diff --git a/go/analysis/passes/unusedresult/testdata/src/typeparams/typeparams.go b/go/analysis/passes/unusedresult/testdata/src/typeparams/typeparams.go
new file mode 100644
index 00000000000..c770ccd44e4
--- /dev/null
+++ b/go/analysis/passes/unusedresult/testdata/src/typeparams/typeparams.go
@@ -0,0 +1,41 @@
+// Copyright 2015 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+//
+//go:build go1.18
+
+package typeparams
+
+import (
+	"bytes"
+	"errors"
+	"fmt"
+	"typeparams/userdefs"
+)
+
+func _[T any]() {
+	fmt.Errorf("") // want "result of fmt.Errorf call not used"
+	_ = fmt.Errorf("")
+
+	errors.New("") // want "result of errors.New call not used"
+
+	err := errors.New("")
+	err.Error() // want `result of \(error\).Error call not used`
+
+	var buf bytes.Buffer
+	buf.String() // want `result of \(bytes.Buffer\).String call not used`
+
+	fmt.Sprint("")  // want "result of fmt.Sprint call not used"
+	fmt.Sprintf("") // want "result of fmt.Sprintf call not used"
+
+	userdefs.MustUse[int](1) // want "result of typeparams/userdefs.MustUse call not used"
+	_ = userdefs.MustUse[int](2)
+
+	s := userdefs.SingleTypeParam[int]{X: 1}
+	s.String() // want `result of \(typeparams/userdefs.SingleTypeParam\[int\]\).String call not used`
+	_ = s.String()
+
+	m := userdefs.MultiTypeParam[int, string]{X: 1, Y: "one"}
+	m.String() // want `result of \(typeparams/userdefs.MultiTypeParam\[int, string\]\).String call not used`
+	_ = m.String()
+}
\ No newline at end of file
diff --git a/go/analysis/passes/unusedresult/testdata/src/typeparams/userdefs/userdefs.go b/go/analysis/passes/unusedresult/testdata/src/typeparams/userdefs/userdefs.go
new file mode 100644
index 00000000000..218cc9ac75e
--- /dev/null
+++ b/go/analysis/passes/unusedresult/testdata/src/typeparams/userdefs/userdefs.go
@@ -0,0 +1,28 @@
+// Copyright 2015 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+//
+//go:build go1.18
+
+package userdefs
+
+func MustUse[T interface{ ~int }](v T) T {
+	return v + 1
+}
+
+type SingleTypeParam[T any] struct {
+	X T
+}
+
+func (_ *SingleTypeParam[T]) String() string {
+	return "SingleTypeParam"
+}
+
+type MultiTypeParam[T any, U any] struct {
+	X T
+	Y U
+}
+
+func (_ *MultiTypeParam[T, U]) String() string {
+	return "MultiTypeParam"
+}
\ No newline at end of file
diff --git a/go/analysis/passes/unusedresult/unusedresult.go b/go/analysis/passes/unusedresult/unusedresult.go
index bececee7e93..fd94508f883 100644
--- a/go/analysis/passes/unusedresult/unusedresult.go
+++ b/go/analysis/passes/unusedresult/unusedresult.go
@@ -17,6 +17,7 @@ import (
 	"golang.org/x/tools/go/analysis/passes/inspect"
 	"golang.org/x/tools/go/analysis/passes/internal/analysisutil"
 	"golang.org/x/tools/go/ast/inspector"
+	"golang.org/x/tools/internal/typeparams"
 )
 
 // TODO(adonovan): make this analysis modular: export a mustUseResult
@@ -70,6 +71,11 @@ func run(pass *analysis.Pass) (interface{}, error) {
 			return // a conversion, not a call
 		}
 
+		index := typeparams.GetIndexExprData(fun)
+		if index != nil {
+			fun = index.X // If this is generic function or method call, skip the instantiation arguments
+		}
+
 		selector, ok := fun.(*ast.SelectorExpr)
 		if !ok {
 			return // neither a method call nor a qualified ident
diff --git a/go/analysis/passes/unusedresult/unusedresult_test.go b/go/analysis/passes/unusedresult/unusedresult_test.go
index 90bf7ba4f0c..a2b079af00e 100644
--- a/go/analysis/passes/unusedresult/unusedresult_test.go
+++ b/go/analysis/passes/unusedresult/unusedresult_test.go
@@ -9,9 +9,16 @@ import (
 
 	"golang.org/x/tools/go/analysis/analysistest"
 	"golang.org/x/tools/go/analysis/passes/unusedresult"
+	"golang.org/x/tools/internal/typeparams"
 )
 
 func Test(t *testing.T) {
 	testdata := analysistest.TestData()
-	analysistest.Run(t, testdata, unusedresult.Analyzer, "a")
+	funcs := "typeparams/userdefs.MustUse,errors.New,fmt.Errorf,fmt.Sprintf,fmt.Sprint"
+	unusedresult.Analyzer.Flags.Set("funcs", funcs)
+	tests := []string{"a"}
+	if typeparams.Enabled {
+		tests = append(tests, "typeparams")
+	}
+	analysistest.Run(t, testdata, unusedresult.Analyzer, tests...)
 }