diff --git a/src/cmd/cgo/gcc.go b/src/cmd/cgo/gcc.go
index 111a309eb5c02..b5e28e325459c 100644
--- a/src/cmd/cgo/gcc.go
+++ b/src/cmd/cgo/gcc.go
@@ -1549,7 +1549,14 @@ func (p *Package) gccBaseCmd() []string {
 func (p *Package) gccMachine() []string {
 	switch goarch {
 	case "amd64":
+		if goos == "darwin" {
+			return []string{"-arch", "x86_64", "-m64"}
+		}
 		return []string{"-m64"}
+	case "arm64":
+		if goos == "darwin" {
+			return []string{"-arch", "arm64"}
+		}
 	case "386":
 		return []string{"-m32"}
 	case "arm":
diff --git a/src/cmd/go/internal/work/exec.go b/src/cmd/go/internal/work/exec.go
index feb2299d40132..af8b78e6618e7 100644
--- a/src/cmd/go/internal/work/exec.go
+++ b/src/cmd/go/internal/work/exec.go
@@ -2435,7 +2435,7 @@ func (b *Builder) fcExe() []string {
 func (b *Builder) compilerExe(envValue string, def string) []string {
 	compiler := strings.Fields(envValue)
 	if len(compiler) == 0 {
-		compiler = []string{def}
+		compiler = strings.Fields(def)
 	}
 	return compiler
 }
@@ -2581,7 +2581,14 @@ func (b *Builder) gccArchArgs() []string {
 	case "386":
 		return []string{"-m32"}
 	case "amd64":
+		if cfg.Goos == "darwin" {
+			return []string{"-arch", "x86_64", "-m64"}
+		}
 		return []string{"-m64"}
+	case "arm64":
+		if cfg.Goos == "darwin" {
+			return []string{"-arch", "arm64"}
+		}
 	case "arm":
 		return []string{"-marm"} // not thumb
 	case "s390x":
diff --git a/src/cmd/go/testdata/script/build_darwin_cc_arch.txt b/src/cmd/go/testdata/script/build_darwin_cc_arch.txt
new file mode 100644
index 0000000000000..2b81b4cf80b69
--- /dev/null
+++ b/src/cmd/go/testdata/script/build_darwin_cc_arch.txt
@@ -0,0 +1,24 @@
+# Test that we pass -arch flag to C compiler on Darwin (issue 43692).
+
+[!darwin] skip
+[!cgo] skip
+
+# clear CC, in case user sets it
+env CC=
+
+env CGO_ENABLED=1
+
+env GOARCH=amd64
+go build -n -x c.go
+stderr 'clang.*-arch x86_64'
+
+env GOARCH=arm64
+go build -n -x c.go
+stderr 'clang.*-arch arm64'
+
+-- c.go --
+package main
+
+import "C"
+
+func main() {}
diff --git a/src/cmd/link/internal/ld/lib.go b/src/cmd/link/internal/ld/lib.go
index bf95745d8d9d7..dd5e8ab2c5cf2 100644
--- a/src/cmd/link/internal/ld/lib.go
+++ b/src/cmd/link/internal/ld/lib.go
@@ -1749,12 +1749,19 @@ func hostlinkArchArgs(arch *sys.Arch) []string {
 	switch arch.Family {
 	case sys.I386:
 		return []string{"-m32"}
-	case sys.AMD64, sys.S390X:
+	case sys.AMD64:
+		if objabi.GOOS == "darwin" {
+			return []string{"-arch", "x86_64", "-m64"}
+		}
+		return []string{"-m64"}
+	case sys.S390X:
 		return []string{"-m64"}
 	case sys.ARM:
 		return []string{"-marm"}
 	case sys.ARM64:
-		// nothing needed
+		if objabi.GOOS == "darwin" {
+			return []string{"-arch", "arm64"}
+		}
 	case sys.MIPS64:
 		return []string{"-mabi=64"}
 	case sys.MIPS: