diff --git a/.release-please-manifest-individual.json b/.release-please-manifest-individual.json
index 44237f86bdcd..cdc48efe416a 100644
--- a/.release-please-manifest-individual.json
+++ b/.release-please-manifest-individual.json
@@ -8,6 +8,6 @@
   "profiler": "0.3.1",
   "pubsub": "1.30.1",
   "pubsublite": "1.8.1",
-  "spanner": "1.45.1",
+  "spanner": "1.46.0",
   "storage": "1.30.1"
 }
diff --git a/spanner/CHANGES.md b/spanner/CHANGES.md
index f51afae47738..2f8408b3eafa 100644
--- a/spanner/CHANGES.md
+++ b/spanner/CHANGES.md
@@ -1,5 +1,18 @@
 # Changes
 
+## [1.46.0](https://github.com/googleapis/google-cloud-go/compare/spanner/v1.45.1...spanner/v1.46.0) (2023-05-12)
+
+
+### Features
+
+* **spanner/admin/database:** Add support for UpdateDatabase in Cloud Spanner ([#7917](https://github.com/googleapis/google-cloud-go/issues/7917)) ([83870f5](https://github.com/googleapis/google-cloud-go/commit/83870f55035d6692e22264b209e39e07fe2823b9))
+* **spanner:** Make leader aware routing default enabled for supported RPC requests. ([#7912](https://github.com/googleapis/google-cloud-go/issues/7912)) ([d0d3755](https://github.com/googleapis/google-cloud-go/commit/d0d37550911f37e09ea9204d0648fb64ff3204ff))
+
+
+### Bug Fixes
+
+* **spanner:** Update grpc to v1.55.0 ([1147ce0](https://github.com/googleapis/google-cloud-go/commit/1147ce02a990276ca4f8ab7a1ab65c14da4450ef))
+
 ## [1.45.1](https://github.com/googleapis/google-cloud-go/compare/spanner/v1.45.0...spanner/v1.45.1) (2023-04-21)
 
 
diff --git a/spanner/internal/version.go b/spanner/internal/version.go
index e7729577cf3b..fc6b11e22267 100644
--- a/spanner/internal/version.go
+++ b/spanner/internal/version.go
@@ -15,4 +15,4 @@
 package internal
 
 // Version is the current tagged release of the library.
-const Version = "1.45.1"
+const Version = "1.46.0"