diff --git a/http2/frame.go b/http2/frame.go
index 184ac45fe..c1f6b90dc 100644
--- a/http2/frame.go
+++ b/http2/frame.go
@@ -662,6 +662,15 @@ func (f *Framer) WriteData(streamID uint32, endStream bool, data []byte) error {
 // It is the caller's responsibility not to violate the maximum frame size
 // and to not call other Write methods concurrently.
 func (f *Framer) WriteDataPadded(streamID uint32, endStream bool, data, pad []byte) error {
+	if err := f.startWriteDataPadded(streamID, endStream, data, pad); err != nil {
+		return err
+	}
+	return f.endWrite()
+}
+
+// startWriteDataPadded is WriteDataPadded, but only writes the frame to the Framer's internal buffer.
+// The caller should call endWrite to flush the frame to the underlying writer.
+func (f *Framer) startWriteDataPadded(streamID uint32, endStream bool, data, pad []byte) error {
 	if !validStreamID(streamID) && !f.AllowIllegalWrites {
 		return errStreamID
 	}
@@ -691,7 +700,7 @@ func (f *Framer) WriteDataPadded(streamID uint32, endStream bool, data, pad []by
 	}
 	f.wbuf = append(f.wbuf, data...)
 	f.wbuf = append(f.wbuf, pad...)
-	return f.endWrite()
+	return nil
 }
 
 // A SettingsFrame conveys configuration parameters that affect how
diff --git a/http2/server.go b/http2/server.go
index 9bd7035bf..8cb14f3c9 100644
--- a/http2/server.go
+++ b/http2/server.go
@@ -843,8 +843,13 @@ type frameWriteResult struct {
 // and then reports when it's done.
 // At most one goroutine can be running writeFrameAsync at a time per
 // serverConn.
-func (sc *serverConn) writeFrameAsync(wr FrameWriteRequest) {
-	err := wr.write.writeFrame(sc)
+func (sc *serverConn) writeFrameAsync(wr FrameWriteRequest, wd *writeData) {
+	var err error
+	if wd == nil {
+		err = wr.write.writeFrame(sc)
+	} else {
+		err = sc.framer.endWrite()
+	}
 	sc.wroteFrameCh <- frameWriteResult{wr: wr, err: err}
 }
 
@@ -1251,9 +1256,16 @@ func (sc *serverConn) startFrameWrite(wr FrameWriteRequest) {
 		sc.writingFrameAsync = false
 		err := wr.write.writeFrame(sc)
 		sc.wroteFrame(frameWriteResult{wr: wr, err: err})
+	} else if wd, ok := wr.write.(*writeData); ok {
+		// Encode the frame in the serve goroutine, to ensure we don't have
+		// any lingering asynchronous references to data passed to Write.
+		// See https://go.dev/issue/58446.
+		sc.framer.startWriteDataPadded(wd.streamID, wd.endStream, wd.p, nil)
+		sc.writingFrameAsync = true
+		go sc.writeFrameAsync(wr, wd)
 	} else {
 		sc.writingFrameAsync = true
-		go sc.writeFrameAsync(wr)
+		go sc.writeFrameAsync(wr, nil)
 	}
 }
 
diff --git a/http2/server_test.go b/http2/server_test.go
index 978cc37b4..d32b2d85b 100644
--- a/http2/server_test.go
+++ b/http2/server_test.go
@@ -4631,3 +4631,78 @@ func TestCanonicalHeaderCacheGrowth(t *testing.T) {
 		}
 	}
 }
+
+// TestServerWriteDoesNotRetainBufferAfterStreamClose checks for access to
+// the slice passed to ResponseWriter.Write after Write returns.
+//
+// Terminating the request stream on the client causes Write to return.
+// We should not access the slice after this point.
+func TestServerWriteDoesNotRetainBufferAfterReturn(t *testing.T) {
+	donec := make(chan struct{})
+	st := newServerTester(t, func(w http.ResponseWriter, r *http.Request) {
+		defer close(donec)
+		buf := make([]byte, 1<<20)
+		var i byte
+		for {
+			i++
+			_, err := w.Write(buf)
+			for j := range buf {
+				buf[j] = byte(i) // trigger race detector
+			}
+			if err != nil {
+				return
+			}
+		}
+	}, optOnlyServer)
+	defer st.Close()
+
+	tr := &Transport{TLSClientConfig: tlsConfigInsecure}
+	defer tr.CloseIdleConnections()
+
+	req, _ := http.NewRequest("GET", st.ts.URL, nil)
+	res, err := tr.RoundTrip(req)
+	if err != nil {
+		t.Fatal(err)
+	}
+	res.Body.Close()
+	<-donec
+}
+
+// TestServerWriteDoesNotRetainBufferAfterServerClose checks for access to
+// the slice passed to ResponseWriter.Write after Write returns.
+//
+// Shutting down the Server causes Write to return.
+// We should not access the slice after this point.
+func TestServerWriteDoesNotRetainBufferAfterServerClose(t *testing.T) {
+	donec := make(chan struct{}, 1)
+	st := newServerTester(t, func(w http.ResponseWriter, r *http.Request) {
+		donec <- struct{}{}
+		defer close(donec)
+		buf := make([]byte, 1<<20)
+		var i byte
+		for {
+			i++
+			_, err := w.Write(buf)
+			for j := range buf {
+				buf[j] = byte(i)
+			}
+			if err != nil {
+				return
+			}
+		}
+	}, optOnlyServer)
+	defer st.Close()
+
+	tr := &Transport{TLSClientConfig: tlsConfigInsecure}
+	defer tr.CloseIdleConnections()
+
+	req, _ := http.NewRequest("GET", st.ts.URL, nil)
+	res, err := tr.RoundTrip(req)
+	if err != nil {
+		t.Fatal(err)
+	}
+	defer res.Body.Close()
+	<-donec
+	st.ts.Config.Close()
+	<-donec
+}