From 68204d6a8c97098c56b665e680822b57c8dae438 Mon Sep 17 00:00:00 2001 From: rgravitvl Date: Mon, 30 Oct 2023 18:19:53 +0530 Subject: [PATCH] fixed bug on internal links --- .../convert/test/fixtures/blog2-semantic.html | 22 +- .../convert/test/fixtures/news-semantic.html | 4 +- .../convert/test/fixtures/news2-semantic.html | 83 ++ .../actions/convert/test/fixtures/news2.html | 946 ++++++++++++++++++ tools/importer/transformers/util.js | 5 + 5 files changed, 1047 insertions(+), 13 deletions(-) create mode 100644 tools/actions/convert/test/fixtures/news2-semantic.html create mode 100644 tools/actions/convert/test/fixtures/news2.html diff --git a/tools/actions/convert/test/fixtures/blog2-semantic.html b/tools/actions/convert/test/fixtures/blog2-semantic.html index 873da365a..a1bfaa2b2 100644 --- a/tools/actions/convert/test/fixtures/blog2-semantic.html +++ b/tools/actions/convert/test/fixtures/blog2-semantic.html @@ -18,12 +18,12 @@

9 Essential Products for Streamlining Your mRNA Development and Manufacturin

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In the realm of life sciences, the tools you employ can significantly influence your work's efficiency and outcomes. For scientists, lab managers, and lab directors involved in mRNA development and manufacturing, having the right instruments at your fingertips can be a game-changer. Here, we spotlight nine indispensable products from Danaher Life Science companies that are revolutionizing this field.

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In the realm of life sciences, the tools you employ can significantly influence your work's efficiency and outcomes. For scientists, lab managers, and lab directors involved in mRNA development and manufacturing, having the right instruments at your fingertips can be a game-changer. Here, we spotlight nine indispensable products from Danaher Life Science companies that are revolutionizing this field.

1. Biomek i7 Automated Liquid Handlers

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The Biomek i7 Automated Liquid Handlers are a boon for anyone involved in cell culture, plasmid purification, or analytical assay preparation such as ELISA or NGS. They provide rapid, reliable, and automated liquid handling, freeing scientists to focus on their research rather than time-consuming manual pipetting. Request a quote today to see how the Biomek i7 can enhance your lab's efficiency.

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The Biomek i7 Automated Liquid Handlers are a boon for anyone involved in cell culture, plasmid purification, or analytical assay preparation such as ELISA or NGS. They provide rapid, reliable, and automated liquid handling, freeing scientists to focus on their research rather than time-consuming manual pipetting. Request a quote today to see how the Biomek i7 can enhance your lab's efficiency.

Learn More

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1. Biomek i7 Automated Liquid Handlers

2. Echo 525 Acoustic Liquid Handlers

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Next up is the Echo 525 Acoustic Liquid Handler. This advanced instrument uses sound to precisely transfer liquids without contact, eliminating the risk of cross-contamination and improving the reproducibility of your experiments. Explore the Echo 525 and request a quote to see how it can streamline your lab operations.

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Next up is the Echo 525 Acoustic Liquid Handler. This advanced instrument uses sound to precisely transfer liquids without contact, eliminating the risk of cross-contamination and improving the reproducibility of your experiments. Explore the Echo 525 and request a quote to see how it can streamline your lab operations.

Learn More

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2. Echo 525 Acoustic Liquid Handlers

3. Intabio ZT System

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The Intabio ZT System is a revolutionary tool for the analysis of protein biotherapeutics. It provides rapid, high-resolution analysis of charge variants, enabling you to monitor product quality. Discover how the Intabio ZT System can accelerate your biotherapeutic development and request a quote today.

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The Intabio ZT System is a revolutionary tool for the analysis of protein biotherapeutics. It provides rapid, high-resolution analysis of charge variants, enabling you to monitor product quality. Discover how the Intabio ZT System can accelerate your biotherapeutic development and request a quote today.

Learn More

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3. Intabio ZT System

4. IDBS Polar

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IDBS Polar is a cloud-based platform that streamlines the management of your biopharmaceutical data. It integrates seamlessly with your existing systems, providing a single source of truth for your data and enabling real-time collaboration across your organization. Discover how IDBS Polar can revolutionize your data management and request a quote today.

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IDBS Polar is a cloud-based platform that streamlines the management of your biopharmaceutical data. It integrates seamlessly with your existing systems, providing a single source of truth for your data and enabling real-time collaboration across your organization. Discover how IDBS Polar can revolutionize your data management and request a quote today.

Learn More

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4. IDBS Polar

5. Biophase 8800 Capillary Electrophoresis Systems

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The Biophase 8800 Capillary Electrophoresis Systems offer high-resolution separation of biomolecules, making them an invaluable tool for protein and nucleic acid analysis. Request a quote to see how the Biophase 8800 can enhance your lab's analytical capabilities.

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The Biophase 8800 Capillary Electrophoresis Systems offer high-resolution separation of biomolecules, making them an invaluable tool for protein and nucleic acid analysis. Request a quote to see how the Biophase 8800 can enhance your lab's analytical capabilities.

Learn More

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5. Biophase 8800 Capillary Electrophoresis Systems

6. SpectraMax Microplate Readers

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The SpectraMax Microplate Readers provide fast, accurate, and reliable detection of a wide range of assays. With their user-friendly interface and robust data analysis capabilities, they are an essential tool for any lab involved in mRNA development and manufacturing. Explore the SpectraMax series and request a quote to see how they can improve your lab's throughput.

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The SpectraMax Microplate Readers provide fast, accurate, and reliable detection of a wide range of assays. With their user-friendly interface and robust data analysis capabilities, they are an essential tool for any lab involved in mRNA development and manufacturing. Explore the SpectraMax series and request a quote to see how they can improve your lab's throughput.

Learn More

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6. SpectraMax Microplate Readers

7. ZenoTOF 7600 Mass Spectrometer

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The ZenoTOF 7600 Mass Spectrometer provides high-resolution mass spectrometry, allowing you to identify and quantify the molecules in your samples with unparalleled accuracy. Explore the ZenoTOF 7600 and request a quote to see how it can elevate your lab's analytical capabilities.

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The ZenoTOF 7600 Mass Spectrometer provides high-resolution mass spectrometry, allowing you to identify and quantify the molecules in your samples with unparalleled accuracy. Explore the ZenoTOF 7600 and request a quote to see how it can elevate your lab's analytical capabilities.

Learn More

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7. ZenoTOF 7600 Mass Spectrometer

8. BioZen Oligo Analytical HPLC Columns

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The BioZen Oligo Analytical HPLC Columns are designed for the analysis of oligonucleotides, offering excellent resolution and reproducibility. Discover the BioZen Oligo and request a quote to see how it can enhance your lab's analytical capabilities.

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The BioZen Oligo Analytical HPLC Columns are designed for the analysis of oligonucleotides, offering excellent resolution and reproducibility. Discover the BioZen Oligo and request a quote to see how it can enhance your lab's analytical capabilities.

Learn More

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8. BioZen Oligo Analytical HPLC Columns

9. Skyland PIMS

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Last but not least, Skyland PIMS is a cloud-based platform that simplifies the management of your process and product data, ensuring compliance with regulatory requirements and facilitating decision-making. Discover how Skyland PIMS can revolutionize your data management and request a quote today.

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Last but not least, Skyland PIMS is a cloud-based platform that simplifies the management of your process and product data, ensuring compliance with regulatory requirements and facilitating decision-making. Discover how Skyland PIMS can revolutionize your data management and request a quote today.

Learn More

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9. Skyland PIMS

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In conclusion, these nine products are revolutionizing mRNA development and manufacturing. By integrating these tools into your workflow, you can accelerate your research, improve your outcomes, and stay at the forefront of life sciences innovation. Explore these products and request a quote today to see how they can transform your lab operations.

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In conclusion, these nine products are revolutionizing mRNA development and manufacturing. By integrating these tools into your workflow, you can accelerate your research, improve your outcomes, and stay at the forefront of life sciences innovation. Explore these products and request a quote today to see how they can transform your lab operations.

diff --git a/tools/actions/convert/test/fixtures/news-semantic.html b/tools/actions/convert/test/fixtures/news-semantic.html index 28cceb86d..dfd6b94e6 100644 --- a/tools/actions/convert/test/fixtures/news-semantic.html +++ b/tools/actions/convert/test/fixtures/news-semantic.html @@ -19,10 +19,10 @@

Gene Editing in Organoids: Accounting for Complexity in Drug Discovery

Gene Editing in Organoids

The genome is the blueprint for life, consisting of genes made up of thousands of pairs of DNA bases. Altering one base pair can drastically change how the gene’s protein product functions, while mutations can lead to the development of a range of genetic disorders.

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CRISPR allows researchers to target and edit specific genes in order to better understand the genome, human diseases and the effects of specific mutations. The development of CRISPR has opened the door to ending diseases by fixing mutations and developing therapies through the process of modeling mutations. Scientists use complex gene editing and disease modeling systems to gain insights on the potential of CRISPR.

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CRISPR allows researchers to target and edit specific genes in order to better understand the genome, human diseases and the effects of specific mutations. The development of CRISPR has opened the door to ending diseases by fixing mutations and developing therapies through the process of modeling mutations. Scientists use complex gene editing and disease modeling systems to gain insights on the potential of CRISPR.

Most gene editing studies are performed in traditional 2D culture systems that model a simplified version of the tissue and biology in question. These 2D culture systems typically consist of one cell type that forms into a single layer of cells. While these studies demonstrate how one cell type behaves when a gene’s sequence is altered, their simplified nature makes it difficult to know how that cell, or the entire tissue, would respond within the body when that same sequence is altered. The need for greater complexity of cell-based systems has led to the development of organoids.

What are organoids?

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Organoids are 3D tissue models consisting of multiple cell types that could bridge the gap between traditional 2Din vitrocultures and the actualin vivotissue of the body. Organoids are developed using primary tissues or induced pluripotent stem cells (iPSCs) derived from standard iPSC cell lines or from cells of patients that carry particular diseases. Typically, iPSCs are developed from blood or skin cell samples, and then differentiated into organoids representing various tissues from the liver, intestine, heart, brain, and other organs. Organoids can also be grown from adult tissues that originate in the intestine or liver, for example, and represent normal or malignant tissues. Developing organoids from human cell sources offers distinct advantages over other commonly used systems like animal models. While animal models are useful for modelingin vivoresponses, the physiological differences between animals and humans make disease modeling and drug efficacy studies less relevant and less predictive. They also present ethical, monetary, and time-related challenges.

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Organoids are 3D tissue models consisting of multiple cell types that could bridge the gap between traditional 2Din vitrocultures and the actualin vivotissue of the body. Organoids are developed using primary tissues or induced pluripotent stem cells (iPSCs) derived from standard iPSC cell lines or from cells of patients that carry particular diseases. Typically, iPSCs are developed from blood or skin cell samples, and then differentiated into organoids representing various tissues from the liver, intestine, heart, brain, and other organs. Organoids can also be grown from adult tissues that originate in the intestine or liver, for example, and represent normal or malignant tissues. Developing organoids from human cell sources offers distinct advantages over other commonly used systems like animal models. While animal models are useful for modelingin vivoresponses, the physiological differences between animals and humans make disease modeling and drug efficacy studies less relevant and less predictive. They also present ethical, monetary, and time-related challenges.

Organoids avoid these challenges by modeling human tissue using human cells. They also capture the tissue environment more closely than 2D cultures by growing 3D cell structures that mimic the organs they are modeling. One of the ways that organoids capture the tissue micro-environment is by featuring more than one cell type. For example, cardiac organoids include cardiac cells, vascular cells and fibroblasts. This is important for observing how cells interact during tissue-level events like inflammation, which contributes to complex conditions like myocardial infarction and stroke. Modeling not only how cardiac cells, but also immune and vascular cells respond to inflammation will provide a more complete picture, especially valuable in the drug development process.

Organoids capture the complexity of real tissue not only by including multiple cell types, but also by displaying a morphological structure that closely mimics the real tissue organisation. For instance, intestinal organoids mimic the crypts that line the intestine, while brain organoids mimic the different neural layers of the brain.

The structures of organoids also make them useful for studying drug penetration, which is important for predicting drug efficiency. Small molecule drugs or biologics need to be delivered via blood vessels and penetrate tissue to get into cells. In 2D cultures, drugs are entered directly into cells, giving no indication of how the drug will penetrate live tissue. Organoids are more suitable for demonstrating how a drug will behave within a live organ.

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ValitaCell Joins Beckman Coulter Life Sciences

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+ ValitaCell Joins Beckman Coulter Life Sciences +

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ValitaCell Joins Beckman Coulter Life Sciences

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Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, announces it has acquired ValitaCell Ltd. (“ValitaCell”), a biotechnology company that creates pioneering analytical products and technologies for the biopharmaceutical industry.

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Headquartered in Dublin, Ireland, ValitaCell creates analytical technologies and products for the biopharmaceutical industry with the goal of reducing new therapeutics' cost and time to market. Compared to other industry IgG quantification assays, the ValitaTiter product outperforms in terms of speed and ease of use, and offers numerous advantages over other long and tedious techniques, like ELISA and HPLC.

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“ValitaCell has a proven record for delivering innovative products and we are excited to build upon our successful partnership with Beckman Coulter Life Sciences,” said Dr. Jerry Clifford, Co-Founder and CEO of ValitaCell. “We never take for granted what our advancements can do for patients while also reducing manual workflow burdens on laboratory staff. Together with Beckman Coulter Life Sciences, we will advance our shared ambition to accelerate and enable the sustainable manufacture of innovative biological medicines to bring them to market faster.”

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ValitaCell technologies are patented in key international markets and the company has been honored with several awards, including the Irish Pharmaceutical Awards’ Pharma Start-up of the Year in 2017 and InterTrade Ireland’s Seedcorn awards. It also was recognized as one of the most successful Irish companies in Horizon 2020.

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“Throughout our trusted partnership with ValitaCell, we have long admired their innovative offerings and industry expertise,” said Jason Lanie, Vice President and General Manager of the Biotechnology Business Unit at Beckman Coulter Life Sciences. “Their leading portfolio of products, including ValitaTiter, Quantum, CellAi, and ChemStress Clone Robustness complement Beckman Coulter Life Sciences’ existing and future product portfolio, and are designed with the same goal of providing faster cellular analysis while decreasing the risk of errors. We are excited to welcome their team and look forward to growing the Ireland Innovation and Development Centers for Biologics to help meet evolving customer needs.”

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ValitaCell locations in Dublin and Galway, Ireland will remain operational and are anticipated to grow in response to business needs.

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About Beckman Coulter Life Sciences

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Life sciences. Research. Precision manufacturing. If your life’s calling is in any of these or related fields, you need to know Beckman Coulter Life Sciences, part of the Danaher Corporation (NYSE: DHR) family of global science and technology companies. Our mission is to empower those seeking answers to life’s important scientific and healthcare questions. Since 1935, the Beckman name has been synonymous with technologies that simplify and automate complex biomedical testing. Decades later, our global organization also came to embody the scientific legacy of the Coulter name. Today, Beckman Coulter Life Sciences is a trusted, worldwide resource for tools to help optimize research and manufacturing efficiency. Centrifuges. Particle counters/analyzers. Automated liquid handlers. Flow cytometers. Genomic reagents. All these products—and many more—continue to make a difference in people’s lives by improving the productivity of dedicated scientists, quality control experts and others. Wherever people need answers, from prestigious universities and major pharmaceutical companies, to small biotech startups, food/beverage and electronics manufacturing facilities, you can find Beckman Coulter Life Sciences. For more details, visit**beckman.com/contact-us.**

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About ValitaCell

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ValitaCell’s mission is to accelerate the pace and reduce the cost of manufacturing innovative medicines. We are focused on enabling our biopharmaceutical customers to bring medicines to the patients that need them most, in the shortest length of time. The majority of drugs that advance to clinical trial fail before they make it to the market. This failure increases costs and delays life-saving treatments for patients. Our team is focused on creating analytical technologies that empower scientists with rich cell data and insights earlier in the drug discovery and development process. We are committed to advancing human healthcare worldwide.

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Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries.

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Contact:Matt McCutcheon, Global External Communications Manager

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mmccutcheon@beckman.com

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317-719-0557

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The original article was published byBeckman Coulter Life Sciences.

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Title
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ValitaCell Joins Beckman Coulter Life Sciences | Danaher Life Sciences
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keywords
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Genomic Medicines,Early Diagnosis & Precision Medicine,Automation,mRNA,Human Systems R&D,Cell Line Development,Data Science & Deep Learning,Next Gen Biomanufacturing
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Description
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Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, announces it has acquired ValitaCell Ltd. (“ValitaCell”), a biotechnology company that creates pioneering analytical products and technologies for the biopharmaceutical industry.
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Beckman Coulter Life Sciences
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Tue, 13 Sep 2022 00:00:00 GMT
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4
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