
         gc.translate_ctm(0.5, 0.5)
@@ -65,6 +66,7 @@ def _window_paint(self, event):
                 self._gc.width(),
                 self._gc.height(),
             )
+            bmp.SetSize(control.GetSize())
             wdc.DrawBitmap(bmp, 0, 0)
 
         control._dc = None
diff --git a/enable/wx/quartz.py b/enable/wx/quartz.py
index 50a02be93..8283a1aa9 100644
--- a/enable/wx/quartz.py
+++ b/enable/wx/quartz.py
@@ -87,9 +87,7 @@ class Window(BaseWindow):
 
     def _create_gc(self, size, pix_format="bgra32"):
         self.dc = wx.ClientDC(self.control)
-        gc = _WindowGraphicsContext(
-            self.dc.GetSizeTuple(), get_macport(self.dc)
-        )
+        gc = _WindowGraphicsContext(self.dc.GetSize(), get_macport(self.dc))
         gc.begin()
         return gc
 
diff --git a/kiva/cairo.py b/kiva/cairo.py
index d9600dcd7..e6ba64aad 100644
--- a/kiva/cairo.py
+++ b/kiva/cairo.py
@@ -97,6 +97,8 @@ def draw_to_wxwindow(self, window, x, y):
         image = wx.EmptyImage(self.width, self.height)
         image.SetDataBuffer(arr.data)
         bmp = wx.BitmapFromImage(image, depth=-1)
+        # Scale HiDPI images to fit window
+        bmp.SetSize(window.GetSize())
 
         window_dc.BeginDrawing()
         window_dc.DrawBitmap(bmp, x, y)