diff --git a/assets/js/util/i18n.js b/assets/js/util/i18n.js
index 313527cfa0c..7ef32a7b097 100644
--- a/assets/js/util/i18n.js
+++ b/assets/js/util/i18n.js
@@ -20,6 +20,7 @@
  * External dependencies
  */
 import { get, isFinite, isPlainObject } from 'lodash';
+import memize from 'memize';
 
 /**
  * WordPress dependencies
@@ -272,6 +273,9 @@ export const numFmt = ( number, options = {} ) => {
 	return numberFormat( number, formatOptions );
 };
 
+// Warn once for a given message.
+const warnOnce = memize( console.warn ); // eslint-disable-line no-console
+
 /**
  * Formats a number using the JS Internationalization Number Format API.
  *
@@ -286,7 +290,50 @@ export const numFmt = ( number, options = {} ) => {
 export const numberFormat = ( number, options = {} ) => {
 	const { locale = getLocale(), ...formatOptions } = options;
 
-	return new Intl.NumberFormat( locale, formatOptions ).format( number );
+	try {
+		/**
+		 * Per https://github.com/google/site-kit-wp/issues/3255 there have been issues with some versions of Safari
+		 * on some operating systems throwing issues with some parameters in the formatOptions.
+		 *
+		 * If an error is thrown, we remove some troublesome params from the formatOptions object and fallback to no formatting.
+		 *
+		 * This allows us to degrade somewhat gracefully without breaking the dashboard for users of unaffected browsers.
+		 */
+		return new Intl.NumberFormat( locale, formatOptions ).format( number );
+	} catch ( error ) {
+		warnOnce( `Site Kit numberFormat error: Intl.NumberFormat( ${ JSON.stringify( locale ) }, ${ JSON.stringify( formatOptions ) } ).format( ${ typeof number } )`, error.message );
+	}
+
+	// Remove these key/values from formatOptions.
+	const unstableFormatOptionValues = {
+		currencyDisplay: 'narrow',
+		currencySign: 'accounting',
+		style: 'unit',
+	};
+
+	// Remove these keys from formatOptions irrespective of value.
+	const unstableFormatOptions = [
+		'signDisplay',
+		'compactDisplay',
+	];
+
+	const reducedFormatOptions = {};
+
+	for ( const [ key, value ] of Object.entries( formatOptions ) ) {
+		if ( unstableFormatOptionValues[ key ] && value === unstableFormatOptionValues[ key ] ) {
+			continue;
+		}
+		if ( unstableFormatOptions.includes( key ) ) {
+			continue;
+		}
+		reducedFormatOptions[ key ] = value;
+	}
+
+	try {
+		return new Intl.NumberFormat( locale, reducedFormatOptions ).format( number );
+	} catch {
+		return new Intl.NumberFormat( locale ).format( number );
+	}
 };
 
 /**
diff --git a/assets/js/util/test/numberFormat.js b/assets/js/util/test/numberFormat.js
index 6dbe5fddbd6..10af9062046 100644
--- a/assets/js/util/test/numberFormat.js
+++ b/assets/js/util/test/numberFormat.js
@@ -87,6 +87,7 @@ describe( 'numberFormat', () => {
 		expect(
 			numberFormat( 123456789.87, { locale: 'de-DE' } )
 		).toStrictEqual( '123.456.789,87' );
+		expect( console ).not.toHaveWarned();
 	} );
 
 	afterEach( () => {
@@ -115,5 +116,99 @@ describe( 'numberFormat', () => {
 	it.each( siteKitLocales )( 'formats numbers correctly with locale variant %s', ( locale, value, expected ) => {
 		setupGoogleSiteKit( locale );
 		expect( numberFormat( value ) ).toStrictEqual( expected );
+		expect( console ).not.toHaveWarned();
+	} );
+
+	describe( 'graceful degradation for problematic options in some browsers', () => {
+		const NumberFormat = Intl.NumberFormat;
+		let NumberFormatSpy;
+
+		beforeEach( () => {
+			NumberFormatSpy = jest.spyOn( global.Intl, 'NumberFormat' );
+		} );
+
+		afterEach( () => {
+			NumberFormatSpy.mockRestore();
+		} );
+
+		// Error message that browser throws on error.
+		const errorMessage = 'TypeError: Failed to initialize NumberFormat since used feature is not supported in the linked ICU version';
+
+		// Replicate a browser behaviour to throw errors when certain option key/values are encountered.
+		const createThrowIfOptionMatch = ( key, value ) => ( locales, options = {} ) => {
+			if ( options[ key ] && (
+				value === options[ key ] || value === undefined
+			) ) {
+				throw new TypeError( errorMessage );
+			}
+			return NumberFormat( locales, options );
+		};
+
+		it( 'degrades gracefully when `signDisplay` has any value other than the default of `auto`', () => {
+			// Regular implementation.
+			expect( numberFormat( -0.0123, {
+				locale: 'en-US',
+				signDisplay: 'never',
+				style: 'percent',
+				maximumFractionDigits: 1,
+			} ) ).toStrictEqual( '1.2%' );
+
+			/*
+			 * Option of `signDisplay: never` causes issues in some browser/os combinations.
+			 *
+			 * @see https://github.com/google/site-kit-wp/issues/3255
+			 */
+			NumberFormatSpy.mockImplementation( createThrowIfOptionMatch( 'signDisplay', 'never' ) );
+
+			expect( numberFormat( -0.0123, {
+				locale: 'en-US',
+				signDisplay: 'never', // This parameter will be removed.
+				style: 'percent',
+				maximumFractionDigits: 1,
+			} ) ).toStrictEqual( '-1.2%' );
+
+			const expectedWarning = 'Site Kit numberFormat error: Intl.NumberFormat( "en-US", {"signDisplay":"never","style":"percent","maximumFractionDigits":1} ).format( number )';
+			expect( console ).toHaveWarnedWith( expectedWarning, errorMessage );
+
+			// Call the same function again to ensure we don't warn again.
+			numberFormat( -0.0123, {
+				locale: 'en-US',
+				signDisplay: 'never', // This parameter will be removed.
+				style: 'percent',
+				maximumFractionDigits: 1,
+			} );
+
+			// Ensure we don't log more than once.
+			expect( console.warn ).toHaveBeenCalledTimes( 1 ); // eslint-disable-line no-console
+		} );
+
+		it( 'degrades gracefully when the `style:unit` option is provided', () => {
+			// Regular implementation.
+			expect( numberFormat( 22, {
+				locale: 'en-US',
+				unitDisplay: 'narrow',
+				style: 'unit',
+				unit: 'second',
+			} ) ).toStrictEqual( '22s' );
+
+			expect( console ).not.toHaveWarned();
+
+			/*
+			 * Option of `style: unit` causes issues in some browser/os combinations.
+			 *
+			 * @see https://github.com/google/site-kit-wp/issues/3255
+			 */
+			NumberFormatSpy.mockImplementation( createThrowIfOptionMatch( 'style', 'unit' ) );
+
+			expect( numberFormat( 22, {
+				locale: 'en-US',
+				unitDisplay: 'narrow',
+				style: 'unit',
+				unit: 'second',
+			} ) ).toStrictEqual( '22' );
+
+			const expectedWarning = 'Site Kit numberFormat error: Intl.NumberFormat( "en-US", {"unitDisplay":"narrow","style":"unit","unit":"second"} ).format( number )';
+			expect( console ).toHaveWarnedWith( expectedWarning, errorMessage );
+		} );
 	} );
 } );