diff --git a/packages/react-native-renderer/src/ReactFabricEventEmitter.js b/packages/react-native-renderer/src/ReactFabricEventEmitter.js
index 959df5bc48732..49abda74eb362 100644
--- a/packages/react-native-renderer/src/ReactFabricEventEmitter.js
+++ b/packages/react-native-renderer/src/ReactFabricEventEmitter.js
@@ -87,7 +87,11 @@ export function dispatchEvent(
   let eventTarget = null;
   if (enableNativeTargetAsInstance) {
     if (targetFiber != null) {
-      eventTarget = targetFiber.stateNode.canonical;
+      const stateNode = targetFiber.stateNode;
+      // Guard against Fiber being unmounted
+      if (stateNode != null) {
+        eventTarget = stateNode.canonical;
+      }
     }
   } else {
     eventTarget = nativeEvent.target;