diff --git a/packages/dev-middleware/src/inspector-proxy/types.js b/packages/dev-middleware/src/inspector-proxy/types.js
index a89bfc9a914d57..ed37c285fc5aa0 100644
--- a/packages/dev-middleware/src/inspector-proxy/types.js
+++ b/packages/dev-middleware/src/inspector-proxy/types.js
@@ -37,6 +37,13 @@ export type TargetCapabilityFlags = $ReadOnly<{
    * In the proxy, this disables intercepting and storing network requests.
    */
   nativeNetworkInspection?: boolean,
+
+  /**
+   * The target supports the modern `rn_fusebox.html` entry point.
+   *
+   * In the launch flow, this controls the Chrome DevTools entrypoint that is used.
+   */
+  prefersFuseboxFrontend?: boolean,
 }>;
 
 // Page information received from the device. New page is created for
diff --git a/packages/dev-middleware/src/middleware/openDebuggerMiddleware.js b/packages/dev-middleware/src/middleware/openDebuggerMiddleware.js
index 6b571f7aa026cd..2f1cf95b5d159e 100644
--- a/packages/dev-middleware/src/middleware/openDebuggerMiddleware.js
+++ b/packages/dev-middleware/src/middleware/openDebuggerMiddleware.js
@@ -107,6 +107,9 @@ export default function openDebuggerMiddleware({
         return;
       }
 
+      const useFuseboxEntryPoint =
+        target.reactNative.capabilities?.prefersFuseboxFrontend;
+
       try {
         switch (launchType) {
           case 'launch':
@@ -122,6 +125,7 @@ export default function openDebuggerMiddleware({
                   experiments,
                   target.webSocketDebuggerUrl,
                   serverBaseUrl,
+                  {useFuseboxEntryPoint},
                 ),
               ),
             );
@@ -133,7 +137,7 @@ export default function openDebuggerMiddleware({
                 experiments,
                 target.webSocketDebuggerUrl,
                 serverBaseUrl,
-                {relative: true},
+                {relative: true, useFuseboxEntryPoint},
               ),
             });
             res.end();
diff --git a/packages/dev-middleware/src/utils/getDevToolsFrontendUrl.js b/packages/dev-middleware/src/utils/getDevToolsFrontendUrl.js
index 7dd33dfd9d08a3..a3cabc78afc092 100644
--- a/packages/dev-middleware/src/utils/getDevToolsFrontendUrl.js
+++ b/packages/dev-middleware/src/utils/getDevToolsFrontendUrl.js
@@ -20,6 +20,7 @@ export default function getDevToolsFrontendUrl(
   devServerUrl: string,
   options?: $ReadOnly<{
     relative?: boolean,
+    useFuseboxEntryPoint?: boolean,
   }>,
 ): string {
   const wsParam = getWsParam({
@@ -29,7 +30,10 @@ export default function getDevToolsFrontendUrl(
 
   const appUrl =
     (options?.relative === true ? '' : devServerUrl) +
-    '/debugger-frontend/rn_inspector.html';
+    '/debugger-frontend/' +
+    (options?.useFuseboxEntryPoint === true
+      ? 'rn_fusebox.html'
+      : 'rn_inspector.html');
 
   const searchParams = new URLSearchParams([
     [wsParam.key, wsParam.value],