diff --git a/CHANGELOG.md b/CHANGELOG.md
index 181d2dcde8d6b..8198d3e1905ff 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,10 +1,10 @@
 ## Main
-
+* [5568](https://github.com/grafana/loki/pull/5568) **afayngelerindbx**: Fix canary panics due to concurrent execution of `confirmMissing`
 * [5552](https://github.com/grafana/loki/pull/5552) **jiachengxu**: Loki mixin: add `DiskSpaceUtilizationPanel`
 * [5541](https://github.com/grafana/loki/pull/5541) **bboreham**: Queries: reject very deeply nested regexps which could crash Loki.
 * [5536](https://github.com/grafana/loki/pull/5536) **jiachengxu**: Loki mixin: make labelsSelector in loki chunks dashboards configurable
 * [5535](https://github.com/grafana/loki/pull/5535) **jiachengxu**: Loki mixins: use labels selector for loki chunks dashboard
-* [5507](https://github.com/grafana/loki/pull/5507) **MichelHollands**: Remove extra param in call for inflightRequests metric. 
+* [5507](https://github.com/grafana/loki/pull/5507) **MichelHollands**: Remove extra param in call for inflightRequests metric.
 * [5356](https://github.com/grafana/loki/pull/5356) **jbschami**: Enhance lambda-promtail to support adding extra labels from an environment variable value
 * [5409](https://github.com/grafana/loki/pull/5409) **ldb**: Enable best effort parsing for Syslog messages
 * [5392](https://github.com/grafana/loki/pull/5392) **MichelHollands**: Etcd credentials are parsed as secrets instead of plain text now.
diff --git a/pkg/canary/comparator/comparator.go b/pkg/canary/comparator/comparator.go
index e48d52484799c..97c0b8cc2db9e 100644
--- a/pkg/canary/comparator/comparator.go
+++ b/pkg/canary/comparator/comparator.go
@@ -431,15 +431,28 @@ func (c *Comparator) pruneEntries(currentTime time.Time) {
 func (c *Comparator) confirmMissing(currentTime time.Time) {
 	// Because we are querying loki timestamps vs the timestamp in the log,
 	// make the range +/- 10 seconds to allow for clock inaccuracies
+	c.missingMtx.Lock()
+	if len(c.missingEntries) == 0 {
+		c.missingMtx.Unlock()
+		return
+	}
 	start := *c.missingEntries[0]
 	start = start.Add(-10 * time.Second)
 	end := *c.missingEntries[len(c.missingEntries)-1]
 	end = end.Add(10 * time.Second)
+	c.missingMtx.Unlock()
+
 	recvd, err := c.rdr.Query(start, end)
 	if err != nil {
 		fmt.Fprintf(c.w, "error querying loki: %s\n", err)
 		return
 	}
+	// Now that query has returned, take out the lock on the missingEntries list so we can modify it
+	// It's possible more entries were added to this list but that's ok, if they match something in the
+	// query result we will remove them, if they don't they won't be old enough yet to remove.
+	c.missingMtx.Lock()
+	defer c.missingMtx.Unlock()
+
 	// This is to help debug some missing log entries when queried,
 	// let's print exactly what we are missing and what Loki sent back
 	for _, r := range c.missingEntries {
@@ -449,11 +462,6 @@ func (c *Comparator) confirmMissing(currentTime time.Time) {
 		fmt.Fprintf(c.w, DebugQueryResult, r.UnixNano())
 	}
 
-	// Now that query has returned, take out the lock on the missingEntries list so we can modify it
-	// It's possible more entries were added to this list but that's ok, if they match something in the
-	// query result we will remove them, if they don't they won't be old enough yet to remove.
-	c.missingMtx.Lock()
-	defer c.missingMtx.Unlock()
 	k := 0
 	for i, m := range c.missingEntries {
 		found := false
diff --git a/pkg/canary/comparator/comparator_test.go b/pkg/canary/comparator/comparator_test.go
index 8f11f3eb16b78..db2c1b341bd6b 100644
--- a/pkg/canary/comparator/comparator_test.go
+++ b/pkg/canary/comparator/comparator_test.go
@@ -218,6 +218,46 @@ func TestEntryNeverReceived(t *testing.T) {
 
 }
 
+// Ensure that if confirmMissing calls pile up and run concurrently, this doesn't cause a panic
+func TestConcurrentConfirmMissing(t *testing.T) {
+	found := []time.Time{
+		time.Unix(0, 0),
+		time.UnixMilli(1),
+		time.UnixMilli(2),
+	}
+	mr := &mockReader{resp: found}
+
+	output := &bytes.Buffer{}
+
+	wait := 30 * time.Millisecond
+	maxWait := 30 * time.Millisecond
+
+	c := NewComparator(output, wait, maxWait, 50*time.Hour, 15*time.Minute, 4*time.Hour, 4*time.Hour, 0, 1*time.Minute, 0, 0, 1, make(chan time.Time), make(chan time.Time), mr, false)
+
+	for _, t := range found {
+		tCopy := t
+		c.missingEntries = append(c.missingEntries, &tCopy)
+	}
+
+	wg := sync.WaitGroup{}
+	for i := 0; i < 10; i++ {
+		wg.Add(1)
+		go func() {
+			defer wg.Done()
+			assert.NotPanics(t, func() { c.confirmMissing(time.UnixMilli(3)) })
+		}()
+	}
+	assert.Eventually(
+		t,
+		func() bool {
+			wg.Wait()
+			return true
+		},
+		time.Second,
+		10*time.Millisecond,
+	)
+}
+
 func TestPruneAckdEntires(t *testing.T) {
 	actual := &bytes.Buffer{}
 	wait := 30 * time.Millisecond