diff --git a/packages/ketcher-core/src/application/formatters/formatProperties.ts b/packages/ketcher-core/src/application/formatters/formatProperties.ts
index 65d40159b8..514455c7c7 100644
--- a/packages/ketcher-core/src/application/formatters/formatProperties.ts
+++ b/packages/ketcher-core/src/application/formatters/formatProperties.ts
@@ -146,4 +146,17 @@ function getPropertiesByFormat(format: SupportedFormat) {
   return formatProperties[format];
 }
 
-export { formatProperties, getPropertiesByFormat, getPropertiesByImgFormat };
+function getFormatMimeTypeByFileName(fileName: string) {
+  const fileExtension = '.' + fileName.split('.').pop();
+  const format = Object.values(formatProperties).find((properties) => {
+    return properties.extensions.includes(fileExtension);
+  });
+  return format?.mime;
+}
+
+export {
+  formatProperties,
+  getPropertiesByFormat,
+  getPropertiesByImgFormat,
+  getFormatMimeTypeByFileName,
+};
diff --git a/packages/ketcher-react/src/script/ui/component/cliparea/cliparea.jsx b/packages/ketcher-react/src/script/ui/component/cliparea/cliparea.jsx
index 42ca411fee..6a24d745ca 100644
--- a/packages/ketcher-react/src/script/ui/component/cliparea/cliparea.jsx
+++ b/packages/ketcher-react/src/script/ui/component/cliparea/cliparea.jsx
@@ -18,6 +18,7 @@ import { Component, createRef } from 'react';
 import clsx from 'clsx';
 import classes from './cliparea.module.less';
 import { KetcherLogger } from 'ketcher-core';
+import { isControlKey } from '../../data/convert/keynorm';
 
 const ieCb = window.clipboardData;
 
@@ -73,6 +74,17 @@ class ClipArea extends Component {
           event.preventDefault();
         }
       },
+      keydown: async (event) => {
+        if (this.props.focused() && this.props.onPaste) {
+          if (isControlKey(event) && event.altKey && event.code === 'KeyV') {
+            const clipboardData = await navigator.clipboard.read();
+            const data = await pasteByKeydown(clipboardData);
+            if (data) {
+              this.props.onPaste(data, true);
+            }
+          }
+        }
+      },
     };
 
     Object.keys(this.listeners).forEach((en) => {
@@ -148,6 +160,19 @@ function paste(cb, formats) {
   return data;
 }
 
+async function pasteByKeydown(cb) {
+  const data = {};
+  if (!cb && ieCb) {
+    data['text/plain'] = ieCb.getData('text');
+  } else {
+    for (const item of cb) {
+      const textPlain = await item.getType('text/plain');
+      data['text/plain'] = await textPlain.text();
+    }
+  }
+  return data;
+}
+
 export const actions = ['cut', 'copy', 'paste'];
 
 export function exec(action) {
diff --git a/packages/ketcher-react/src/script/ui/data/convert/keynorm.js b/packages/ketcher-react/src/script/ui/data/convert/keynorm.js
index 5ce1ece767..b047d98a64 100644
--- a/packages/ketcher-react/src/script/ui/data/convert/keynorm.js
+++ b/packages/ketcher-react/src/script/ui/data/convert/keynorm.js
@@ -82,6 +82,10 @@ function normalizeKeyEvent(event, base = false) {
     : modifiers(KN.base[event.keyCode], event, true);
 }
 
+export function isControlKey(event) {
+  return mac ? event.metaKey : event.ctrlKey;
+}
+
 function keyNorm(obj) {
   if (obj instanceof KeyboardEvent)
     // eslint-disable-line no-undef
diff --git a/packages/ketcher-react/src/script/ui/state/hotkeys.ts b/packages/ketcher-react/src/script/ui/state/hotkeys.ts
index c8b3ef39cf..c842c74e59 100644
--- a/packages/ketcher-react/src/script/ui/state/hotkeys.ts
+++ b/packages/ketcher-react/src/script/ui/state/hotkeys.ts
@@ -292,7 +292,7 @@ export function initClipboard(dispatch) {
       editor.selection(null);
       return data;
     },
-    onPaste(data) {
+    onPaste(data, isSmarts: boolean) {
       const structStr =
         data[ChemicalMimeType.KET] ||
         data[ChemicalMimeType.Mol] ||
@@ -300,7 +300,13 @@ export function initClipboard(dispatch) {
         data['text/plain'];
 
       if (structStr || !rxnTextPlain.test(data['text/plain']))
-        loadStruct(structStr, { fragment: true, isPaste: true });
+        isSmarts
+          ? loadStruct(structStr, {
+              fragment: true,
+              isPaste: true,
+              'input-format': ChemicalMimeType.DaylightSmarts,
+            })
+          : loadStruct(structStr, { fragment: true, isPaste: true });
     },
   };
 }
diff --git a/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.container.ts b/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.container.ts
index 17aa597d00..9d21967cba 100644
--- a/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.container.ts
+++ b/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.container.ts
@@ -44,6 +44,7 @@ const mapDispatchToProps = (dispatch): DispatchProps => ({
       load(result.structStr, {
         badHeaderRecover: true,
         fragment: result.fragment,
+        'input-format': result['input-format'],
       }),
       // TODO: Removed ownProps.onOk call. consider refactoring of load function in release 2.4
       // See PR #731 (https://github.com/epam/ketcher/pull/731)
diff --git a/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.tsx b/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.tsx
index 15969cbacf..755282848f 100644
--- a/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.tsx
+++ b/packages/ketcher-react/src/script/ui/views/modal/components/document/Open/Open.tsx
@@ -22,6 +22,7 @@ import Recognize from '../../process/Recognize/Recognize';
 import { fileOpener } from '../../../../../utils/';
 import { DialogActionButton } from './components/DialogActionButton';
 import { ViewSwitcher } from './components/ViewSwitcher';
+import { getFormatMimeTypeByFileName } from 'ketcher-core';
 
 interface OpenProps {
   server: any;
@@ -115,7 +116,8 @@ const Open: FC<Props> = (props) => {
   const { onOk } = rest;
 
   const copyHandler = () => {
-    onOk({ structStr, fragment: true });
+    const format = getFormatMimeTypeByFileName(fileName);
+    onOk({ structStr, fragment: true, 'input-format': format });
   };
 
   const openHandler = () => {
diff --git a/packages/ketcher-standalone/src/infrastructure/services/struct/indigoWorker.ts b/packages/ketcher-standalone/src/infrastructure/services/struct/indigoWorker.ts
index cb660f47e1..8bb2fe08a9 100644
--- a/packages/ketcher-standalone/src/infrastructure/services/struct/indigoWorker.ts
+++ b/packages/ketcher-standalone/src/infrastructure/services/struct/indigoWorker.ts
@@ -109,8 +109,15 @@ self.onmessage = (e: MessageEvent<InputMessage<CommandData>>) => {
     case Command.Layout: {
       const data: LayoutCommandData = message.data as LayoutCommandData;
       handle(
-        (indigo, indigoOptions) =>
-          indigo.layout(data.struct, data.format, indigoOptions),
+        (indigo, indigoOptions) => {
+          const response = indigo.layout(
+            data.struct,
+            data.format,
+            indigoOptions,
+          );
+          const { struct } = JSON.parse(response);
+          return struct;
+        },
         data.options,
         Command.Layout,
       );
diff --git a/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts b/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts
index 8c3c2903ca..635c237c73 100644
--- a/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts
+++ b/packages/ketcher-standalone/src/infrastructure/services/struct/standaloneStructService.ts
@@ -266,7 +266,9 @@ class IndigoService implements StructService {
           reject(msg.error);
         }
       };
-
+      if (options?.['input-format']) {
+        delete options['input-format'];
+      }
       const commandOptions: CommandOptions = {
         ...this.defaultOptions,
         ...options,
@@ -315,6 +317,7 @@ class IndigoService implements StructService {
       const commandOptions: CommandOptions = {
         ...this.defaultOptions,
         ...options,
+        'output-content-type': 'application/json',
       };
 
       const commandData: LayoutCommandData = {