diff --git a/src/coreclr/jit/compiler.cpp b/src/coreclr/jit/compiler.cpp
index 968d9eb9716413..d0f775b9efc157 100644
--- a/src/coreclr/jit/compiler.cpp
+++ b/src/coreclr/jit/compiler.cpp
@@ -9539,6 +9539,11 @@ void cTreeFlags(Compiler* comp, GenTree* tree)
                 {
                     chars += printf("[BOX_VALUE]");
                 }
+
+                if (tree->gtFlags & GTF_BOX_CLONED)
+                {
+                    chars += printf("[BOX_CLONED]");
+                }
                 break;
 
             case GT_ARR_ADDR:
diff --git a/src/coreclr/jit/gentree.cpp b/src/coreclr/jit/gentree.cpp
index 8381c11b026c51..65809969a120b2 100644
--- a/src/coreclr/jit/gentree.cpp
+++ b/src/coreclr/jit/gentree.cpp
@@ -8508,6 +8508,8 @@ GenTree* Compiler::gtCloneExpr(
                 copy = new (this, GT_BOX)
                     GenTreeBox(tree->TypeGet(), tree->AsOp()->gtOp1, tree->AsBox()->gtAsgStmtWhenInlinedBoxValue,
                                tree->AsBox()->gtCopyStmtWhenInlinedBoxValue);
+                tree->AsBox()->SetCloned();
+                copy->AsBox()->SetCloned();
                 break;
 
             case GT_INTRINSIC:
@@ -13612,6 +13614,13 @@ GenTree* Compiler::gtTryRemoveBoxUpstreamEffects(GenTree* op, BoxRemovalOptions
         return nullptr;
     }
 
+    // If this box is no longer single-use, bail.
+    if (box->WasCloned())
+    {
+        JITDUMP(" bailing; unsafe to remove box that has been cloned\n");
+        return nullptr;
+    }
+
     // If we're eventually going to return the type handle, remember it now.
     GenTree* boxTypeHandle = nullptr;
     if ((options == BR_REMOVE_AND_NARROW_WANT_TYPE_HANDLE) || (options == BR_DONT_REMOVE_WANT_TYPE_HANDLE))
diff --git a/src/coreclr/jit/gentree.h b/src/coreclr/jit/gentree.h
index a088f4c2241b70..e9d512e16c6d18 100644
--- a/src/coreclr/jit/gentree.h
+++ b/src/coreclr/jit/gentree.h
@@ -543,6 +543,7 @@ enum GenTreeFlags : unsigned int
     GTF_QMARK_CAST_INSTOF       = 0x80000000, // GT_QMARK -- Is this a top (not nested) level qmark created for
                                               //             castclass or instanceof?
 
+    GTF_BOX_CLONED              = 0x40000000, // GT_BOX -- this box and its operand has been cloned, cannot assume it to be single-use anymore
     GTF_BOX_VALUE               = 0x80000000, // GT_BOX -- "box" is on a value type
 
     GTF_ARR_ADDR_NONNULL        = 0x80000000, // GT_ARR_ADDR -- this array's address is not null
@@ -3874,6 +3875,16 @@ struct GenTreeBox : public GenTreeUnOp
     {
     }
 #endif
+
+    bool WasCloned()
+    {
+        return (gtFlags & GTF_BOX_CLONED) != 0;
+    }
+
+    void SetCloned()
+    {
+        gtFlags |= GTF_BOX_CLONED;
+    }
 };
 
 // GenTreeField -- data member ref (GT_FIELD)