diff --git a/.changelog/26012.txt b/.changelog/26012.txt
new file mode 100644
index 000000000000..9a5ca4bba143
--- /dev/null
+++ b/.changelog/26012.txt
@@ -0,0 +1,3 @@
+```release-note:bug
+resource/aws_appmesh_gateway_route: Fix crash when only one of hostname rewrite or path rewrite is configured
+```
\ No newline at end of file
diff --git a/internal/service/appmesh/gateway_route.go b/internal/service/appmesh/gateway_route.go
index 0a76e351f6dd..15b8c3e44536 100644
--- a/internal/service/appmesh/gateway_route.go
+++ b/internal/service/appmesh/gateway_route.go
@@ -779,7 +779,7 @@ func expandHTTPGatewayRouteRewrite(vHttpRouteRewrite []interface{}) *appmesh.Htt
 	mRouteRewrite := vHttpRouteRewrite[0].(map[string]interface{})
 	routeRewrite := &appmesh.HttpGatewayRouteRewrite{}
 
-	if vRouteHostnameRewrite, ok := mRouteRewrite["hostname"].([]interface{}); ok {
+	if vRouteHostnameRewrite, ok := mRouteRewrite["hostname"].([]interface{}); ok && len(vRouteHostnameRewrite) > 0 && vRouteHostnameRewrite[0] != nil {
 		mRouteHostnameRewrite := vRouteHostnameRewrite[0].(map[string]interface{})
 		routeHostnameRewrite := &appmesh.GatewayRouteHostnameRewrite{}
 		if vDefaultTargetHostname, ok := mRouteHostnameRewrite["default_target_hostname"].(string); ok && vDefaultTargetHostname != "" {
@@ -788,7 +788,7 @@ func expandHTTPGatewayRouteRewrite(vHttpRouteRewrite []interface{}) *appmesh.Htt
 		routeRewrite.Hostname = routeHostnameRewrite
 	}
 
-	if vRoutePrefixRewrite, ok := mRouteRewrite["prefix"].([]interface{}); ok {
+	if vRoutePrefixRewrite, ok := mRouteRewrite["prefix"].([]interface{}); ok && len(vRoutePrefixRewrite) > 0 && vRoutePrefixRewrite[0] != nil {
 		mRoutePrefixRewrite := vRoutePrefixRewrite[0].(map[string]interface{})
 		routePrefixRewrite := &appmesh.HttpGatewayRoutePrefixRewrite{}
 		if vDefaultPrefix, ok := mRoutePrefixRewrite["default_prefix"].(string); ok && vDefaultPrefix != "" {