diff --git a/.circleci/config.yml b/.circleci/config.yml
index e24c9fa6..13679ae7 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -39,21 +39,15 @@ jobs:
   docs:
     <<: *common
     docker:
-      - image: circleci/python:3.8
+      - image: circleci/python:3.10
         environment:
           TOXENV: docs
   lint:
     <<: *common
     docker:
-      - image: circleci/python:3.8
+      - image: circleci/python:3.10
         environment:
           TOXENV: lint
-  py36-core:
-    <<: *common
-    docker:
-      - image: circleci/python:3.6
-        environment:
-          TOXENV: py36-core
   py37-core:
     <<: *common
     docker:
@@ -66,12 +60,25 @@ jobs:
       - image: circleci/python:3.8
         environment:
           TOXENV: py38-core
+  py39-core:
+    <<: *common
+    docker:
+      - image: circleci/python:3.9
+        environment:
+          TOXENV: py39-core
+  py310-core:
+    <<: *common
+    docker:
+      - image: circleci/python:3.10
+        environment:
+          TOXENV: py310-core
 workflows:
   version: 2
   test:
     jobs:
       - docs
       - lint
-      - py36-core
       - py37-core
       - py38-core
+      - py39-core
+      - py310-core
diff --git a/newsfragments/156.feature.rst b/newsfragments/156.feature.rst
new file mode 100644
index 00000000..1ef41465
--- /dev/null
+++ b/newsfragments/156.feature.rst
@@ -0,0 +1 @@
+Drop Python 3.6 support, add Python 3.9 and 3.10 support. Update any dependencies accordingly
diff --git a/setup.py b/setup.py
index 8a9bb55c..594223cc 100644
--- a/setup.py
+++ b/setup.py
@@ -12,9 +12,9 @@
         HYPOTHESIS_REQUIREMENT,
     ],
     'test': [
-        "pytest==4.4.1",
+        "pytest>=6.2.5,<7",
         "pytest-pythonpath>=0.7.1",
-        "pytest-xdist==1.22.3",
+        "pytest-xdist>=2.5.0,<3",
         "tox>=2.9.1,<3",
         "eth-hash[pycryptodome]",
         HYPOTHESIS_REQUIREMENT,
@@ -67,7 +67,7 @@
         'eth-typing>=3.0.0,<4.0.0',
         'parsimonious>=0.8.0,<0.9.0',
     ],
-    python_requires='>=3.6, <4',
+    python_requires='>=3.7, <4',
     extras_require=extras_require,
     py_modules=['eth_abi'],
     license="MIT",
@@ -81,7 +81,9 @@
         'License :: OSI Approved :: MIT License',
         'Natural Language :: English',
         'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.6',
         'Programming Language :: Python :: 3.7',
+        'Programming Language :: Python :: 3.8',
+        'Programming Language :: Python :: 3.9',
+        'Programming Language :: Python :: 3.10',
     ],
 )
diff --git a/tox.ini b/tox.ini
index 9062cbf9..19ec735a 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 envlist=
-    py{36,37,38}-core
+    py{37,38,39,310}-core
     lint
     docs
 
@@ -26,9 +26,10 @@ commands=
     docs: make build-docs
 basepython =
     docs: python
-    py36: python3.6
     py37: python3.7
     py38: python3.8
+    py39: python3.9
+    py310: python3.10
 extras=
     test
     docs: doc