diff --git a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/add-default-presets.spec.ts b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/add-default-presets.spec.ts
index 4bcbbbf1dc..0216031b35 100644
--- a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/add-default-presets.spec.ts
+++ b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/add-default-presets.spec.ts
@@ -5,11 +5,14 @@ import {
   takePageScreenshot,
   waitForPageInit,
 } from '@utils';
+import { toggleRnaBuilderAccordion } from '@utils/macromolecules/rnaBuilder';
 
 test.describe('Macromolecules default presets', () => {
   test.beforeEach(async ({ page }) => {
     await waitForPageInit(page);
     await turnOnMacromoleculesEditor(page);
+    await page.getByText('RNA').click();
+    await toggleRnaBuilderAccordion(page);
   });
 
   test('Check Guanine in default presets', async ({ page }) => {
@@ -17,9 +20,6 @@ test.describe('Macromolecules default presets', () => {
     Test case: #2934 - rna builder: add default presets
     Description: Switch to Polymer Editor
     */
-    await page.getByText('RNA').click();
-
-    await page.getByTestId('cancel-btn').click();
     await page.getByTestId('G_G_R_P').click();
     await takePageScreenshot(page);
   });
@@ -28,9 +28,6 @@ test.describe('Macromolecules default presets', () => {
     /* 
     Test case: #2507 - Add RNA monomers to canvas (by click)
     */
-    await page.getByText('RNA').click();
-    await page.getByTestId('cancel-btn').click();
-
     await page.click('[data-testid="G_G_R_P"]');
 
     await page.click('#polymer-editor-canvas');
diff --git a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts
index 59c3b2fc6f..32f8ccc2cc 100644
--- a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts
+++ b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts
@@ -3,10 +3,12 @@ import { RNA_TAB } from '@constants/testIdConstants';
 import { waitForPageInit } from '@utils/common';
 import { takePageScreenshot } from '@utils';
 import { turnOnMacromoleculesEditor } from '@utils/macromolecules';
+import { toggleRnaBuilderAccordion } from '@utils/macromolecules/rnaBuilder';
 
 async function gotoRNA(page: Page) {
   await turnOnMacromoleculesEditor(page);
   await page.getByTestId(RNA_TAB).click();
+  await toggleRnaBuilderAccordion(page);
 }
 
 test.describe('Macromolecules delete RNA presets', () => {
@@ -20,21 +22,15 @@ test.describe('Macromolecules delete RNA presets', () => {
   });
 
   test('Should not delete default RNA preset', async ({ page }) => {
-    await page.getByTestId('cancel-btn').click();
-
     await page.getByTestId('A_A_R_P').click({ button: 'right' });
   });
 
   test('Delete copy RNA preset', async ({ page }) => {
-    await page.getByTestId('cancel-btn').click();
-
     await page.getByTestId('A_A_R_P').click({ button: 'right' });
 
-    const duplicateAndEditButton = await page.getByTestId('duplicateandedit');
-    await duplicateAndEditButton.click();
-    await duplicateAndEditButton.waitFor({ state: 'hidden' });
+    await page.getByTestId('duplicateandedit').click();
+    await page.getByTestId('save-btn').click();
 
-    await page.getByTestId('A_Copy_A_R_P').click();
     await page.getByTestId('A_Copy_A_R_P').click({ button: 'right' });
 
     await page.getByTestId('deletepreset').click();
diff --git a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-1-chromium-linux.png b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-1-chromium-linux.png
index 6de147ebf0..3e6e992b2e 100644
Binary files a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-1-chromium-linux.png and b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-1-chromium-linux.png differ
diff --git a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-2-chromium-linux.png b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-2-chromium-linux.png
index 707ee07d49..e7b85c6b58 100644
Binary files a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-2-chromium-linux.png and b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Delete-copy-RNA-preset-2-chromium-linux.png differ
diff --git a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Should-not-delete-default-RNA-preset-1-chromium-linux.png b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Should-not-delete-default-RNA-preset-1-chromium-linux.png
index cc067382ad..a04bb4bff0 100644
Binary files a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Should-not-delete-default-RNA-preset-1-chromium-linux.png and b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/delete-preset.spec.ts-snapshots/Macromolecules-delete-RNA-presets-Should-not-delete-default-RNA-preset-1-chromium-linux.png differ
diff --git a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/rna-layout.spec.ts b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/rna-layout.spec.ts
index 42084ef842..318db106ec 100644
--- a/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/rna-layout.spec.ts
+++ b/ketcher-autotests/tests/Macromolecule-editor/RNAEditor/rna-layout.spec.ts
@@ -3,6 +3,7 @@ import { RNA_TAB } from '@constants/testIdConstants';
 import { waitForPageInit } from '@utils/common';
 import { takePageScreenshot } from '@utils';
 import { turnOnMacromoleculesEditor } from '@utils/macromolecules';
+import { toggleRnaBuilderAccordion } from '@utils/macromolecules/rnaBuilder';
 
 /* 
 Test case: #3063 - Add e2e tests for Macromolecule editor
@@ -10,6 +11,7 @@ Test case: #3063 - Add e2e tests for Macromolecule editor
 async function createRNA(page: Page) {
   await turnOnMacromoleculesEditor(page);
   await page.getByTestId(RNA_TAB).click();
+  await toggleRnaBuilderAccordion(page);
   await page.fill('[placeholder="Name your structure"]', 'MyRNA');
   await page.press('[placeholder="Name your structure"]', 'Enter');
 }
@@ -30,6 +32,6 @@ test.describe('RNA layout', () => {
   });
 
   test('RNA Builder panel is collapsed', async ({ page }) => {
-    await page.getByText('RNA Builder').locator('button').click();
+    await toggleRnaBuilderAccordion(page);
   });
 });
diff --git a/ketcher-autotests/tests/utils/macromolecules/rnaBuilder.ts b/ketcher-autotests/tests/utils/macromolecules/rnaBuilder.ts
new file mode 100644
index 0000000000..cb5371b9ac
--- /dev/null
+++ b/ketcher-autotests/tests/utils/macromolecules/rnaBuilder.ts
@@ -0,0 +1,5 @@
+import { Page } from '@playwright/test';
+
+export async function toggleRnaBuilderAccordion(page: Page) {
+  await page.getByText('RNA Builder').locator('button').click();
+}
diff --git a/packages/ketcher-polymer-editor-react/src/components/contextMenu/RNAContextMenu.tsx b/packages/ketcher-polymer-editor-react/src/components/contextMenu/RNAContextMenu.tsx
index d4bb0e30a8..9a9a1d998f 100644
--- a/packages/ketcher-polymer-editor-react/src/components/contextMenu/RNAContextMenu.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/contextMenu/RNAContextMenu.tsx
@@ -3,12 +3,14 @@ import { openModal } from 'state/modal';
 import { useAppDispatch, useAppSelector } from 'hooks';
 import { ReactElement } from 'react';
 import { CONTEXT_MENU_ID } from './types';
-import { selectActivePreset } from 'state/rna-builder';
+import { selectActivePresetForContextMenu } from 'state/rna-builder';
 import { StyledMenu } from './styles';
 
 export const RNAContextMenu = () => {
   const dispatch = useAppDispatch();
-  const activePreset = useAppSelector(selectActivePreset);
+  const activePresetForContextMenu = useAppSelector(
+    selectActivePresetForContextMenu,
+  );
   const RNAMenus = [
     { name: 'duplicateandedit', title: 'Duplicate and Edit...' },
     { name: 'edit', title: 'Edit...', seperator: true },
@@ -16,7 +18,7 @@ export const RNAContextMenu = () => {
   ];
 
   const isItemDisabled = (name: string) => {
-    if (name === 'deletepreset' && activePreset?.default) {
+    if (name === 'deletepreset' && activePresetForContextMenu?.default) {
       return true;
     }
     return false;
@@ -25,10 +27,10 @@ export const RNAContextMenu = () => {
   const handleMenuChange = ({ id, props }: ItemParams) => {
     switch (id) {
       case 'duplicateandedit':
-        props.duplicatePreset();
+        props.duplicatePreset(activePresetForContextMenu);
         break;
       case 'edit':
-        props.activateEditMode();
+        props.editPreset(activePresetForContextMenu);
         break;
       case 'deletepreset':
         dispatch(openModal('delete'));
diff --git a/packages/ketcher-polymer-editor-react/src/components/modal/Delete/Delete.tsx b/packages/ketcher-polymer-editor-react/src/components/modal/Delete/Delete.tsx
index 43e9b404e7..0d3059536b 100644
--- a/packages/ketcher-polymer-editor-react/src/components/modal/Delete/Delete.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/modal/Delete/Delete.tsx
@@ -18,7 +18,7 @@ import { useCallback } from 'react';
 import { useAppDispatch, useAppSelector } from 'hooks';
 import {
   deletePreset,
-  selectActivePreset,
+  selectActivePresetForContextMenu,
   selectPresets,
   setActivePreset,
   setIsEditMode,
@@ -33,7 +33,9 @@ export interface Props {
 const Delete = ({ isModalOpen, onClose }: Props) => {
   const dispatch = useAppDispatch();
   const presets = useAppSelector(selectPresets);
-  const activePreset = useAppSelector(selectActivePreset);
+  const activePresetForContextMenu = useAppSelector(
+    selectActivePresetForContextMenu,
+  );
   const onCloseCallback = useCallback(() => {
     onClose();
   }, [onClose]);
@@ -44,7 +46,7 @@ const Delete = ({ isModalOpen, onClose }: Props) => {
 
   const deleteHandler = () => {
     onCloseCallback();
-    dispatch(deletePreset(activePreset));
+    dispatch(deletePreset(activePresetForContextMenu));
     dispatch(setIsEditMode(false));
     if (presets.length !== 0) {
       dispatch(setActivePreset(presets[0]));
@@ -60,7 +62,7 @@ const Delete = ({ isModalOpen, onClose }: Props) => {
       <Modal.Content>
         <div data-testid="delete-preset-popup-content">
           <div>You are about to delete</div>
-          <div>"{activePreset.name}" RNA preset.</div>
+          <div>"{activePresetForContextMenu.name}" RNA preset.</div>
           <div>This operation cannot be undone.</div>
         </div>
       </Modal.Content>
diff --git a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx
index ec5432dd69..7069a87051 100644
--- a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx
@@ -45,9 +45,11 @@ import {
   selectActivePreset,
   selectActivePresetMonomerGroup,
   selectActiveRnaBuilderItem,
+  selectIsActivePresetNewAndEmpty,
   selectIsEditMode,
   selectPresets,
   setActivePreset,
+  setActivePresetForContextMenu,
   setActivePresetMonomerGroup,
   setActiveRnaBuilderItem,
   setIsEditMode,
@@ -74,11 +76,7 @@ interface IGroupsDataItem {
   }[];
 }
 
-export const RnaAccordion = ({
-  libraryName,
-  duplicatePreset,
-  activateEditMode,
-}) => {
+export const RnaAccordion = ({ libraryName, duplicatePreset, editPreset }) => {
   const monomers = useAppSelector(selectFilteredMonomers);
   const items = selectMonomersInCategory(monomers, libraryName);
   const activeRnaBuilderItem = useAppSelector(selectActiveRnaBuilderItem);
@@ -87,6 +85,9 @@ export const RnaAccordion = ({
   const presets = useAppSelector(selectPresets);
   const isEditMode = useAppSelector(selectIsEditMode);
   const editor = useAppSelector(selectEditor);
+  const isActivePresetNewAndEmpty = useAppSelector(
+    selectIsActivePresetNewAndEmpty,
+  );
 
   const [expandedAccordion, setExpandedAccordion] =
     useState<RnaBuilderItem | null>(activeRnaBuilderItem);
@@ -143,12 +144,12 @@ export const RnaAccordion = ({
   };
 
   const handleContextMenu = (preset: IRnaPreset) => (event: MouseEvent) => {
-    dispatch(setActivePreset(preset));
+    dispatch(setActivePresetForContextMenu(preset));
     show({
       event,
       props: {
         duplicatePreset,
-        activateEditMode,
+        editPreset,
       },
     });
   };
@@ -170,6 +171,8 @@ export const RnaAccordion = ({
   const selectPreset = (preset: IRnaPreset) => {
     dispatch(setActivePreset(preset));
     editor.events.selectPreset.dispatch(preset);
+    if (preset === activePreset.presetInList) return;
+    dispatch(setIsEditMode(false));
   };
 
   const onClickNewPreset = () => {
@@ -216,7 +219,7 @@ export const RnaAccordion = ({
                 </ItemsContainer>
                 <RNAContextMenu />
               </GroupContainer>
-              {isEditMode && <DisabledArea />}
+              {isEditMode && !isActivePresetNewAndEmpty && <DisabledArea />}
             </DetailsContainer>
           ) : (
             <DetailsContainer>
diff --git a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaBuilder.tsx b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaBuilder.tsx
index f669c933c1..1b389a6227 100644
--- a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaBuilder.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaBuilder.tsx
@@ -49,11 +49,11 @@ export const RnaBuilder = ({ libraryName }) => {
     dispatch(setDefaultPresets(defaultPresets));
   }, [dispatch]);
 
-  const duplicatePreset = () => {
+  const duplicatePreset = (preset?: IRnaPreset) => {
     const duplicatedPreset = {
-      ...activePreset,
+      ...(preset || activePreset),
       presetInList: undefined,
-      name: `${activePreset.name}_Copy`,
+      name: `${preset?.name || activePreset.name}_Copy`,
       default: false,
     };
     dispatch(setActivePreset(duplicatedPreset));
@@ -66,6 +66,11 @@ export const RnaBuilder = ({ libraryName }) => {
     dispatch(setIsEditMode(true));
   };
 
+  const editPreset = (preset: IRnaPreset) => {
+    dispatch(setActivePreset(preset));
+    activateEditMode();
+  };
+
   return (
     <RnaBuilderContainer>
       <RnaEditor
@@ -75,7 +80,7 @@ export const RnaBuilder = ({ libraryName }) => {
       <RnaAccordion
         libraryName={libraryName}
         duplicatePreset={duplicatePreset}
-        activateEditMode={activateEditMode}
+        editPreset={editPreset}
       />
       <Modal isOpen={hasError} title="Error Message" onClose={closeErrorModal}>
         <Modal.Content>
diff --git a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx
index 28a3bd02f7..499e7ccb54 100644
--- a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx
@@ -65,22 +65,27 @@ export const RnaEditor = ({ duplicatePreset, activateEditMode }) => {
     dispatch(setIsEditModeAction(value));
   };
 
+  const [expanded, setExpanded] = useState(false);
+
   useEffect(() => {
-    if (activePreset) return;
+    if (activePreset) {
+      if (activePreset.name || isEditMode) setExpanded(true);
+      return;
+    }
 
     if (hasPresets) {
       dispatch(setActivePreset(presets[0]));
     } else {
       dispatch(createNewPreset());
       dispatch(setActiveRnaBuilderItem(RnaBuilderPresetsItem.Presets));
-      setIsEditMode(true);
     }
-  }, []);
-
-  const [expanded, setExpanded] = useState(true);
+  }, [activePreset]);
 
   const expandEditor = () => {
     setExpanded(!expanded);
+    if (!activePreset.presetInList) {
+      setIsEditMode(true);
+    }
   };
 
   useEffect(() => {
diff --git a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorCollapsed/RnaEditorCollapsed.tsx b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorCollapsed/RnaEditorCollapsed.tsx
index 39807d1e75..d006f66ca7 100644
--- a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorCollapsed/RnaEditorCollapsed.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorCollapsed/RnaEditorCollapsed.tsx
@@ -25,13 +25,13 @@ export const RnaEditorCollapsed = ({
   name,
   fullName,
 }: IRnaEditorCollapsedProps) => {
-  return (
+  return name || fullName ? (
     <RnaEditorCollapsedContainer>
       <TextContainer>
-        <MonomerName grey={!name && !fullName}>
-          {name || fullName || 'Untitled'}
-        </MonomerName>
+        <MonomerName grey={!name && !fullName}>{name || fullName}</MonomerName>
       </TextContainer>
     </RnaEditorCollapsedContainer>
+  ) : (
+    <></>
   );
 };
diff --git a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/monomerLibraryList/MonomerList.tsx b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/monomerLibraryList/MonomerList.tsx
index 42b4995491..c50d93a161 100644
--- a/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/monomerLibraryList/MonomerList.tsx
+++ b/packages/ketcher-polymer-editor-react/src/components/monomerLibrary/monomerLibraryList/MonomerList.tsx
@@ -38,7 +38,6 @@ export type Group = {
 const MonomerList = ({ onItemClick, libraryName }: IMonomerListProps) => {
   const monomers = useAppSelector(selectFilteredMonomers);
   const activeTool = useAppSelector(selectEditorActiveTool);
-
   const items =
     libraryName !== MONOMER_LIBRARY_FAVORITES
       ? selectMonomersInCategory(monomers, libraryName)
diff --git a/packages/ketcher-polymer-editor-react/src/state/rna-builder/rnaBuilderSlice.ts b/packages/ketcher-polymer-editor-react/src/state/rna-builder/rnaBuilderSlice.ts
index 8cb8ecdcca..b143049d56 100644
--- a/packages/ketcher-polymer-editor-react/src/state/rna-builder/rnaBuilderSlice.ts
+++ b/packages/ketcher-polymer-editor-react/src/state/rna-builder/rnaBuilderSlice.ts
@@ -32,6 +32,7 @@ interface IRnaBuilderState {
   activeRnaBuilderItem?: RnaBuilderItem | null;
   isEditMode: boolean;
   hasUniqueNameError: boolean;
+  activePresetForContextMenu: IRnaPreset | null;
 }
 
 const initialState: IRnaBuilderState = {
@@ -40,6 +41,7 @@ const initialState: IRnaBuilderState = {
   activeRnaBuilderItem: null,
   isEditMode: false,
   hasUniqueNameError: false,
+  activePresetForContextMenu: null,
 };
 export const monomerGroupToPresetGroup = {
   [MonomerGroups.BASES]: 'base',
@@ -65,6 +67,12 @@ export const rnaBuilderSlice = createSlice({
         presetInList: action.payload,
       };
     },
+    setActivePresetForContextMenu: (
+      state,
+      action: PayloadAction<IRnaPreset>,
+    ) => {
+      state.activePresetForContextMenu = action.payload;
+    },
     setActivePresetName: (state, action: PayloadAction<string>) => {
       state.activePreset!.name = action.payload;
     },
@@ -186,6 +194,22 @@ export const selectHasUniqueNameError = (state: RootState) => {
   return state.rnaBuilder.hasUniqueNameError;
 };
 
+export const selectIsActivePresetNewAndEmpty = (state: RootState): boolean => {
+  const activePreset = state.rnaBuilder.activePreset;
+  return (
+    activePreset &&
+    !activePreset.presetInList &&
+    !activePreset.name &&
+    !activePreset.sugar &&
+    !activePreset.base &&
+    !activePreset.phosphate
+  );
+};
+
+export const selectActivePresetForContextMenu = (state: RootState) => {
+  return state.rnaBuilder.activePresetForContextMenu;
+};
+
 export const {
   setActivePreset,
   setActivePresetName,
@@ -197,6 +221,7 @@ export const {
   setIsEditMode,
   setHasUniqueNameError,
   setDefaultPresets,
+  setActivePresetForContextMenu,
 } = rnaBuilderSlice.actions;
 
 export const rnaBuilderReducer = rnaBuilderSlice.reducer;