diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6ffddb833..831ca8df1 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -21,6 +21,7 @@
 
 ### Changes
 
+- `tracePropagationTargets` defaults to all targets on mobile and same origin on the web ([#4083](https://github.com/getsentry/sentry-react-native/pull/4083))
 - Move `_experiments.profilesSampleRate` to `profilesSampleRate` root options object [#3851](https://github.com/getsentry/sentry-react-native/pull/3851))
 - Add Android Logger when new frame event is not emitted ([#4081](https://github.com/getsentry/sentry-react-native/pull/4081))
 - React Native Tracing Deprecations ([#4073](https://github.com/getsentry/sentry-react-native/pull/4073))
diff --git a/packages/core/src/js/tracing/reactnativetracing.ts b/packages/core/src/js/tracing/reactnativetracing.ts
index 996c85c70..b6ee5e178 100644
--- a/packages/core/src/js/tracing/reactnativetracing.ts
+++ b/packages/core/src/js/tracing/reactnativetracing.ts
@@ -3,6 +3,7 @@ import { instrumentOutgoingRequests } from '@sentry/browser';
 import { getClient } from '@sentry/core';
 import type { Client, Event, Integration, StartSpanOptions } from '@sentry/types';
 
+import { isWeb } from '../utils/environment';
 import { addDefaultOpForSpanFrom, defaultIdleOptions } from './span';
 
 export const INTEGRATION_NAME = 'ReactNativeTracing';
@@ -60,7 +61,12 @@ export interface ReactNativeTracingOptions {
   shouldCreateSpanForRequest?(this: void, url: string): boolean;
 }
 
-const DEFAULT_TRACE_PROPAGATION_TARGETS = ['localhost', /^\/(?!\/)/];
+function getDefaultTracePropagationTargets(): RegExp[] | undefined {
+  if (isWeb()) {
+    return undefined;
+  }
+  return [/.*/];
+}
 
 export const defaultReactNativeTracingOptions: ReactNativeTracingOptions = {
   traceFetch: true,
@@ -98,7 +104,7 @@ export const reactNativeTracingIntegration = (
       traceFetch: finalOptions.traceFetch,
       traceXHR: finalOptions.traceXHR,
       shouldCreateSpanForRequest: finalOptions.shouldCreateSpanForRequest,
-      tracePropagationTargets: client.getOptions().tracePropagationTargets || DEFAULT_TRACE_PROPAGATION_TARGETS,
+      tracePropagationTargets: client.getOptions().tracePropagationTargets || getDefaultTracePropagationTargets(),
     });
   };
 
diff --git a/packages/core/src/js/utils/environment.ts b/packages/core/src/js/utils/environment.ts
index 19b120a56..214532b03 100644
--- a/packages/core/src/js/utils/environment.ts
+++ b/packages/core/src/js/utils/environment.ts
@@ -53,6 +53,11 @@ export function getExpoSdkVersion(): string | undefined {
   return expoSdkVersion;
 }
 
+/** Checks if the current platform is web */
+export function isWeb(): boolean {
+  return Platform.OS === 'web';
+}
+
 /** Checks if the current platform is not web */
 export function notWeb(): boolean {
   return Platform.OS !== 'web';
diff --git a/packages/core/test/tracing/reactnativetracing.test.ts b/packages/core/test/tracing/reactnativetracing.test.ts
index 2b049f5ed..3605a25f7 100644
--- a/packages/core/test/tracing/reactnativetracing.test.ts
+++ b/packages/core/test/tracing/reactnativetracing.test.ts
@@ -1,12 +1,3 @@
-jest.mock('@sentry/utils', () => {
-  const originalUtils = jest.requireActual('@sentry/utils');
-
-  return {
-    ...originalUtils,
-    timestampInSeconds: jest.fn(originalUtils.timestampInSeconds),
-  };
-});
-
 import * as SentryBrowser from '@sentry/browser';
 import type { Event } from '@sentry/types';
 
@@ -31,7 +22,18 @@ jest.mock('../../src/js/tracing/utils', () => {
   };
 });
 
+jest.mock('@sentry/utils', () => {
+  const originalUtils = jest.requireActual('@sentry/utils');
+
+  return {
+    ...originalUtils,
+    timestampInSeconds: jest.fn(originalUtils.timestampInSeconds),
+  };
+});
+
+jest.mock('../../src/js/utils/environment');
 import { reactNativeTracingIntegration } from '../../src/js/tracing/reactnativetracing';
+import { isWeb } from '../../src/js/utils/environment';
 import type { TestClient } from '../mocks/client';
 import { setupTestClient } from '../mocks/client';
 
@@ -66,7 +68,24 @@ describe('ReactNativeTracing', () => {
       );
     });
 
-    it('uses defaults', () => {
+    it('uses mobile defaults', () => {
+      (isWeb as jest.MockedFunction<typeof isWeb>).mockReturnValue(false);
+      const instrumentOutgoingRequests = jest.spyOn(SentryBrowser, 'instrumentOutgoingRequests');
+      setupTestClient({
+        enableStallTracking: false,
+        integrations: [reactNativeTracingIntegration()],
+      });
+
+      expect(instrumentOutgoingRequests).toBeCalledWith(
+        expect.anything(),
+        expect.objectContaining({
+          tracePropagationTargets: [/.*/],
+        }),
+      );
+    });
+
+    it('uses web defaults', () => {
+      (isWeb as jest.MockedFunction<typeof isWeb>).mockReturnValue(true);
       const instrumentOutgoingRequests = jest.spyOn(SentryBrowser, 'instrumentOutgoingRequests');
       setupTestClient({
         enableStallTracking: false,
@@ -76,7 +95,7 @@ describe('ReactNativeTracing', () => {
       expect(instrumentOutgoingRequests).toBeCalledWith(
         expect.anything(),
         expect.objectContaining({
-          tracePropagationTargets: ['localhost', /^\/(?!\/)/],
+          tracePropagationTargets: undefined,
         }),
       );
     });