diff --git a/Libraries/ActionSheetIOS/ActionSheetIOS.js b/Libraries/ActionSheetIOS/ActionSheetIOS.js
index bc3a935dee298b..1fc86a0fd8872c 100644
--- a/Libraries/ActionSheetIOS/ActionSheetIOS.js
+++ b/Libraries/ActionSheetIOS/ActionSheetIOS.js
@@ -33,6 +33,7 @@ const ActionSheetIOS = {
    * - `destructiveButtonIndex` (int or array of ints) - index or indices of destructive buttons in `options`
    * - `title` (string) - a title to show above the action sheet
    * - `message` (string) - a message to show below the title
+   * - `disabledButtonIndices` (array of numbers) - a list of button indices which should be disabled
    *
    * The 'callback' function takes one parameter, the zero-based index
    * of the selected item.
@@ -49,6 +50,7 @@ const ActionSheetIOS = {
       +anchor?: ?number,
       +tintColor?: ColorValue | ProcessedColorValue,
       +userInterfaceStyle?: string,
+      +disabledButtonIndices?: Array<number>,
     |},
     callback: (buttonIndex: number) => void,
   ) {
diff --git a/Libraries/ActionSheetIOS/NativeActionSheetManager.js b/Libraries/ActionSheetIOS/NativeActionSheetManager.js
index 063d9147e1d69b..6d86200d9accd6 100644
--- a/Libraries/ActionSheetIOS/NativeActionSheetManager.js
+++ b/Libraries/ActionSheetIOS/NativeActionSheetManager.js
@@ -25,6 +25,7 @@ export interface Spec extends TurboModule {
       +anchor?: ?number,
       +tintColor?: ?number,
       +userInterfaceStyle?: ?string,
+      +disabledButtonIndices?: Array<number>,
     |},
     callback: (buttonIndex: number) => void,
   ) => void;
diff --git a/React/CoreModules/RCTActionSheetManager.mm b/React/CoreModules/RCTActionSheetManager.mm
index 754e461157349d..c2eae7c9fe8808 100644
--- a/React/CoreModules/RCTActionSheetManager.mm
+++ b/React/CoreModules/RCTActionSheetManager.mm
@@ -73,9 +73,15 @@ - (void)presentViewController:(UIViewController *)alertController
   NSArray<NSString *> *buttons = RCTConvertOptionalVecToArray(options.options(), ^id(NSString *element) {
     return element;
   });
+  NSArray<NSNumber *> *disabledButtonIndices;
   NSInteger cancelButtonIndex =
       options.cancelButtonIndex() ? [RCTConvert NSInteger:@(*options.cancelButtonIndex())] : -1;
   NSArray<NSNumber *> *destructiveButtonIndices;
+  if (options.disabledButtonIndices()) {
+    disabledButtonIndices = RCTConvertVecToArray(*options.disabledButtonIndices(), ^id(double element) {
+      return @(element);
+    });
+  }
   if (options.destructiveButtonIndices()) {
     destructiveButtonIndices = RCTConvertVecToArray(*options.destructiveButtonIndices(), ^id(double element) {
       return @(element);
@@ -98,6 +104,7 @@ - (void)presentViewController:(UIViewController *)alertController
       @"destructiveButtonIndices" : destructiveButtonIndices,
       @"anchor" : anchor,
       @"tintColor" : tintColor,
+      @"disabledButtonIndices" : disabledButtonIndices,
     });
     return;
   }
@@ -132,6 +139,17 @@ - (void)presentViewController:(UIViewController *)alertController
     index++;
   }
 
+  if (disabledButtonIndices) {
+    for (NSNumber *disabledButtonIndex in disabledButtonIndices) {
+      if ([disabledButtonIndex integerValue] < buttons.count) {
+        [alertController.actions[[disabledButtonIndex integerValue]] setEnabled:false];
+      } else {
+        RCTLogError(@"Index %@ from `disabledButtonIndices` is out of bounds. Maximum index value is %@.", @([disabledButtonIndex integerValue]), @(buttons.count - 1));
+        return;
+      }
+    }
+  }
+
   alertController.view.tintColor = tintColor;
 #if defined(__IPHONE_OS_VERSION_MAX_ALLOWED) && defined(__IPHONE_13_0) && \
     __IPHONE_OS_VERSION_MAX_ALLOWED >= __IPHONE_13_0
diff --git a/packages/rn-tester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js b/packages/rn-tester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js
index 786811a725d53f..917cba05c0ce09 100644
--- a/packages/rn-tester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js
+++ b/packages/rn-tester/js/examples/ActionSheetIOS/ActionSheetIOSExample.js
@@ -25,6 +25,7 @@ const ScreenshotManager = NativeModules.ScreenshotManager;
 const BUTTONS = ['Option 0', 'Option 1', 'Option 2', 'Delete', 'Cancel'];
 const DESTRUCTIVE_INDEX = 3;
 const CANCEL_INDEX = 4;
+const DISABLED_BUTTON_INDICES = [1, 2];
 
 type Props = $ReadOnly<{||}>;
 type State = {|clicked: string|};
@@ -138,6 +139,37 @@ class ActionSheetAnchorExample extends React.Component<
   };
 }
 
+class ActionSheetDisabledExample extends React.Component<Props, State> {
+  state = {
+    clicked: 'none',
+  };
+
+  render() {
+    return (
+      <View>
+        <Text onPress={this.showActionSheet} style={style.button}>
+          Click to show the ActionSheet
+        </Text>
+        <Text>Clicked button: {this.state.clicked}</Text>
+      </View>
+    );
+  }
+
+  showActionSheet = () => {
+    ActionSheetIOS.showActionSheetWithOptions(
+      {
+        options: BUTTONS,
+        cancelButtonIndex: CANCEL_INDEX,
+        destructiveButtonIndex: DESTRUCTIVE_INDEX,
+        disabledButtonIndices: DISABLED_BUTTON_INDICES,
+      },
+      buttonIndex => {
+        this.setState({clicked: BUTTONS[buttonIndex]});
+      },
+    );
+  };
+}
+
 class ShareActionSheetExample extends React.Component<
   $FlowFixMeProps,
   $FlowFixMeState,
@@ -316,6 +348,12 @@ exports.examples = [
       return <ActionSheetAnchorExample />;
     },
   },
+  {
+    title: 'Show Action Sheet with disabled buttons',
+    render(): React.Element<any> {
+      return <ActionSheetDisabledExample />;
+    },
+  },
   {
     title: 'Show Share Action Sheet',
     render(): React.Element<any> {