diff --git a/sentry_sdk/integrations/django/asgi.py b/sentry_sdk/integrations/django/asgi.py
index 48b27c50c8..bd785a23c2 100644
--- a/sentry_sdk/integrations/django/asgi.py
+++ b/sentry_sdk/integrations/django/asgi.py
@@ -8,6 +8,8 @@
 
 import asyncio
 
+from django.core.handlers.wsgi import WSGIRequest
+
 from sentry_sdk import Hub, _functools
 from sentry_sdk._types import TYPE_CHECKING
 from sentry_sdk.consts import OP
@@ -16,26 +18,21 @@
 from sentry_sdk.integrations.asgi import SentryAsgiMiddleware
 from sentry_sdk.utils import capture_internal_exceptions
 
-from django.core.handlers.wsgi import WSGIRequest
-
 
 if TYPE_CHECKING:
-    from typing import Any
-    from typing import Dict
-    from typing import Union
-    from typing import Callable
+    from collections.abc import Callable
+    from typing import Any, Union
 
     from django.core.handlers.asgi import ASGIRequest
     from django.http.response import HttpResponse
 
-    from sentry_sdk.integrations.django import DjangoIntegration
     from sentry_sdk._types import EventProcessor
 
 
-def _make_asgi_request_event_processor(request, integration):
-    # type: (ASGIRequest, DjangoIntegration) -> EventProcessor
+def _make_asgi_request_event_processor(request):
+    # type: (ASGIRequest) -> EventProcessor
     def asgi_request_event_processor(event, hint):
-        # type: (Dict[str, Any], Dict[str, Any]) -> Dict[str, Any]
+        # type: (dict[str, Any], dict[str, Any]) -> dict[str, Any]
         # if the request is gone we are fine not logging the data from
         # it.  This might happen if the processor is pushed away to
         # another thread.
@@ -103,9 +100,7 @@ def sentry_patched_create_request(self, *args, **kwargs):
                 # (otherwise Django closes the body stream and makes it impossible to read it again)
                 _ = request.body
 
-                scope.add_event_processor(
-                    _make_asgi_request_event_processor(request, integration)
-                )
+                scope.add_event_processor(_make_asgi_request_event_processor(request))
 
                 return request, error_response
 
diff --git a/sentry_sdk/integrations/django/signals_handlers.py b/sentry_sdk/integrations/django/signals_handlers.py
index 87b6b22ff8..097a56c8aa 100644
--- a/sentry_sdk/integrations/django/signals_handlers.py
+++ b/sentry_sdk/integrations/django/signals_handlers.py
@@ -7,12 +7,12 @@
 from sentry_sdk._functools import wraps
 from sentry_sdk._types import TYPE_CHECKING
 from sentry_sdk.consts import OP
+from sentry_sdk.integrations.django import DJANGO_VERSION
 
 
 if TYPE_CHECKING:
-    from typing import Any
-    from typing import Callable
-    from typing import List
+    from collections.abc import Callable
+    from typing import Any, Union
 
 
 def _get_receiver_name(receiver):
@@ -42,17 +42,27 @@ def _get_receiver_name(receiver):
 
 def patch_signals():
     # type: () -> None
-    """Patch django signal receivers to create a span"""
+    """
+    Patch django signal receivers to create a span.
+
+    This only wraps sync receivers. Django>=5.0 introduced async receivers, but
+    since we don't create transactions for ASGI Django, we don't wrap them.
+    """
     from sentry_sdk.integrations.django import DjangoIntegration
 
     old_live_receivers = Signal._live_receivers
 
     def _sentry_live_receivers(self, sender):
-        # type: (Signal, Any) -> List[Callable[..., Any]]
+        # type: (Signal, Any) -> Union[tuple[list[Callable[..., Any]], list[Callable[..., Any]]], list[Callable[..., Any]]]
         hub = Hub.current
-        receivers = old_live_receivers(self, sender)
 
-        def sentry_receiver_wrapper(receiver):
+        if DJANGO_VERSION >= (5, 0):
+            sync_receivers, async_receivers = old_live_receivers(self, sender)
+        else:
+            sync_receivers = old_live_receivers(self, sender)
+            async_receivers = []
+
+        def sentry_sync_receiver_wrapper(receiver):
             # type: (Callable[..., Any]) -> Callable[..., Any]
             @wraps(receiver)
             def wrapper(*args, **kwargs):
@@ -69,9 +79,12 @@ def wrapper(*args, **kwargs):
 
         integration = hub.get_integration(DjangoIntegration)
         if integration and integration.signals_spans:
-            for idx, receiver in enumerate(receivers):
-                receivers[idx] = sentry_receiver_wrapper(receiver)
+            for idx, receiver in enumerate(sync_receivers):
+                sync_receivers[idx] = sentry_sync_receiver_wrapper(receiver)
 
-        return receivers
+        if DJANGO_VERSION >= (5, 0):
+            return sync_receivers, async_receivers
+        else:
+            return sync_receivers
 
     Signal._live_receivers = _sentry_live_receivers
diff --git a/tests/integrations/django/asgi/test_asgi.py b/tests/integrations/django/asgi/test_asgi.py
index 57145b698d..c7f5f1dfd9 100644
--- a/tests/integrations/django/asgi/test_asgi.py
+++ b/tests/integrations/django/asgi/test_asgi.py
@@ -26,6 +26,7 @@
 
 @pytest.mark.parametrize("application", APPS)
 @pytest.mark.asyncio
+@pytest.mark.forked
 async def test_basic(sentry_init, capture_events, application):
     sentry_init(integrations=[DjangoIntegration()], send_default_pii=True)
 
@@ -58,6 +59,7 @@ async def test_basic(sentry_init, capture_events, application):
 
 @pytest.mark.parametrize("application", APPS)
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -85,6 +87,7 @@ async def test_async_views(sentry_init, capture_events, application):
 @pytest.mark.parametrize("application", APPS)
 @pytest.mark.parametrize("endpoint", ["/sync/thread_ids", "/async/thread_ids"])
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -119,6 +122,7 @@ async def test_active_thread_id(sentry_init, capture_envelopes, endpoint, applic
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -152,6 +156,7 @@ async def test_async_views_concurrent_execution(sentry_init, settings):
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -189,6 +194,7 @@ async def test_async_middleware_that_is_function_concurrent_execution(
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -238,6 +244,7 @@ async def test_async_middleware_spans(
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -267,6 +274,7 @@ async def test_has_trace_if_performance_enabled(sentry_init, capture_events):
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -293,6 +301,7 @@ async def test_has_trace_if_performance_disabled(sentry_init, capture_events):
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -328,6 +337,7 @@ async def test_trace_from_headers_if_performance_enabled(sentry_init, capture_ev
 
 
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
@@ -373,6 +383,7 @@ async def test_trace_from_headers_if_performance_disabled(sentry_init, capture_e
     ],
 )
 @pytest.mark.asyncio
+@pytest.mark.forked
 @pytest.mark.skipif(
     django.VERSION < (3, 1), reason="async views have been introduced in Django 3.1"
 )
diff --git a/tox.ini b/tox.ini
index d5e0d753a9..072b561b07 100644
--- a/tox.ini
+++ b/tox.ini
@@ -79,6 +79,8 @@ envlist =
     {py3.6,py3.7,py3.8,py3.9,py3.10,py3.11}-django-v{3.2}
     # - Django 4.x
     {py3.8,py3.9,py3.10,py3.11,py3.12}-django-v{4.0,4.1,4.2}
+    # - Django 5.x
+    {py3.10,py3.11,py3.12}-django-v{5.0}
 
     # Falcon
     {py2.7,py3.5,py3.6,py3.7}-falcon-v{1.4}
@@ -288,17 +290,16 @@ deps =
     django: Werkzeug<2.1.0
     django-v{1.11,2.0,2.1,2.2,3.0,3.1,3.2}: djangorestframework>=3.0.0,<4.0.0
 
-    {py3.7,py3.8,py3.9,py3.10,py3.11}-django-v{1.11,2.0,2.1,2.2,3.0,3.1,3.2,4.0,4.1,4.2}: pytest-asyncio
-    {py3.7,py3.8,py3.9,py3.10,py3.11}-django-v{1.11,2.0,2.1,2.2,3.0,3.1,3.2,4.0,4.1,4.2}: channels[daphne]>2
+    {py3.7,py3.8,py3.9,py3.10,py3.11,py3.12}-django-v{1.11,2.0,2.1,2.2,3.0,3.1,3.2,4.0,4.1,4.2,5.0}: pytest-asyncio
+    {py3.7,py3.8,py3.9,py3.10,py3.11,py3.12}-django-v{1.11,2.0,2.1,2.2,3.0,3.1,3.2,4.0,4.1,4.2,5.0}: channels[daphne]>2
 
     django-v{1.8,1.9,1.10,1.11,2.0,2.1}: pytest-django<4.0
     django-v{2.2,3.0,3.1,3.2}: pytest-django>=4.0
     django-v{2.2,3.0,3.1,3.2}: Werkzeug<2.0
-
-    django-v{4.0,4.1,4.2}: djangorestframework
-    django-v{4.0,4.1,4.2}: pytest-asyncio
-    django-v{4.0,4.1,4.2}: pytest-django
-    django-v{4.0,4.1,4.2}: Werkzeug
+    django-v{4.0,4.1,4.2,5.0}: djangorestframework
+    django-v{4.0,4.1,4.2,5.0}: pytest-asyncio
+    django-v{4.0,4.1,4.2,5.0}: pytest-django
+    django-v{4.0,4.1,4.2,5.0}: Werkzeug
 
     django-v1.8: Django>=1.8,<1.9
     django-v1.9: Django>=1.9,<1.10
@@ -313,6 +314,8 @@ deps =
     django-v4.0: Django>=4.0,<4.1
     django-v4.1: Django>=4.1,<4.2
     django-v4.2: Django>=4.2,<4.3
+    # TODO: change to final when available
+    django-v5.0: Django==5.0b1
 
     # Falcon
     falcon-v1.4: falcon>=1.4,<1.5