diff --git a/app/code/Magento/InventoryCatalog/Model/CanManageSourceItemsBySku.php b/app/code/Magento/InventoryCatalog/Model/CanManageSourceItemsBySku.php
new file mode 100644
index 0000000000000..4ae1e1b64fcc8
--- /dev/null
+++ b/app/code/Magento/InventoryCatalog/Model/CanManageSourceItemsBySku.php
@@ -0,0 +1,74 @@
+<?php
+/**
+ * Copyright © Magento, Inc. All rights reserved.
+ * See COPYING.txt for license details.
+ */
+declare(strict_types=1);
+
+namespace Magento\InventoryCatalog\Model;
+
+use Magento\CatalogInventory\Model\Configuration;
+use Magento\Framework\App\Config\ScopeConfigInterface;
+use Magento\InventoryCatalog\Api\DefaultStockProviderInterface;
+use Magento\InventoryConfigurationApi\Api\GetStockItemConfigurationInterface;
+
+/**
+ * Check source items should be managed for given product sku
+ */
+class CanManageSourceItemsBySku
+{
+    /**
+     * Provides manage stock global config value.
+     *
+     * @var ScopeConfigInterface
+     */
+    private $config;
+
+    /**
+     * Provides default stock id for current website in order to get correct stock configuration for product.
+     *
+     * @var DefaultStockProviderInterface
+     */
+    private $defaultStockProvider;
+
+    /**
+     * Provides stock item configuration for given product sku.
+     *
+     * @var GetStockItemConfigurationInterface
+     */
+    private $getStockItemConfiguration;
+
+    /**
+     * @param ScopeConfigInterface $config
+     * @param GetStockItemConfigurationInterface $getStockItemConfiguration
+     * @param DefaultStockProviderInterface $defaultStockProvider
+     */
+    public function __construct(
+        ScopeConfigInterface $config,
+        GetStockItemConfigurationInterface $getStockItemConfiguration,
+        DefaultStockProviderInterface $defaultStockProvider
+    ) {
+        $this->config = $config;
+        $this->defaultStockProvider = $defaultStockProvider;
+        $this->getStockItemConfiguration = $getStockItemConfiguration;
+    }
+
+    /**
+     * @param string $sku Sku can be null if product is new
+     * @return bool
+     */
+    public function execute(string $sku = null): bool
+    {
+        if (null !== $sku) {
+            $stockId = $this->defaultStockProvider->getId();
+            $itemConfiguration = $this->getStockItemConfiguration->execute($sku, $stockId);
+
+            if (null !== $itemConfiguration) {
+                return $itemConfiguration->isUseConfigManageStock()
+                    ? (bool)$this->config->getValue(Configuration::XML_PATH_MANAGE_STOCK)
+                    : $itemConfiguration->isManageStock();
+            }
+        }
+        return (bool)$this->config->getValue(Configuration::XML_PATH_MANAGE_STOCK);
+    }
+}
diff --git a/app/code/Magento/InventoryCatalog/Ui/DataProvider/Product/Form/Modifier/SourceItems.php b/app/code/Magento/InventoryCatalog/Ui/DataProvider/Product/Form/Modifier/SourceItems.php
index bb8ab6c08eb89..cbb46dbebe326 100644
--- a/app/code/Magento/InventoryCatalog/Ui/DataProvider/Product/Form/Modifier/SourceItems.php
+++ b/app/code/Magento/InventoryCatalog/Ui/DataProvider/Product/Form/Modifier/SourceItems.php
@@ -7,14 +7,15 @@
 
 namespace Magento\InventoryCatalog\Ui\DataProvider\Product\Form\Modifier;
 
-use Magento\Catalog\Ui\DataProvider\Product\Form\Modifier\AbstractModifier;
 use Magento\Catalog\Model\Locator\LocatorInterface;
+use Magento\Catalog\Ui\DataProvider\Product\Form\Modifier\AbstractModifier;
 use Magento\Framework\App\ResourceConnection;
 use Magento\Inventory\Model\ResourceModel\Source as SourceResourceModel;
 use Magento\Inventory\Model\ResourceModel\SourceItem\Collection;
 use Magento\Inventory\Model\ResourceModel\SourceItem\CollectionFactory;
 use Magento\InventoryApi\Api\Data\SourceInterface;
 use Magento\InventoryApi\Api\Data\SourceItemInterface;
+use Magento\InventoryCatalog\Model\CanManageSourceItemsBySku;
 use Magento\InventoryCatalog\Model\IsSingleSourceModeInterface;
 use Magento\InventoryConfiguration\Model\IsSourceItemsAllowedForProductTypeInterface;
 
@@ -48,25 +49,33 @@ class SourceItems extends AbstractModifier
      */
     private $resourceConnection;
 
+    /**
+     * @var CanManageSourceItemsBySku
+     */
+    private $canManageSourceItemsBySku;
+
     /**
      * @param IsSourceItemsAllowedForProductTypeInterface $isSourceItemsAllowedForProductType
      * @param IsSingleSourceModeInterface $isSingleSourceMode
      * @param LocatorInterface $locator
      * @param CollectionFactory $sourceItemCollectionFactory
      * @param ResourceConnection $resourceConnection
+     * @param CanManageSourceItemsBySku $canManageSourceItemsBySku
      */
     public function __construct(
         IsSourceItemsAllowedForProductTypeInterface $isSourceItemsAllowedForProductType,
         IsSingleSourceModeInterface $isSingleSourceMode,
         LocatorInterface $locator,
         CollectionFactory $sourceItemCollectionFactory,
-        ResourceConnection $resourceConnection
+        ResourceConnection $resourceConnection,
+        CanManageSourceItemsBySku $canManageSourceItemsBySku
     ) {
         $this->isSourceItemsAllowedForProductType = $isSourceItemsAllowedForProductType;
         $this->isSingleSourceMode = $isSingleSourceMode;
         $this->locator = $locator;
         $this->sourceItemCollectionFactory = $sourceItemCollectionFactory;
         $this->resourceConnection = $resourceConnection;
+        $this->canManageSourceItemsBySku = $canManageSourceItemsBySku;
     }
 
     /**
@@ -128,6 +137,7 @@ public function modifyMeta(array $meta)
             return $meta;
         }
 
+        $canMangeSourceItems = $this->canManageSourceItemsBySku->execute($product->getSku());
         $meta['sources'] = [
             'arguments' => [
                 'data' => [
@@ -136,7 +146,32 @@ public function modifyMeta(array $meta)
                     ],
                 ],
             ],
+            'children' => [
+                'assign_sources_container' => [
+                    'children' => [
+                        'assign_sources_button' => [
+                            'arguments' => [
+                                'data' => [
+                                    'config' => [
+                                        'visible' => $canMangeSourceItems,
+                                    ],
+                                ],
+                            ],
+                        ],
+                    ],
+                ],
+                'assigned_sources' => [
+                    'arguments' => [
+                        'data' => [
+                            'config' => [
+                                'visible' => $canMangeSourceItems,
+                            ],
+                        ],
+                    ],
+                ],
+            ],
         ];
+
         return $meta;
     }
 }
diff --git a/app/code/Magento/InventoryCatalog/composer.json b/app/code/Magento/InventoryCatalog/composer.json
index a499ecaec4dbc..77e0e96dd5fc3 100644
--- a/app/code/Magento/InventoryCatalog/composer.json
+++ b/app/code/Magento/InventoryCatalog/composer.json
@@ -8,6 +8,7 @@
     "magento/module-catalog-inventory": "100.3.*",
     "magento/module-inventory": "100.0.*",
     "magento/module-inventory-api": "100.0.*",
+    "magento/module-inventory-configuration-api": "100.0.*",
     "magento/module-ui": "100.0.*",
     "magento/module-store": "100.3.*",
     "magento/module-inventory-configuration": "100.0.*",
diff --git a/app/code/Magento/InventoryCatalog/view/adminhtml/ui_component/product_form.xml b/app/code/Magento/InventoryCatalog/view/adminhtml/ui_component/product_form.xml
index caa85dab1a553..9742dcf76f8fb 100644
--- a/app/code/Magento/InventoryCatalog/view/adminhtml/ui_component/product_form.xml
+++ b/app/code/Magento/InventoryCatalog/view/adminhtml/ui_component/product_form.xml
@@ -6,7 +6,7 @@
  */
 -->
 <form xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:noNamespaceSchemaLocation="urn:magento:module:Magento_Ui:etc/ui_configuration.xsd">
-    <fieldset name="sources" sortOrder="5">
+    <fieldset name="sources" sortOrder="5" component="Magento_InventoryCatalog/js/product/form/components/source-items">
         <settings>
             <label translate="true">Sources</label>
             <collapsible>true</collapsible>
@@ -37,6 +37,9 @@
                         <item name="additionalForGroup" xsi:type="boolean">true</item>
                         <item name="additionalClasses" xsi:type="string">admin__field-medium</item>
                         <item name="dataScope" xsi:type="string"/>
+                        <item name="imports" xsi:type="array">
+                            <item name="visible" xsi:type="string">${ $.provider }:data.product.stock_data.manage_stock</item>
+                        </item>
                     </item>
                 </argument>
             </container>
@@ -85,6 +88,9 @@
                     <param name="enabled" xsi:type="boolean">false</param>
                 </dndConfig>
                 <columnsHeader>true</columnsHeader>
+                <imports>
+                    <link name="visible">${ $.provider }:data.product.stock_data.manage_stock</link>
+                </imports>
             </settings>
             <container name="record" component="Magento_Ui/js/dynamic-rows/record">
                 <argument name="data" xsi:type="array">
diff --git a/app/code/Magento/InventoryCatalog/view/adminhtml/web/js/product/form/components/source-items.js b/app/code/Magento/InventoryCatalog/view/adminhtml/web/js/product/form/components/source-items.js
new file mode 100644
index 0000000000000..acb4d9227afe9
--- /dev/null
+++ b/app/code/Magento/InventoryCatalog/view/adminhtml/web/js/product/form/components/source-items.js
@@ -0,0 +1,28 @@
+/**
+ * Copyright © Magento, Inc. All rights reserved.
+ * See COPYING.txt for license details.
+ */
+
+define([
+    'Magento_Ui/js/form/components/fieldset'
+], function (Fieldset) {
+    'use strict';
+
+    return Fieldset.extend({
+        defaults: {
+            imports: {
+                onStockChange: '${ $.provider }:data.product.stock_data.manage_stock'
+            }
+        },
+
+        /**
+         * Disable all child elements if manage stock is zero
+         * @param {Integer} canManageStock
+         */
+        onStockChange: function (canManageStock) {
+            if (canManageStock === 0) {
+                this.delegate('disabled', true);
+            }
+        }
+    });
+});