diff --git a/gapic/schema/api.py b/gapic/schema/api.py
index 11cb77f286..c6b69cf34a 100644
--- a/gapic/schema/api.py
+++ b/gapic/schema/api.py
@@ -262,12 +262,16 @@ def build(
             file_descriptors,
         ), opts=opts)
 
+        # "metadata", "retry", "timeout", and "request" are reserved words in client methods.
+        invalid_module_names = set(keyword.kwlist) | {
+            "metadata", "retry", "timeout", "request"}
+
         def disambiguate_keyword_fname(
                 full_path: str,
                 visited_names: Container[str]) -> str:
             path, fname = os.path.split(full_path)
             name, ext = os.path.splitext(fname)
-            if name in keyword.kwlist or full_path in visited_names:
+            if name in invalid_module_names or full_path in visited_names:
                 name += "_"
                 full_path = os.path.join(path, name + ext)
                 if full_path in visited_names:
diff --git a/tests/unit/schema/test_api.py b/tests/unit/schema/test_api.py
index eae44b84b1..212c86daed 100644
--- a/tests/unit/schema/test_api.py
+++ b/tests/unit/schema/test_api.py
@@ -233,7 +233,27 @@ def test_proto_keyword_fname():
             name='class.proto',
             package='google.keywords.v1',
             messages=(make_message_pb2(name='ClassRequest', fields=()),),
-        )
+        ),
+        make_file_pb2(
+            name='metadata.proto',
+            package='google.keywords.v1',
+            messages=(make_message_pb2(name='MetadataRequest', fields=()),),
+        ),
+        make_file_pb2(
+            name='retry.proto',
+            package='google.keywords.v1',
+            messages=(make_message_pb2(name='RetryRequest', fields=()),),
+        ),
+        make_file_pb2(
+            name='timeout.proto',
+            package='google.keywords.v1',
+            messages=(make_message_pb2(name='TimeoutRequest', fields=()),),
+        ),
+        make_file_pb2(
+            name='request.proto',
+            package='google.keywords.v1',
+            messages=(make_message_pb2(name='RequestRequest', fields=()),),
+        ),
     )
 
     # We can't create new collisions, so check that renames cascade.
@@ -243,6 +263,10 @@ def test_proto_keyword_fname():
         'import__.proto',
         'class_.proto',
         'class__.proto',
+        'metadata_.proto',
+        'retry_.proto',
+        'timeout_.proto',
+        'request_.proto',
     }