diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/build-cjs.mjs b/dev-packages/e2e-tests/test-applications/node-profiling/build-cjs.mjs
deleted file mode 100644
index 4a9aa83d0eec..000000000000
--- a/dev-packages/e2e-tests/test-applications/node-profiling/build-cjs.mjs
+++ /dev/null
@@ -1,20 +0,0 @@
-// Because bundlers can now predetermine a static set of binaries we need to ensure those binaries
-// actually exists, else we risk a compile time error when bundling the package. This could happen
-// if we added a new binary in cpu_profiler.ts, but forgot to prebuild binaries for it. Because CI
-// only runs integration and unit tests, this change would be missed and could end up in a release.
-// Therefor, once all binaries are precompiled in CI and tests pass, run esbuild with bundle:true
-// which will copy all binaries to the outfile folder and throw if any of them are missing.
-import esbuild from 'esbuild';
-
-console.log('Running build using esbuild version', esbuild.version);
-
-esbuild.buildSync({
-  platform: 'node',
-  entryPoints: ['./index.ts'],
-  outfile: './dist/cjs/index.js',
-  target: 'esnext',
-  format: 'cjs',
-  bundle: true,
-  loader: { '.node': 'copy' },
-  external: ['@sentry/node', '@sentry/profiling-node'],
-});
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/build-esm.mjs b/dev-packages/e2e-tests/test-applications/node-profiling/build-esm.mjs
deleted file mode 100644
index 294e53d50635..000000000000
--- a/dev-packages/e2e-tests/test-applications/node-profiling/build-esm.mjs
+++ /dev/null
@@ -1,20 +0,0 @@
-// Because bundlers can now predetermine a static set of binaries we need to ensure those binaries
-// actually exists, else we risk a compile time error when bundling the package. This could happen
-// if we added a new binary in cpu_profiler.ts, but forgot to prebuild binaries for it. Because CI
-// only runs integration and unit tests, this change would be missed and could end up in a release.
-// Therefor, once all binaries are precompiled in CI and tests pass, run esbuild with bundle:true
-// which will copy all binaries to the outfile folder and throw if any of them are missing.
-import esbuild from 'esbuild';
-
-console.log('Running build using esbuild version', esbuild.version);
-
-esbuild.buildSync({
-  platform: 'node',
-  entryPoints: ['./index.ts'],
-  outfile: './dist/esm/index.mjs',
-  target: 'esnext',
-  format: 'esm',
-  bundle: true,
-  loader: { '.node': 'copy' },
-  external: ['@sentry/node', '@sentry/profiling-node'],
-});
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/esbuild.mjs b/dev-packages/e2e-tests/test-applications/node-profiling/esbuild.mjs
new file mode 100644
index 000000000000..6a7a20d8c9d0
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling/esbuild.mjs
@@ -0,0 +1,16 @@
+import esbuild from 'esbuild';
+
+console.log('Running build using esbuild version', esbuild.version);
+
+const output = esbuild.buildSync({
+  logLevel: 'debug',
+  platform: 'node',
+  entryPoints: ['./index.js'],
+  outfile: './dist/esbuild/index.js',
+  target: 'esnext',
+  format: 'cjs',
+  bundle: true,
+  loader: { '.node': 'copy' },
+});
+
+process.exit(output.errors.length);
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/index.js b/dev-packages/e2e-tests/test-applications/node-profiling/index.js
new file mode 100644
index 000000000000..e692b4cb6317
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling/index.js
@@ -0,0 +1,31 @@
+const Sentry = require('@sentry/node');
+const { nodeProfilingIntegration } = require('@sentry/profiling-node');
+const { inspect } = require('util');
+
+const wait = ms => new Promise(resolve => setTimeout(resolve, ms));
+
+function transport(_) {
+  return {
+    send(envelope) {
+      // eslint-disable-next-line no-console
+      console.log(inspect(envelope, false, null, true));
+      return Promise.resolve({ statusCode: 200 });
+    },
+    flush() {
+      return new Promise(resolve => setTimeout(() => resolve(true), 1000));
+    },
+  };
+}
+
+Sentry.init({
+  debug: true,
+  dsn: 'https://7fa19397baaf433f919fbe02228d5470@o1137848.ingest.sentry.io/6625302',
+  integrations: [nodeProfilingIntegration()],
+  tracesSampleRate: 1.0,
+  profilesSampleRate: 1.0,
+  transport,
+});
+
+Sentry.startSpan({ name: 'Precompile test' }, async () => {
+  await wait(500);
+});
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/index.ts b/dev-packages/e2e-tests/test-applications/node-profiling/index.ts
deleted file mode 100644
index e956a1d9de33..000000000000
--- a/dev-packages/e2e-tests/test-applications/node-profiling/index.ts
+++ /dev/null
@@ -1,15 +0,0 @@
-import * as Sentry from '@sentry/node';
-import { nodeProfilingIntegration } from '@sentry/profiling-node';
-
-const wait = (ms: number) => new Promise(resolve => setTimeout(resolve, ms));
-
-Sentry.init({
-  dsn: 'https://7fa19397baaf433f919fbe02228d5470@o1137848.ingest.sentry.io/6625302',
-  integrations: [nodeProfilingIntegration()],
-  tracesSampleRate: 1.0,
-  profilesSampleRate: 1.0,
-});
-
-Sentry.startSpan({ name: 'Precompile test' }, async () => {
-  await wait(500);
-});
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/package.json b/dev-packages/e2e-tests/test-applications/node-profiling/package.json
index d78ca10fa25d..a4e704ce7cba 100644
--- a/dev-packages/e2e-tests/test-applications/node-profiling/package.json
+++ b/dev-packages/e2e-tests/test-applications/node-profiling/package.json
@@ -3,13 +3,15 @@
   "version": "1.0.0",
   "private": true,
   "scripts": {
-    "typecheck": "tsc --noEmit",
-    "build": "node build-cjs.mjs && node build-esm.mjs",
-    "test": "node dist/cjs/index.js && node --experimental-require-module dist/cjs/index.js && node dist/esm/index.mjs",
+    "test": "node dist/cjs/index.js && node dist/cjs/index.js && node dist/esm/index.mjs",
     "clean": "npx rimraf node_modules dist",
     "test:electron": "$(pnpm bin)/electron-rebuild && playwright test",
-    "test:build": "pnpm run typecheck && pnpm run build",
-    "test:assert": "pnpm run test && pnpm run test:electron"
+    "test:build": "npm run test:build:esbuild && npm run test:build:webpack",
+    "test:build:webpack": "webpack --config webpack.config.mjs",
+    "test:build:esbuild": "node esbuild.mjs",
+    "test:assert": "npm run test:assert:esbuild && npm run test:assert:webpack",
+    "test:assert:esbuild": "node dist/esbuild/index.js",
+    "test:assert:webpack": "node dist/webpack/index.js"
   },
   "dependencies": {
     "@electron/rebuild": "^3.7.0",
@@ -18,7 +20,10 @@
     "@sentry/node": "latest || *",
     "@sentry/profiling-node": "latest || *",
     "electron": "^33.2.0",
-    "esbuild": "0.20.0"
+    "esbuild": "0.24.2",
+    "webpack": "5.97.1",
+    "webpack-cli": "6.0.1",
+    "node-loader": "2.1.0"
   },
   "volta": {
     "extends": "../../package.json"
diff --git a/dev-packages/e2e-tests/test-applications/node-profiling/webpack.config.mjs b/dev-packages/e2e-tests/test-applications/node-profiling/webpack.config.mjs
new file mode 100644
index 000000000000..a8026318c1af
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/node-profiling/webpack.config.mjs
@@ -0,0 +1,24 @@
+import * as path from 'path';
+
+const __dirname = path.dirname(new URL(import.meta.url).pathname);
+
+export default {
+  mode: 'production',
+  entry: './index.js',
+  target: 'node',
+  output: {
+    path: path.resolve(__dirname, 'dist', 'webpack'),
+    filename: 'index.js',
+  },
+  resolve: {
+    extensions: ['.js', '.node'],
+  },
+  module: {
+    rules: [
+      {
+        test: /\.node$/,
+        loader: 'node-loader',
+      },
+    ],
+  },
+};
diff --git a/packages/profiling-node/lib/esm/index.js b/packages/profiling-node/lib/esm/index.js
new file mode 100644
index 000000000000..e4a4d45ef49d
--- /dev/null
+++ b/packages/profiling-node/lib/esm/index.js
@@ -0,0 +1,2 @@
+import { nodeProfilingIntegration } from '../cjs/index.js';
+export { nodeProfilingIntegration };
diff --git a/packages/profiling-node/lib/esm/package.json b/packages/profiling-node/lib/esm/package.json
new file mode 100644
index 000000000000..3dbc1ca591c0
--- /dev/null
+++ b/packages/profiling-node/lib/esm/package.json
@@ -0,0 +1,3 @@
+{
+  "type": "module"
+}
diff --git a/packages/profiling-node/rollup.npm.config.mjs b/packages/profiling-node/rollup.npm.config.mjs
index a9c148306709..dbedf9e8ae19 100644
--- a/packages/profiling-node/rollup.npm.config.mjs
+++ b/packages/profiling-node/rollup.npm.config.mjs
@@ -17,4 +17,7 @@ export default makeNPMConfigVariants(
       ],
     },
   }),
+  {
+    emitEsm: false,
+  },
 );
diff --git a/packages/profiling-node/src/cpu_profiler.ts b/packages/profiling-node/src/cpu_profiler.ts
index a9a6d65ce191..6e3eb8f442e0 100644
--- a/packages/profiling-node/src/cpu_profiler.ts
+++ b/packages/profiling-node/src/cpu_profiler.ts
@@ -1,9 +1,6 @@
-import { createRequire } from 'node:module';
 import { arch as _arch, platform as _platform } from 'node:os';
 import { join, resolve } from 'node:path';
-import { dirname } from 'node:path';
 import { env, versions } from 'node:process';
-import { fileURLToPath, pathToFileURL } from 'node:url';
 import { threadId } from 'node:worker_threads';
 import { familySync } from 'detect-libc';
 import { getAbi } from 'node-abi';
@@ -18,8 +15,6 @@ import type {
 } from './types';
 import type { ProfileFormat } from './types';
 
-declare const __IMPORT_META_URL_REPLACEMENT__: string;
-
 const stdlib = familySync();
 const platform = process.env['BUILD_PLATFORM'] || _platform();
 const arch = process.env['BUILD_ARCH'] || _arch();
@@ -31,27 +26,16 @@ const identifier = [platform, arch, stdlib, abi].filter(c => c !== undefined &&
  */
 // eslint-disable-next-line complexity
 export function importCppBindingsModule(): PrivateV8CpuProfilerBindings {
-  // We need to work around using import.meta.url directly with __IMPORT_META_URL_REPLACEMENT__ because jest complains about it.
-  const importMetaUrl =
-    typeof __IMPORT_META_URL_REPLACEMENT__ !== 'undefined'
-      ? // This case is always hit when the SDK is built
-        __IMPORT_META_URL_REPLACEMENT__
-      : // This case is hit when the tests are run
-        pathToFileURL(__filename).href;
-
-  const createdRequire = createRequire(importMetaUrl);
-  const esmCompatibleDirname = dirname(fileURLToPath(importMetaUrl));
-
   // If a binary path is specified, use that.
   if (env['SENTRY_PROFILER_BINARY_PATH']) {
     const envPath = env['SENTRY_PROFILER_BINARY_PATH'];
-    return createdRequire(envPath);
+    return require(envPath);
   }
 
   // If a user specifies a different binary dir, they are in control of the binaries being moved there
   if (env['SENTRY_PROFILER_BINARY_DIR']) {
     const binaryPath = join(resolve(env['SENTRY_PROFILER_BINARY_DIR']), `sentry_cpu_profiler-${identifier}`);
-    return createdRequire(`${binaryPath}.node`);
+    return require(`${binaryPath}.node`);
   }
 
   // We need the fallthrough so that in the end, we can fallback to the dynamic require.
@@ -59,31 +43,31 @@ export function importCppBindingsModule(): PrivateV8CpuProfilerBindings {
   if (platform === 'darwin') {
     if (arch === 'x64') {
       if (abi === '93') {
-        return createdRequire('../sentry_cpu_profiler-darwin-x64-93.node');
+        return require('../sentry_cpu_profiler-darwin-x64-93.node');
       }
       if (abi === '108') {
-        return createdRequire('../sentry_cpu_profiler-darwin-x64-108.node');
+        return require('../sentry_cpu_profiler-darwin-x64-108.node');
       }
       if (abi === '115') {
-        return createdRequire('../sentry_cpu_profiler-darwin-x64-115.node');
+        return require('../sentry_cpu_profiler-darwin-x64-115.node');
       }
       if (abi === '127') {
-        return createdRequire('../sentry_cpu_profiler-darwin-x64-127.node');
+        return require('../sentry_cpu_profiler-darwin-x64-127.node');
       }
     }
 
     if (arch === 'arm64') {
       if (abi === '93') {
-        return createdRequire('../sentry_cpu_profiler-darwin-arm64-93.node');
+        return require('../sentry_cpu_profiler-darwin-arm64-93.node');
       }
       if (abi === '108') {
-        return createdRequire('../sentry_cpu_profiler-darwin-arm64-108.node');
+        return require('../sentry_cpu_profiler-darwin-arm64-108.node');
       }
       if (abi === '115') {
-        return createdRequire('../sentry_cpu_profiler-darwin-arm64-115.node');
+        return require('../sentry_cpu_profiler-darwin-arm64-115.node');
       }
       if (abi === '127') {
-        return createdRequire('../sentry_cpu_profiler-darwin-arm64-127.node');
+        return require('../sentry_cpu_profiler-darwin-arm64-127.node');
       }
     }
   }
@@ -91,16 +75,16 @@ export function importCppBindingsModule(): PrivateV8CpuProfilerBindings {
   if (platform === 'win32') {
     if (arch === 'x64') {
       if (abi === '93') {
-        return createdRequire('../sentry_cpu_profiler-win32-x64-93.node');
+        return require('../sentry_cpu_profiler-win32-x64-93.node');
       }
       if (abi === '108') {
-        return createdRequire('../sentry_cpu_profiler-win32-x64-108.node');
+        return require('../sentry_cpu_profiler-win32-x64-108.node');
       }
       if (abi === '115') {
-        return createdRequire('../sentry_cpu_profiler-win32-x64-115.node');
+        return require('../sentry_cpu_profiler-win32-x64-115.node');
       }
       if (abi === '127') {
-        return createdRequire('../sentry_cpu_profiler-win32-x64-127.node');
+        return require('../sentry_cpu_profiler-win32-x64-127.node');
       }
     }
   }
@@ -109,68 +93,68 @@ export function importCppBindingsModule(): PrivateV8CpuProfilerBindings {
     if (arch === 'x64') {
       if (stdlib === 'musl') {
         if (abi === '93') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-musl-93.node');
+          return require('../sentry_cpu_profiler-linux-x64-musl-93.node');
         }
         if (abi === '108') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-musl-108.node');
+          return require('../sentry_cpu_profiler-linux-x64-musl-108.node');
         }
         if (abi === '115') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-musl-115.node');
+          return require('../sentry_cpu_profiler-linux-x64-musl-115.node');
         }
         if (abi === '127') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-musl-127.node');
+          return require('../sentry_cpu_profiler-linux-x64-musl-127.node');
         }
       }
       if (stdlib === 'glibc') {
         if (abi === '93') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-glibc-93.node');
+          return require('../sentry_cpu_profiler-linux-x64-glibc-93.node');
         }
         if (abi === '108') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-glibc-108.node');
+          return require('../sentry_cpu_profiler-linux-x64-glibc-108.node');
         }
         if (abi === '115') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-glibc-115.node');
+          return require('../sentry_cpu_profiler-linux-x64-glibc-115.node');
         }
         if (abi === '127') {
-          return createdRequire('../sentry_cpu_profiler-linux-x64-glibc-127.node');
+          return require('../sentry_cpu_profiler-linux-x64-glibc-127.node');
         }
       }
     }
     if (arch === 'arm64') {
       if (stdlib === 'musl') {
         if (abi === '93') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-musl-93.node');
+          return require('../sentry_cpu_profiler-linux-arm64-musl-93.node');
         }
         if (abi === '108') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-musl-108.node');
+          return require('../sentry_cpu_profiler-linux-arm64-musl-108.node');
         }
         if (abi === '115') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-musl-115.node');
+          return require('../sentry_cpu_profiler-linux-arm64-musl-115.node');
         }
         if (abi === '127') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-musl-127.node');
+          return require('../sentry_cpu_profiler-linux-arm64-musl-127.node');
         }
       }
 
       if (stdlib === 'glibc') {
         if (abi === '93') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-glibc-93.node');
+          return require('../sentry_cpu_profiler-linux-arm64-glibc-93.node');
         }
         if (abi === '108') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-glibc-108.node');
+          return require('../sentry_cpu_profiler-linux-arm64-glibc-108.node');
         }
         if (abi === '115') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-glibc-115.node');
+          return require('../sentry_cpu_profiler-linux-arm64-glibc-115.node');
         }
         if (abi === '127') {
-          return createdRequire('../sentry_cpu_profiler-linux-arm64-glibc-127.node');
+          return require('../sentry_cpu_profiler-linux-arm64-glibc-127.node');
         }
       }
     }
   }
 
-  const built_from_source_path = resolve(esmCompatibleDirname, '..', `sentry_cpu_profiler-${identifier}`);
-  return createdRequire(`${built_from_source_path}.node`);
+  const built_from_source_path = resolve(__dirname, '..', `sentry_cpu_profiler-${identifier}`);
+  return require(`${built_from_source_path}.node`);
 }
 
 const PrivateCpuProfilerBindings: PrivateV8CpuProfilerBindings = importCppBindingsModule();