diff --git a/Modules/_blake2/impl/blake2b.c b/Modules/_blake2/impl/blake2b.c
index c1068e8640546a..cef22838917d9d 100644
--- a/Modules/_blake2/impl/blake2b.c
+++ b/Modules/_blake2/impl/blake2b.c
@@ -27,7 +27,7 @@
 #if defined(HAVE_SSE2)
 #include <emmintrin.h>
 // MSVC only defines  _mm_set_epi64x for x86_64...
-#if defined(_MSC_VER) && !defined(_M_X64)
+#if defined(_MSC_VER) && !defined(_M_X64) && !defined(__clang__)
 static inline __m128i _mm_set_epi64x( const uint64_t u1, const uint64_t u0 )
 {
   return _mm_set_epi32( u1 >> 32, u1, u0 >> 32, u0 );
diff --git a/Modules/_blake2/impl/blake2s.c b/Modules/_blake2/impl/blake2s.c
index 47514685b8f30b..e7f63fd274f212 100644
--- a/Modules/_blake2/impl/blake2s.c
+++ b/Modules/_blake2/impl/blake2s.c
@@ -27,7 +27,7 @@
 #if defined(HAVE_SSE2)
 #include <emmintrin.h>
 // MSVC only defines  _mm_set_epi64x for x86_64...
-#if defined(_MSC_VER) && !defined(_M_X64)
+#if defined(_MSC_VER) && !defined(_M_X64) && !defined(__clang__)
 static inline __m128i _mm_set_epi64x( const uint64_t u1, const uint64_t u0 )
 {
   return _mm_set_epi32( u1 >> 32, u1, u0 >> 32, u0 );