diff --git a/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Cml-files/cml-files.spec.ts b/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Cml-files/cml-files.spec.ts
index 09df163388..9c52804aa5 100644
--- a/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Cml-files/cml-files.spec.ts
+++ b/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Cml-files/cml-files.spec.ts
@@ -109,34 +109,31 @@ test.describe('CML files', () => {
     expect(cmlFile).toEqual(cmlFileExpected);
   });
 
-  test.fail(
-    'Open and Save file - CML - CML for R-group and other features',
-    async ({ page }) => {
-      /**
-       * Test case: EPMLSOPKET-1948
-       * Description: Saved cml file with structure is compering with paste R-group from a mol file
-       * It needs to be investigated why the test is failing.
-       * We have bug https://github.com/epam/Indigo/issues/2497
-       */
-
-      await openFileAddToCanvasTakeScreenshot(
-        page,
-        'Molfiles-V2000/cml-1948-R-group.mol',
-      );
-      // check that structure opened from file is displayed correctly
+  test('Open and Save file - CML - CML for R-group and other features', async ({
+    page,
+  }) => {
+    /**
+     * Test case: EPMLSOPKET-1948
+     * Description: Saved cml file with structure is compering with paste R-group from a mol file
+     */
 
-      const expectedFile = await getCml(page);
-      await saveToFile('CML/cml-1948-r-group-expected.cml', expectedFile);
-      const { file: cmlFile, fileExpected: cmlFileExpected } =
-        await receiveFileComparisonData({
-          page,
-          expectedFileName: 'tests/test-data/CML/cml-1948-r-group-expected.cml',
-        });
-      // comparing cml file with golden cml file
+    await openFileAddToCanvasTakeScreenshot(
+      page,
+      'Molfiles-V2000/cml-1948-R-group.mol',
+    );
+    // check that structure opened from file is displayed correctly
 
-      expect(cmlFile).toEqual(cmlFileExpected);
-    },
-  );
+    const expectedFile = await getCml(page);
+    await saveToFile('CML/cml-1948-r-group-expected.cml', expectedFile);
+    const { file: cmlFile, fileExpected: cmlFileExpected } =
+      await receiveFileComparisonData({
+        page,
+        expectedFileName: 'tests/test-data/CML/cml-1948-r-group-expected.cml',
+      });
+    // comparing cml file with golden cml file
+
+    expect(cmlFile).toEqual(cmlFileExpected);
+  });
 
   test('Validate that unsplit nucleotides connected with peptides could be saved to CML file and loaded back', async ({
     page,
diff --git a/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Save-File/save-file.spec.ts b/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Save-File/save-file.spec.ts
index 39e3a66cc2..ae4039de2c 100644
--- a/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Save-File/save-file.spec.ts
+++ b/ketcher-autotests/tests/File-Management/Open-And-Save-Files/Save-File/save-file.spec.ts
@@ -178,35 +178,33 @@ test.describe('Save files', () => {
     },
   );
 
-  test.fail(
-    'Automatic selection of MDL Molfile v3000 encoding is work if the number of atoms (or bonds) exceeds 999',
-    async ({ page }) => {
-      /**
-       * IMPORTANT: Test fails because we have bug https://github.com/epam/Indigo/issues/2494
-       * Test case: EPMLSOPKET-5260
-       * Description: Structure is saved according to automated selected format MDL Molfile v3000
-       */
-
-      await openFileAndAddToCanvas(
-        'Molfiles-V3000/structure-where-atoms-exceeds999.mol',
+  test('Automatic selection of MDL Molfile v3000 encoding is work if the number of atoms (or bonds) exceeds 999', async ({
+    page,
+  }) => {
+    /**
+     * Test case: EPMLSOPKET-5260
+     * Description: Structure is saved according to automated selected format MDL Molfile v3000
+     */
+
+    await openFileAndAddToCanvas(
+      'Molfiles-V3000/structure-where-atoms-exceeds999.mol',
+      page,
+    );
+    const expectedFile = await getMolfile(page);
+    await saveToFile(
+      'Molfiles-V3000/structure-where-atoms-exceeds999-expected.mol',
+      expectedFile,
+    );
+    const METADATA_STRING_INDEX = [1];
+    const { fileExpected: molFileExpected, file: molFile } =
+      await receiveFileComparisonData({
         page,
-      );
-      const expectedFile = await getMolfile(page);
-      await saveToFile(
-        'Molfiles-V3000/structure-where-atoms-exceeds999-expected.mol',
-        expectedFile,
-      );
-      const METADATA_STRING_INDEX = [1];
-      const { fileExpected: molFileExpected, file: molFile } =
-        await receiveFileComparisonData({
-          page,
-          expectedFileName:
-            'tests/test-data/Molfiles-V3000/structure-where-atoms-exceeds999-expected.mol',
-          metaDataIndexes: METADATA_STRING_INDEX,
-        });
-      expect(molFile).toEqual(molFileExpected);
-    },
-  );
+        expectedFileName:
+          'tests/test-data/Molfiles-V3000/structure-where-atoms-exceeds999-expected.mol',
+        metaDataIndexes: METADATA_STRING_INDEX,
+      });
+    expect(molFile).toEqual(molFileExpected);
+  });
 
   test('The file formats in the Save Structure window match the mockup', async ({
     page,