diff --git a/deno_dist/types.ts b/deno_dist/types.ts
index 9d6d44e3b..6f9f6e0fe 100644
--- a/deno_dist/types.ts
+++ b/deno_dist/types.ts
@@ -394,11 +394,7 @@ export interface HandlerInterface<
   >(
     path: P,
     handler: H<E2, MergedPath, I, R>
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x2)
   <
@@ -412,11 +408,7 @@ export interface HandlerInterface<
   >(
     path: P,
     ...handlers: [H<E2, MergedPath, I>, H<E3, MergedPath, I2, R>]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I2['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I2['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x3)
   <
@@ -432,11 +424,7 @@ export interface HandlerInterface<
   >(
     path: P,
     ...handlers: [H<E2, MergedPath, I>, H<E3, MergedPath, I2>, H<E4, MergedPath, I3, R>]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I3['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I3['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x4)
   <
@@ -459,11 +447,7 @@ export interface HandlerInterface<
       H<E4, MergedPath, I3>,
       H<E5, MergedPath, I4, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I4['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I4['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x5)
   <
@@ -489,11 +473,7 @@ export interface HandlerInterface<
       H<E5, MergedPath, I4>,
       H<E6, MergedPath, I5, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I5['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I5['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x6)
   <
@@ -522,11 +502,7 @@ export interface HandlerInterface<
       H<E6, MergedPath, I5>,
       H<E7, MergedPath, I6, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I6['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I6['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x7)
   <
@@ -558,11 +534,7 @@ export interface HandlerInterface<
       H<E7, MergedPath, I6>,
       H<E8, MergedPath, I7, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I7['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I7['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x8)
   <
@@ -597,11 +569,7 @@ export interface HandlerInterface<
       H<E8, MergedPath, I7>,
       H<E9, MergedPath, I8, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8, E9]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I8['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I8['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x9)
   <
@@ -639,11 +607,7 @@ export interface HandlerInterface<
       H<E9, MergedPath, I8>,
       H<E10, MergedPath, I9, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8, E9, E10]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I9['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I9['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x10)
   <
@@ -685,7 +649,7 @@ export interface HandlerInterface<
       H<E11, MergedPath, I10, R>
     ]
   ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8, E9, E10, E11]>,
+    E,
     S & ToSchema<M, MergePath<BasePath, P>, I10['in'], MergeTypedResponseData<R>>,
     BasePath
   >
diff --git a/src/types.test.ts b/src/types.test.ts
index b3b4fe08f..2f64e8544 100644
--- a/src/types.test.ts
+++ b/src/types.test.ts
@@ -836,158 +836,6 @@ describe('c.var with chaining - test only types', () => {
       return c.json(0)
     })
 
-    // app.get('/', handler...)
-
-    new Hono().get('/', mw1).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4, mw5).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4, mw5, mw6).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, mw8).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo8')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo8).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, mw8, mw9).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo8')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo9')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo8).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo9).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
-    new Hono().get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, mw8, mw9, mw10).get('/', (c) => {
-      expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo8')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo9')).toEqualTypeOf<string>()
-      expectTypeOf(c.get('foo10')).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo8).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo9).toEqualTypeOf<string>()
-      expectTypeOf(c.var.foo10).toEqualTypeOf<string>()
-      return c.json(0)
-    })
-
     new Hono().get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, mw8, mw9, (c) => {
       expectTypeOf(c.req.valid('query')).toMatchTypeOf<{
         bar1: number
@@ -1003,6 +851,390 @@ describe('c.var with chaining - test only types', () => {
 
       return c.json(0)
     })
+
+    type Env = {
+      Variables: {
+        init: number
+      }
+    }
+
+    new Hono<Env>()
+      .get('/', mw1, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, mw4, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        // @ts-expect-error foo4 is not typed
+        c.get('foo4')
+        // @ts-expect-error foo4 is not typed
+        c.var.foo4
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, mw4, mw5, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        // @ts-expect-error foo4 is not typed
+        c.get('foo4')
+        // @ts-expect-error foo4 is not typed
+        c.var.foo4
+        // @ts-expect-error foo5 is not typed
+        c.get('foo5')
+        // @ts-expect-error foo5 is not typed
+        c.var.foo5
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, mw4, mw5, mw6, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        // @ts-expect-error foo4 is not typed
+        c.get('foo4')
+        // @ts-expect-error foo4 is not typed
+        c.var.foo4
+        // @ts-expect-error foo5 is not typed
+        c.get('foo5')
+        // @ts-expect-error foo5 is not typed
+        c.var.foo5
+        // @ts-expect-error foo6 is not typed
+        c.get('foo6')
+        // @ts-expect-error foo6 is not typed
+        c.var.foo6
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        // @ts-expect-error foo4 is not typed
+        c.get('foo4')
+        // @ts-expect-error foo4 is not typed
+        c.var.foo4
+        // @ts-expect-error foo5 is not typed
+        c.get('foo5')
+        // @ts-expect-error foo5 is not typed
+        c.var.foo5
+        // @ts-expect-error foo6 is not typed
+        c.get('foo6')
+        // @ts-expect-error foo6 is not typed
+        c.var.foo6
+        // @ts-expect-error foo7 is not typed
+        c.get('foo7')
+        // @ts-expect-error foo7 is not typed
+        c.var.foo7
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, mw8, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo8')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo8).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        // @ts-expect-error foo4 is not typed
+        c.get('foo4')
+        // @ts-expect-error foo4 is not typed
+        c.var.foo4
+        // @ts-expect-error foo5 is not typed
+        c.get('foo5')
+        // @ts-expect-error foo5 is not typed
+        c.var.foo5
+        // @ts-expect-error foo6 is not typed
+        c.get('foo6')
+        // @ts-expect-error foo6 is not typed
+        c.var.foo6
+        // @ts-expect-error foo7 is not typed
+        c.get('foo7')
+        // @ts-expect-error foo7 is not typed
+        c.var.foo7
+        // @ts-expect-error foo8 is not typed
+        c.get('foo8')
+        // @ts-expect-error foo8 is not typed
+        c.var.foo8
+        return c.json(0)
+      })
+
+    new Hono<Env>()
+      .get('/', mw1, mw2, mw3, mw4, mw5, mw6, mw7, mw8, mw9, (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        expectTypeOf(c.get('foo1')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo1).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo2')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo2).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo3')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo3).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo4')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo4).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo5')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo5).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo6')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo6).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo7')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo7).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo8')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo8).toEqualTypeOf<string>()
+        expectTypeOf(c.get('foo9')).toEqualTypeOf<string>()
+        expectTypeOf(c.var.foo9).toEqualTypeOf<string>()
+        return c.json(0)
+      })
+      .get('/', (c) => {
+        expectTypeOf(c.get('init')).toEqualTypeOf<number>()
+        expectTypeOf(c.var.init).toEqualTypeOf<number>()
+        // @ts-expect-error foo1 is not typed
+        c.get('foo1')
+        // @ts-expect-error foo1 is not typed
+        c.var.foo1
+        // @ts-expect-error foo2 is not typed
+        c.get('foo2')
+        // @ts-expect-error foo2 is not typed
+        c.var.foo2
+        // @ts-expect-error foo3 is not typed
+        c.get('foo3')
+        // @ts-expect-error foo3 is not typed
+        c.var.foo3
+        // @ts-expect-error foo4 is not typed
+        c.get('foo4')
+        // @ts-expect-error foo4 is not typed
+        c.var.foo4
+        // @ts-expect-error foo5 is not typed
+        c.get('foo5')
+        // @ts-expect-error foo5 is not typed
+        c.var.foo5
+        // @ts-expect-error foo6 is not typed
+        c.get('foo6')
+        // @ts-expect-error foo6 is not typed
+        c.var.foo6
+        // @ts-expect-error foo7 is not typed
+        c.get('foo7')
+        // @ts-expect-error foo7 is not typed
+        c.var.foo7
+        // @ts-expect-error foo8 is not typed
+        c.get('foo8')
+        // @ts-expect-error foo8 is not typed
+        c.var.foo8
+        // @ts-expect-error foo9 is not typed
+        c.get('foo9')
+        // @ts-expect-error foo9 is not typed
+        c.var.foo9
+        return c.json(0)
+      })
   })
 })
 
diff --git a/src/types.ts b/src/types.ts
index df23cba4e..aa554ef3b 100644
--- a/src/types.ts
+++ b/src/types.ts
@@ -394,11 +394,7 @@ export interface HandlerInterface<
   >(
     path: P,
     handler: H<E2, MergedPath, I, R>
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x2)
   <
@@ -412,11 +408,7 @@ export interface HandlerInterface<
   >(
     path: P,
     ...handlers: [H<E2, MergedPath, I>, H<E3, MergedPath, I2, R>]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I2['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I2['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x3)
   <
@@ -432,11 +424,7 @@ export interface HandlerInterface<
   >(
     path: P,
     ...handlers: [H<E2, MergedPath, I>, H<E3, MergedPath, I2>, H<E4, MergedPath, I3, R>]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I3['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I3['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x4)
   <
@@ -459,11 +447,7 @@ export interface HandlerInterface<
       H<E4, MergedPath, I3>,
       H<E5, MergedPath, I4, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I4['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I4['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x5)
   <
@@ -489,11 +473,7 @@ export interface HandlerInterface<
       H<E5, MergedPath, I4>,
       H<E6, MergedPath, I5, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I5['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I5['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x6)
   <
@@ -522,11 +502,7 @@ export interface HandlerInterface<
       H<E6, MergedPath, I5>,
       H<E7, MergedPath, I6, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I6['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I6['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x7)
   <
@@ -558,11 +534,7 @@ export interface HandlerInterface<
       H<E7, MergedPath, I6>,
       H<E8, MergedPath, I7, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I7['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I7['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x8)
   <
@@ -597,11 +569,7 @@ export interface HandlerInterface<
       H<E8, MergedPath, I7>,
       H<E9, MergedPath, I8, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8, E9]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I8['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I8['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x9)
   <
@@ -639,11 +607,7 @@ export interface HandlerInterface<
       H<E9, MergedPath, I8>,
       H<E10, MergedPath, I9, R>
     ]
-  ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8, E9, E10]>,
-    S & ToSchema<M, MergePath<BasePath, P>, I9['in'], MergeTypedResponseData<R>>,
-    BasePath
-  >
+  ): Hono<E, S & ToSchema<M, MergePath<BasePath, P>, I9['in'], MergeTypedResponseData<R>>, BasePath>
 
   // app.get(path, handler x10)
   <
@@ -685,7 +649,7 @@ export interface HandlerInterface<
       H<E11, MergedPath, I10, R>
     ]
   ): Hono<
-    IntersectNonAnyTypes<[E, E2, E3, E4, E5, E6, E7, E8, E9, E10, E11]>,
+    E,
     S & ToSchema<M, MergePath<BasePath, P>, I10['in'], MergeTypedResponseData<R>>,
     BasePath
   >